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15 January 2016
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Cover Image
Cover Image
The cover shows a section of a liver tissue specimen from a patient with hepatocellular carcinoma. Immunohistochemical staining shows a reduced HNF-6 expression within tumor cells. For details, see the article by Sun and colleagues on page 502 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
Reviews
Quantitative Imaging in Cancer Clinical Trials
Thomas E. Yankeelov; David A. Mankoff; Lawrence H. Schwartz; Frank S. Lieberman; John M. Buatti; James M. Mountz; Bradley J. Erickson; Fiona M.M. Fennessy; Wei Huang; Jayashree Kalpathy-Cramer; Richard L. Wahl; Hannah M. Linden; Paul E. Kinahan; Binsheng Zhao; Nola M. Hylton; Robert J. Gillies; Laurence Clarke; Robert Nordstrom; Daniel L. Rubin
Cancer Therapy: Clinical
Clinical and Translational Results of a Phase II, Randomized Trial of an Anti–IGF-1R (Cixutumumab) in Women with Breast Cancer That Progressed on Endocrine Therapy
William J. Gradishar; Denise A. Yardley; Rachel Layman; Joseph A. Sparano; Ellen Chuang; Donald W. Northfelt; Gary N. Schwartz; Hagop Youssoufian; Shande Tang; Ruslan Novosiadly; Amelie Forest; Tuan S. Nguyen; Jan Cosaert; Dmitri Grebennik; Paul Haluska
A Randomized Phase II Crossover Study of Imatinib or Rituximab for Cutaneous Sclerosis after Hematopoietic Cell Transplantation
Sally Arai; Joseph Pidala; Iskra Pusic; Xiaoyu Chai; Samantha Jaglowski; Nandita Khera; Jeanne Palmer; George L. Chen; Madan H. Jagasia; Sebastian A. Mayer; William A. Wood; Michael Green; Teresa S. Hyun; Yoshihiro Inamoto; Barry E. Storer; David B. Miklos; Howard M. Shulman; Paul J. Martin; Stefanie Sarantopoulos; Stephanie J. Lee; Mary E.D. Flowers
Personalized Medicine and Imaging
Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial)
Marta Epeldegui; Jeannette Y. Lee; Anna C. Martínez; Daniel P. Widney; Larry I. Magpantay; Deborah Regidor; Ronald Mitsuyasu; Joseph A. Sparano; Richard F. Ambinder; Otoniel Martínez-Maza
Subtype-Specific Metagene-Based Prediction of Outcome after Neoadjuvant and Adjuvant Treatment in Breast Cancer
Maurizio Callari; Vera Cappelletti; Francesca D'Aiuto; Valeria Musella; Antonio Lembo; Fabien Petel; Thomas Karn; Takayuki Iwamoto; Paolo Provero; Maria Grazia Daidone; Luca Gianni; Giampaolo Bianchini
Extent and Location of Tumor-Infiltrating Lymphocytes in Microsatellite-Stable Colon Cancer Predict Outcome to Adjuvant Active Specific Immunotherapy
Annelies W. Turksma; Veerle M.H. Coupé; Marc C. Shamier; Kevin L.H. Lam; Vincent A. de Weger; Jeroen A.M. Belien; Alfons J. van den Eertwegh; Gerrit A. Meijer; Chris J.L.M. Meijer; Erik Hooijberg
Real-time In Vivo Tissue Characterization with Diffuse Reflectance Spectroscopy during Transthoracic Lung Biopsy: A Clinical Feasibility Study
Jarich W. Spliethoff; Warner Prevoo; Mark A.J. Meier; Jeroen de Jong; Houke M. Klomp; Daniel J. Evers; Hendricus J.C.M. Sterenborg; Gerald W. Lucassen; Benno H.W. Hendriks; Theodoor J.M. Ruers
Using Whole-Exome Sequencing to Identify Genetic Markers for Carboplatin and Gemcitabine-Induced Toxicities
Henrik Gréen; Johanna Hasmats; Ilya Kupershmidt; Daniel Edsgärd; Luigi de Petris; Rolf Lewensohn; Fiona Blackhall; Svante Vikingsson; Benjamin Besse; Andrea Lindgren; Eva Brandén; Hirsh Koyi; Curt Peterson; Joakim Lundeberg
Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma
Melissa A. Wilson; Fengmin Zhao; Sanika Khare; Jason Roszik; Scott E. Woodman; Kurt D'Andrea; Bradley Wubbenhorst; David L. Rimm; John M. Kirkwood; Harriet M. Kluger; Lynn M. Schuchter; Sandra J. Lee; Keith T. Flaherty; Katherine L. Nathanson
Cancer Therapy: Preclinical
Nuclear Trapping through Inhibition of Exosomal Export by Indomethacin Increases Cytostatic Efficacy of Doxorubicin and Pixantrone
Raphael Koch; Thiha Aung; Daniel Vogel; Bjoern Chapuy; Dirk Wenzel; Sabrina Becker; Ursula Sinzig; Vivek Venkataramani; Tobias von Mach; Ralf Jacob; Lorenz Truemper; Gerald G. Wulf
Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma
Valentina Pirazzoli; Deborah Ayeni; Catherine B. Meador; Basavaraju G. Sanganahalli; Fahmeed Hyder; Elisa de Stanchina; Sarah B. Goldberg; William Pao; Katerina Politi
Blockade of Programmed Death 1 Augments the Ability of Human T Cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer
Edmund K. Moon; Raghuveer Ranganathan; Evgeniy Eruslanov; Soyeon Kim; Kheng Newick; Shaun O'Brien; Albert Lo; Xiaojun Liu; Yangbing Zhao; Steven M. Albelda
Biology of Human Tumors
Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
Paula J. Hurley; Debasish Sundi; Brian Shinder; Brian W. Simons; Robert M. Hughes; Rebecca M. Miller; Benjamin Benzon; Sheila F. Faraj; George J. Netto; Ismael A. Vergara; Nicholas Erho; Elai Davicioni; R. Jeffrey Karnes; Guifang Yan; Charles Ewing; Sarah D. Isaacs; David M. Berman; Jennifer R. Rider; Kristina M. Jordahl; Lorelei A. Mucci; Jessie Huang; Steven S. An; Ben H. Park; William B. Isaacs; Luigi Marchionni; Ashley E. Ross; Edward M. Schaeffer
Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia
Pavlina Janovska; Lucie Poppova; Karla Plevova; Hana Plesingerova; Martin Behal; Marketa Kaucka; Petra Ovesna; Michaela Hlozkova; Marek Borsky; Olga Stehlikova; Yvona Brychtova; Michael Doubek; Michaela Machalova; Sivasubramanian Baskar; Alois Kozubik; Sarka Pospisilova; Sarka Pavlova; Vitezslav Bryja
PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma
Francesco Sabbatino; Vincenzo Villani; Jennifer H. Yearley; Vikram Deshpande; Lei Cai; Ioannis T. Konstantinidis; Christina Moon; Sjoerd Nota; Yangyang Wang; Ahmad Al-Sukaini; Andrew X. Zhu; Lipika Goyal; David T. Ting; Nabeel Bardeesy; Theodore S. Hong; Carlos Fernandez-del Castillo; Kenneth K. Tanabe; Keith D. Lillemoe; Soldano Ferrone; Cristina R. Ferrone
SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer
Wilbert Zwart; Koen D. Flach; Bharath Rudraraju; Tarek M.A. Abdel-Fatah; Ondrej Gojis; Sander Canisius; David Moore; Ekaterina Nevedomskaya; Mark Opdam; Marjolein Droog; Ingrid Hofland; Steve Chan; Jacqui Shaw; Ian O. Ellis; R. Charles Coombes; Jason S. Carroll; Simak Ali; Carlo Palmieri
Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15–CCR1 Chemokine Axis
Susumu Inamoto; Yoshiro Itatani; Takamasa Yamamoto; Sachiko Minamiguchi; Hideyo Hirai; Masayoshi Iwamoto; Suguru Hasegawa; Makoto Mark Taketo; Yoshiharu Sakai; Kenji Kawada
Letter to the Editor
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