Skip Nav Destination
Issues
15 March 2016
-
Cover Image
Cover Image
![issue cover]()
The cover shows a model of pazopanib (light pink carbons) bound to HLA-B*57:01. Abacavir (orange carbons) from the crystal structure of abacavir bound to HLA-B*57:01 (grey carbons) is overlaid for reference. For details, see the article by Xu and colleagues on page 1371 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Molecular Pathways
Review
Clinical Trial Brief Report
Cancer Therapy: Clinical
Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients—Report of a Phase I/IIa Clinical Trial
Amandine Legat; Hélène Maby-El Hajjami; Petra Baumgaertner; Laurène Cagnon; Samia Abed Maillard; Christine Geldhof; Emanuela M. Iancu; Luc Lebon; Philippe Guillaume; Danijel Dojcinovic; Olivier Michielin; Emanuela Romano; Grégoire Berthod; Donata Rimoldi; Frédéric Triebel; Immanuel Luescher; Nathalie Rufer; Daniel E. Speiser
A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti–Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors
Kyriakos P. Papadopoulos; Robin Kate Kelley; Anthony W. Tolcher; Albiruni R. Abdul Razak; Katherine Van Loon; Amita Patnaik; Philippe L. Bedard; Ariceli A. Alfaro; Muralidhar Beeram; Lieve Adriaens; Carrie M. Brownstein; Israel Lowy; Ana Kostic; Pamela A. Trail; Bo Gao; A. Thomas DiCioccio; Lillian L. Siu
Androgen Receptor Modulation Optimized for Response (ARMOR) Phase I and II Studies: Galeterone for the Treatment of Castration-Resistant Prostate Cancer
Bruce Montgomery; Mario A. Eisenberger; Matthew B. Rettig; Franklin Chu; Roberto Pili; Joseph J. Stephenson; Nicholas J. Vogelzang; Alan J. Koletsky; Luke T. Nordquist; William J. Edenfield; Khalid Mamlouk; Karen J. Ferrante; Mary-Ellen Taplin
HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer
Chun-Fang Xu; Toby Johnson; Xiaojing Wang; Chris Carpenter; Alan P. Graves; Liling Warren; Zhengyu Xue; Karen S. King; Dana J. Fraser; Sandy Stinnett; Linda P. Briley; Ionel Mitrica; Colin F. Spraggs; Matthew R. Nelson; Hiroomi Tada; Andreas du Bois; Thomas Powles; Neil Kaplowitz; Lini N. Pandite
Bone Marker–Directed Dosing of Zoledronic Acid for the Prevention of Skeletal Complications in Patients with Multiple Myeloma: Results of the Z-MARK Study
Noopur Raje; Robert Vescio; Charles W. Montgomery; Ashraf Badros; Nikhil Munshi; Richard Orlowski; Joseph T. Hadala; Ghulam Warsi; Eliza Argonza-Aviles; Solveig G. Ericson; Kenneth C. Anderson
Personalized Medicine and Imaging
Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy
Cesar A. Santa-Maria; Amanda Blackford; Anne T. Nguyen; Todd C. Skaar; Santosh Philips; Steffi Oesterreich; James M. Rae; Zeruesenay Desta; Jason Robarge; Norah Lynn Henry; Anna M. Storniolo; Daniel F. Hayes; Roger S. Blumenthal; Pamela Ouyang; Wendy S. Post; David A. Flockhart; Vered Stearns; Consortium on Breast Cancer Pharmacogenomics (COBRA)
Fluorescent Image–Guided Surgery with an Anti-Prostate Stem Cell Antigen (PSCA) Diabody Enables Targeted Resection of Mouse Prostate Cancer Xenografts in Real Time
Geoffrey A. Sonn; Andrew S. Behesnilian; Ziyue Karen Jiang; Kirstin A. Zettlitz; Eric J. Lepin; Laurent A. Bentolila; Scott M. Knowles; Daniel Lawrence; Anna M. Wu; Robert E. Reiter
Cancer Therapy: Preclinical
IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation
Zhuonan Zhuang; Huai-Qiang Ju; Mitzi Aguilar; Takashi Gocho; Hao Li; Tomonori Iida; Harold Lee; Xiaoqiang Fan; Haijun Zhou; Jianhua Ling; Zhongkui Li; Jie Fu; Min Wu; Min Li; Davide Melisi; Yoichiro Iwakura; Kesen Xu; Jason B. Fleming; Paul J. Chiao
Author Choice
A Novel Bioavailable BH3 Mimetic Efficiently Inhibits Colon Cancer via Cascade Effects of Mitochondria
Xuefeng Wang; Chen Zhang; Xiangming Yan; Bin Lan; Jianyong Wang; Chongyang Wei; Xingxin Cao; Renxiao Wang; Jianhua Yao; Tao Zhou; Mi Zhou; Qiaoling Liu; Biao Jiang; Pengfei Jiang; Santosh Kesari; Xinjian Lin; Fang Guo
Author Choice
Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation
Jessica A. Couch; Gu Zhang; Joseph C. Beyer; Christina L. Zuch de Zafra; Priyanka Gupta; Amrita V. Kamath; Nicholas Lewin-Koh; Jacqueline Tarrant; Krishna P. Allamneni; Gary Cain; Sharon Yee; Sarajane Ross; Ryan Cook; Siao Ping Tsai; Jane Ruppel; John Brady Ridgway; Maciej Paluch; Philip E. Hass; Jayme Franklin; Minhong Yan
Biology of Human Tumors
Genomic Landscape of CXCR4 Mutations in Waldenström Macroglobulinemia
Stéphanie Poulain; Christophe Roumier; Aurélie Venet-Caillault; Martin Figeac; Charles Herbaux; Guillemette Marot; Emmanuelle Doye; Elisabeth Bertrand; Sandrine Geffroy; Frédéric Lepretre; Olivier Nibourel; Audrey Decambron; Eileen Mary Boyle; Aline Renneville; Sabine Tricot; Agnès Daudignon; Bruno Quesnel; Patrick Duthilleul; Claude Preudhomme; Xavier Leleu
Prognostic Utility of Molecular Factors by Age at Diagnosis of Colorectal Cancer
Nadine J. McCleary; Kaori Sato; Reiko Nishihara; Kentaro Inamura; Teppei Morikawa; Xuehong Zhang; Kana Wu; Mai Yamauchi; Sun A. Kim; Yasutaka Sukawa; Kosuke Mima; Zhi Rong Qian; Charles S. Fuchs; Shuji Ogino; Jeffrey A. Meyerhardt
RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors
Sherene Loi; Sathana Dushyanthen; Paul A. Beavis; Roberto Salgado; Carsten Denkert; Peter Savas; Susan Combs; David L. Rimm; Jennifer M. Giltnane; Monica V. Estrada; Violeta Sánchez; Melinda E. Sanders; Rebecca S. Cook; Mark A. Pilkinton; Simon A. Mallal; Kai Wang; Vincent A. Miller; Phil J. Stephens; Roman Yelensky; Franco D. Doimi; Henry Gómez; Sergey V. Ryzhov; Phillip K. Darcy; Carlos L. Arteaga; Justin M. Balko
The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer
Himisha Beltran; Adam Jendrisak; Mark Landers; Juan Miguel Mosquera; Myriam Kossai; Jessica Louw; Rachel Krupa; Ryon P. Graf; Nicole A. Schreiber; David M. Nanus; Scott T. Tagawa; Dena Marrinucci; Ryan Dittamore; Howard I. Scher
Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers
Ana M. Aparicio; Li Shen; Elsa Li Ning Tapia; Jing-Fang Lu; Hsiang-Chun Chen; Jiexin Zhang; Guanglin Wu; Xuemei Wang; Patricia Troncoso; Paul Corn; Timothy C. Thompson; Bradley Broom; Keith Baggerly; Sankar N. Maity; Christopher J. Logothetis
Advertisement
