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Volume 23, Issue 10
15 May 2017
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  • Cover Image

    Cover Image

    issue cover
    The cover shows a section of lung from the hepatocellular carcinoma mouse model. Hematoxylin-eosin staining shows there are many metastatic nodules in the lung tissues near the blood vessel and bronchial tissue. For details, see the article by Chang and colleagues on page 2593 of this issue.
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ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Drug Updates

FDA Approval Summary: Sonidegib for Locally Advanced Basal Cell Carcinoma
Denise Casey; Suzanne Demko; Stacy Shord; Hong Zhao; Huanyu Chen; Kun He; Alexander Putman; Whitney Helms; Patricia Keegan; Richard Pazdur
View articletitled, FDA Approval Summary: Sonidegib for Locally Advanced Basal Cell Carcinoma
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Molecular Pathways

Molecular Pathways: Hypoxia-Activated Prodrugs in Cancer Therapy
Natalia Baran; Marina Konopleva
View articletitled, Molecular Pathways: Hypoxia-Activated Prodrugs in Cancer Therapy
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Review

Emerging Role of MicroRNAs as Liquid Biopsy Biomarkers in Gastrointestinal Cancers
Kunitoshi Shigeyasu; Shusuke Toden; Timothy J. Zumwalt; Yoshinaga Okugawa; Ajay Goel
View articletitled, Emerging Role of MicroRNAs as Liquid Biopsy Biomarkers in Gastrointestinal Cancers
Supplementary data
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Clinical Trial Brief Report

Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214)
Steven P. Treon; Kirsten Meid; Christina Tripsas; Leonard T. Heffner; Herbert Eradat; Ashraf Z. Badros; Lian Xu; Zachary R. Hunter; Guang Yang; Christopher J. Patterson; Joshua Gustine; Jorge J. Castillo; Jeffrey Matous; Irene M. Ghobrial
View articletitled, Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214)
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Cancer Therapy: Clinical

A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma
Thomas C.C. Yau; Riccardo Lencioni; Wattana Sukeepaisarnjaroen; Yee Chao; Chia-Jui Yen; Wirote Lausoontornsiri; Pei-Jer Chen; Theeranun Sanpajit; Aaron Camp; Donna S. Cox; Robert C. Gagnon; Yuan Liu; Kristen E. Raffensperger; Diptee A. Kulkarni; Howard Kallender; Lone Harild Ottesen; Ronnie T.P. Poon; Donald P. Bottaro
View articletitled, A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma
Supplementary data
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Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer
Filippo Pietrantonio; Claudio Vernieri; Giulia Siravegna; Alessia Mennitto; Rosa Berenato; Federica Perrone; Annunziata Gloghini; Elena Tamborini; Sara Lonardi; Federica Morano; Benedetta Picciani; Adele Busico; Chiara Costanza Volpi; Antonia Martinetti; Francesca Battaglin; Ilaria Bossi; Alessio Pellegrinelli; Massimo Milione; Chiara Cremolini; Maria Di Bartolomeo; Alberto Bardelli; Filippo de Braud
View articletitled, Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer
Supplementary data
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Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors
Jeffrey R. Infante; Antoine Hollebecque; Sophie Postel-Vinay; Todd M. Bauer; Elizabeth M. Blackwood; Marie Evangelista; Sami Mahrus; Franklin V. Peale; Xuyang Lu; Srikumar Sahasranaman; Rui Zhu; Yuan Chen; Xiao Ding; Elaine R. Murray; Jennifer L. Schutzman; Jennifer O. Lauchle; Jean-Charles Soria; Patricia M. LoRusso
View articletitled, Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors
Supplementary data
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Author Choice
A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors
Birgit Geoerger; Franck Bourdeaut; Steven G. DuBois; Matthias Fischer; James I. Geller; Nicholas G. Gottardo; Aurélien Marabelle; Andrew D.J. Pearson; Shakeel Modak; Thomas Cash; Giles W. Robinson; Marlyane Motta; Alessandro Matano; Suraj G. Bhansali; Jason R. Dobson; Sudha Parasuraman; Susan N. Chi
View articletitled, A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors
Supplementary data
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Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN
Laura Q.M. Chow; Chihiro Morishima; Keith D. Eaton; Christina S. Baik; Bernardo H. Goulart; Leslie N. Anderson; Kristi L. Manjarrez; Gregory N. Dietsch; James Kyle Bryan; Robert M. Hershberg; Mary L. Disis; Renato G. Martins
View articletitled, Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN
Supplementary data
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Author Choice
Sequencing of Sipuleucel-T and Androgen Deprivation Therapy in Men with Hormone-Sensitive Biochemically Recurrent Prostate Cancer: A Phase II Randomized Trial
Emmanuel S. Antonarakis; for the STAND Investigators; Adam S. Kibel; for the STAND Investigators; Evan Y. Yu; for the STAND Investigators; Lawrence I. Karsh; for the STAND Investigators; Aymen Elfiky; for the STAND Investigators; Neal D. Shore; for the STAND Investigators; Nicholas J. Vogelzang; for the STAND Investigators; John M. Corman; for the STAND Investigators; Frederick E. Millard; for the STAND Investigators; Johnathan C. Maher; for the STAND Investigators; Nancy N. Chang; for the STAND Investigators; Todd DeVries; for the STAND Investigators; Nadeem A. Sheikh; for the STAND Investigators; Charles G. Drake; for the STAND Investigators
View articletitled, Sequencing of Sipuleucel-T and Androgen Deprivation Therapy in Men with Hormone-Sensitive Biochemically Recurrent Prostate Cancer: A Phase II Randomized Trial
Supplementary data
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Personalized Medicine and Imaging

BRM Promoter Polymorphisms and Survival of Advanced Non–Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial
Geoffrey Liu; Sinead Cuffe; Shermi Liang; Abul Kalam Azad; Lu Cheng; Yonathan Brhane; Xin Qiu; David W. Cescon; Jeffrey Bruce; Zhuo Chen; Dangxiao Cheng; Devalben Patel; Brandon C. Tse; Scott A. Laurie; Glenwood Goss; Natasha B. Leighl; Rayjean Hung; Penelope A. Bradbury; Lesley Seymour; Frances A. Shepherd; Ming Sound Tsao; Bingshu E. Chen; Wei Xu; David N. Reisman
View articletitled, BRM Promoter Polymorphisms and Survival of Advanced Non–Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial
Supplementary data
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The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA
Sonya Parpart-Li; Bjarne Bartlett; Maria Popoli; Vilmos Adleff; Laura Tucker; Rebecca Steinberg; Andrew Georgiadis; Jill Phallen; Julie Brahmer; Nilo Azad; Ilene Browner; Daniel Laheru; Victor E. Velculescu; Mark Sausen; Luis A. Diaz, Jr
View articletitled, The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA
Supplementary data
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Cancer Therapy: Preclinical

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Clare Y. Slaney; Bianca von Scheidt; Alexander J. Davenport; Paul A. Beavis; Jennifer A. Westwood; Sherly Mardiana; David C. Tscharke; Sarah Ellis; H. Miles Prince; Joseph A. Trapani; Ricky W. Johnstone; Mark J. Smyth; Michele W. Teng; Aesha Ali; Zhiya Yu; Steven A. Rosenberg; Nicholas P. Restifo; Paul Neeson; Phillip K. Darcy; Michael H. Kershaw
View articletitled, Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary data
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Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression
Maria Parkhurst; Alena Gros; Anna Pasetto; Todd Prickett; Jessica S. Crystal; Paul Robbins; Steven A. Rosenberg
View articletitled, Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression
Supplementary data
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T-cell Receptor Signaling Activates an ITK/NF-κB/GATA-3 axis in T-cell Lymphomas Facilitating Resistance to Chemotherapy
Tianjiao Wang; Ye Lu; Avery Polk; Pinki Chowdhury; Carlos Murga Zamalloa; Hiroshi Fujiwara; Koichiro Suemori; Niklas Beyersdorf; Alexandra C. Hristov; Megan S. Lim; Nathanael G. Bailey; Ryan A. Wilcox
View articletitled, T-cell Receptor Signaling Activates an ITK/NF-κB/GATA-3 axis in T-cell Lymphomas Facilitating Resistance to Chemotherapy
Supplementary data
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5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma
Samuel A. Kerk; Kelsey A. Finkel; Alexander T. Pearson; Kristy A. Warner; Zhaocheng Zhang; Felipe Nör; Vivian P. Wagner; Pablo A. Vargas; Max S. Wicha; Elaine M. Hurt; Robert E. Hollingsworth; David A. Tice; Jacques E. Nör
View articletitled, 5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma
Supplementary data
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The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia
Thomas Vercruysse; Jolien De Bie; Jasper E. Neggers; Maarten Jacquemyn; Els Vanstreels; Jonathan L. Schmid-Burgk; Veit Hornung; Erkan Baloglu; Yosef Landesman; William Senapedis; Sharon Shacham; Antonis Dagklis; Jan Cools; Dirk Daelemans
View articletitled, The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia
Supplementary data
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Author Choice
c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer
Angela Nebbioso; Vincenzo Carafa; Mariarosaria Conte; Francesco Paolo Tambaro; Ciro Abbondanza; Joost Martens; Matthias Nees; Rosaria Benedetti; Isabella Pallavicini; Saverio Minucci; Guillermo Garcia-Manero; Francesco Iovino; Gabriella Lania; Concetta Ingenito; Valeria Belsito Petrizzi; Hendrik G. Stunnenberg; Lucia Altucci
View articletitled, c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer
Supplementary data
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Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non–Small Cell Lung Cancer Cell Lines and Tumor Models
David Y.A. Dadey; Vaishali Kapoor; Kelly Hoye; Arpine Khudanyan; Andrea Collins; Dinesh Thotala; Dennis E. Hallahan
View articletitled, Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non–Small Cell Lung Cancer Cell Lines and Tumor Models
Supplementary data
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KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells
Cheryl A. London; Heather L. Gardner; Sarah Rippy; Gerald Post; Krista La Perle; Linda Crew; Lori Lopresti-Morrow; Andrew J. Garton; Gerald McMahon; Theresa M. LaVallee; Richard Gedrich
View articletitled, KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells
Supplementary data
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Biology of Human Tumors

A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Matthew P. Humphries; Sreekumar Sundara Rajan; Alastair Droop; Charlotte A.B. Suleman; Carmine Carbone; Cecilia Nilsson; Hedieh Honarpisheh; Gabor Cserni; Jo Dent; Laura Fulford; Lee B. Jordan; J. Louise Jones; Rani Kanthan; Maria Litwiniuk; Anna Di Benedetto; Marcella Mottolese; Elena Provenzano; Sami Shousha; Mark Stephens; Rosemary A. Walker; Janina Kulka; Ian O. Ellis; Margaret Jeffery; Helene H. Thygesen; Vera Cappelletti; Maria G. Daidone; Ingrid A. Hedenfalk; Marie-Louise Fjällskog; Davide Melisi; Lucy F. Stead; Abeer M. Shaaban; Valerie Speirs
View articletitled, A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Supplementary data
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Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes
Jingmei Li; Emma Ivansson; Daniel Klevebring; Nicholas P. Tobin; Linda Sofie Lindström; Johanna Holm; Gabriela Prochazka; Camilla Cristando; Juni Palmgren; Sven Törnberg; Keith Humphreys; Johan Hartman; Jan Frisell; Mattias Rantalainen; Johan Lindberg; Per Hall; Jonas Bergh; Henrik Grönberg; Kamila Czene
View articletitled, Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes
Supplementary data
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miRNA-487a Promotes Proliferation and Metastasis in Hepatocellular Carcinoma
Rui-Min Chang; Shuai Xiao; Xiong Lei; Hao Yang; Feng Fang; Lian-Yue Yang
View articletitled, miRNA-487a Promotes Proliferation and Metastasis in Hepatocellular Carcinoma
Supplementary data
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Correction

Correction: Integration of Novel Agents into the Care of Patients with Multiple Myeloma
View articletitled, Correction: Integration of Novel Agents into the Care of Patients with Multiple Myeloma
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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