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15 February 2016
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Cover Image
Cover Image
At 24 hours after intravenous injection, PLP nanoparticles enabled fluorescence imaging of a tumor with considerable specificity and accuracy at the cellular level. For details, see the article by Muhanna and colleagues on page 961 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
Molecular Pathways
Reviews
Cancer Therapy: Clinical
Author Choice
Safety, Pharmacokinetics, and Pharmacodynamics of a Humanized Anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Solid Tumors
Amita Patnaik; Glen J. Weiss; John E. Leonard; Drew Warren Rasco; Jasgit C. Sachdev; Terrence L. Fisher; Laurie A. Winter; Christine Reilly; Robert B. Parker; Danielle Mutz; Lisa Blaydorn; Anthony W. Tolcher; Maurice Zauderer; Ramesh K. Ramanathan
Efficacy and Biological Activity of Imatinib in Metastatic Dermatofibrosarcoma Protuberans (DFSP)
Silvia Stacchiotti; Maria A. Pantaleo; Tiziana Negri; Annalisa Astolfi; Marcella Tazzari; Gian Paolo Dagrada; Milena Urbini; Valentina Indio; Roberta Maestro; Alessandro Gronchi; Marco Fiore; Angelo P. Dei Tos; Elena Conca; Elena Palassini; Bruno Vincenzi; Federica Grosso; Silvana Pilotti; Chiara Castelli; Paolo G. Casali
Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors
John Sarantopoulos; Geoffrey I. Shapiro; Roger B. Cohen; Jeffrey W. Clark; John S. Kauh; Glen J. Weiss; James M. Cleary; Devalingam Mahalingam; Michael D. Pickard; Hélène M. Faessel; Allison J. Berger; Kristine Burke; George Mulligan; Bruce J. Dezube; R. Donald Harvey
Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors
Didier Meulendijks; Ulrik N. Lassen; Lillian L. Siu; Alwin D.R. Huitema; Vaios Karanikas; Morten Mau-Sorensen; Derek J. Jonker; Aaron R. Hansen; Mary E. Simcox; Kathleen J. Schostack; Dean Bottino; Hua Zhong; Markus Roessler; Suzana M. Vega-Harring; Tiantom Jarutat; David Geho; Karen Wang; Mark DeMario; Glenwood D. Goss; Jan H.M. Schellens
Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia
Michael Andreeff; Kevin R. Kelly; Karen Yee; Sarit Assouline; Roger Strair; Leslie Popplewell; David Bowen; Giovanni Martinelli; Mark W. Drummond; Paresh Vyas; Mark Kirschbaum; Swaminathan Padmanabhan Iyer; Vivian Ruvolo; Graciela M. Nogueras González; Xuelin Huang; Gong Chen; Bradford Graves; Steven Blotner; Peter Bridge; Lori Jukofsky; Steve Middleton; Monica Reckner; Ruediger Rueger; Jianguo Zhi; Gwen Nichols; Kensuke Kojima
First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors
Didier Meulendijks; Wolfgang Jacob; Maria Martinez-Garcia; Alvaro Taus; Martijn P. Lolkema; Emile E. Voest; Marlies H.G. Langenberg; Tania Fleitas Kanonnikoff; Andres Cervantes; Maja J. De Jonge; Stefan Sleijfer; Morten Mau Soerensen; Marlene Thomas; Maurizio Ceppi; Georgina Meneses-Lorente; Ian James; Celine Adessi; Francesca Michielin; Keelara Abiraj; Birgit Bossenmaier; Jan H.M. Schellens; Martin Weisser; Ulrik N. Lassen
Personalized Medicine and Imaging
Triple-Negative versus Non–Triple-Negative Breast Cancers in High-Risk Women: Phenotype Features and Survival from the HIBCRIT-1 MRI-Including Screening Study
Franca Podo; Filippo Santoro; Giovanni Di Leo; Siranoush Manoukian; Clelia de Giacomi; Stefano Corcione; Laura Cortesi; Luca A. Carbonaro; Rubina M. Trimboli; Anna Cilotti; Lorenzo Preda; Bernardo Bonanni; Matilde Pensabene; Laura Martincich; Antonella Savarese; Alma Contegiacomo; Francesco Sardanelli
HAGE in Triple-Negative Breast Cancer Is a Novel Prognostic, Predictive, and Actionable Biomarker: A Transcriptomic and Protein Expression Analysis
Tarek M.A. Abdel-Fatah; Stephanie E.B. McArdle; Devika Agarwal; Paul M. Moseley; Andrew R. Green; Graham R. Ball; A. Graham Pockley; Ian O. Ellis; Robert C. Rees; Stephen Y.T. Chan
Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients
Cloud P. Paweletz; Adrian G. Sacher; Chris K. Raymond; Ryan S. Alden; Allison O'Connell; Stacy L. Mach; Yanan Kuang; Leena Gandhi; Paul Kirschmeier; Jessie M. English; Lee P. Lim; Pasi A. Jänne; Geoffrey R. Oxnard
Cancer Therapy: Preclinical
MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer
Karina E. Hew; Philip C. Miller; Dorraya El-Ashry; Jun Sun; Alexandra H. Besser; Tan A. Ince; Mengnan Gu; Zhi Wei; Gao Zhang; Patricia Brafford; Wei Gao; Yiling Lu; Gordon B. Mills; Joyce M. Slingerland; Fiona Simpkins
Biology of Human Tumors
Global Hypomethylation (LINE-1) and Gene-Specific Hypermethylation (GSTP1) on Initial Negative Prostate Biopsy as Markers of Prostate Cancer on a Rebiopsy
Renata Zelic; Valentina Fiano; Daniela Zugna; Chiara Grasso; Luisa Delsedime; Lorenzo Daniele; Diego Galliano; Andreas Pettersson; Anna Gillio-Tos; Franco Merletti; Lorenzo Richiardi
ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients
David Chu; Costanza Paoletti; Christina Gersch; Dustin A. VanDenBerg; Daniel J. Zabransky; Rory L. Cochran; Hong Yuen Wong; Patricia Valda Toro; Justin Cidado; Sarah Croessmann; Bracha Erlanger; Karen Cravero; Kelly Kyker-Snowman; Berry Button; Heather A. Parsons; W. Brian Dalton; Riaz Gillani; Arielle Medford; Kimberly Aung; Nahomi Tokudome; Arul M. Chinnaiyan; Anne Schott; Dan Robinson; Karen S. Jacks; Josh Lauring; Paula J. Hurley; Daniel F. Hayes; James M. Rae; Ben Ho Park
Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use
Apurva K. Srivastava; Soumya Jaganathan; Laurie Stephen; Melinda G. Hollingshead; Adam Layhee; Eric Damour; Jeevan Prasaad Govindharajulu; Jennifer Donohue; Dominic Esposito; James P. Mapes; Robert J. Kinders; Naoko Takebe; Joseph E. Tomaszewski; Shivaani Kummar; James H. Doroshow; Ralph E. Parchment
Author Choice
Well-Differentiated Neuroendocrine Tumors with a Morphologically Apparent High-Grade Component: A Pathway Distinct from Poorly Differentiated Neuroendocrine Carcinomas
Laura H. Tang; Brian R. Untch; Diane L. Reidy; Eileen O'Reilly; Deepti Dhall; Lily Jih; Olca Basturk; Peter J. Allen; David S. Klimstra
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