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15 December 2017
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Cover Image
Cover Image
The cover shows a section of a HBCx-22 AR/ER+ breast cancer patient-derived xenograft. Immunohistochemical staining shows AR expression in both the cytoplasm and the nuclei. For details, see the article by Yu and colleagues on page 7608 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Statistics in CCR
CCR Drug Updates
FDA Approval Summary: Trabectedin for Unresectable or Metastatic Liposarcoma or Leiomyosarcoma Following an Anthracycline-Containing Regimen
Amy Barone; Dow-Chung Chi; Marc R. Theoret; Huanyu Chen; Kun He; Dubravka Kufrin; Whitney S. Helms; Sriram Subramaniam; Hong Zhao; Anuja Patel; Kirsten B. Goldberg; Patricia Keegan; Richard Pazdur
Cancer Therapy: Clinical
Author Choice
A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non–small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations
Helena A. Yu; Alexander Spira; Leora Horn; Jared Weiss; Howard West; Giuseppe Giaccone; Tracey Evans; Ronan J. Kelly; Bhardwaj Desai; Andrew Krivoshik; Diarmuid Moran; Srinivasu Poondru; Fei Jie; Kouji Aoyama; Anne Keating; Geoffrey R. Oxnard
Immune Activation in Early-Stage Non–Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab
John S. Yi; Neal Ready; Patrick Healy; Chelsae Dumbauld; Robyn Osborne; Mark Berry; Debra Shoemaker; Jeffrey Clarke; Jeffrey Crawford; Betty Tong; David Harpole; Thomas A. D'Amico; Frances McSherry; Frank Dunphy; Shannon J. McCall; Jared D. Christensen; Xiaofei Wang; Kent J. Weinhold
A Randomized Phase II Trial of Adjuvant Galinpepimut-S, WT-1 Analogue Peptide Vaccine, After Multimodality Therapy for Patients with Malignant Pleural Mesothelioma
Marjorie G. Zauderer; Anne S. Tsao; Tao Dao; Katherine Panageas; W. Victoria Lai; Andreas Rimner; Valerie W. Rusch; Prasad S. Adusumilli; Michelle S. Ginsberg; Daniel Gomez; David Rice; Reza Mehran; David A. Scheinberg; Lee M. Krug
A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors
Antonio Jimeno; Michael Gordon; Rashmi Chugh; Wells Messersmith; David Mendelson; Jakob Dupont; Robert Stagg; Ann M. Kapoun; Lu Xu; Shailaja Uttamsingh; Rainer K. Brachmann; David C. Smith
Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab
Jakub Krejcik; Kris A. Frerichs; Inger S. Nijhof; Berris van Kessel; Jeroen F. van Velzen; Andries C. Bloem; Marloes E.C. Broekmans; Sonja Zweegman; Johan van Meerloo; René J.P. Musters; Pino J. Poddighe; Richard W.J. Groen; Christopher Chiu; Torben Plesner; Henk M. Lokhorst; A. Kate Sasser; Tuna Mutis; Niels W.C.J. van de Donk
Personalized Medicine and Imaging
Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts
Arian Lundberg; Linda S. Lindström; J. Chuck Harrell; Claudette Falato; Joseph W. Carlson; Paul K. Wright; Theodoros Foukakis; Charles M. Perou; Kamila Czene; Jonas Bergh; Nicholas P. Tobin
Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer
Eric Y. Zhao; Yaoqing Shen; Erin Pleasance; Katayoon Kasaian; Sreeja Leelakumari; Martin Jones; Pinaki Bose; Carolyn Ch'ng; Caralyn Reisle; Peter Eirew; Richard Corbett; Karen L. Mungall; Nina Thiessen; Yussanne Ma; Jacqueline E. Schein; Andrew J. Mungall; Yongjun Zhao; Richard A. Moore; Wendie Den Brok; Sheridan Wilson; Diego Villa; Tamara Shenkier; Caroline Lohrisch; Stephen Chia; Stephen Yip; Karen Gelmon; Howard Lim; Daniel Renouf; Sophie Sun; Kasmintan A. Schrader; Sean Young; Ian Bosdet; Aly Karsan; Janessa Laskin; Marco A. Marra; Steven J.M. Jones
Author Choice
Pharmacogenetic Analysis of the UK MRC (Medical Research Council) MAGIC Trial: Association of Polymorphisms with Toxicity and Survival in Patients Treated with Perioperative Epirubicin, Cisplatin, and 5-fluorouracil (ECF) Chemotherapy
Elizabeth Smyth; Shenli Zhang; David Cunningham; Andrew Wotherspoon; Richie Soong; Clare Peckitt; Nicola Valeri; Matteo Fassan; Massimo Rugge; Alicia Okines; William Allum; Sally Stenning; Matthew Nankivell; Ruth Langley; Patrick Tan
Common TDP1 Polymorphisms in Relation to Survival among Small Cell Lung Cancer Patients: A Multicenter Study from the International Lung Cancer Consortium
Pawadee Lohavanichbutr; Lori C. Sakoda; Christopher I. Amos; Susanne M. Arnold; David C. Christiani; Michael P.A. Davies; John K. Field; Eric B. Haura; Rayjean J. Hung; Takashi Kohno; Maria Teresa Landi; Geoffrey Liu; Yi Liu; Michael W. Marcus; Grainne M. O'Kane; Matthew B. Schabath; Kouya Shiraishi; Stacey A. Slone; Adonina Tardón; Ping Yang; Kazushi Yoshida; Ruyang Zhang; Xuchen Zong; Gary E. Goodman; Noel S. Weiss; Chu Chen
Cancer Therapy: Preclinical
Author Choice
Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia
Amit Budhraja; Meghan E. Turnis; Michelle L. Churchman; Anisha Kothari; Xue Yang; Haiyan Xu; Ewa Kaminska; John C. Panetta; David Finkelstein; Charles G. Mullighan; Joseph T. Opferman
CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors
Irene M. Min; Enda Shevlin; Yogindra Vedvyas; Marjan Zaman; Brian Wyrwas; Theresa Scognamiglio; Maureen D. Moore; Weibin Wang; Susan Park; Spencer Park; Suraj Panjwani; Katherine D. Gray; Andrew B. Tassler; Rasa Zarnegar; Thomas J. Fahey, III; Moonsoo M. Jin
Author Choice
Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors
James T. Lynch; Urszula M. Polanska; Oona Delpuech; Urs Hancox; Antonio G. Trinidad; Filippos Michopoulos; Carol Lenaghan; Robert McEwen; James Bradford; Radek Polanski; Rebecca Ellston; Alvaro Avivar-Valderas; James Pilling; Anna Staniszewska; Marie Cumberbatch; Susan E. Critchlow; Francisco Cruzalegui; Simon T. Barry
Mutational Analysis of Gene Fusions Predicts Novel MHC Class I–Restricted T-Cell Epitopes and Immune Signatures in a Subset of Prostate Cancer
Jennifer L. Kalina; David S. Neilson; Yen-Yi Lin; Phineas T. Hamilton; Alexandra P. Comber; Emma M.H. Loy; S. Cenk Sahinalp; Colin C. Collins; Faraz Hach; Julian J. Lum
Biology of Human Tumors
Author Choice
A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer
Caroline Kreuzinger; Angelika Geroldinger; Dominiek Smeets; Elena Ioana Braicu; Jalid Sehouli; Julia Koller; Andrea Wolf; Silvia Darb-Esfahani; Korinna Joehrens; Ignace Vergote; Adriaan Vanderstichele; Bram Boeckx; Diether Lambrechts; Hani Gabra; G. Bea A. Wisman; Fabian Trillsch; Georg Heinze; Reinhard Horvat; Stephan Polterauer; Els Berns; Charles Theillet; Dan Cacsire Castillo-Tong
The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma
Susanna L. Cooke; Darren Ennis; Lisa Evers; Suzanne Dowson; Mei Yen Chan; James Paul; Lynn Hirschowitz; Rosalind M. Glasspool; Naveena Singh; Sarah Bell; Elizabeth Day; Agata Kochman; Nafisa Wilkinson; Philip Beer; Sancha Martin; David Millan; Andrew V. Biankin; Iain A. McNeish; On Behalf of the Scottish Genomes Partnership
Author Choice
Head and Neck Squamous Cell Carcinomas Are Characterized by a Stable Immune Signature Within the Primary Tumor Over Time and Space
Oliver Wood; James Clarke; Jeongmin Woo; Adal H. Mirza; Christopher H. Woelk; Gareth J. Thomas; Pandurangan Vijayanand; Emma King; Christian H. Ottensmeier
Acknowledgment to Reviewers
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