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15 January 2017
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Cover Image
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The cover shows a tumor subclone derived from a clinical glioblastoma sample giving rise to multinucleated giant cells in vitro. Immunofluorescence depicts expression of βIII-tubulin (green) and glial fibrillary acidic protein (GFAP, red). Cellular nuclei were DAPI stained. For details, see the article by Reinartz and colleagues on page 562 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
U.S. Food and Drug Administration Approval: Cabozantinib for the Treatment of Advanced Renal Cell Carcinoma
Harpreet Singh; Michael Brave; Julia A. Beaver; Joyce Cheng; Shenghui Tang; Eias Zahalka; Todd R. Palmby; Rajesh Venugopal; Pengfei Song; Qi Liu; Chao Liu; Jingyu Yu; Xiao Hong Chen; Xing Wang; Yaning Wang; Paul G. Kluetz; Selena R. Daniels; Elektra J. Papadopoulos; Rajeshwari Sridhara; Amy E. McKee; Amna Ibrahim; Geoffrey Kim; Richard Pazdur
Molecular Pathways
Review
Cancer Therapy: Clinical
Branched Chain RNA In Situ Hybridization for Androgen Receptor Splice Variant AR-V7 as a Prognostic Biomarker for Metastatic Castration-Sensitive Prostate Cancer
Philip J. Saylor; Richard J. Lee; Kshitij S. Arora; Vikram Deshpande; Rong Hu; Kara Olivier; Erika Meneely; Miguel N. Rivera; David T. Ting; Chin-Lee Wu; David T. Miyamoto
Personalized Medicine and Imaging
Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer
Heather A. Parsons; Julia A. Beaver; Ashley Cimino-Mathews; Siraj M. Ali; Jennifer Axilbund; David Chu; Roisin M. Connolly; Rory L. Cochran; Sarah Croessmann; Travis A. Clark; Christopher D. Gocke; Stacie C. Jeter; Mark R. Kennedy; Josh Lauring; Justin Lee; Doron Lipson; Vincent A. Miller; Geoff A. Otto; Gary L. Rosner; Jeffrey S. Ross; Shannon Slater; Philip J. Stephens; Dustin A. VanDenBerg; Antonio C. Wolff; Lauren E. Young; Daniel J. Zabransky; Zhe Zhang; Jane Zorzi; Vered Stearns; Ben H. Park
Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry
Anne Trinh; Kari Trumpi; Felipe De Sousa E Melo; Xin Wang; Joan H. de Jong; Evelyn Fessler; Peter J.K. Kuppen; Marlies S. Reimers; Marloes Swets; Miriam Koopman; Iris D. Nagtegaal; Marnix Jansen; Gerrit K.J. Hooijer; George J.A. Offerhaus; Onno Kranenburg; Cornelis J. Punt; Jan Paul Medema; Florian Markowetz; Louis Vermeulen
Estrogen Receptor Binding (18F-FES PET) and Glycolytic Activity (18F-FDG PET) Predict Progression-Free Survival on Endocrine Therapy in Patients with ER+ Breast Cancer
Brenda F. Kurland; Lanell M. Peterson; Jean H. Lee; Erin K. Schubert; Erin R. Currin; Jeanne M. Link; Kenneth A. Krohn; David A. Mankoff; Hannah M. Linden
Cancer Therapy: Preclinical
Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target
Alfredo Perales-Puchalt; Nikolaos Svoronos; Melanie R. Rutkowski; Michael J. Allegrezza; Amelia J. Tesone; Kyle K. Payne; Jayamanna Wickramasinghe; Jenny M. Nguyen; Shane W. O'Brien; Kiranmai Gumireddy; Qihong Huang; Mark G. Cadungog; Denise C. Connolly; Julia Tchou; Tyler J. Curiel; Jose R. Conejo-Garcia
PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors
Adrian M. Seifert; Shan Zeng; Jennifer Q. Zhang; Teresa S. Kim; Noah A. Cohen; Michael J. Beckman; Benjamin D. Medina; Joanna H. Maltbaek; Jennifer K. Loo; Megan H. Crawley; Ferdinand Rossi; Peter Besmer; Cristina R. Antonescu; Ronald P. DeMatteo
Preclinical Assessment of CD171-Directed CAR T-cell Adoptive Therapy for Childhood Neuroblastoma: CE7 Epitope Target Safety and Product Manufacturing Feasibility
Annette Künkele; Agne Taraseviciute; Laura S. Finn; Adam J. Johnson; Carolina Berger; Olivia Finney; Cindy A. Chang; Lisa S. Rolczynski; Christopher Brown; Stephanie Mgebroff; Michael Berger; Julie R. Park; Michael C. Jensen
Targeting Alpha-Fetoprotein (AFP)–MHC Complex with CAR T-Cell Therapy for Liver Cancer
Hong Liu; Yiyang Xu; Jingyi Xiang; Li Long; Shon Green; Zhiyuan Yang; Bryan Zimdahl; Jingwei Lu; Neal Cheng; Lucas H. Horan; Bin Liu; Su Yan; Pei Wang; Juan Diaz; Lu Jin; Yoko Nakano; Javier F. Morales; Pengbo Zhang; Lian-xing Liu; Binnaz K. Staley; Saul J. Priceman; Christine E. Brown; Stephen J. Forman; Vivien W. Chan; Cheng Liu
IL-21 Enhances Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells
Elizabeth L. McMichael; Alena Cristina Jaime-Ramirez; Kristan D. Guenterberg; Eric Luedke; Lakhvir S. Atwal; Amanda R. Campbell; Zhiwei Hu; Armika S. Tatum; Sri Vidya Kondadasula; Xiaokui Mo; Susheela Tridandapani; Mark Bloomston; E. Christopher Ellison; Terence M. Williams; Tanios Bekaii-Saab; William E. Carson, III
RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer
Yajing Liu; Monika L. Burness; Rachel Martin-Trevino; Joey Guy; Shoumin Bai; Ramdane Harouaka; Michael D. Brooks; Li Shang; Alex Fox; Tahra K. Luther; April Davis; Trenton L. Baker; Justin Colacino; Shawn G. Clouthier; Zhi-ming Shao; Max S. Wicha; Suling Liu
PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer
Benjamin H. Lok; Eric E. Gardner; Valentina E. Schneeberger; Andy Ni; Patrice Desmeules; Natasha Rekhtman; Elisa de Stanchina; Beverly A. Teicher; Nadeem Riaz; Simon N. Powell; John T. Poirier; Charles M. Rudin
Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Rafael Duran; Sahar Mirpour; Vasily Pekurovsky; Shanmugasundaram Ganapathy-Kanniappan; Cory F. Brayton; Toby C. Cornish; Boris Gorodetski; Juvenal Reyes; Julius Chapiro; Rüdiger E. Schernthaner; Constantine Frangakis; MingDe Lin; Jessica D. Sun; Charles P. Hart; Jean-François Geschwind
ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet–associated Colon Cancer
Reba Mustafi; Urszula Dougherty; Devkumar Mustafi; Fatma Ayaloglu-Butun; Michelle Fletcher; Sarbani Adhikari; Farhana Sadiq; Katherine Meckel; Haider I. Haider; Abdurahman Khalil; Joel Pekow; Vani Konda; Loren Joseph; John Hart; Alessandro Fichera; Yan Chun Li; Marc Bissonnette
Biology of Human Tumors
Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma
Roman Reinartz; Shanshan Wang; Sied Kebir; Daniel J. Silver; Anja Wieland; Tong Zheng; Marius Küpper; Laurèl Rauschenbach; Rolf Fimmers; Timothy M. Shepherd; Daniel Trageser; Andreas Till; Niklas Schäfer; Martin Glas; Axel M. Hillmer; Sven Cichon; Amy A. Smith; Torsten Pietsch; Ying Liu; Brent A. Reynolds; Anthony Yachnis; David W. Pincus; Matthias Simon; Oliver Brüstle; Dennis A. Steindler; Björn Scheffler
Author Choice
Genetic and Methylation-Induced Loss of miR-181a2/181b2 within chr9q33.3 Facilitates Tumor Growth of Cervical Cancer through the PIK3R3/Akt/FoxO Signaling Pathway
Qian Mei; Xiang Li; Kang Zhang; Zhiqiang Wu; Xiaolei Li; Yuanguang Meng; Mingzhou Guo; Guangbin Luo; Xiaobing Fu; Weidong Han
Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors
Aatur D. Singhi; Ta-Chiang Liu; Justin L. Roncaioli; Dengfeng Cao; Herbert J. Zeh; Amer H. Zureikat; Allan Tsung; J. Wallis Marsh; Kenneth K. Lee; Melissa E. Hogg; Nathan Bahary; Randall E. Brand; Kevin M. McGrath; Adam Slivka; Kristi L. Cressman; Kimberly Fuhrer; Roderick J. O'Sullivan
Corrections
Retraction
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