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1 April 2017
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Estrogen receptor expression and response to antiendocrine therapy in luminal breast cancer are dependent on fibroblast subtypes present in the tumor microenvironment. The cover shows strong estrogen receptor alpha staining (red) in luminal breast cancer cells (green) supported by the presence of CD146pos fibroblasts. For details, see the article by Brechbuhl and colleagues on page 1710 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Drug Updates
CCR Focus
Cancer Therapy: Clinical
Effects of Budesonide on Cabazitaxel Pharmacokinetics and Cabazitaxel-Induced Diarrhea: A Randomized, Open-Label Multicenter Phase II Study
Annemieke J.M. Nieuweboer; Anne-Joy M. de Graan; Paul Hamberg; Sander Bins; Robert J. van Soest; Robbert J. van Alphen; Andries M. Bergman; Aart Beeker; Henk van Halteren; Albert J. ten Tije; Hanneke Zuetenhorst; Nelly van der Meer; Dana Chitu; Ronald de Wit; Ron H.J. Mathijssen; on behalf of the Dutch Uro-Oncology Studygroup (DUOS)
Time-Degenerative Factors and the Risk of Hepatocellular Carcinoma after Antiviral Therapy among Hepatitis C Virus Patients: A Model for Prioritization of Treatment
Ming-Lung Yu; Chung-Feng Huang; Ming-Lun Yeh; Pei-Chien Tsai; Ching-I. Huang; Meng-Hsuan Hsieh; Ming-Yen Hsieh; Zu-Yau Lin; Shinn-Cherng Chen; Jee-Fu Huang; Chia-Yen Dai; Wan-Long Chuang
Personalized Medicine and Imaging
Author Choice
Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
Heather M. Brechbuhl; Jessica Finlay-Schultz; Tomomi M. Yamamoto; Austin E. Gillen; Diana M. Cittelly; Aik-Choon Tan; Sharon B. Sams; Manoj M. Pillai; Anthony D. Elias; William A. Robinson; Carol A. Sartorius; Peter Kabos
Author Choice
Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters
Anders Carlsson; Peter Kuhn; Madelyn S. Luttgen; Kevin Keomanee-Dizon; Patricia Troncoso; Paul G. Corn; Anand Kolatkar; James B. Hicks; Christopher J. Logothetis; Amado J. Zurita
Cancer Therapy: Preclinical
The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway
Katia Beider; Evgenia Rosenberg; Hanna Bitner; Avichai Shimoni; Merav Leiba; Maya Koren-Michowitz; Elena Ribakovsky; Shiri Klein; Devorah Olam; Lola Weiss; Hanna Wald; Michal Abraham; Eithan Galun; Amnon Peled; Arnon Nagler
Author Choice
Liver Microvascular Injury and Thrombocytopenia of Antibody–Calicheamicin Conjugates in Cynomolgus Monkeys—Mechanism and Monitoring
Magali Guffroy; Hadi Falahatpisheh; Kathleen Biddle; John Kreeger; Leslie Obert; Karen Walters; Richard Goldstein; Germaine Boucher; Timothy Coskran; William Reagan; Danielle Sullivan; Chunli Huang; Sharon Sokolowski; Richard Giovanelli; Hans-Peter Gerber; Martin Finkelstein; Nasir Khan
Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma
Lori S. Hart; JulieAnn Rader; Pichai Raman; Vandana Batra; Mike R. Russell; Matthew Tsang; Maria Gagliardi; Lucy Chen; Daniel Martinez; Yimei Li; Andrew Wood; Sunkyu Kim; Sudha Parasuraman; Scott Delach; Kristina A. Cole; Shiva Krupa; Markus Boehm; Malte Peters; Giordano Caponigro; John M. Maris
Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression
Heather Nesbitt; Niall M. Byrne; S. Nicole Williams; Louise Ming; Jenny Worthington; Rachel J. Errington; Laurence H. Patterson; Paul J. Smith; Stephanie R. McKeown; Declan J. McKenna
BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection—Implications for Oncolytic Viral Therapy
Chelsea Bolyard; W. Hans Meisen; Yeshavanth Banasavadi-Siddegowda; Jayson Hardcastle; Ji Young Yoo; Eric S. Wohleb; Jeffrey Wojton; Jun-Ge Yu; Samuel Dubin; Maninder Khosla; Bo Xu; Jonathan Smith; Christopher Alvarez-Breckenridge; Pete Pow-anpongkul; Flavia Pichiorri; Jianying Zhang; Matthew Old; Dan Zhu; Erwin G. Van Meir; Jonathan P. Godbout; Michael A. Caligiuri; Jianhua Yu; Balveen Kaur
Biology of Human Tumors
Author Choice
The T-cell Receptor Repertoire Influences the Tumor Microenvironment and Is Associated with Survival in Aggressive B-cell Lymphoma
Colm Keane; Clare Gould; Kimberley Jones; David Hamm; Dipti Talaulikar; Jonathan Ellis; Frank Vari; Simone Birch; Erica Han; Peter Wood; Kim-Anh Le-Cao; Michael R. Green; Pauline Crooks; Sanjiv Jain; Josh Tobin; Raymond J. Steptoe; Maher K. Gandhi
Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer
Johannes Brägelmann; Niklas Klümper; Anne Offermann; Anne von Mässenhausen; Diana Böhm; Mario Deng; Angela Queisser; Christine Sanders; Isabella Syring; Axel S. Merseburger; Wenzel Vogel; Elisabeth Sievers; Ignacija Vlasic; Jessica Carlsson; Ove Andrén; Peter Brossart; Stefan Duensing; Maria A. Svensson; David Adler; Jutta Kirfel; Sven Perner
Landscape of Genomic Alterations in Pituitary Adenomas
Wenya Linda Bi; Peleg Horowitz; Noah F. Greenwald; Malak Abedalthagafi; Pankaj K. Agarwalla; Wiliam J. Gibson; Yu Mei; Steven E. Schumacher; Uri Ben-David; Aaron Chevalier; Scott Carter; Grace Tiao; Priscilla K. Brastianos; Azra H. Ligon; Matthew Ducar; Laura MacConaill; Edward R. Laws, Jr; Sandro Santagata; Rameen Beroukhim; Ian F. Dunn
Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors
Amy L. Sherborne; Vincent Lavergne; Katharine Yu; Leah Lee; Philip R. Davidson; Tali Mazor; Ivan V. Smirnoff; Andrew E. Horvai; Mignon Loh; Steven G. DuBois; Robert E. Goldsby; Joseph P. Neglia; Sue Hammond; Leslie L. Robison; Rosanna Wustrack; Joseph F. Costello; Alice O. Nakamura; Kevin M. Shannon; Smita Bhatia; Jean L. Nakamura
Author Choice
Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition
George Au-Yeung; Franziska Lang; Walid J. Azar; Chris Mitchell; Kate E. Jarman; Kurt Lackovic; Diar Aziz; Carleen Cullinane; Richard B. Pearson; Linda Mileshkin; Danny Rischin; Alison M. Karst; Ronny Drapkin; Dariush Etemadmoghadam; David D.L. Bowtell
Correction
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