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1 November 2017
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Cover Image
The cover shows a section of low-grade serous ovarian carcinoma. Inhibition of neurotensin receptor 1 in ovarian cancer is correlated with higher carboplatin response. For details, see the article by Liu and colleagues on page 6516 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
CCR Pediatric Oncology Series: Articles from the AACR Childhood Cancer Predisposition Workshop
Highlights of This Issue
CCR Translations
CCR Drug Updates
Molecular Pathways
Cancer Therapy: Clinical
Differential Toxicity in Patients with and without DNA Repair Mutations: Phase I Study of Carboplatin and Talazoparib in Advanced Solid Tumors
Mallika S. Dhawan; Imke H. Bartelink; Rahul Raj Aggarwal; Jim Leng; Jenna Z. Zhang; Nela Pawlowska; Manuela Terranova-Barberio; Jennifer A. Grabowsky; Andrew Gewitz; Amy J. Chien; Mark Moasser; Robin K. Kelley; Tayeba Maktabi; Scott Thomas; Pamela N. Munster
Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies
Philippe Aftimos; Christian Rolfo; Sylvie Rottey; Fritz Offner; Dominique Bron; Marie Maerevoet; Jean-Charles Soria; Mahan Moshir; Torsten Dreier; Luc Van Rompaey; Jean-Marie Michot; Karen Silence; Anna Hultberg; Domenica Gandini; Hans de Haard; Vincent Ribrag; Marc Peeters; Alain Thibault; Nicolas Leupin; Ahmad Awada
Author Choice
Outcome of Azacitidine Therapy in Acute Myeloid Leukemia Is not Improved by Concurrent Vorinostat Therapy but Is Predicted by a Diagnostic Molecular Signature
Charles F. Craddock; Aimee E. Houlton; Lynn Swun Quek; Paul Ferguson; Emma Gbandi; Corran Roberts; Marlen Metzner; Natalia Garcia-Martin; Alison Kennedy; Angela Hamblin; Manoj Raghavan; Sandeep Nagra; Louise Dudley; Keith Wheatley; Mary Frances McMullin; Srinivas P. Pillai; Richard J. Kelly; Shamyla Siddique; Michael Dennis; Jamie D. Cavenagh; Paresh Vyas
Author Choice
A Pilot Trial of Humanized Anti-GD2 Monoclonal Antibody (hu14.18K322A) with Chemotherapy and Natural Killer Cells in Children with Recurrent/Refractory Neuroblastoma
Sara M. Federico; M. Beth McCarville; Barry L. Shulkin; Paul M. Sondel; Jacquelyn A. Hank; Paul Hutson; Michael Meagher; Aaron Shafer; Catherine Y. Ng; Wing Leung; William E. Janssen; Jianrong Wu; Shenghua Mao; Rachel C. Brennan; Victor M. Santana; Alberto S. Pappo; Wayne L. Furman
Personalized Medicine and Imaging
Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment
Elena Martinez-Garcia; Antoine Lesur; Laura Devis; Silvia Cabrera; Xavier Matias-Guiu; Marc Hirschfeld; Jasmin Asberger; Jan van Oostrum; María de los Ángeles Casares de Cal; Antonio Gómez-Tato; Jaume Reventos; Bruno Domon; Eva Colas; Antonio Gil-Moreno
A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors
Kurt W. Evans; Erkan Yuca; Argun Akcakanat; Stephen M. Scott; Natalia Paez Arango; Xiaofeng Zheng; Ken Chen; Coya Tapia; Emily Tarco; Agda K. Eterovic; Dalliah M. Black; Jennifer K. Litton; Timothy A. Yap; Debu Tripathy; Gordon B. Mills; Funda Meric-Bernstam
An Integrative Scoring System for Survival Prediction Following Umbilical Cord Blood Transplantation in Acute Leukemia
Roni Shouval; Annalisa Ruggeri; Myriam Labopin; Mohamad Mohty; Guillermo Sanz; Gerard Michel; Jürgen Kuball; Patrice Chevallier; Amal Al-Seraihy; Noel-Jean Milpied; Cristina Diaz de Heredia; William Arcese; Didier Blaise; Vanderson Rocha; Joshua Fein; Ron Unger; Frederic Baron; Peter Bader; Eliane Gluckman; Arnon Nagler
Author Choice
Circulating Tumor DNA Reveals Clinically Actionable Somatic Genome of Metastatic Bladder Cancer
Gillian Vandekerkhove; Tilman Todenhöfer; Matti Annala; Werner J. Struss; Amanda Wong; Kevin Beja; Elie Ritch; Sonal Brahmbhatt; Stanislav V. Volik; Jörg Hennenlotter; Matti Nykter; Kim N. Chi; Scott North; Arnulf Stenzl; Colin C. Collins; Bernhard J. Eigl; Peter C. Black; Alexander W. Wyatt
Cancer Therapy: Preclinical
Neurotensin Receptor 1 Antagonist SR48692 Improves Response to Carboplatin by Enhancing Apoptosis and Inhibiting Drug Efflux in Ovarian Cancer
Jin Liu; Mikaël Agopiantz; Joël Poupon; Zherui Wu; Pierre-Alexandre Just; Bruno Borghese; Evelyne Ségal-Bendirdjian; Guillaume Gauchotte; Anne Gompel; Patricia Forgez
Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer
Robert Cornelison; Zachary C. Dobbin; Ashwini A. Katre; Dae Hoon Jeong; Yinfeng Zhang; Dongquan Chen; Yuliya Petrova; Danielle C. Llaneza; Adam D. Steg; Laura Parsons; David A. Schneider; Charles N. Landen
Author Choice
Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation
Noriaki Tanaka; Ameeta A. Patel; Lin Tang; Natalie L. Silver; Antje Lindemann; Hideaki Takahashi; Roman Jaksik; Xiayu Rao; Nene N. Kalu; Tseng-Cheng Chen; Jiping Wang; Mitchell J. Frederick; Faye Johnson; Frederico O. Gleber-Netto; Siqing Fu; Marek Kimmel; Jing Wang; Walter N. Hittelman; Curtis R. Pickering; Jeffrey N. Myers; Abdullah A. Osman
Author Choice
In Vivo Validation of PAPSS1 (3′-phosphoadenosine 5′-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target
Ada W.Y. Leung; Chansey J. Veinotte; Nicole Melong; Min Hee Oh; Kent Chen; Katey S.S. Enfield; Ian Backstrom; Corinna Warburton; Donald Yapp; Jason N. Berman; Marcel B. Bally; William W. Lockwood
Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation
Puyu Shi; You-Take Oh; Liang Deng; Guojing Zhang; Guoqing Qian; Shuo Zhang; Hui Ren; Grant Wu; Benjamin Legendre, Jr; Emily Anderson; Suresh S. Ramalingam; Taofeek K. Owonikoko; Mingwei Chen; Shi-Yong Sun
The Phosphatidylinositol 3-Kinase Pathway as a Potential Therapeutic Target in Bladder Cancer
Shu-Xiong Zeng; Yanjun Zhu; Ai-Hong Ma; Weimin Yu; Hongyong Zhang; Tzu-Yin Lin; Wei Shi; Clifford G. Tepper; Paul T. Henderson; Susan Airhart; Jian-Ming Guo; Chuan-Liang Xu; Ralph W. deVere White; Chong-Xian Pan
Preclinical Evaluation of Intravesical Cisplatin Nanoparticles for Non–Muscle-Invasive Bladder Cancer
Max Kates; Abhijit Date; Takahiro Yoshida; Umara Afzal; Pranjali Kanvinde; Taarika Babu; Nikolai A. Sopko; Hotaka Matsui; Noah M. Hahn; David J. McConkey; Alexander Baras; Justin Hanes; Laura Ensign; Trinity J. Bivalacqua
Amiloride, An Old Diuretic Drug, Is a Potential Therapeutic Agent for Multiple Myeloma
Elizabeta A. Rojas; Luis Antonio Corchete; Laura San-Segundo; Juan F. Martínez-Blanch; Francisco M. Codoñer; Teresa Paíno; Noemí Puig; Ramón García-Sanz; María Victoria Mateos; Enrique M. Ocio; Irena Misiewicz-Krzeminska; Norma C. Gutiérrez
Biology of Human Tumors
p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy
Myrthala Moreno-Smith; Anna Lakoma; Zaowen Chen; Ling Tao; Kathleen A. Scorsone; Linda Schild; Kevin Aviles-Padilla; Rana Nikzad; Yankai Zhang; Rikhia Chakraborty; Jan J. Molenaar; Sanjeev A. Vasudevan; Vivien Sheehan; Eugene S. Kim; Silke Paust; Jason M. Shohet; Eveline Barbieri
Author Choice
Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival
Lijie Zhai; Erik Ladomersky; Kristen L. Lauing; Meijing Wu; Matthew Genet; Galina Gritsina; Balázs Győrffy; Priscilla K. Brastianos; David C. Binder; Jeffrey A. Sosman; Francis J. Giles; Charles D. James; Craig Horbinski; Roger Stupp; Derek A. Wainwright
Author Choice
Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models
Lars D. Engstrom; Ruth Aranda; Matthew Lee; Elizabeth A. Tovar; Curt J. Essenburg; Zachary Madaj; Harrah Chiang; David Briere; Jill Hallin; Pedro P. Lopez-Casas; Natalia Baños; Camino Menendez; Manuel Hidalgo; Vanessa Tassell; Richard Chao; Darya I. Chudova; Richard B. Lanman; Peter Olson; Lyudmilla Bazhenova; Sandip Pravin Patel; Carrie Graveel; Mizuki Nishino; Geoffrey I. Shapiro; Nir Peled; Mark M. Awad; Pasi A. Jänne; James G. Christensen
Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape
Zixing Wang; Tae Beom Kim; Bo Peng; Jose Karam; Chad Creighton; Aron Joon; Fumi Kawakami; Patricia Trevisan; Eric Jonasch; Chi-Wan Chow; Jaime Rodriguez Canales; Pheroze Tamboli; Nizar Tannir; Christopher Wood; Federico Monzon; Keith Baggerly; Marileila Varella-Garcia; Bogdan Czerniak; Ignacio Wistuba; Gordon Mills; Kenna Shaw; Ken Chen; Kanishka Sircar
Author Choice
Dasatinib Reversibly Disrupts Endothelial Vascular Integrity by Increasing Non-Muscle Myosin II Contractility in a ROCK-Dependent Manner
Anna Kreutzman; Beatriz Colom-Fernández; Ana Marcos Jiménez; Mette Ilander; Carlos Cuesta-Mateos; Yaiza Pérez-García; Cristina Delgado Arévalo; Oscar Brück; Henna Hakanen; Jani Saarela; Alvaro Ortega-Carrión; Ana de Rosendo; Alba Juanes-García; Juan Luis Steegmann; Satu Mustjoki; Miguel Vicente-Manzanares; Cecilia Muñoz-Calleja
Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer
Britta Weigelt; Iñaki Comino-Méndez; Ino de Bruijn; Lei Tian; Jane L. Meisel; Isaac García-Murillas; Charlotte Fribbens; Ros Cutts; Luciano G. Martelotto; Charlotte K.Y. Ng; Raymond S. Lim; Pier Selenica; Salvatore Piscuoglio; Carol Aghajanian; Larry Norton; Rajmohan Murali; David M. Hyman; Laetitia Borsu; Maria E. Arcila; Jason Konner; Jorge S. Reis-Filho; Roger A. Greenberg; Mark E. Robson; Nicholas C. Turner
Author Choice
Burden and Profile of Somatic Mutation in Duodenal Adenomas from Patients with Familial Adenomatous- and MUTYH-associated Polyposis
Laura E. Thomas; Joanna J. Hurley; Elena Meuser; Sian Jose; Kevin E. Ashelford; Matthew Mort; Shelley Idziaszczyk; Julie Maynard; Helena Leon Brito; Manon Harry; Angharad Walters; Meera Raja; Sarah-Jane Walton; Sunil Dolwani; Geraint T. Williams; Meleri Morgan; Morgan Moorghen; Susan K. Clark; Julian R. Sampson
Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance
Amber E. Bannon; Jason Kent; Isaac Forquer; Ajia Town; Lillian R. Klug; Kelly McCann; Carol Beadling; Oliver Harismendy; Jason K. Sicklick; Christopher Corless; Ujwal Shinde; Michael C. Heinrich
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