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15 June 2017
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Cover Image
Cover Image
The cover shows a section of an oropharynx tumor from a patient with HPV-associated head and neck cancer. Immunohistochemical staining shows strong membranous HER3 expression in a small area of the tumor. For details, see the article by Brand and colleagues on page 3072 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Issue Sections
Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition
Carolina Pereira; Pol Gimenez-Xavier; Eva Pros; Maria J. Pajares; Massimo Moro; Antonio Gomez; Alejandro Navarro; Enric Condom; Sebastian Moran; Gonzalo Gomez-Lopez; Osvaldo Graña; Miriam Rubio-Camarillo; Alex Martinez-Martí; Jun Yokota; Julian Carretero; Jose M. Galbis; Ernest Nadal; David Pisano; Gabriella Sozzi; Enriqueta Felip; Luis M. Montuenga; Luca Roz; Alberto Villanueva; Montse Sanchez-Cespedes
CCR Pediatric Oncology Series: Articles from the AACR Childhood Cancer Predisposition Workshop
Von Hippel–Lindau and Hereditary Pheochromocytoma/Paraganglioma Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood
Surya P. Rednam; Ayelet Erez; Harriet Druker; Katherine A. Janeway; Junne Kamihara; Wendy K. Kohlmann; Katherine L. Nathanson; Lisa J. States; Gail E. Tomlinson; Anita Villani; Stephan D. Voss; Joshua D. Schiffman; Jonathan D. Wasserman
PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood
Kris Ann P. Schultz; Surya P. Rednam; Junne Kamihara; Leslie Doros; Maria Isabel Achatz; Jonathan D. Wasserman; Lisa R. Diller; Laurence Brugières; Harriet Druker; Katherine A. Schneider; Rose B. McGee; William D. Foulkes
Recommendations for Cancer Surveillance in Individuals with RASopathies and Other Rare Genetic Conditions with Increased Cancer Risk
Anita Villani; Mary-Louise C. Greer; Jennifer M. Kalish; Akira Nakagawara; Katherine L. Nathanson; Kristian W. Pajtler; Stefan M. Pfister; Michael F. Walsh; Jonathan D. Wasserman; Kristin Zelley; Christian P. Kratz
Highlights of This Issue
CCR Translations
CCR Drug Updates
Molecular Pathways
Cancer Therapy: Clinical
Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody
George A. Dominguez; Thomas Condamine; Sridevi Mony; Ayumi Hashimoto; Fang Wang; Qin Liu; Andres Forero; Johanna Bendell; Robert Witt; Neil Hockstein; Prasanna Kumar; Dmitry I. Gabrilovich
Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients
Jana Portnow; Timothy W. Synold; Behnam Badie; Revathiswari Tirughana; Simon F. Lacey; Massimo D'Apuzzo; Marianne Z. Metz; Joseph Najbauer; Victoria Bedell; Tien Vo; Margarita Gutova; Paul Frankel; Mike Chen; Karen S. Aboody
Author Choice
Dendritic Cell Vaccination Enhances Immune Responses and Induces Regression of HER2pos DCIS Independent of Route: Results of Randomized Selection Design Trial
Lea Lowenfeld; Rosemarie Mick; Jashodeep Datta; Shuwen Xu; Elizabeth Fitzpatrick; Carla S. Fisher; Kevin R. Fox; Angela DeMichele; Paul J. Zhang; Susan P. Weinstein; Robert E. Roses; Brian J. Czerniecki
Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab
Sandra P. D'Angelo; Alexander N. Shoushtari; Mary Louise Keohan; Mark A. Dickson; Mrinal M. Gounder; Ping Chi; Jennifer K. Loo; Leigh Gaffney; Lee Schneider; Zarine Patel; Joseph Patrick Erinjeri; Mark J. Bluth; Ana Sjoberg; Howard Streicher; Naoko Takebe; Li-Xuan Qin; Cristina Antonescu; Ronald P. DeMatteo; Richard D. Carvajal; William D. Tap
Author Choice
Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations
Gang G. Li; Romel Somwar; James Joseph; Roger S. Smith; Takuo Hayashi; Leenus Martin; Aleksandra Franovic; Anni Schairer; Eric Martin; Gregory J. Riely; Jason Harris; Shunqi Yan; Ge Wei; Jennifer W. Oliver; Rupal Patel; Pratik Multani; Marc Ladanyi; Alexander Drilon
Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer
Kelly K. Hunt; Cansu Karakas; Min Jin Ha; Anna Biernacka; Min Yi; Aysegul A. Sahin; Opoku Adjapong; Gabriel N. Hortobagyi; Melissa L. Bondy; Patricia A. Thompson; Kwok Leung Cheung; Ian O. Ellis; Sarah Bacus; W. Fraser Symmans; Kim-Anh Do; Khandan Keyomarsi
A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157
Noah M. Hahn; Trinity J. Bivalacqua; Ashley E. Ross; George J. Netto; Alex Baras; Jong Chul Park; Carolyn Chapman; Timothy A. Masterson; Michael O. Koch; Richard Bihrle; Richard S. Foster; Thomas A. Gardner; Liang Cheng; David R. Jones; Kyle McElyea; George E. Sandusky; Timothy Breen; Ziyue Liu; Costantine Albany; Marietta L. Moore; Rhoda L. Loman; Angela Reed; Scott A. Turner; Francine B. De Abreu; Torrey Gallagher; Gregory J. Tsongalis; Elizabeth R. Plimack; Richard E. Greenberg; Daniel M. Geynisman
Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma
Zhong-Yi Dong; Wen-Zhao Zhong; Xu-Chao Zhang; Jian Su; Zhi Xie; Si-Yang Liu; Hai-Yan Tu; Hua-Jun Chen; Yue-Li Sun; Qing Zhou; Jin-Ji Yang; Xue-Ning Yang; Jia-Xin Lin; Hong-Hong Yan; Hao-Ran Zhai; Li-Xu Yan; Ri-Qiang Liao; Si-Pei Wu; Yi-Long Wu
Personalized Medicine and Imaging
An miRNA–DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia
Françoise Solly; Catherine Koering; Aminetou Mint Mohamed; Delphine Maucort-Boulch; Guillaume Robert; Patrick Auberger; Pascale Flandrin-Gresta; Lionel Adès; Pierre Fenaux; Olivier Kosmider; Emmanuelle Tavernier-Tardy; Jérôme Cornillon; Denis Guyotat; Lydia Campos; Franck Mortreux; Eric Wattel
Author Choice
A PAM50-Based Chemoendocrine Score for Hormone Receptor–Positive Breast Cancer with an Intermediate Risk of Relapse
Aleix Prat; Ana Lluch; Arran K. Turnbull; Anita K. Dunbier; Lourdes Calvo; Joan Albanell; Juan de la Haba-Rodríguez; Angels Arcusa; José Ignacio Chacón; Pedro Sánchez-Rovira; Arrate Plazaola; Montserrat Muñoz; Laia Paré; Joel S. Parker; Nuria Ribelles; Begoña Jimenez; Abdul Aziz Bin Aiderus; Rosalía Caballero; Barbara Adamo; Mitch Dowsett; Eva Carrasco; Miguel Martín; J. Michael Dixon; Charles M. Perou; Emilio Alba
18F-Fluoroestradiol PET/CT Measurement of Estrogen Receptor Suppression during a Phase I Trial of the Novel Estrogen Receptor-Targeted Therapeutic GDC-0810: Using an Imaging Biomarker to Guide Drug Dosage in Subsequent Trials
Yingbing Wang; Karen L. Ayres; Debra A. Goldman; Maura N. Dickler; Aditya Bardia; Ingrid A. Mayer; Eric Winer; Jill Fredrickson; Carlos L. Arteaga; José Baselga; Henry C. Manning; Umar Mahmood; Gary A. Ulaner
Cancer Therapy: Preclinical
Author Choice
Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients
Toni M. Brand; Stefan Hartmann; Neil E. Bhola; Noah D. Peyser; Hua Li; Yan Zeng; Erin Isaacson Wechsler; Max V. Ranall; Sourav Bandyopadhyay; Umamaheswar Duvvuri; Theresa M. LaVallee; Richard C.K. Jordan; Daniel E. Johnson; Jennifer R. Grandis
Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug-Drug Combination with Ibrutinib
Jennifer E. Amengual; Sathyen A. Prabhu; Maximilian Lombardo; Kelly Zullo; Paul M. Johannet; Yulissa Gonzalez; Luigi Scotto; Xavier Jirau Serrano; Ying Wei; Jimmy Duong; Renu Nandakumar; Serge Cremers; Akanksha Verma; Olivier Elemento; Owen A. O'Connor
Author Choice
Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells
Prajwal Rajappa; William S. Cobb; Emma Vartanian; Yujie Huang; Laura Daly; Caitlin Hoffman; Jane Zhang; Beiyi Shen; Rachel Yanowitch; Kunal Garg; Babacar Cisse; Sara Haddock; Jason Huse; David J. Pisapia; Timothy A. Chan; David C. Lyden; Jacqueline F. Bromberg; Jeffrey P. Greenfield
Biology of Human Tumors
Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ Hybridization
Matthias Holdhoff; Gunes Guner; Fausto J. Rodriguez; Jessica L. Hicks; Qizhi Zheng; Michael S. Forman; Xiaobu Ye; Stuart A. Grossman; Alan K. Meeker; Christopher M. Heaphy; Charles G. Eberhart; Angelo M. De Marzo; Ravit Arav-Boger
Author Choice
Transcriptional Mechanisms of Resistance to Anti–PD-1 Therapy
Maria L. Ascierto; Alvin Makohon-Moore; Evan J. Lipson; Janis M. Taube; Tracee L. McMiller; Alan E. Berger; Jinshui Fan; Genevieve J. Kaunitz; Tricia R. Cottrell; Zachary A. Kohutek; Alexander Favorov; Vladimir Makarov; Nadeem Riaz; Timothy A. Chan; Leslie Cope; Ralph H. Hruban; Drew M. Pardoll; Barry S. Taylor; David B. Solit; Christine A. Iacobuzio-Donahue; Suzanne L. Topalian
Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho
Reeti Behera; Amanpreet Kaur; Marie R. Webster; Suyeon Kim; Abibatou Ndoye; Curtis H. Kugel, III; Gretchen M. Alicea; Joshua Wang; Kanad Ghosh; Phil Cheng; Sofia Lisanti; Katie Marchbank; Vanessa Dang; Mitchell Levesque; Reinhard Dummer; Xiaowei Xu; Meenhard Herlyn; Andrew E. Aplin; Alexander Roesch; Cecilia Caino; Dario C. Altieri; Ashani T. Weeraratna
Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition
Carolina Pereira; Pol Gimenez-Xavier; Eva Pros; Maria J. Pajares; Massimo Moro; Antonio Gomez; Alejandro Navarro; Enric Condom; Sebastian Moran; Gonzalo Gomez-Lopez; Osvaldo Graña; Miriam Rubio-Camarillo; Alex Martinez-Martí; Jun Yokota; Julian Carretero; Jose M. Galbis; Ernest Nadal; David Pisano; Gabriella Sozzi; Enriqueta Felip; Luis M. Montuenga; Luca Roz; Alberto Villanueva; Montse Sanchez-Cespedes
Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma
Kent W. Mouw; James M. Cleary; Brendan Reardon; Jonathan Pike; Lior Z. Braunstein; Jaegil Kim; Ali Amin-Mansour; Diana Miao; Alexis Damish; Joanna Chin; Patrick A. Ott; Charles S. Fuchs; Neil E. Martin; Gad Getz; Scott Carter; Harvey J. Mamon; Jason L. Hornick; Eliezer M. Van Allen; Alan D. D'Andrea
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