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1 December 2017
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Cover Image
Cover Image
The cover shows a section of a colorectal tumor tissue of an AOM/DSS-induced Pld1+/+ mouse. Immunohistochemical staining shows low ICAT expression within a tumor. For details, see the article by Kang and colleagues on page 7340 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Statistics in CCR
CCR Drug Updates
FDA Approval Summary: Rucaparib for the Treatment of Patients with Deleterious BRCA Mutation–Associated Advanced Ovarian Cancer
Sanjeeve Balasubramaniam; Julia A. Beaver; Sara Horton; Laura L. Fernandes; Shenghui Tang; Hisani N. Horne; Jinzhong Liu; Chao Liu; Sarah J. Schrieber; Jingyu Yu; Pengfei Song; William Pierce; Kim J. Robertson; Todd R. Palmby; Haw-Jyh Chiu; Eunice Y. Lee; Reena Philip; Robert Schuck; Rosane Charlab; Anamitro Banerjee; Xiao Hong Chen; Xing Wang; Kirsten B. Goldberg; Rajeshwari Sridhara; Geoffrey Kim; Richard Pazdur
Cancer Therapy: Clinical
Therapeutic Drug Monitoring of Carboplatin in High-Dose Protocol (TI-CE) for Advanced Germ Cell Tumors: Pharmacokinetic Results of a Phase II Multicenter Study
Sotheara Moeung; Christine Chevreau; Sophie Broutin; Jérôme Guitton; Bénédicte Lelièvre; Joseph Ciccolini; Christophe Massart; Aude Fléchon; Rémy Delva; Gwenaëlle Gravis; Jean-Pierre Lotz; Jacques-Olivier Bay; Marine Gross-Goupil; Angelo Paci; Sabrina Marsili; Laurence Malard; Etienne Chatelut; Fabienne Thomas
Phase III Clinical Trial (RERISE study) Results of Efficacy and Safety of Radotinib Compared with Imatinib in Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia
Jae-Yong Kwak; Sung-Hyun Kim; Suk Joong Oh; Dae Young Zang; Hawk Kim; Jeong-A Kim; Young Rok Do; Hyeoung Joon Kim; Joon Seong Park; Chul Won Choi; Won Sik Lee; Yeung-Chul Mun; Jee Hyun Kong; Joo Seop Chung; Ho-Jin Shin; Dae-Young Kim; Jinny Park; Chul Won Jung; Udomsak Bunworasate; Narcisa Sonia Comia; Saengsuree Jootar; Arry Harryanto Reksodiputro; Priscilla B. Caguioa; Sung-Eun Lee; Dong-Wook Kim
High BCR–ABL/GUSIS Levels at Diagnosis of Chronic Phase CML Are Associated with Unfavorable Responses to Standard-Dose Imatinib
Paolo Vigneri; Fabio Stagno; Stefania Stella; Alessandra Cupri; Stefano Forte; Michele Massimino; Agostino Antolino; Sergio Siragusa; Donato Mannina; Stefana Stella Impera; Caterina Musolino; Alessandra Malato; Giuseppe Mineo; Carmela Tomaselli; Pamela Murgano; Maurizio Musso; Fortunato Morabito; Stefano Molica; Bruno Martino; Livia Manzella; Martin C. Müller; Andreas Hochhaus; Francesco Di Raimondo
Immunomodulation by Entinostat in Renal Cell Carcinoma Patients Receiving High-Dose Interleukin 2: A Multicenter, Single-Arm, Phase I/II Trial (NCI-CTEP#7870)
Roberto Pili; David I. Quinn; Hans J. Hammers; Paul Monk; Saby George; Tanya B. Dorff; Thomas Olencki; Li Shen; Ashley Orillion; Dominick Lamonica; Roberto S. Fragomeni; Zsolt Szabo; Alan Hutson; Adrienne Groman; Susan M. Perkins; Richard Piekarz; Michael A. Carducci
Personalized Medicine and Imaging
PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients
Nicholas P. Tobin; for the TEX Trialists Group; Arian Lundberg; for the TEX Trialists Group; Linda S. Lindström; for the TEX Trialists Group; J. Chuck Harrell; for the TEX Trialists Group; Theodoros Foukakis; for the TEX Trialists Group; Lena Carlsson; for the TEX Trialists Group; Zakaria Einbeigi; for the TEX Trialists Group; Barbro K. Linderholm; for the TEX Trialists Group; Niklas Loman; for the TEX Trialists Group; Martin Malmberg; for the TEX Trialists Group; Mårten Fernö; for the TEX Trialists Group; Kamila Czene; for the TEX Trialists Group; Charles M. Perou; for the TEX Trialists Group; Jonas Bergh; for the TEX Trialists Group; Thomas Hatschek; for the TEX Trialists Group
Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma
Jeroen Depreeuw; Ellen Stelloo; Elisabeth M. Osse; Carien L. Creutzberg; Remi A. Nout; Matthieu Moisse; Diego A. Garcia-Dios; Michael Dewaele; Karen Willekens; Jean-Christophe Marine; Xavier Matias-Guiu; Frédéric Amant; Diether Lambrechts; Tjalling Bosse
Cancer Therapy: Preclinical
4-1BB Agonist Focuses CD8+ Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer
Donastas Sakellariou-Thompson; Marie-Andrée Forget; Caitlin Creasy; Vincent Bernard; Li Zhao; Young Uk Kim; Mark W. Hurd; Naohiro Uraoka; Edwin Roger Parra; Ya'an Kang; Christopher A. Bristow; Jaime Rodriguez-Canales; Jason B. Fleming; Gauri Varadhachary; Milind Javle; Michael J. Overman; Hector A. Alvarez; Timothy P. Heffernan; Jianhua Zhang; Patrick Hwu; Anirban Maitra; Cara Haymaker; Chantale Bernatchez
Author Choice
Demethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer
Asel Biktasova; Michael Hajek; Andrew Sewell; Cyril Gary; Gary Bellinger; Hari A. Deshpande; Aarti Bhatia; Barbara Burtness; Benjamin Judson; Saral Mehra; Wendell G. Yarbrough; Natalia Issaeva
Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma
Christine M. Heske; Mindy I. Davis; Joshua T. Baumgart; Kelli Wilson; Michael V. Gormally; Lu Chen; Xiaohu Zhang; Michele Ceribelli; Damien Y. Duveau; Rajarshi Guha; Marc Ferrer; Fernanda I. Arnaldez; Jiuping Ji; Huong-Lan Tran; Yiping Zhang; Arnulfo Mendoza; Lee J. Helman; Craig J. Thomas
Biology of Human Tumors
Discrimination of Germline EGFR T790M Mutations in Plasma Cell-Free DNA Allows Study of Prevalence Across 31,414 Cancer Patients
Yuebi Hu; Ryan S. Alden; Justin I. Odegaard; Stephen R. Fairclough; Ruthia Chen; Jennifer Heng; Nora Feeney; Rebecca J. Nagy; Jayshree Shah; Bryan Ulrich; Martin Gutierrez; Richard B. Lanman; Judy E. Garber; Cloud P. Paweletz; Geoffrey R. Oxnard
CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Tony Avril; Amandine Etcheverry; Raphaël Pineau; Joanna Obacz; Gwénaële Jegou; Florence Jouan; Pierre-Jean Le Reste; Masumeh Hatami; Rivka R. Colen; Brett L. Carlson; Paul A. Decker; Jann N. Sarkaria; Elodie Vauléon; Dan Cristian Chiforeanu; Anne Clavreul; Jean Mosser; Eric Chevet; Véronique Quillien
BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer
Víctor G. Martínez; Carolina Rubio; Mónica Martínez-Fernández; Cristina Segovia; Fernando López-Calderón; Marina I. Garín; Alicia Teijeira; Ester Munera-Maravilla; Alberto Varas; Rosa Sacedón; Félix Guerrero; Felipe Villacampa; Federico de la Rosa; Daniel Castellano; Eduardo López-Collazo; Jesús M. Paramio; Ángeles Vicente; Marta Dueñas
In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets
Elsa Arbajian; Florian Puls; Cristina R. Antonescu; Fernanda Amary; Raf Sciot; Maria Debiec-Rychter; Vaiyapuri P. Sumathi; Marcus Järås; Linda Magnusson; Jenny Nilsson; Jakob Hofvander; Fredrik Mertens
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