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1 September 2017
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Cover Image
Cover Image
The cover shows a section of non-small cell lung cancer histospot. Immunohistochemistry stain shows simultaneous detection of B7-H3 (red channel), B7-H4 (blue channel), and cytokeratin (green channel). Visually, in this histospot, B7-H3 and B7-H4 proteins do not show colocalization. For details, see the article by Altan and colleagues on page 5202 of this issue - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Focus
Cancer Therapy: Clinical
Author Choice
Genome-wide DNA Methylation Analysis Reveals GABBR2 as a Novel Epigenetic Target for EGFR 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment
Xiaomin Niu; Fatao Liu; Yi Zhou; Zhen Zhou; Daizhan Zhou; Ting Wang; Ziming Li; Xiangyun Ye; Yongfeng Yu; Xiaoling Weng; Hong Zhang; Junyi Ye; Meilin Liao; Yun Liu; Zhiwei Chen; Shun Lu
Author Choice
A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies
Dejan Juric; Johann S. de Bono; Patricia M. LoRusso; John Nemunaitis; Elisabeth I. Heath; Eunice L. Kwak; Teresa Macarulla Mercadé; Elena Geuna; Maria Jose de Miguel-Luken; Chirag Patel; Keisuke Kuida; Serap Sankoh; Eric H. Westin; Fabian Zohren; Yaping Shou; Josep Tabernero
Dynamic Changes in PD-L1 Expression and Immune Infiltrates Early During Treatment Predict Response to PD-1 Blockade in Melanoma
Ricardo E. Vilain; Alexander M. Menzies; James S. Wilmott; Hojabr Kakavand; Jason Madore; Alexander Guminski; Elizabeth Liniker; Benjamin Y. Kong; Adam J. Cooper; Julie R. Howle; Robyn P.M. Saw; Valerie Jakrot; Serigne Lo; John F. Thompson; Matteo S. Carlino; Richard F. Kefford; Georgina V. Long; Richard A. Scolyer
Immune Correlates of GM-CSF and Melanoma Peptide Vaccination in a Randomized Trial for the Adjuvant Therapy of Resected High-Risk Melanoma (E4697)
Lisa H. Butterfield; Fengmin Zhao; Sandra Lee; Ahmad A. Tarhini; Kim A. Margolin; Richard L. White; Michael B. Atkins; Gary I. Cohen; Theresa L. Whiteside; John M. Kirkwood; David H. Lawson
A Pilot Study of Stereotactic Body Radiation Therapy Combined with Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma
Anurag K. Singh; Timothy B. Winslow; Mohammad Habiby Kermany; Vincent Goritz; Lilia Heit; Austin Miller; Nicholas C. Hoffend; Leighton C. Stein; Lalith K. Kumaraswamy; Graham W. Warren; Wiam Bshara; Kunle Odunsi; Junko Matsuzaki; Scott I. Abrams; Thomas Schwaab; Jason B. Muhitch
Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study
Ni Jiang; Guoliang Qiao; Xiaoli Wang; Michael A. Morse; William R. Gwin; Lei Zhou; Yuguang Song; Yanjie Zhao; Feng Chen; Xinna Zhou; Lefu Huang; Amy Hobeika; Xin Yi; Xuefeng Xia; Yanfang Guan; Jin Song; Jun Ren; H. Kim Lyerly
Personalized Medicine and Imaging
Author Choice
Tumor Cell–Free DNA Copy Number Instability Predicts Therapeutic Response to Immunotherapy
Glen J. Weiss; Julia Beck; Donald P. Braun; Kristen Bornemann-Kolatzki; Heather Barilla; Rhiannon Cubello; Walter Quan, Jr; Ashish Sangal; Vivek Khemka; Jordan Waypa; William M. Mitchell; Howard Urnovitz; Ekkehard Schütz
Clinical Utility of Risk Models to Refer Patients with Adnexal Masses to Specialized Oncology Care: Multicenter External Validation Using Decision Curve Analysis
Laure Wynants; Dirk Timmerman; Jan Y. Verbakel; Antonia Testa; Luca Savelli; Daniela Fischerova; Dorella Franchi; Caroline Van Holsbeke; Elisabeth Epstein; Wouter Froyman; Stefano Guerriero; Alberto Rossi; Robert Fruscio; Francesco PG Leone; Tom Bourne; Lil Valentin; Ben Van Calster
Author Choice
The Novel Association of Circulating Tumor Cells and Circulating Megakaryocytes with Prostate Cancer Prognosis
Lei Xu; Xueying Mao; Tianyu Guo; Pui Ying Chan; Greg Shaw; John Hines; Elzbieta Stankiewicz; Yuqin Wang; R. Tim D. Oliver; Amar Sabri Ahmad; Daniel Berney; Jonathan Shamash; Yong-Jie Lu
Cancer Therapy: Preclinical
HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer
Xiaowei Xu; Carmine De Angelis; Kathleen A. Burke; Agostina Nardone; Huizhong Hu; Lanfang Qin; Jamunarani Veeraraghavan; Vidyalakshmi Sethunath; Laura M. Heiser; Nicholas Wang; Charlotte K.Y. Ng; Edward S. Chen; Alexander Renwick; Tao Wang; Sarmistha Nanda; Martin Shea; Tamika Mitchell; Mahitha Rajendran; Ian Waters; Daniel J. Zabransky; Kenneth L. Scott; Carolina Gutierrez; Chandandeep Nagi; Felipe C. Geyer; Gary C. Chamness; Ben H. Park; Chad A. Shaw; Susan G. Hilsenbeck; Mothaffar F. Rimawi; Joe W. Gray; Britta Weigelt; Jorge S. Reis-Filho; C. Kent Osborne; Rachel Schiff
In Vivo Hemin Conditioning Targets the Vascular and Immunologic Compartments and Restrains Prostate Tumor Development
Felipe M. Jaworski; Lucas D. Gentilini; Geraldine Gueron; Roberto P. Meiss; Emiliano G. Ortiz; Paula M. Berguer; Asif Ahmed; Nora Navone; Gabriel A. Rabinovich; Daniel Compagno; Diego J. Laderach; Elba S. Vazquez
Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors
Chiara Ratti; Laura Botti; Valeria Cancila; Silvia Galvan; Ilaria Torselli; Cecilia Garofalo; Maria Cristina Manara; Lucia Bongiovanni; Cesare F. Valenti; Alessia Burocchi; Mariella Parenza; Barbara Cappetti; Sabina Sangaletti; Claudio Tripodo; Katia Scotlandi; Mario P. Colombo; Claudia Chiodoni
SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells
Hiroyuki Ozawa; Ruchira S. Ranaweera; Evgeny Izumchenko; Eugene Makarev; Alex Zhavoronkov; Elana J. Fertig; Jason D. Howard; Ana Markovic; Atul Bedi; Rajani Ravi; Jimena Perez; Quynh-Thu Le; Christina S. Kong; Richard C. Jordan; Hao Wang; Hyunseok Kang; Harry Quon; David Sidransky; Christine H. Chung
Entinostat Neutralizes Myeloid-Derived Suppressor Cells and Enhances the Antitumor Effect of PD-1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma
Ashley Orillion; Ayumi Hashimoto; Nur Damayanti; Li Shen; Remi Adelaiye-Ogala; Sreevani Arisa; Sreenivasulu Chintala; Peter Ordentlich; Chingai Kao; Bennett Elzey; Dmitry Gabrilovich; Roberto Pili
Biology of Human Tumors
MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR+/HER2− Metastatic Breast Cancer
Maura N. Dickler; Sara M. Tolaney; Hope S. Rugo; Javier Cortés; Véronique Diéras; Debra Patt; Hans Wildiers; Clifford A. Hudis; Joyce O'Shaughnessy; Esther Zamora; Denise A. Yardley; Martin Frenzel; Andrew Koustenis; José Baselga
Gene Expression Profiling in BRAF-Mutated Melanoma Reveals Patient Subgroups with Poor Outcomes to Vemurafenib That May Be Overcome by Cobimetinib Plus Vemurafenib
Matthew J. Wongchenko; Grant A. McArthur; Brigitte Dréno; James Larkin; Paolo A. Ascierto; Jeffrey Sosman; Luc Andries; Mark Kockx; Stephen D. Hurst; Ivor Caro; Isabelle Rooney; Priti S. Hegde; Luciana Molinero; Huibin Yue; Ilsung Chang; Lukas Amler; Yibing Yan; Antoni Ribas
Can Microsatellite Status of Colorectal Cancer Be Reliably Assessed after Neoadjuvant Therapy?
Jennifer B. Goldstein; William Wu; Ester Borras; Gita Masand; Amanda Cuddy; Maureen E. Mork; Sarah A. Bannon; Patrick M. Lynch; Miguel Rodriguez-Bigas; Melissa W. Taggart; Ji Wu; Paul Scheet; Scott Kopetz; Y. Nancy You; Eduardo Vilar
miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5
Verena Stiegelbauer; Petra Vychytilova-Faltejskova; Michael Karbiener; Anna-Maria Pehserl; Andreas Reicher; Margit Resel; Ellen Heitzer; Cristina Ivan; Marc Bullock; Hui Ling; Alexander Deutsch; Annika Wulf-Goldenberg; Jan Basri Adiprasito; Herbert Stoeger; Johannes Haybaeck; Marek Svoboda; Michael Stotz; Gerald Hoefler; Ondrej Slaby; George Adrian Calin; Armin Gerger; Martin Pichler
Author Choice
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer
Alexandre Prieur; Monica Cappellini; Guillaume Habif; Marie-Paule Lefranc; Thibault Mazard; Eric Morency; Jean-Marc Pascussi; Maud Flacelière; Nathalie Cahuzac; Bérengère Vire; Benjamin Dubuc; Amandine Durochat; Pierre Liaud; Jérémy Ollier; Caroline Pfeiffer; Sophie Poupeau; Véronique Saywell; Chris Planque; Eric Assenat; Frédéric Bibeau; Jean-François Bourgaux; Pascal Pujol; Alain Sézeur; Marc Ychou; Dominique Joubert
miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis–Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD
Joel Pekow; Katherine Meckel; Urszula Dougherty; Yong Huang; Xindi Chen; Anas Almoghrabi; Reba Mustafi; Fatma Ayaloglu-Butun; Zifeng Deng; Haider I. Haider; John Hart; David T. Rubin; John H. Kwon; Marc Bissonnette
Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes
Aliki Xochelli; Panagiotis Baliakas; Ioannis Kavakiotis; Andreas Agathangelidis; Lesley-Ann Sutton; Eva Minga; Stavroula Ntoufa; Eugen Tausch; Xiao-Jie Yan; Tait Shanafelt; Karla Plevova; Myriam Boudjogra; Davide Rossi; Zadie Davis; Alba Navarro; Yorick Sandberg; Fie Juhl Vojdeman; Lydia Scarfo; Niki Stavroyianni; Andrey Sudarikov; Silvio Veronese; Tatiana Tzenou; Teodora Karan-Djurasevic; Mark Catherwood; Dirk Kienle; Maria Chatzouli; Monica Facco; Jasmin Bahlo; Christiane Pott; Lone Bredo Pedersen; Larry Mansouri; Karin E. Smedby; Charles C. Chu; Véronique Giudicelli; Marie-Paule Lefranc; Panagiotis Panagiotidis; Gunnar Juliusson; Achilles Anagnostopoulos; Ioannis Vlahavas; Darko Antic; Livio Trentin; Marco Montillo; Carsten Niemann; Hartmut Döhner; Anton W. Langerak; Sarka Pospisilova; Michael Hallek; Elias Campo; Nicholas Chiorazzi; Nikos Maglaveras; David Oscier; Gianluca Gaidano; Diane F. Jelinek; Stephan Stilgenbauer; Ioanna Chouvarda; Nikos Darzentas; Chrysoula Belessi; Frederic Davi; Anastasia Hadzidimitriou; Richard Rosenquist; Paolo Ghia; Kostas Stamatopoulos
Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non–Small Cell Lung Cancer Using Next-Generation Sequencing
Xiance Jin; Yanfan Chen; Hanbin Chen; Shaoran Fei; Didi Chen; Xiaona Cai; Linger Liu; Baochai Lin; Huafang Su; Lihao Zhao; Meng Su; Huanle Pan; Lanxiao Shen; Deyao Xie; Congying Xie
Letter to the Editor
Retraction
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