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15 July 2017
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Cover Image
Cover Image
The cover shows a section of a tumor tissue from a patient with breast cancer. Immunohistochemical staining shows strong poly-ADP-ribosylation in the tumor tissue while adjacent tissue shows negative programmed death-ligand-1 expression (not shown here). For details, see the article by Jiao and colleagues on page 3711 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Drug Updates
U.S. FDA Approval Summary: Nivolumab for Treatment of Unresectable or Metastatic Melanoma Following Progression on Ipilimumab
Maitreyee Hazarika; Meredith K. Chuk; Marc R. Theoret; Sirisha Mushti; Kun He; Shawna L. Weis; Alexander H. Putman; Whitney S. Helms; Xianhua Cao; Hongshan Li; Hong Zhao; Liang Zhao; Joel Welch; Laurie Graham; Meredith Libeg; Rajeshwari Sridhara; Patricia Keegan; Richard Pazdur
Review
Cancer Therapy: Clinical
Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells
Miyuki Tanaka; Haruko Tashiro; Bilal Omer; Natasha Lapteva; Jun Ando; Minhtran Ngo; Birju Mehta; Gianpietro Dotti; Paul R. Kinchington; Ann M. Leen; Claudia Rossig; Cliona M. Rooney
Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical Trial
Mark A. Exley; Phillip Friedlander; Nadia Alatrakchi; Lianne Vriend; Simon Yue; Tetsuro Sasada; Wanyong Zeng; Yo Mizukami; Justice Clark; David Nemer; Kenneth LeClair; Christine Canning; Heather Daley; Glenn Dranoff; Anita Giobbie-Hurder; F. Stephen Hodi; Jerome Ritz; Steven P. Balk
Phase Ib Study of Safety and Pharmacokinetics of the PI3K Inhibitor SAR245408 with the HER3-Neutralizing Human Antibody SAR256212 in Patients with Solid Tumors
Vandana G. Abramson; Jeffrey G. Supko; Tarah Ballinger; James M. Cleary; John F. Hilton; Sara M. Tolaney; Nicole G. Chau; Daniel C. Cho; Joseph Pearlberg; Joanne Lager; Geoffrey I. Shapiro; Carlos L. Arteaga
Phase I Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+-Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC)
Stacy L. Moulder; Virginia F. Borges; Tara Baetz; Tessa Mcspadden; Gina Fernetich; Rashmi K. Murthy; Renae Chavira; Kari Guthrie; Emma Barrett; Stephen K. Chia
Safety and Antitumor Activity of Apalutamide (ARN-509) in Metastatic Castration-Resistant Prostate Cancer with and without Prior Abiraterone Acetate and Prednisone
Dana E. Rathkopf; Emmanuel S. Antonarakis; Neal D. Shore; Ronald F. Tutrone; Joshi J. Alumkal; Charles J. Ryan; Mansoor Saleh; Ralph J. Hauke; Rajesh Bandekar; Edna Chow Maneval; Carla J. de Boer; Margaret K. Yu; Howard I. Scher
The DART Study: Results from the Dose-Escalation and Expansion Cohorts Evaluating the Combination of Dalantercept plus Axitinib in Advanced Renal Cell Carcinoma
Martin H. Voss; Rupal S. Bhatt; Elizabeth R. Plimack; Brian I. Rini; Robert S. Alter; J. Thaddeus Beck; Dawn Wilson; Xiaosha Zhang; Musa Mutyaba; Chad Glasser; Kenneth M. Attie; Matthew L. Sherman; Shuchi S. Pandya; Michael B. Atkins
Author Choice
Intratumoral Injection of HSV1716, an Oncolytic Herpes Virus, Is Safe and Shows Evidence of Immune Response and Viral Replication in Young Cancer Patients
Keri A. Streby; James I. Geller; Mark A. Currier; Patrick S. Warren; John M. Racadio; Alexander J. Towbin; Michele R. Vaughan; Melinda Triplet; Kristy Ott-Napier; Devon J. Dishman; Lori R. Backus; Beth Stockman; Marianne Brunner; Kathleen Simpson; Robert Spavin; Joe Conner; Timothy P. Cripe
Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy
Orin Bloch; Michael Lim; Michael E. Sughrue; Ricardo J. Komotar; John M. Abrahams; Donald M. O'Rourke; Anthony D'Ambrosio; Jeffrey N. Bruce; Andrew T. Parsa
Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic Renal Cell Carcinoma
Vivek Narayan; Stephen Keefe; Naomi Haas; Le Wang; Igor Puzanov; Mary Putt; Anna Catino; James Fang; Neeraj Agarwal; David Hyman; Amanda M. Smith; Brian S. Finkelman; Hari K. Narayan; Steven Ewer; Chantal ElAmm; Daniel Lenihan; Bonnie Ky
Personalized Medicine and Imaging
DNA Damage Response and Repair Gene Alterations Are Associated with Improved Survival in Patients with Platinum-Treated Advanced Urothelial Carcinoma
Min Yuen Teo; Richard M. Bambury; Emily C. Zabor; Emmet Jordan; Hikmat Al-Ahmadie; Mariel E. Boyd; Nancy Bouvier; Stephanie A. Mullane; Eugene K. Cha; Nitin Roper; Irina Ostrovnaya; David M. Hyman; Bernard H. Bochner; Maria E. Arcila; David B. Solit; Michael F. Berger; Dean F. Bajorin; Joaquim Bellmunt; Gopakumar Iyer; Jonathan E. Rosenberg
Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk – Combined Results from Two Screening Trials
Steven J. Skates; Mark H. Greene; Saundra S. Buys; Phuong L. Mai; Powel Brown; Marion Piedmonte; Gustavo Rodriguez; John O. Schorge; Mark Sherman; Mary B. Daly; Thomas Rutherford; Wendy R. Brewster; David M. O'Malley; Edward Partridge; John Boggess; Charles W. Drescher; Claudine Isaacs; Andrew Berchuck; Susan Domchek; Susan A. Davidson; Robert Edwards; Steven A. Elg; Katie Wakeley; Kelly-Anne Phillips; Deborah Armstrong; Ira Horowitz; Carol J. Fabian; Joan Walker; Patrick M. Sluss; William Welch; Lori Minasian; Nora K. Horick; Carol H. Kasten; Susan Nayfield; David Alberts; Dianne M. Finkelstein; Karen H. Lu
Author Choice
Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study
Ramesh K. Ramanathan; Ronald L. Korn; Natarajan Raghunand; Jasgit C. Sachdev; Ronald G. Newbold; Gayle Jameson; Gerald J. Fetterly; Joshua Prey; Stephan G. Klinz; Jaeyeon Kim; Jason Cain; Bart S. Hendriks; Daryl C. Drummond; Eliel Bayever; Jonathan B. Fitzgerald
Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group
Katherine Tarlock; Todd A. Alonzo; Michael R. Loken; Robert B. Gerbing; Rhonda E. Ries; Richard Aplenc; Lillian Sung; Susana C. Raimondi; Betsy A. Hirsch; Samir B. Kahwash; Amy McKenney; E. Anders Kolb; Alan S. Gamis; Soheil Meshinchi
Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers
Takeo Fujii; Afsaneh Barzi; Andrea Sartore-Bianchi; Andrea Cassingena; Giulia Siravegna; Daniel D. Karp; Sarina A. Piha-Paul; Vivek Subbiah; Apostolia M. Tsimberidou; Helen J. Huang; Silvio Veronese; Federica Di Nicolantonio; Sandeep Pingle; Cecile Rose T. Vibat; Saege Hancock; David Berz; Vladislava O. Melnikova; Mark G. Erlander; Rajyalakshmi Luthra; E. Scott Kopetz; Funda Meric-Bernstam; Salvatore Siena; Heinz-Josef Lenz; Alberto Bardelli; Filip Janku
Pathological Complete Response to Neoadjuvant Trastuzumab Is Dependent on HER2/CEP17 Ratio in HER2-Amplified Early Breast Cancer
Christian F. Singer; Yen Y. Tan; Florian Fitzal; Guenther G. Steger; Daniel Egle; Angelika Reiner; Margaretha Rudas; Farid Moinfar; Christine Gruber; Edgar Petru; Rupert Bartsch; Kristina A. Tendl; David Fuchs; Michael Seifert; Ruth Exner; Marija Balic; Zsuzsanna Bago-Horvath; Martin Filipits; Michael Gnant; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group; for the Austrian Breast and Colorectal Cancer Study Group
Author Choice
CT Perfusion as an Early Biomarker of Treatment Efficacy in Advanced Ovarian Cancer: An ACRIN and GOG Study
Chaan S. Ng; Zheng Zhang; Susanna I. Lee; Helga S. Marques; Kyle Burgers; Feng Su; Joseph Bauza; Robert S. Mannel; Joan L. Walker; Warner King Huh; Stephen C. Rubin; Paul DiSilvestro; Lainie P. Martin; John K. Chan; Michael A. Bookman; Robert L. Coleman; Ting-Yim Lee
Cancer Therapy: Preclinical
PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression
Shiping Jiao; Weiya Xia; Hirohito Yamaguchi; Yongkun Wei; Mei-Kuang Chen; Jung-Mao Hsu; Jennifer L. Hsu; Wen-Hsuan Yu; Yi Du; Heng-Huan Lee; Chia-Wei Li; Chao-Kai Chou; Seung-Oe Lim; Shih-Shin Chang; Jennifer Litton; Banu Arun; Gabriel N. Hortobagyi; Mien-Chie Hung
Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
S. Rubina Baglio; Tonny Lagerweij; Maria Pérez-Lanzón; Xuan Dung Ho; Nicolas Léveillé; Sonia A. Melo; Anne-Marie Cleton-Jansen; Ekaterina S. Jordanova; Laura Roncuzzi; Michelina Greco; Monique A.J. van Eijndhoven; Giulia Grisendi; Massimo Dominici; Roberta Bonafede; Sinead M. Lougheed; Tanja D. de Gruijl; Nicoletta Zini; Silvia Cervo; Agostino Steffan; Vincenzo Canzonieri; Aare Martson; Katre Maasalu; Sulev Köks; Tom Wurdinger; Nicola Baldini; D. Michiel Pegtel
An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma
Francesca Citron; Joshua Armenia; Giovanni Franchin; Jerry Polesel; Renato Talamini; Sara D'Andrea; Sandro Sulfaro; Carlo M. Croce; William Klement; David Otasek; Chiara Pastrello; Tomas Tokar; Igor Jurisica; Deborah French; Riccardo Bomben; Emanuela Vaccher; Diego Serraino; Barbara Belletti; Andrea Vecchione; Luigi Barzan; Gustavo Baldassarre
Preclinical Development of a Nontoxic Oral Formulation of Monoethanolamine, a Lipid Precursor, for Prostate Cancer Treatment
Roopali Saxena; Chunhua Yang; Mukkavilli Rao; Ravi Chakra Turaga; Chakravarthy Garlapati; Sushma Reddy Gundala; Kimberly Myers; Ahmed Ghareeb; Shristi Bhattarai; Golnaz Kamalinia; Sangina Bristi; Dan Su; Giovanni Gadda; Padmashree C.G. Rida; Guilherme H. Cantuaria; Ritu Aneja
Bevacizumab May Differentially Improve Ovarian Cancer Outcome in Patients with Proliferative and Mesenchymal Molecular Subtypes
Stefan Kommoss; Boris Winterhoff; Ann L. Oberg; Gottfried E. Konecny; Chen Wang; Shaun M. Riska; Jian-Bing Fan; Matthew J. Maurer; Craig April; Viji Shridhar; Friedrich Kommoss; Andreas du Bois; Felix Hilpert; Sven Mahner; Klaus Baumann; Willibald Schroeder; Alexander Burges; Ulrich Canzler; Jeremy Chien; Andrew C. Embleton; Mahesh Parmar; Richard Kaplan; Timothy Perren; Lynn C. Hartmann; Ellen L. Goode; Sean C. Dowdy; Jacobus Pfisterer
Active Estrogen Receptor-alpha Signaling in Ovarian Cancer Models and Clinical Specimens
Courtney L. Andersen; Matthew J. Sikora; Michelle M. Boisen; Tianzhou Ma; Alec Christie; George Tseng; Yongseok Park; Soumya Luthra; Uma Chandran; Paul Haluska; Gina M. Mantia-Smaldone; Kunle Odunsi; Karen McLean; Adrian V. Lee; Esther Elishaev; Robert P. Edwards; Steffi Oesterreich
Biology of Human Tumors
Genome-wide DNA Methylation Profiling Reveals Methylation Markers Associated with 3q Gain for Detection of Cervical Precancer and Cancer
Wina Verlaat; Peter J.F. Snijders; Putri W. Novianti; Saskia M. Wilting; Lise M.A. De Strooper; Geert Trooskens; Johan Vandersmissen; Wim Van Criekinge; G. Bea A. Wisman; Chris J.L.M. Meijer; Daniëlle A.M. Heideman; Renske D.M. Steenbergen
Author Choice
The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer
Valeria Governa; Emanuele Trella; Valentina Mele; Luigi Tornillo; Francesca Amicarella; Eleonora Cremonesi; Manuele Giuseppe Muraro; Hui Xu; Raoul Droeser; Silvio R. Däster; Martin Bolli; Raffaele Rosso; Daniel Oertli; Serenella Eppenberger-Castori; Luigi M. Terracciano; Giandomenica Iezzi; Giulio C. Spagnoli
The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas
Charlotte K.Y. Ng; Salvatore Piscuoglio; Felipe C. Geyer; Kathleen A. Burke; Fresia Pareja; Carey A. Eberle; Raymond S. Lim; Rachael Natrajan; Nadeem Riaz; Odette Mariani; Larry Norton; Anne Vincent-Salomon; Y. Hannah Wen; Britta Weigelt; Jorge S. Reis-Filho
Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition
Ahmed Atef Ibrahim; Christian Schmithals; Erik Kowarz; Verena Köberle; Bianca Kakoschky; Thomas Pleli; Otto Kollmar; Scarlett Nitsch; Oliver Waidmann; Fabian Finkelmeier; Stefan Zeuzem; Horst-Werner Korf; Tobias Schmid; Andreas Weigert; Bernd Kronenberger; Rolf Marschalek; Albrecht Piiper
MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Imayavaramban Lakshmanan; Shereen Salfity; Parthasarathy Seshacharyulu; Satyanarayana Rachagani; Abigail Thomas; Srustidhar Das; Prabin D. Majhi; Rama Krishna Nimmakayala; Raghupathy Vengoji; Subodh M. Lele; Moorthy P. Ponnusamy; Surinder K. Batra; Apar Kishor Ganti
Author Choice
Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF
John Charles Rotondo; Ilaria Bononi; Andrea Puozzo; Marcello Govoni; Valentina Foschi; Giovanni Lanza; Roberta Gafà; Pauline Gaboriaud; Françoise Antoine Touzé; Rita Selvatici; Fernanda Martini; Mauro Tognon
Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers
Tatsuo Hata; Marco Dal Molin; Seung-Mo Hong; Koji Tamura; Masaya Suenaga; Jun Yu; Hiraku Sedogawa; Matthew J. Weiss; Christopher L. Wolfgang; Anne Marie Lennon; Ralph H. Hruban; Michael G. Goggins
Alterations in the Immune Cell Composition in Premalignant Breast Tissue that Precede Breast Cancer Development
Amy C. Degnim; Tanya L. Hoskin; Muhammad Arshad; Marlene H. Frost; Stacey J. Winham; Rushin A. Brahmbhatt; Alvaro Pena; Jodi M. Carter; Melody L. Stallings-Mann; Linda M. Murphy; Erin E. Miller; Lori A. Denison; Celine M. Vachon; Keith L. Knutson; Derek C. Radisky; Daniel W. Visscher
In Hepatocellular Carcinoma miR-221 Modulates Sorafenib Resistance through Inhibition of Caspase-3–Mediated Apoptosis
Francesca Fornari; Daniela Pollutri; Clarissa Patrizi; Tiziana La Bella; Sara Marinelli; Andrea Casadei Gardini; Giorgia Marisi; Marco Baron Toaldo; Michele Baglioni; Veronica Salvatore; Elisa Callegari; Maurizio Baldassarre; Marzia Galassi; Catia Giovannini; Matteo Cescon; Matteo Ravaioli; Massimo Negrini; Luigi Bolondi; Laura Gramantieri
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