Skip Nav Destination
Issues
15 November 2017
-
Cover Image
Cover Image
The cover shows a section of a MET-amplified patient-derived xenograft analyzed by MET:GRB2 proximity ligation assay. Analysis of MET:GRB2 signaling-associated complexes may help predict response to MET tyrosine kinase inhbitors. For details, see the article by Smith and colleagues on page 7084 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Drug Updates
Review
Cancer Therapy: Clinical
Author Choice
Low-Dose Cyclophosphamide Induces Antitumor T-Cell Responses, which Associate with Survival in Metastatic Colorectal Cancer
Martin Scurr; Tom Pembroke; Anja Bloom; David Roberts; Amanda Thomson; Kathryn Smart; Hayley Bridgeman; Richard Adams; Alison Brewster; Robert Jones; Sarah Gwynne; Daniel Blount; Richard Harrop; Robert Hills; Awen Gallimore; Andrew Godkin
Author Choice
Genomic Characterization of Vulvar (Pre)cancers Identifies Distinct Molecular Subtypes with Prognostic Significance
Linda S. Nooij; Natalja T. ter Haar; Dina Ruano; Natalia Rakislova; Tom van Wezel; Vincent T.H.B.M. Smit; Baptist J.B.M.Z. Trimbos; Jaume Ordi; Mariette I.E. van Poelgeest; Tjalling Bosse
Author Choice
Single Dose of the CXCR4 Antagonist BL-8040 Induces Rapid Mobilization for the Collection of Human CD34+ Cells in Healthy Volunteers
Michal Abraham; Yaron Pereg; Baruch Bulvik; Shiri Klein; Inbal Mishalian; Hana Wald; Orly Eizenberg; Katia Beider; Arnon Nagler; Rottem Golan; Abi Vainstein; Arnon Aharon; Eithan Galun; Yoseph Caraco; Reuven Or; Amnon Peled
Author Choice
Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy
Himisha Beltran; Alexander W. Wyatt; Edmund C. Chedgy; Adam Donoghue; Matti Annala; Evan W. Warner; Kevin Beja; Michael Sigouros; Fan Mo; Ladan Fazli; Colin C. Collins; James Eastham; Michael Morris; Mary-Ellen Taplin; Andrea Sboner; Susan Halabi; Martin E. Gleave
Expression of PD-L1 in Hormone-naïve and Treated Prostate Cancer Patients Receiving Neoadjuvant Abiraterone Acetate plus Prednisone and Leuprolide
Carla Calagua; Joshua Russo; Yue Sun; Rachel Schaefer; Rosina Lis; Zhenwei Zhang; Kathleen Mahoney; Glenn J. Bubley; Massimo Loda; Mary-Ellen Taplin; Steven P. Balk; Huihui Ye
A Phase II Trial of Neoadjuvant MK-2206, an AKT Inhibitor, with Anastrozole in Clinical Stage II or III PIK3CA-Mutant ER-Positive and HER2-Negative Breast Cancer
Cynthia X. Ma; Vera Suman; Matthew P. Goetz; Donald Northfelt; Mark E. Burkard; Foluso Ademuyiwa; Michael Naughton; Julie Margenthaler; Rebecca Aft; Richard Gray; Amye Tevaarwerk; Lee Wilke; Tufia Haddad; Timothy Moynihan; Charles Loprinzi; Tina Hieken; Erica K. Barnell; Zachary L. Skidmore; Yan-Yang Feng; Kilannin Krysiak; Jeremy Hoog; Zhanfang Guo; Leslie Nehring; Kari B. Wisinski; Elaine Mardis; Ian S. Hagemann; Kiran Vij; Souzan Sanati; Hussam Al-Kateb; Obi L. Griffith; Malachi Griffith; Laurence Doyle; Charles Erlichman; Matthew J. Ellis
Author Choice
Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury
Christopher R. Heery; Claudia Palena; Sheri McMahon; Renee N. Donahue; Lauren M. Lepone; Italia Grenga; Ulrike Dirmeier; Lisa Cordes; Jenn Marté; William Dahut; Harpreet Singh; Ravi A. Madan; Romaine I. Fernando; Duane H. Hamilton; Jeffrey Schlom; James L. Gulley
Author Choice
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Jörg Felsberg; Bettina Hentschel; Kerstin Kaulich; Dorothee Gramatzki; Angela Zacher; Bastian Malzkorn; Marcel Kamp; Michael Sabel; Matthias Simon; Manfred Westphal; Gabriele Schackert; Jörg C. Tonn; Torsten Pietsch; Andreas von Deimling; Markus Loeffler; Guido Reifenberger; Michael Weller; for the German Glioma Network
Personalized Medicine and Imaging
MSH2 Loss in Primary Prostate Cancer
Liana B. Guedes; Emmanuel S. Antonarakis; Michael T. Schweizer; Nooshin Mirkheshti; Fawaz Almutairi; Jong Chul Park; Stephanie Glavaris; Jessica Hicks; Mario A. Eisenberger; Angelo M. De Marzo; Jonathan I. Epstein; William B. Isaacs; James R. Eshleman; Colin C. Pritchard; Tamara L. Lotan
Cancer Therapy: Preclinical
Author Choice
Frequent Genetic Aberrations in the CDK4 Pathway in Acral Melanoma Indicate the Potential for CDK4/6 Inhibitors in Targeted Therapy
Yan Kong; Xinan Sheng; Xiaowen Wu; Junya Yan; Meng Ma; Jiayi Yu; Lu Si; Zhihong Chi; Chuanliang Cui; Jie Dai; Yiqian Li; Huan Yu; Tianxiao Xu; Huan Tang; Bixia Tang; Lili Mao; Bin Lian; Xuan Wang; Xieqiao Yan; Siming Li; Jun Guo
Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms
Inan Olmez; Breanna Brenneman; Aizhen Xiao; Vlad Serbulea; Mouadh Benamar; Ying Zhang; Laryssa Manigat; Tarek Abbas; Jeongwu Lee; Ichiro Nakano; Jakub Godlewski; Agnieszka Bronisz; Roger Abounader; Norbert Leitinger; Benjamin Purow
Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
Laura Simon; Vincent-Philippe Lavallée; Marie-Eve Bordeleau; Jana Krosl; Irène Baccelli; Geneviève Boucher; Bernhard Lehnertz; Jalila Chagraoui; Tara MacRae; Réjean Ruel; Yves Chantigny; Sébastien Lemieux; Anne Marinier; Josée Hébert; Guy Sauvageau
Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer
MohammadA Sabbaghi; Gabriel Gil-Gómez; Cristina Guardia; Sonia Servitja; Oriol Arpí; Sara García-Alonso; Silvia Menendez; Montserrat Arumi-Uria; Laia Serrano; Marta Salido; Aura Muntasell; Maria Martínez-García; Sandra Zazo; Cristina Chamizo; Paula González-Alonso; Juan Madoz-Gúrpide; Pilar Eroles; Joaquin Arribas; Ignasi Tusquets; Ana Lluch; Atanasio Pandiella; Federico Rojo; Ana Rovira; Joan Albanell
Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice
Marina Pajic; Sohvi Blatter; Charlotte Guyader; Maaike Gonggrijp; Ariena Kersbergen; Aslι Küçükosmanoğlu; Wendy Sol; Rinske Drost; Jos Jonkers; Piet Borst; Sven Rottenberg
Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression
Heather J. Dalton; Sunila Pradeep; Michael McGuire; Yared Hailemichael; Shaolin MA; Yasmin Lyons; Guillermo N. Armaiz-Pena; Rebecca A. Previs; Jean Marie Hansen; Rajesha Rupaimoole; Vianey Gonzalez-Villasana; Min Soon Cho; Sherry Y. Wu; Lingegowda S. Mangala; Nicholas B. Jennings; Wei Hu; Robert Langley; Hong Mu; Michael Andreeff; Menashe Bar-Eli; Willem Overwijk; Prahlad Ram; Gabriel Lopez-Berestein; Robert L. Coleman; Anil K. Sood
Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFNβ in Glioblastomas
Sung Hugh Choi; Daniel W. Stuckey; Sara Pignatta; Clemens Reinshagen; Jasneet Kaur Khalsa; Nicolaas Roozendaal; Jordi Martinez-Quintanilla; Kaoru Tamura; Erhan Keles; Khalid Shah
Biology of Human Tumors
Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival
Gaëlle Müller-Greven; Cathleen R. Carlin; Monica E. Burgett; Manmeet S. Ahluwalia; Adam Lauko; Amy S. Nowacki; Cameron J. Herting; Maha A. Qadan; Markus Bredel; Steven A. Toms; Justin D. Lathia; Dolores Hambardzumyan; Jann N. Sarkaria; Petra Hamerlik; Candece L. Gladson
TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup
David P. Labbé; Christopher J. Sweeney; Myles Brown; Phillip Galbo; Spencer Rosario; Kristine M. Wadosky; Sheng-Yu Ku; Martin Sjöström; Mohammed Alshalalfa; Nicholas Erho; Elai Davicioni; R. Jeffrey Karnes; Edward M. Schaeffer; Robert B. Jenkins; Robert B. Den; Ashley E. Ross; Michaela Bowden; Ying Huang; Kathryn P. Gray; Felix Y. Feng; Daniel E. Spratt; David W. Goodrich; Kevin H. Eng; Leigh Ellis
MET–GRB2 Signaling-Associated Complexes Correlate with Oncogenic MET Signaling and Sensitivity to MET Kinase Inhibitors
Matthew A. Smith; Thomas Licata; Aliya Lakhani; Marileila Varella Garcia; Hans-Ulrich Schildhaus; Vincent Vuaroqueaux; Balazs Halmos; Alain C. Borczuk; Y. Ann Chen; Benjamin C. Creelan; Theresa A. Boyle; Eric B. Haura
MITF-High and MITF-Low Cells and a Novel Subpopulation Expressing Genes of Both Cell States Contribute to Intra- and Intertumoral Heterogeneity of Primary Melanoma
Marie Ennen; Céline Keime; Giovanni Gambi; Alice Kieny; Sebastien Coassolo; Christelle Thibault-Carpentier; Fanny Margerin-Schaller; Guillaume Davidson; Constance Vagne; Dan Lipsker; Irwin Davidson
Author Choice
Downregulation of SAFB Sustains the NF-κB Pathway by Targeting TAK1 during the Progression of Colorectal Cancer
Hong-Li Jiao; Ya-Ping Ye; Run-Wei Yang; Hui-Ying Sun; Shu-Yang Wang; Yong-Xia Wang; Zhi-Yuan Xiao; Liu-Qing He; Juan-Juan Cai; Wen-Ting Wei; Yan-Ru Chen; Chun-Cai Gu; Yue-Long Cai; Yun-Teng Hu; Qiu-Hua Lai; Jun-Feng Qiu; Li Liang; Guang-Wen Cao; Wen-Ting Liao; Yan-Qing Ding
Antagonism of EG-VEGF Receptors as Targeted Therapy for Choriocarcinoma Progression In Vitro and In Vivo
Wael Traboulsi; Frédéric Sergent; Houssine Boufettal; Sophie Brouillet; Rima Slim; Pascale Hoffmann; Mohammed Benlahfid; Qun Y. Zhou; Gianfranco Balboni; Valentina Onnis; Pierre A. Bolze; Aude Salomon; Philippe Sauthier; François Mallet; Touria Aboussaouira; Jean J. Feige; Mohamed Benharouga; Nadia Alfaidy
A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non–Small Cell Lung Cancer and Serum DNA
Akira Ooki; Zahra Maleki; Jun-Chieh J. Tsay; Chandra Goparaju; Mariana Brait; Nitesh Turaga; Hae-Seong Nam; William N. Rom; Harvey I. Pass; David Sidransky; Rafael Guerrero-Preston; Mohammad Obaidul Hoque
Advertisement
