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1 February 2016
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Cover Image
Cover Image
The cover shows a section of a tumor from a patient with high-grade serous ovarian cancer. Immunofluorescent staining shows tumor-infiltrating lymphocytes coexpressing CD8 and CD27. For details, see the article by Wouters and colleagues on page 714 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Molecular Pathways
Review
Cancer Therapy: Clinical
Personalized Medicine and Imaging
Author Choice
Prediction of Response to Neoadjuvant Chemotherapy Using Core Needle Biopsy Samples with the Prosigna Assay
Aleix Prat; Patricia Galván; Begoña Jimenez; Wesley Buckingham; H. Arthur Jeiranian; Carl Schaper; Maria Vidal; Martina Álvarez; Sherley Díaz; Catherine Ellis; Paolo Nuciforo; Sean Ferree; Nuria Ribelles; Barbara Adamo; Santiago Ramón y Cajal; Vicente Peg; Emilio Alba
Author Choice
Correlation of BRAF Mutation Status in Circulating-Free DNA and Tumor and Association with Clinical Outcome across Four BRAFi and MEKi Clinical Trials
Ademi Santiago-Walker; Robert Gagnon; Jolly Mazumdar; Michelle Casey; Georgina V. Long; Dirk Schadendorf; Keith Flaherty; Richard Kefford; Axel Hauschild; Patrick Hwu; Patricia Haney; Anne O'Hagan; Jennifer Carver; Vicki Goodman; Jeffrey Legos; Anne-Marie Martin
The Impact of T2/FLAIR Evaluation per RANO Criteria on Response Assessment of Recurrent Glioblastoma Patients Treated with Bevacizumab
Raymond Y. Huang; Rifaquat Rahman; Karla V. Ballman; Sara J. Felten; S. Keith Anderson; Benjamin M. Ellingson; Lakshmi Nayak; Eudocia Q. Lee; Lauren E. Abrey; Evanthia Galanis; David A. Reardon; Whitney B. Pope; Timothy F. Cloughesy; Patrick Y. Wen
Cancer Therapy: Preclinical
Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma
Christina D. Pham; Catherine Flores; Changlin Yang; Elaine M. Pinheiro; Jennifer H. Yearley; Elias J. Sayour; Yanxin Pei; Colin Moore; Roger E. McLendon; Jianping Huang; John H. Sampson; Robert Wechsler-Reya; Duane A. Mitchell
The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas
Maximillian Rosario; Bai Liu; Lin Kong; Lynne I. Collins; Stephanie E. Schneider; Xiaoyue Chen; Kaiping Han; Emily K. Jeng; Peter R. Rhode; Jeffrey W. Leong; Timothy Schappe; Brea A. Jewell; Catherine R. Keppel; Keval Shah; Brian Hess; Rizwan Romee; David R. Piwnica-Worms; Amanda F. Cashen; Nancy L. Bartlett; Hing C. Wong; Todd A. Fehniger
A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition
Milena P. Mak; Pan Tong; Lixia Diao; Robert J. Cardnell; Don L. Gibbons; William N. William; Ferdinandos Skoulidis; Edwin R. Parra; Jaime Rodriguez-Canales; Ignacio I. Wistuba; John V. Heymach; John N. Weinstein; Kevin R. Coombes; Jing Wang; Lauren Averett Byers
Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer
Oriol Arqués; Irene Chicote; Isabel Puig; Stephan P. Tenbaum; Guillem Argilés; Rodrigo Dienstmann; Natalia Fernández; Ginevra Caratù; Judit Matito; Daniel Silberschmidt; Jordi Rodon; Stefania Landolfi; Aleix Prat; Eloy Espín; Ramón Charco; Paolo Nuciforo; Ana Vivancos; Wenlin Shao; Josep Tabernero; Héctor G. Palmer
Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell–Mediated Tumor Control in the Genital Tract
Yun-Yan Sun; Shiwen Peng; Liping Han; Jin Qiu; Liwen Song; Yachea Tsai; Benjamin Yang; Richard B.S. Roden; Cornelia L. Trimble; Chien-Fu Hung; T.-C. Wu
Author Choice
NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Deborah H. Charych; Ute Hoch; John L. Langowski; Steve R. Lee; Murali K. Addepalli; Peter B. Kirk; Dawei Sheng; Xiaofeng Liu; Paul W. Sims; Laurie A. VanderVeen; Cherie F. Ali; Thomas K. Chang; Marina Konakova; Rhoneil L. Pena; Rupesh S. Kanhere; Yolanda M. Kirksey; Chunmei Ji; Yujun Wang; Jicai Huang; Theresa D. Sweeney; Seema S. Kantak; Stephen K. Doberstein
Biology of Human Tumors
The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma
Hai-Feng Zhang; Ye Chen; Chengsheng Wu; Zhi-Yong Wu; David J. Tweardy; Abdulraheem Alshareef; Lian-Di Liao; Yu-Jie Xue; Jian-Yi Wu; Bo Chen; Xiu-E Xu; Keshav Gopal; Nidhi Gupta; En-Min Li; Li-Yan Xu; Raymond Lai
Evaluation of PD-L1 Expression and Associated Tumor-Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma
Maria Vassilakopoulou; Margaritis Avgeris; Vamsidhar Velcheti; Vassiliki Kotoula; Theodore Rampias; Kyriakos Chatzopoulos; Christos Perisanidis; Christos K. Kontos; Aris I. Giotakis; Andreas Scorilas; David Rimm; Clarence Sasaki; George Fountzilas; Amanda Psyrri
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer
Maartje C.A. Wouters; Fenne L. Komdeur; Hagma H. Workel; Harry G. Klip; Annechien Plat; Neeltje M. Kooi; G. Bea A. Wisman; Marian J.E. Mourits; Henriette J.G. Arts; Maaike H.M. Oonk; Refika Yigit; Steven de Jong; Cornelis J.M. Melief; Harry Hollema; Evelien W. Duiker; Toos Daemen; Marco de Bruyn; Hans W. Nijman
Novel MYBL1 Gene Rearrangements with Recurrent MYBL1–NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations
Yoshitsugu Mitani; Bin Liu; Pulivarthi H. Rao; Vishnupriya J. Borra; Mark Zafereo; Randal S. Weber; Merrill Kies; Guillermina Lozano; P. Andrew Futreal; Carlos Caulin; Adel K. El-Naggar
The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I
Julia E. Maxson; Samuel B. Luty; Jason D. MacManiman; Jason C. Paik; Jason Gotlib; Peter Greenberg; Swaleh Bahamadi; Samantha L. Savage; Melissa L. Abel; Christopher A. Eide; Marc M. Loriaux; Emily A. Stevens; Jeffrey W. Tyner
Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer
Donghao Lu; Jennifer A. Sinnott; Unnur Valdimarsdóttir; Fang Fang; Travis Gerke; Svitlana Tyekucheva; Michelangelo Fiorentino; Mats Lambe; Howard D. Sesso; Christopher J. Sweeney; Kathryn M. Wilson; Edward L. Giovannucci; Massimo Loda; Lorelei A. Mucci; Katja Fall
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