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15 March 2017
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Cover Image
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The cover shows an area of a human pancreatic ductal adenocarcinoma with moderate tumor cellularity stained with Movat's pentachrome staining visualizing tumor cells (red), intratumoral collagen fibres (yellow) and mucin/ground substance (blue). For details, see the article by Heid and colleagues on page 1461 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Molecular Pathways
Review
Cancer Therapy: Clinical
Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells
Chad Tang; James W. Welsh; Patricia de Groot; Erminia Massarelli; Joe Y. Chang; Kenneth R. Hess; Sreyashi Basu; Michael A. Curran; Maria E. Cabanillas; Vivek Subbiah; Siqing Fu; Apostolia M. Tsimberidou; Daniel Karp; Daniel R. Gomez; Adi Diab; Ritsuko Komaki; John V. Heymach; Padmanee Sharma; Aung Naing; David S. Hong
Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer
Jung-Min Lee; Cody J. Peer; Minshu Yu; Lauren Amable; Nicolas Gordon; Christina M. Annunziata; Nicole Houston; Andrew K.L. Goey; Tristan M. Sissung; Bernard Parker; Lori Minasian; Victoria L. Chiou; Robert F. Murphy; Brigitte C. Widemann; William D. Figg; Elise C. Kohn
Clinical Trial Characteristics and Barriers to Participant Accrual: The MD Anderson Cancer Center Experience over 30 years, a Historical Foundation for Trial Improvement
Chad Tang; Steven I. Sherman; Mellanie Price; Jun Weng; Suzanne E. Davis; David S. Hong; James C. Yao; Aman Buzdar; George Wilding; J. Jack Lee
Personalized Medicine and Imaging
Serum Metabolomic Profiles Identify ER-Positive Early Breast Cancer Patients at Increased Risk of Disease Recurrence in a Multicenter Population
Christopher D. Hart; Alessia Vignoli; Leonardo Tenori; Gemma Leonora Uy; Ta Van To; Clement Adebamowo; Syed Mozammel Hossain; Laura Biganzoli; Emanuela Risi; Richard R. Love; Claudio Luchinat; Angelo Di Leo
Author Choice
18F-fluoromisonidazole PET and Activity of Neoadjuvant Nintedanib in Early HER2-Negative Breast Cancer: A Window-of-Opportunity Randomized Trial
Miguel Quintela-Fandino; Ana Lluch; Luis Manso; Isabel Calvo; Javier Cortes; José Angel García-Saenz; Miguel Gil-Gil; Noelia Martinez-Jánez; Antonio Gonzalez-Martin; Encarna Adrover; Raquel de Andres; Gemma Viñas; Antonio Llombart-Cussac; Emilio Alba; Juan Guerra; Begoña Bermejo; Esther Zamora; Fernando Moreno-Anton; Sonia Pernas Simon; Alfredo Carrato; Antonio Lopez-Alonso; María José Escudero; Ruth Campo; Eva Carrasco; José Palacios; Francisca Mulero; Ramon Colomer
Identification of Keratin 19–Positive Cancer Stem Cells Associating Human Hepatocellular Carcinoma Using 18F-Fluorodeoxyglucose Positron Emission Tomography
Takayuki Kawai; Kentaro Yasuchika; Satoru Seo; Tatsuya Higashi; Takamichi Ishii; Yuya Miyauchi; Hidenobu Kojima; Ryoya Yamaoka; Hokahiro Katayama; Elena Yukie Yoshitoshi; Satoshi Ogiso; Sadahiko Kita; Katsutaro Yasuda; Ken Fukumitsu; Yuji Nakamoto; Etsuro Hatano; Shinji Uemoto
Co-clinical Assessment of Tumor Cellularity in Pancreatic Cancer
Irina Heid; Katja Steiger; Marija Trajkovic-Arsic; Marcus Settles; Manuela R. Eßwein; Mert Erkan; Jörg Kleeff; Carsten Jäger; Helmut Friess; Bernhard Haller; Andreas Steingötter; Roland M. Schmid; Markus Schwaiger; Ernst J. Rummeny; Irene Esposito; Jens T. Siveke; Rickmer F. Braren
Cancer Therapy: Preclinical
UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia Models
Deborah DeRyckere; Alisa B. Lee-Sherick; Madeline G. Huey; Amanda A. Hill; Jeffrey W. Tyner; Kristen M. Jacobsen; Lauren S. Page; Gregory G. Kirkpatrick; Fatma Eryildiz; Stephanie A. Montgomery; Weihe Zhang; Xiaodong Wang; Stephen V. Frye; H. Shelton Earp; Douglas K. Graham
The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia–Microenvironment Interactions in Chronic Lymphocytic Leukemia
Alba Matas-Céspedes; Anna Vidal-Crespo; Vanina Rodriguez; Neus Villamor; Julio Delgado; Eva Giné; Heleia Roca-Ho; Pablo Menéndez; Elías Campo; Armando López-Guillermo; Dolors Colomer; Gaël Roué; Adrian Wiestner; Paul W.H.I. Parren; Parul Doshi; Jeroen Lammerts van Bueren; Patricia Pérez-Galán
Author Choice
MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies
Liqin Liu; Chia-Ying K. Lam; Vatana Long; Lusiana Widjaja; Yinhua Yang; Hua Li; Linda Jin; Steve Burke; Sergey Gorlatov; Jennifer Brown; Ralph Alderson; Margaret D. Lewis; Jeffrey L. Nordstrom; Scott Koenig; Paul A. Moore; Syd Johnson; Ezio Bonvini
Author Choice
Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus
Mohanraj Ramachandran; Di Yu; Matheus Dyczynski; Sathishkumar Baskaran; Lei Zhang; Aleksei Lulla; Valeria Lulla; Sirle Saul; Sven Nelander; Anna Dimberg; Andres Merits; Justyna Leja-Jarblad; Magnus Essand
AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non–Small Cell Lung Cancer Cells Following EGFR Inhibition
Hannah A. Scarborough; Barbara A. Helfrich; Matias Casás-Selves; Alwin G. Schuller; Shaun E. Grosskurth; Jihye Kim; Aik-Choon Tan; Daniel C. Chan; Zhiyong Zhang; Vadym Zaberezhnyy; Paul A. Bunn; James DeGregori
Author Choice
Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer
Ying Chen; Sandra Catalina Camacho; Thomas R. Silvers; Albiruni R.A. Razak; Nashat Y. Gabrail; John F. Gerecitano; Eva Kalir; Elena Pereira; Brad R. Evans; Susan J. Ramus; Fei Huang; Nolan Priedigkeit; Estefania Rodriguez; Michael Donovan; Faisal Khan; Tamara Kalir; Robert Sebra; Andrew Uzilov; Rong Chen; Rileen Sinha; Richard Halpert; Jean-Noel Billaud; Sharon Shacham; Dilara McCauley; Yosef Landesman; Tami Rashal; Michael Kauffman; Mansoor R. Mirza; Morten Mau-Sørensen; Peter Dottino; John A. Martignetti
Biology of Human Tumors
Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Phu Hung Nguyen; Julie Giraud; Lucie Chambonnier; Pierre Dubus; Linda Wittkop; Geneviève Belleannée; Denis Collet; Isabelle Soubeyran; Serge Evrard; Benoit Rousseau; Nathalie Senant-Dugot; Francis Mégraud; Frédéric Mazurier; Christine Varon
Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival
Joo Young Kim; Jacqueline A. Brosnan-Cashman; Soyeon An; Sung Joo Kim; Ki-Byung Song; Min-Sun Kim; Mi-Ju Kim; Dae Wook Hwang; Alan K. Meeker; Eunsil Yu; Song Cheol Kim; Ralph H. Hruban; Christopher M. Heaphy; Seung-Mo Hong
Author Choice
Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer
Yi Zhong; Anne Macgregor-Das; Tyler Saunders; Martin C. Whittle; Alvin Makohon-Moore; Zachary A. Kohutek; Justin Poling; Brian T. Herbst; Breanna M. Javier; Leslie Cope; Steven D. Leach; Sunil R. Hingorani; Christine A. Iacobuzio-Donahue
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