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15 September 2017
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The cover shows Masson Trichome staining of a section of a mammary gland treated with high-score patient-derived interstitial fluid. For details, see the article by Kenny and colleagues on page 5446 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
Editorial
CCR Translations
Review
Cancer Therapy: Clinical
Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic BRAF-Mutant Melanoma
Jean-Pierre Delord; Caroline Robert; Marta Nyakas; Grant A. McArthur; Ragini Kudchakar; Amit Mahipal; Yasuhide Yamada; Ryan Sullivan; Ana Arance; Richard F. Kefford; Matteo S. Carlino; Manuel Hidalgo; Carlos Gomez-Roca; Daniela Michel; Abdelkader Seroutou; Vassilios Aslanis; Giordano Caponigro; Darrin D. Stuart; Laure Moutouh-de Parseval; Tim Demuth; Reinhard Dummer
Author Choice
Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors
Anthony W. Tolcher; Mario Sznol; Siwen Hu-Lieskovan; Kyriakos P. Papadopoulos; Amita Patnaik; Drew W. Rasco; Donna Di Gravio; Bo Huang; Dhiraj Gambhire; Ying Chen; Aron D. Thall; Nuzhat Pathan; Emmett V. Schmidt; Laura Q.M. Chow
Author Choice
A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers
Paul K. Paik; Ronglai Shen; Michael F. Berger; David Ferry; Jean-Charles Soria; Alastair Mathewson; Claire Rooney; Neil R. Smith; Marie Cullberg; Elaine Kilgour; Donal Landers; Paul Frewer; Nigel Brooks; Fabrice André
Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis
Araz Marachelian; Judith G. Villablanca; Cathy W. Liu; Betty Liu; Fariba Goodarzian; Hollie A. Lai; Hiroyuki Shimada; Hung C. Tran; Jaime A. Parra; Richard Gallego; Nora Bedrossian; Sabrina Young; Scarlett Czarnecki; Rebekah Kennedy; Brian D. Weiss; Kelly Goldsmith; Meaghan Granger; Katherine K. Matthay; Susan Groshen; Shahab Asgharzadeh; Richard Sposto; Robert C. Seeger
Prognostic Impact of Circulating Tumor Cells for Breast Cancer Patients Treated in the Neoadjuvant "Geparquattro" Trial
Sabine Riethdorf; Volkmar Müller; Sibylle Loibl; Valentina Nekljudova; Karsten Weber; Jens Huober; Tanja Fehm; Iris Schrader; Jörn Hilfrich; Frank Holms; Hans Tesch; Christian Schem; Gunter von Minckwitz; Michael Untch; Klaus Pantel
Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity
Didier Meulendijks; Wolfgang Jacob; Emile E. Voest; Morten Mau-Sorensen; Maria Martinez-Garcia; Alvaro Taus; Tania Fleitas; Andres Cervantes; Martijn P. Lolkema; Marlies H.G. Langenberg; Maja J. De Jonge; Stefan Sleijfer; Ji-Youn Han; Antonio Calles; Enriqueta Felip; Sang-We Kim; Jan H.M. Schellens; Sabine Wilson; Marlene Thomas; Maurizio Ceppi; Georgina Meneses-Lorente; Ian James; Suzana Vega-Harring; Rajiv Dua; Maitram Nguyen; Lori Steiner; Celine Adessi; Francesca Michielin; Birgit Bossenmaier; Martin Weisser; Ulrik N. Lassen
Personalized Medicine and Imaging
Early Evaluation of Circulating Tumor DNA as Marker of Therapeutic Efficacy in Metastatic Colorectal Cancer Patients (PLACOL Study)
Fanny Garlan; Pierre Laurent-Puig; David Sefrioui; Nathalie Siauve; Audrey Didelot; Nasrin Sarafan-Vasseur; Pierre Michel; Geraldine Perkins; Claire Mulot; Hélène Blons; Julien Taieb; Frederic Di Fiore; Valerie Taly; Aziz Zaanan
Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer
Lone V. Schøler; Thomas Reinert; Mai-Britt W. Ørntoft; Christine G. Kassentoft; Sigrid S. Árnadóttir; Søren Vang; Iver Nordentoft; Michael Knudsen; Philippe Lamy; Ditte Andreasen; Frank V. Mortensen; Anders R. Knudsen; Katrine Stribolt; Kim Sivesgaard; Peter Mouritzen; Hans J. Nielsen; Søren Laurberg; Torben F. Ørntoft; Claus L. Andersen
Detection of Driver and Resistance Mutations in Leptomeningeal Metastases of NSCLC by Next-Generation Sequencing of Cerebrospinal Fluid Circulating Tumor Cells
Ben-Yuan Jiang; Yang-Si Li; Wei-Bang Guo; Xu-Chao Zhang; Zhi-Hong Chen; Jian Su; Wen-Zhao Zhong; Xue-Ning Yang; Jin-Ji Yang; Yang Shao; Biao Huang; Yan-Hui Liu; Qing Zhou; Hai-Yan Tu; Hua-Jun Chen; Zhen Wang; Chong-Rui Xu; Bin-Chao Wang; Shu-Yu Wu; Cun-Yi Gao; Xian Zhang; Yi-Long Wu
Cancer Therapy: Preclinical
The HGF/c-MET Pathway Is a Driver and Biomarker of VEGFR-inhibitor Resistance and Vascular Remodeling in Non–Small Cell Lung Cancer
Tina Cascone; Li Xu; Heather Y. Lin; Wenbin Liu; Hai T. Tran; Yuan Liu; Kathryn Howells; Vincent Haddad; Emer Hanrahan; Monique B. Nilsson; Maria A. Cortez; Uma Giri; Humam Kadara; Babita Saigal; Yun-Yong Park; Weiyi Peng; Ju-Seog Lee; Anderson J. Ryan; Juliane M. Jüergensmeier; Roy S. Herbst; Jing Wang; Robert R. Langley; Ignacio I. Wistuba; Jack J. Lee; John V. Heymach
Fractionated Radiation Therapy Stimulates Antitumor Immunity Mediated by Both Resident and Infiltrating Polyclonal T-cell Populations when Combined with PD-1 Blockade
Simon J. Dovedi; Eleanor J. Cheadle; Amy L. Popple; Edmund Poon; Michelle Morrow; Ross Stewart; Erik C. Yusko; Catherine M. Sanders; Marissa Vignali; Ryan O. Emerson; Harlan S. Robins; Robert W. Wilkinson; Jamie Honeychurch; Timothy M. Illidge
Author Choice
Mechanisms of Primary Drug Resistance in FGFR1-Amplified Lung Cancer
Florian Malchers; Meryem Ercanoglu; Daniel Schütte; Roberta Castiglione; Verena Tischler; Sebastian Michels; Ilona Dahmen; Johannes Brägelmann; Roopika Menon; Johannes M. Heuckmann; Julie George; Sascha Ansén; Martin L. Sos; Alex Soltermann; Martin Peifer; Jürgen Wolf; Reinhard Büttner; Roman K. Thomas
Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations
Yung-mae M. Yao; Gregory P. Donoho; Philip W. Iversen; Youyan Zhang; Robert D. Van Horn; Amelie Forest; Ruslan D. Novosiadly; Yue Wang Webster; Philip Ebert; Steven Bray; Jason C. Ting; Amit Aggarwal; James R. Henry; Ramon V. Tiu; Gregory D. Plowman; Sheng-Bin Peng
Author Choice
Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer
Uzma S. Asghar; Alexis R. Barr; Ros Cutts; Matthew Beaney; Irina Babina; Deepak Sampath; Jennifer Giltnane; Jennifer Arca Lacap; Lisa Crocker; Amy Young; Alex Pearson; Maria Teresa Herrera-Abreu; Chris Bakal; Nicholas C. Turner
Biology of Human Tumors
ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types
Anderly C. Chüeh; Janson W.T. Tse; Michael Dickinson; Paul Ioannidis; Laura Jenkins; Lars Togel; BeeShin Tan; Ian Luk; Mercedes Davalos-Salas; Rebecca Nightingale; Matthew R. Thompson; Bryan R.G. Williams; Guillaume Lessene; Erinna F. Lee; Walter D. Fairlie; Amardeep S. Dhillon; John M. Mariadason
Overexpression of RCC2 Enhances Cell Motility and Promotes Tumor Metastasis in Lung Adenocarcinoma by Inducing Epithelial–Mesenchymal Transition
Bo Pang; Nan Wu; Rongwei Guan; Lin Pang; Xinlei Li; Su Li; Liudi Tang; Ying Guo; Jialei Chen; Donglin Sun; Haiming Sun; Jialin Dai; Jing Bai; Guohua Ji; Peng Liu; An Liu; Qiushi Wang; Sheng Xiao; Songbin Fu; Yan Jin
Age and Gender Associations of Virus Positivity in Merkel Cell Carcinoma Characterized Using a Novel RNA In Situ Hybridization Assay
Lisha Wang; Paul W. Harms; Nallasivam Palanisamy; Shannon Carskadon; Xuhong Cao; Javed Siddiqui; Rajiv M. Patel; Sylvia Zelenka-Wang; Alison B. Durham; Douglas R. Fullen; Kelly L. Harms; Fengyun Su; Sudhanshu Shukla; Rohit Mehra; Arul M. Chinnaiyan
Author Choice
BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma
Atul Kulkarni; Husam Al-Hraishawi; Srilatha Simhadri; Kim M. Hirshfield; Suzie Chen; Sharon Pine; Chandrika Jeyamohan; Levi Sokol; Siraj Ali; Man Lung Teo; Eileen White; Lorna Rodriguez-Rodriguez; Janice M. Mehnert; Shridar Ganesan
Treatment of Pancreatic Cancer Patient–Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin
N.V. Rajeshkumar; Shinichi Yabuuchi; Shweta G. Pai; Elizabeth De Oliveira; Jurre J. Kamphorst; Joshua D. Rabinowitz; Héctor Tejero; Fátima Al-Shahrour; Manuel Hidalgo; Anirban Maitra; Chi V. Dang
Development and Validation of an Ultradeep Next-Generation Sequencing Assay for Testing of Plasma Cell-Free DNA from Patients with Advanced Cancer
Filip Janku; Shile Zhang; Jill Waters; Li Liu; Helen J. Huang; Vivek Subbiah; David S. Hong; Daniel D. Karp; Siqing Fu; Xuyu Cai; Nishma M. Ramzanali; Kiran Madwani; Goran Cabrilo; Debra L. Andrews; Yue Zhao; Milind Javle; E. Scott Kopetz; Rajyalakshmi Luthra; Hyunsung J. Kim; Sante Gnerre; Ravi Vijaya Satya; Han-Yu Chuang; Kristina M. Kruglyak; Jonathan Toung; Chen Zhao; Richard Shen; John V. Heymach; Funda Meric-Bernstam; Gordon B. Mills; Jian-Bing Fan; Neeraj S. Salathia
Letter to the Editor
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