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15 November 2016
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Cover Image
Cover Image
The cover shows immunohistochemical staining of tumor-associated lymphocytes in a tumor biopsy of a nivolumab-treated patient with mRCC. Immunohistochemical staining shows enrichment in CD3+ (brown) and a modest enrichment in CD4+ (purple) cells at cycle 2, day 8 of nivolumab treatment relative to baseline (not shown). FoxP3 (nuclei, red) stain is also included. For details, see the article by Choueiri and colleagues on page 5461 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
Review
Challenges Facing Early Phase Trials Sponsored by the National Cancer Institute: An Analysis of Corrective Action Plans to Improve Accrual
Holly A. Massett; Grace Mishkin; Larry Rubinstein; S. Percy Ivy; Andrea Denicoff; Elizabeth Godwin; Kate DiPiazza; Jennifer Bolognese; James A. Zwiebel; Jeffrey S. Abrams
CCR Focus
Cancer Therapy: Clinical
Author Choice
Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma
Toni K. Choueiri; Mayer N. Fishman; Bernard Escudier; David F. McDermott; Charles G. Drake; Harriet Kluger; Walter M. Stadler; Jose Luis Perez-Gracia; Douglas G. McNeel; Brendan Curti; Michael R. Harrison; Elizabeth R. Plimack; Leonard Appleman; Lawrence Fong; Laurence Albiges; Lewis Cohen; Tina C. Young; Scott D. Chasalow; Petra Ross-Macdonald; Shivani Srivastava; Maria Jure-Kunkel; John F. Kurland; Jason S. Simon; Mario Sznol
Personalized Medicine and Imaging
Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab
Benjamin Weide; Alexander Martens; Jessica C. Hassel; Carola Berking; Michael A. Postow; Kees Bisschop; Ester Simeone; Johanna Mangana; Bastian Schilling; Anna Maria Di Giacomo; Nicole Brenner; Katharina Kähler; Lucie Heinzerling; Ralf Gutzmer; Armin Bender; Christoffer Gebhardt; Emanuela Romano; Friedegund Meier; Peter Martus; Michele Maio; Christian Blank; Dirk Schadendorf; Reinhard Dummer; Paolo A. Ascierto; Geke Hospers; Claus Garbe; Jedd D. Wolchok
Noninvasive Detection of Metastases and Follicle Density in Ovarian Tissue Using Full-Field Optical Coherence Tomography
Inge T.A. Peters; Paulien L. Stegehuis; Ronald Peek; Florine L. Boer; Erik W. van Zwet; Jeroen Eggermont; Johan R. Westphal; Peter J.K. Kuppen; J. Baptist Trimbos; Carina G.J.M. Hilders; Boudewijn P.F. Lelieveldt; Cornelis J.H. van de Velde; Tjalling Bosse; Jouke Dijkstra; Alexander L. Vahrmeijer
Cancer Therapy: Preclinical
Author Choice
The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models
Sen Zhang; Rana Anjum; Rachel Squillace; Sara Nadworny; Tianjun Zhou; Jeff Keats; Yaoyu Ning; Scott D. Wardwell; David Miller; Youngchul Song; Lindsey Eichinger; Lauren Moran; Wei-Sheng Huang; Shuangying Liu; Dong Zou; Yihan Wang; Qurish Mohemmad; Hyun Gyung Jang; Emily Ye; Narayana Narasimhan; Frank Wang; Juan Miret; Xiaotian Zhu; Tim Clackson; David Dalgarno; William C. Shakespeare; Victor M. Rivera
The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer
Richard J. Rebello; Eric Kusnadi; Donald P. Cameron; Helen B. Pearson; Analia Lesmana; Jennifer R. Devlin; Denis Drygin; Ashlee K. Clark; Laura Porter; John Pedersen; Shahneen Sandhu; Gail P. Risbridger; Richard B. Pearson; Ross D. Hannan; Luc Furic
Biology of Human Tumors
Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma
Laurence Feldmeyer; Courtney W. Hudgens; Genevieve Ray-Lyons; Priyadharsini Nagarajan; Phyu P. Aung; Jonathan L. Curry; Carlos A. Torres-Cabala; Barbara Mino; Jaime Rodriguez-Canales; Alexandre Reuben; Pei-Ling Chen; Jennifer S. Ko; Steven D. Billings; Roland L. Bassett; Ignacio I. Wistuba; Zachary A. Cooper; Victor G. Prieto; Jennifer A. Wargo; Michael T. Tetzlaff
Author Choice
Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma
Mathieu Chicard; Sandrine Boyault; Leo Colmet Daage; Wilfrid Richer; David Gentien; Gaelle Pierron; Eve Lapouble; Angela Bellini; Nathalie Clement; Isabelle Iacono; Stéphanie Bréjon; Marjorie Carrere; Cécile Reyes; Toby Hocking; Virginie Bernard; Michel Peuchmaur; Nadège Corradini; Cécile Faure-Conter; Carole Coze; Dominique Plantaz; Anne Sophie Defachelles; Estelle Thebaud; Marion Gambart; Frédéric Millot; Dominique Valteau-Couanet; Jean Michon; Alain Puisieux; Olivier Delattre; Valérie Combaret; Gudrun Schleiermacher
Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis
Kensuke Yamamura; Yoshifumi Baba; Shigeki Nakagawa; Kosuke Mima; Keisuke Miyake; Kenichi Nakamura; Hiroshi Sawayama; Koichi Kinoshita; Takatsugu Ishimoto; Masaaki Iwatsuki; Yasuo Sakamoto; Yoichi Yamashita; Naoya Yoshida; Masayuki Watanabe; Hideo Baba
Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group
Ariadne H.A.G. Ooms; Samantha Gadd; Daniela S. Gerhard; Malcolm A. Smith; Jaime M. Guidry Auvil; Daoud Meerzaman; Qing-Rong Chen; Chih Hao Hsu; Chunhua Yan; Cu Nguyen; Ying Hu; Yussanne Ma; Zusheng Zong; Andrew J. Mungall; Richard A. Moore; Marco A. Marra; Vicki Huff; Jeffrey S. Dome; Yueh-Yun Chi; Jing Tian; James I. Geller; Charles G. Mullighan; Jing Ma; David A. Wheeler; Oliver A. Hampton; Amy L. Walz; Marry M. van den Heuvel-Eibrink; Ronald R. de Krijger; Nicole Ross; Julie M. Gastier-Foster; Elizabeth J. Perlman
Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry–Based Phosphotyrosine Proteomics
Scott M. Haake; Jiannong Li; Yun Bai; Fumi Kinose; Bin Fang; Eric A. Welsh; Roy Zent; Jasreman Dhillon; Julio M. Pow-Sang; Y. Ann Chen; John M. Koomen; W. Kimryn Rathmell; Mayer Fishman; Eric B. Haura
Letter to the Editor
Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials—Letter
Mogens Groenvold; Neil K. Aaronson; Anne-Sophie E. Darlington; Deborah Fitzsimmons; Eva Greimel; Bernhard Holzner; Jaap C. Reijneveld; Krzysztof A. Tomaszewski; Irma Verdonck-de Leeuw; Lonneke van de Poll-Franse; on behalf of the EORTC Quality of Life Group
Correction
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