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Volume 23, Issue 5
1 March 2017
Clinical Cancer Research Cover Image for Volume 23, Issue 5
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  • Cover Image

    Cover Image

    issue cover
    The cover shows a micrograph of the intracranial subventricular zone of an 11-day-old mouse that was injected 10 days prior with DNA encoding NRAS and SV40-LgT to generate glioblastoma. Cells expressing the chemokine CXCL12 are shown in magenta. Some of these cells have taken up the DNA, as evidenced by expression of SV40-LgT (green). For details see the article by Calinescu and colleagues on page 1250 of this issue.
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
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CCR Translations

Author Choice
Combining Molecularly Targeted Agents: Is More Always Better?
Raghav Sundar; Nicola Valeri; Kevin J. Harrington; Timothy A. Yap
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CCR New Strategies

New Strategies in Metastatic Hormone Receptor–Positive Breast Cancer: Searching for Biomarkers to Tailor Endocrine and Other Targeted Therapies
Rachel C. Jankowitz; Steffi Oesterreich; Adrian V. Lee; Nancy E. Davidson
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Molecular Pathways

Molecular Pathways: The Necrosome—A Target for Cancer Therapy
Lena Seifert; George Miller
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Review

Author Choice
Exploring the Benefit/Risk Associated with Antiangiogenic Agents for the Treatment of Non–Small Cell Lung Cancer Patients
Razelle Kurzrock; David J. Stewart
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Clinical Trial Brief Report

Author Choice
Extended Treatment with Single-Agent Ibrutinib at the 420 mg Dose Leads to Durable Responses in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Steven E. Coutré; Richard R. Furman; Ian W. Flinn; Jan A. Burger; Kristie Blum; Jeff Sharman; Jeffrey Jones; William Wierda; Weiqiang Zhao; Nyla A. Heerema; Amy J. Johnson; Anh Tran; Cathy Zhou; Elizabeth Bilotti; Danelle F. James; John C. Byrd; Susan O'Brien
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Cancer Therapy: Clinical

Author Choice
Autologous T Cells Expressing CD30 Chimeric Antigen Receptors for Relapsed or Refractory Hodgkin Lymphoma: An Open-Label Phase I Trial
Chun-Meng Wang; Zhi-Qiang Wu; Yao Wang; Ye-Lei Guo; Han-Ren Dai; Xiao-Hui Wang; Xiang Li; Ya-Jing Zhang; Wen-Ying Zhang; Mei-Xia Chen; Yan Zhang; Kai-Chao Feng; Yang Liu; Su-Xia Li; Qing-Ming Yang; Wei-Dong Han
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Phase I Study of the Anti-CD22 Antibody–Drug Conjugate Pinatuzumab Vedotin with/without Rituximab in Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Ranjana H. Advani; Daniel Lebovic; Andy Chen; Mark Brunvand; Andre Goy; Julie E. Chang; Ephraim Hochberg; Sreeni Yalamanchili; Robert Kahn; Dan Lu; Priya Agarwal; Randall C. Dere; Hsin-Ju Hsieh; Surai Jones; Yu-Waye Chu; Bruce D. Cheson
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Author Choice
A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors
Emiliano Calvo; Jean-Charles Soria; Wen Wee Ma; Tao Wang; Rastilav Bahleda; Anthony W. Tolcher; Diana Gernhardt; Joseph O'Connell; Robert Millham; Nagdeep Giri; Michael J. Wick; Alex A. Adjei; Manuel Hidalgo
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Safety and Pharmacodynamics of the PDE4 Inhibitor Roflumilast in Advanced B-cell Malignancies
Kevin Kelly; Alex Mejia; Avvaru N. Suhasini; An-Ping Lin; John Kuhn; Anand B. Karnad; Steven Weitman; Ricardo C.T. Aguiar
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Author Choice
Intratumor Heterogeneity of Homologous Recombination Deficiency in Primary Breast Cancer
Marie-Kristin von Wahlde; Kirsten M. Timms; Anees Chagpar; Vikram B. Wali; Tingting Jiang; Veerle Bossuyt; Ozlen Saglam; Julia Reid; Alexander Gutin; Chris Neff; Jerry S. Lanchbury; Christos Hatzis; Erin Hofstatter; Lajos Pusztai
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Personalized Medicine and Imaging

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer
Manuela Salvucci; Maximilian L. Würstle; Clare Morgan; Sarah Curry; Mattia Cremona; Andreas U. Lindner; Orna Bacon; Alexa J. Resler; Áine C. Murphy; Robert O'Byrne; Lorna Flanagan; Sonali Dasgupta; Nadege Rice; Camilla Pilati; Elisabeth Zink; Lisa M. Schöller; Sinead Toomey; Mark Lawler; Patrick G. Johnston; Richard Wilson; Sophie Camilleri-Broët; Manuel Salto-Tellez; Deborah A. McNamara; Elaine W. Kay; Pierre Laurent-Puig; Sandra Van Schaeybroeck; Bryan T. Hennessy; Daniel B. Longley; Markus Rehm; Jochen H.M. Prehn
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A Threshold of Systemic MAGE-A Gene Expression Predicting Survival in Resected Non–Small Cell Lung Cancer
Ingo Mecklenburg; Wulf Sienel; Severin Schmid; Bernward Passlick; Peter Kufer
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Author Choice
Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer
Julie George; Motonobu Saito; Koji Tsuta; Reika Iwakawa; Kouya Shiraishi; Andreas H. Scheel; Shinsuke Uchida; Shun-ichi Watanabe; Ryo Nishikawa; Masayuki Noguchi; Martin Peifer; Se Jin Jang; Iver Petersen; Reinhard Büttner; Curtis C. Harris; Jun Yokota; Roman K. Thomas; Takashi Kohno
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Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy
María Apellániz-Ruiz; Héctor Tejero; Lucía Inglada-Pérez; Lara Sánchez-Barroso; Gerardo Gutiérrez-Gutiérrez; Isabel Calvo; Beatriz Castelo; Andrés Redondo; Jesús García-Donás; Nuria Romero-Laorden; María Sereno; María Merino; María Currás-Freixes; Cristina Montero-Conde; Veronika Mancikova; Elisabeth Åvall-Lundqvist; Henrik Green; Fátima Al-Shahrour; Alberto Cascón; Mercedes Robledo; Cristina Rodríguez-Antona
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BRCA1-Mutated Estrogen Receptor–Positive Breast Cancer Shows BRCAness, Suggesting Sensitivity to Drugs Targeting Homologous Recombination Deficiency
Esther H. Lips; Rashmie D. Debipersad; Caroline E. Scheerman; Lennart Mulder; Gabe S. Sonke; Lizet E. van der Kolk; Jelle Wesseling; Frans B.L. Hogervorst; Petra M. Nederlof
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Cancer Therapy: Preclinical

Plerixafor Improves Primary Tumor Response and Reduces Metastases in Cervical Cancer Treated with Radio-Chemotherapy
Naz Chaudary; Melania Pintilie; Salomeh Jelveh; Patricia Lindsay; Richard P. Hill; Michael Milosevic
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Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism
Anda-Alexandra Calinescu; Viveka Nand Yadav; Erica Carballo; Padma Kadiyala; Dustin Tran; Daniel B. Zamler; Robert Doherty; Maithreyi Srikanth; Pedro Ricardo Lowenstein; Maria Graciela Castro
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Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics
Joyce F. Liu; Sangeetha Palakurthi; Qing Zeng; Shan Zhou; Elena Ivanova; Wei Huang; Ioannis K. Zervantonakis; Laura M. Selfors; Yiping Shen; Colin C. Pritchard; Mei Zheng; Vilmos Adleff; Eniko Papp; Huiying Piao; Marian Novak; Susan Fotheringham; Gerburg M. Wulf; Jessie English; Paul T. Kirschmeier; Victor E. Velculescu; Cloud Paweletz; Gordon B. Mills; David M. Livingston; Joan S. Brugge; Ursula A. Matulonis; Ronny Drapkin
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Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative
Tine Cuppens; Daniela Annibali; An Coosemans; Jone Trovik; Natalja ter Haar; Eva Colas; Angel Garcia-Jimenez; Koen Van de Vijver; Roy P.M. Kruitwagen; Mariël Brinkhuis; Michal Zikan; Pavel Dundr; Jutta Huvila; Olli Carpén; Johannes Haybaeck; Farid Moinfar; Helga B. Salvesen; Maciej Stukan; Carole Mestdagh; Ronald P. Zweemer; Leonardus F. Massuger; Michael R. Mallmann; Eva Wardelmann; Miriam Mints; Godelieve Verbist; Debby Thomas; Ellen Gommé; Els Hermans; Philippe Moerman; Tjalling Bosse; Frédéric Amant
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PI3K–mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models
Fan Lin; Mark C. de Gooijer; Diana Hanekamp; Gayathri Chandrasekaran; Levi C.M. Buil; Nishita Thota; Rolf W. Sparidans; Jos H. Beijnen; Tom Würdinger; Olaf van Tellingen
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Biology of Human Tumors

Essential Role of DNA Methyltransferase 1–mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors
Hye-Young Min; Su-Chan Lee; Jong Kyu Woo; Hyun Jin Jung; Kwan Hee Park; Hae Min Jeong; Seung Yeob Hyun; Jaebeom Cho; Wooin Lee; Ji Eun Park; So Jung Kwon; Hyo-Jong Lee; Xiao Ni; Young Kee Shin; Faye M. Johnson; Madeleine Duvic; Ho-Young Lee
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Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer
Kunitoshi Shigeyasu; Yoshinaga Okugawa; Shusuke Toden; C. Richard Boland; Ajay Goel
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Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis
Martin Pichler; Verena Stiegelbauer; Petra Vychytilova-Faltejskova; Cristina Ivan; Hui Ling; Elke Winter; Xinna Zhang; Matthew Goblirsch; Annika Wulf-Goldenberg; Masahisa Ohtsuka; Johannes Haybaeck; Marek Svoboda; Yoshinaga Okugawa; Armin Gerger; Gerald Hoefler; Ajay Goel; Ondrej Slaby; George Adrian Calin
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Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RETM918T Tumors
Veronika Mancikova; Cristina Montero-Conde; Javier Perales-Paton; Agustin Fernandez; María Santacana; Karolina Jodkowska; Lucia Inglada-Pérez; Esmeralda Castelblanco; Salud Borrego; Mario Encinas; Xavier Matias-Guiu; Mario Fraga; Mercedes Robledo
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Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer
Santosh Gupta; Jing Li; Gabor Kemeny; Rhonda L. Bitting; Joshua Beaver; Jason A. Somarelli; Kathryn E. Ware; Simon Gregory; Andrew J. Armstrong
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Corrections

Correction: PAK1 Is a Novel Therapeutic Target in Tyrosine Kinase Inhibitor–Resistant Lung Adenocarcinoma Activated by the PI3K/AKT Signaling Regardless of EGFR Mutation
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Correction: Bortezomib Treatment Sensitizes Oncolytic HSV-1–Treated Tumors to NK Cell Immunotherapy
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Correction: PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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