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15 April 2016
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Expression of NOTCH1 (green) in cancer stem cells isolated from salivary adenoid cystic carcinoma. For details, see the article by Panaccione and colleagues on page 2083 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
CCR Focus
Special Report
Research Priorities, Measures, and Recommendations for Assessment of Tobacco Use in Clinical Cancer Research
Stephanie R. Land; Benjamin A. Toll; Carol M. Moinpour; Sandra A. Mitchell; Jamie S. Ostroff; Dorothy K. Hatsukami; Sonia A. Duffy; Ellen R. Gritz; Nancy A. Rigotti; Thomas H. Brandon; Sheila A. Prindiville; Linda P. Sarna; Robert A. Schnoll; Roy S. Herbst; Paul M. Cinciripini; Scott J. Leischow; Carolyn M. Dresler; Michael C. Fiore; Graham W. Warren
Cancer Therapy: Clinical
Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients
Antonio Curti; Loredana Ruggeri; Sarah Parisi; Andrea Bontadini; Elisa Dan; Maria Rosa Motta; Simonetta Rizzi; Sara Trabanelli; Darina Ocadlikova; Mariangela Lecciso; Valeria Giudice; Fiorenza Fruet; Elena Urbani; Cristina Papayannidis; Giovanni Martinelli; Giuseppe Bandini; Francesca Bonifazi; Russell E. Lewis; Michele Cavo; Andrea Velardi; Roberto M. Lemoli
Author Choice
Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer
Esme J. Hill; Corran Roberts; Jamie M. Franklin; Monica Enescu; Nicholas West; Thomas P. MacGregor; Kwun-Ye Chu; Lucy Boyle; Claire Blesing; Lai-Mun Wang; Somnath Mukherjee; Ewan M. Anderson; Gina Brown; Susan Dutton; Sharon B. Love; Julia A. Schnabel; Phil Quirke; Ruth Muschel; William G. McKenna; Michael Partridge; Ricky A. Sharma
First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies
Pamela Munster; Rahul Aggarwal; David Hong; Jan H.M. Schellens; Ruud van der Noll; Jennifer Specht; Petronella O. Witteveen; Theresa L. Werner; E. Claire Dees; Emily Bergsland; Neeraj Agarwal; Joseph F. Kleha; Michael Durante; Laurel Adams; Deborah A. Smith; Thomas A. Lampkin; Shannon R. Morris; Razelle Kurzrock
Author Choice
KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib
Monique B. Nilsson; Uma Giri; Jayanthi Gudikote; Ximing Tang; Wei Lu; Hai Tran; Youhong Fan; Andrew Koo; Lixia Diao; Pan Tong; Jing Wang; Roy Herbst; Bruce E. Johnson; Andy Ryan; Alan Webster; Philip Rowe; Ignacio I. Wistuba; John V. Heymach
Gemtuzumab Ozogamicin Reduces Relapse Risk in FLT3/ITD Acute Myeloid Leukemia: A Report from the Children's Oncology Group
Katherine Tarlock; Todd A. Alonzo; Robert B. Gerbing; Susana C. Raimondi; Betsy A. Hirsch; Lillian Sung; Jessica A. Pollard; Richard Aplenc; Michael R. Loken; Alan S. Gamis; Soheil Meshinchi
Personalized Medicine and Imaging
The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine
Paraskevi Miltiades; Eleftheria Lamprianidou; Theodoros P. Vassilakopoulos; Sotirios G. Papageorgiou; Athanasios G. Galanopoulos; Christos K. Kontos; Panagiotis G. Adamopoulos; Evangelia Nakou; Sofia Vakalopoulou; Vassilia Garypidou; Maria Papaioannou; Evdoxia Hatjiharissi; Helen A. Papadaki; Emmanuil Spanoudakis; Vassiliki Pappa; Andreas Scorilas; Constantinos Tsatalas; Ioannis Kotsianidis; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group; on behalf of the Hellenic MDS Study Group
The Immune Checkpoint Regulator PD-L1 Is Highly Expressed in Aggressive Primary Prostate Cancer
Heidrun Gevensleben; Dimo Dietrich; Carsten Golletz; Susanne Steiner; Maria Jung; Thore Thiesler; Michael Majores; Johannes Stein; Barbara Uhl; Stefan Müller; Jörg Ellinger; Carsten Stephan; Klaus Jung; Peter Brossart; Glen Kristiansen
Cancer Therapy: Preclinical
Author Choice
AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma
Fernando Doñate; Arthur Raitano; Kendall Morrison; Zili An; Linnette Capo; Hector Aviña; Sher Karki; Karen Morrison; Peng Yang; Jimmy Ou; Ryuichi Moriya; Yuriy Shostak; Faisal Malik; Rossana Nadell; Wendy Liu; Daulet Satpayev; John Atkinson; Ingrid B.J. Joseph; Daniel S. Pereira; Pia M. Challita-Eid; David R. Stover
Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations
Zachary S. Zumsteg; Natasha Morse; Gabriel Krigsfeld; Gaorav Gupta; Daniel S. Higginson; Nancy Y. Lee; Luc Morris; Ian Ganly; Stephan L. Shiao; Simon N. Powell; Christine H. Chung; Maurizio Scaltriti; José Baselga
Biology of Human Tumors
An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors
Vasilis Bikos; Maria Karypidou; Evangelia Stalika; Panagiotis Baliakas; Aliki Xochelli; Lesley-Ann Sutton; George Papadopoulos; Andreas Agathangelidis; Evdoxia Papadopoulou; Zadie Davis; Patricia Algara; George Kanellis; Alexandra Traverse-Glehen; Manuela Mollejo; Achilles Anagnostopoulos; Maurilio Ponzoni; David Gonzalez; Sarka Pospisilova; Estella Matutes; Miguel Angel Piris; Theodora Papadaki; Paolo Ghia; Richard Rosenquist; David Oscier; Nikos Darzentas; Dimitrios Tzovaras; Chrysoula Belessi; Anastasia Hadzidimitriou; Kostas Stamatopoulos
Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML
Irina Sadovnik; Andrea Hoelbl-Kovacic; Harald Herrmann; Gregor Eisenwort; Sabine Cerny-Reiterer; Wolfgang Warsch; Gregor Hoermann; Georg Greiner; Katharina Blatt; Barbara Peter; Gabriele Stefanzl; Daniela Berger; Martin Bilban; Susanne Herndlhofer; Heinz Sill; Wolfgang R. Sperr; Berthold Streubel; Christine Mannhalter; Tessa L. Holyoake; Veronika Sexl; Peter Valent
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling
Lindsey E. Romick-Rosendale; Elizabeth E. Hoskins; Lisa M. Privette Vinnedge; Grant D. Foglesong; Marion G. Brusadelli; S. Steven Potter; Kakajan Komurov; Samantha A. Brugmann; Paul F. Lambert; Randall J. Kimple; Elizabeth L. Virts; Helmut Hanenberg; Maura L. Gillison; Susanne I. Wells
NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Alex Panaccione; Michael T. Chang; Beatrice E. Carbone; Yan Guo; Christopher A. Moskaluk; Renu K. Virk; Luis Chiriboga; Manju L. Prasad; Benjamin Judson; Saral Mehra; Wendell G. Yarbrough; Sergey V. Ivanov
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