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1 June 2017
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Cover Image
Cover Image
The cover shows patients with primary breast cancer colocalization of VEGF-A expression (red) and a systemically injected near-infrared fluorescent tracer bevacizumab-IRDye800CW (green) through Multiplex Advanced Pathology Imaging (MAPI). For details, see the article by Lamberts and colleagues on page 2730 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
CCR Pediatric Oncology Series: Articles from the AACR Childhood Cancer Predisposition Workshop
Recommendations for Childhood Cancer Screening and Surveillance in DNA Repair Disorders
Michael F. Walsh; Vivian Y. Chang; Wendy K. Kohlmann; Hamish S. Scott; Christopher Cunniff; Franck Bourdeaut; Jan J. Molenaar; Christopher C. Porter; John T. Sandlund; Sharon E. Plon; Lisa L. Wang; Sharon A. Savage
Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome
Christian P. Kratz; Maria Isabel Achatz; Laurence Brugières; Thierry Frebourg; Judy E. Garber; Mary-Louise C. Greer; Jordan R. Hansford; Katherine A. Janeway; Wendy K. Kohlmann; Rose McGee; Charles G. Mullighan; Kenan Onel; Kristian W. Pajtler; Stefan M. Pfister; Sharon A. Savage; Joshua D. Schiffman; Katherine A. Schneider; Louise C. Strong; D. Gareth R. Evans; Jonathan D. Wasserman; Anita Villani; David Malkin
Highlights of This Issue
CCR Focus
Clinical Trial Brief Report
Adverse Metaphase Cytogenetics Can Be Overcome by Adding Bortezomib and Thalidomide to Fractionated Melphalan Transplants
Yogesh S. Jethava; Alan Mitchell; Joshua Epstein; Maurizio Zangari; Shmuel Yaccoby; Erming Tian; Sarah Waheed; Rashid Khan; Xenofon Papanikolaou; Monica Grazziutti; Michele Cottler-Fox; Nathan Petty; Douglas Steward; Susan Panozzo; Clyde Bailey; Antje Hoering; John Crowley; Jeffrey Sawyer; Gareth Morgan; Bart Barlogie; Frits van Rhee
Cancer Therapy: Clinical
Phase I Study of Epigenetic Priming with Azacitidine Prior to Standard Neoadjuvant Chemotherapy for Patients with Resectable Gastric and Esophageal Adenocarcinoma: Evidence of Tumor Hypomethylation as an Indicator of Major Histopathologic Response
Bryan J. Schneider; Manish A. Shah; Kelsey Klute; Allyson Ocean; Elizabeta Popa; Nasser Altorki; Michael Lieberman; Andrew Schreiner; Rhonda Yantiss; Paul J. Christos; Romae Palmer; Daoqi You; Agnes Viale; Pouneh Kermani; Joseph M. Scandura
Circulating Tumor Cells Expressing Markers of Tumor-Initiating Cells Predict Poor Survival and Cancer Recurrence in Patients with Pancreatic Ductal Adenocarcinoma
Katherine E. Poruk; Amanda L. Blackford; Matthew J. Weiss; John L. Cameron; Jin He; Michael Goggins; Zeshaan A. Rasheed; Christopher L. Wolfgang; Laura D. Wood
Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study
Roisin M. Connolly; Huili Li; Rachel C. Jankowitz; Zhe Zhang; Michelle A. Rudek; Stacie C. Jeter; Shannon A. Slater; Penny Powers; Antonio C. Wolff; John H. Fetting; Adam Brufsky; Richard Piekarz; Nita Ahuja; Peter W. Laird; Hui Shen; Daniel J. Weisenberger; Leslie Cope; James G. Herman; George Somlo; Agustin A. Garcia; Peter A. Jones; Stephen B. Baylin; Nancy E. Davidson; Cynthia A. Zahnow; Vered Stearns
Author Choice
The Prognostic Role of Androgen Receptor in Patients with Early-Stage Breast Cancer: A Meta-analysis of Clinical and Gene Expression Data
Ivana Bozovic-Spasojevic; Dimitrios Zardavas; Sylvain Brohée; Lieveke Ameye; Debora Fumagalli; Felipe Ades; Evandro de Azambuja; Yacine Bareche; Martine Piccart; Marianne Paesmans; Christos Sotiriou
Personalized Medicine and Imaging
Author Choice
Integrative Analysis Identifies a Novel AXL–PI3 Kinase–PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer
Heath D. Skinner; Uma Giri; Liang P. Yang; Manish Kumar; Ying Liu; Michael D. Story; Curtis R. Pickering; Lauren A. Byers; Michelle D. Williams; Jing Wang; Li Shen; Suk Y. Yoo; You Hong Fan; David P. Molkentine; Beth M. Beadle; Raymond E. Meyn; Jeffrey N. Myers; John V. Heymach
E6 and E7 Antibody Levels Are Potential Biomarkers of Recurrence in Patients with Advanced-Stage Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma
Matthew E. Spector; Assuntina G. Sacco; Emily Bellile; Jeremy M.G. Taylor; Tamara Jones; Kan Sun; William C. Brown; Andrew C. Birkeland; Carol R. Bradford; Gregory T. Wolf; Mark E. Prince; Jeffrey S. Moyer; Kelly Malloy; Paul Swiecicki; Avraham Eisbruch; Jonathan B. McHugh; Douglas B. Chepeha; Laura Rozek; Francis P. Worden
Author Choice
Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study
Laetitia E. Lamberts; Maximillian Koch; Johannes S. de Jong; Arthur L.L. Adams; Jürgen Glatz; Mariëtte E.G. Kranendonk; Anton G.T. Terwisscha van Scheltinga; Liesbeth Jansen; Jakob de Vries; Marjolijn N. Lub-de Hooge; Carolien P. Schröder; Annelies Jorritsma-Smit; Matthijs D. Linssen; Esther de Boer; Bert van der Vegt; Wouter B. Nagengast; Sjoerd G. Elias; Sabrina Oliveira; Arjen J. Witkamp; Willem P.Th.M. Mali; Elsken Van der Wall; Paul J. van Diest; Elisabeth G.E. de Vries; Vasilis Ntziachristos; Gooitzen M. van Dam
Cancer Therapy: Preclinical
Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast Cancer
Sarah R. Hosford; Lloye M. Dillon; Stephanie J. Bouley; Rachele Rosati; Wei Yang; Vivian S. Chen; Eugene Demidenko; Rocco P. Morra, Jr; Todd W. Miller
Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
Wilhem Leconet; Myriam Chentouf; Stanislas du Manoir; Clément Chevalier; Audrey Sirvent; Imade Aït-Arsa; Muriel Busson; Marta Jarlier; Nina Radosevic-Robin; Charles Theillet; Dany Chalbos; Jean-Max Pasquet; André Pèlegrin; Christel Larbouret; Bruno Robert
Author Choice
Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion
Sinnie Sin Man Ng; Bethany A. Nagy; Shawn M. Jensen; Xintao Hu; Candido Alicea; Bernard A. Fox; Barbara K. Felber; Cristina Bergamaschi; George N. Pavlakis
The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia
Sarah E.M. Herman; Arnau Montraveta; Carsten U. Niemann; Helena Mora-Jensen; Michael Gulrajani; Fanny Krantz; Rose Mantel; Lisa L. Smith; Fabienne McClanahan; Bonnie K. Harrington; Dolors Colomer; Todd Covey; John C. Byrd; Raquel Izumi; Allard Kaptein; Roger Ulrich; Amy J. Johnson; Brian J. Lannutti; Adrian Wiestner; Jennifer A. Woyach
Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma
Andrew C. Wood; Kateryna Krytska; Hannah T. Ryles; Nicole R. Infarinato; Renata Sano; Theodore D. Hansel; Lori S. Hart; Frederick J. King; Timothy R. Smith; Edward Ainscow; Kathryn B. Grandinetti; Tove Tuntland; Sunkyu Kim; Giordano Caponigro; You Qun He; Shiva Krupa; Nanxin Li; Jennifer L. Harris; Yaël P. Mossé
Biology of Human Tumors
Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers
Katrien Van Roosbroeck; Francesca Fanini; Tetsuro Setoyama; Cristina Ivan; Cristian Rodriguez-Aguayo; Enrique Fuentes-Mattei; Lianchun Xiao; Ivan Vannini; Roxana S. Redis; Lucilla D'Abundo; Xinna Zhang; Milena S. Nicoloso; Simona Rossi; Vianey Gonzalez-Villasana; Rajesha Rupaimoole; Manuela Ferracin; Fortunato Morabito; Antonino Neri; Peter P. Ruvolo; Vivian R. Ruvolo; Chad V. Pecot; Dino Amadori; Lynne Abruzzo; Steliana Calin; Xuemei Wang; M. James You; Alessandra Ferrajoli; Robert Orlowski; William Plunkett; Tara M. Lichtenberg; Ramana V. Davuluri; Ioana Berindan-Neagoe; Massimo Negrini; Ignacio I. Wistuba; Hagop M. Kantarjian; Anil K. Sood; Gabriel Lopez-Berestein; Michael J. Keating; Muller Fabbri; George A. Calin
Author Choice
microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma
Xiao-yan He; Zheng-lan Tan; Qin Mou; Fang-jie Liu; Shan Liu; Chao-wen Yu; Jin Zhu; Lin-ya Lv; Jun Zhang; Shan Wang; Li-ming Bao; Bin Peng; Hui Zhao; Lin Zou
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