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1 October 2016
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Cover Image
Cover Image
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The cover shows a section of a double immunofluorescence staining of lumican (green) and SMAD4 (red) expressions in human pancreatic stellate cells after treatment with TGF-β and SB431542 at 2-hour exposure. For details, see the article by Kang and colleagues on page 4934 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
Editorial
CCR Translations
Review
Cancer Therapy: Clinical
A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma
Roy Rampling; Sharon Peoples; Paul J. Mulholland; Allan James; Omar Al-Salihi; Christopher J. Twelves; Catherine McBain; Sarah Jefferies; Alan Jackson; Willie Stewart; Juha Lindner; Sarah Kutscher; Norbert Hilf; Lesley McGuigan; Jane Peters; Karen Hill; Oliver Schoor; Harpreet Singh-Jasuja; Sarah E. Halford; James W.A. Ritchie
Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial
Ran Xu; Fumiko Shimizu; Koos Hovinga; Kathryn Beal; Sasan Karimi; Leif Droms; Kyung K. Peck; Philip Gutin; J. Bryan Iorgulescu; Thomas Kaley; Lisa DeAngelis; Elena Pentsova; Craig Nolan; Christian Grommes; Timothy Chan; Dylan Bobrow; Adilia Hormigo; Justin R. Cross; Nian Wu; Naoko Takebe; Katherine Panageas; Percy Ivy; Jeffrey G. Supko; Viviane Tabar; Antonio Omuro
Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082)
Wolfgang Wick; Thierry Gorlia; Pierre Bady; Michael Platten; Martin J. van den Bent; Martin J.B. Taphoorn; Jonathan Steuve; Alba A. Brandes; Marie-France Hamou; Antje Wick; Markus Kosch; Michael Weller; Roger Stupp; Patrick Roth; Vassilis Golfinopoulos; Jean-Sebastien Frenel; Mario Campone; Damien Ricard; Christine Marosi; Salvador Villa; Astrid Weyerbrock; Kirsten Hopkins; Krisztian Homicsko; Benoit Lhermitte; Gianfranco Pesce; Monika E. Hegi
Phase I Study of Inotuzumab Ozogamicin Combined with R-CVP for Relapsed/Refractory CD22+ B-cell Non-Hodgkin Lymphoma
Michinori Ogura; Kensei Tobinai; Kiyohiko Hatake; Andrew Davies; Michael Crump; Revathi Ananthakrishnan; Taro Ishibashi; M. Luisa Paccagnella; Joseph Boni; Erik Vandendries; David MacDonald
Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
Katy J. McCann; Ann Mander; Angelica Cazaly; Lindsey Chudley; Jana Stasakova; Stephen M. Thirdborough; Andrew King; Paul Lloyd-Evans; Emily Buxton; Ceri Edwards; Sarah Halford; Andrew Bateman; Ann O'Callaghan; Sally Clive; Alan Anthoney; Duncan I. Jodrell; Toni Weinschenk; Petra Simon; Ugur Sahin; Gareth J. Thomas; Freda K. Stevenson; Christian H. Ottensmeier
Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors
Sandra Ortiz-Cuaran; Matthias Scheffler; Dennis Plenker; llona Dahmen; Andreas H. Scheel; Lynnette Fernandez-Cuesta; Lydia Meder; Christine M. Lovly; Thorsten Persigehl; Sabine Merkelbach-Bruse; Marc Bos; Sebastian Michels; Rieke Fischer; Kerstin Albus; Katharina König; Hans-Ulrich Schildhaus; Jana Fassunke; Michaela A. Ihle; Helen Pasternack; Carina Heydt; Christian Becker; Janine Altmüller; Hongbin Ji; Christian Müller; Alexandra Florin; Johannes M. Heuckmann; Peter Nuernberg; Sascha Ansén; Lukas C. Heukamp; Johannes Berg; William Pao; Martin Peifer; Reinhard Buettner; Jürgen Wolf; Roman K. Thomas; Martin L. Sos
Personalized Medicine and Imaging
Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab
Alexander Martens; Kilian Wistuba-Hamprecht; Jianda Yuan; Michael A. Postow; Phillip Wong; Mariaelena Capone; Gabriele Madonna; Amir Khammari; Bastian Schilling; Antje Sucker; Dirk Schadendorf; Peter Martus; Brigitte Dreno; Paolo A. Ascierto; Jedd D. Wolchok; Graham Pawelec; Claus Garbe; Benjamin Weide
Author Choice
Biomarker Analyses of Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib with or without Erlotinib in the SEARCH Trial
Andrew X. Zhu; Yoon-Koo Kang; Olivier Rosmorduc; T.R. Jeffry Evans; Armando Santoro; Paul Ross; Edward Gane; Arndt Vogel; Michael Jeffers; Gerold Meinhardt; Carol E.A. Peña
Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy
Daniel L. Hertz; Kouros Owzar; Sherrie Lessans; Claudia Wing; Chen Jiang; William Kevin Kelly; Jai Patel; Susan Halabi; Yoichi Furukawa; Heather E. Wheeler; Alexander B. Sibley; Cameron Lassiter; Lois Weisman; Dorothy Watson; Stefanie D. Krens; Flora Mulkey; Cynthia L. Renn; Eric J. Small; Phillip G. Febbo; Ivo Shterev; Deanna L. Kroetz; Paula N. Friedman; John F. Mahoney; Michael A. Carducci; Michael J. Kelley; Yusuke Nakamura; Michiaki Kubo; Susan G. Dorsey; M. Eileen Dolan; Michael J. Morris; Mark J. Ratain; Howard L. McLeod
Cancer Therapy: Preclinical
Lenalidomide, Thalidomide, and Pomalidomide Reactivate the Epstein–Barr Virus Lytic Cycle through Phosphoinositide 3-Kinase Signaling and Ikaros Expression
Richard J. Jones; Tawin Iempridee; Xiaobin Wang; Hans C. Lee; Janet E. Mertz; Shannon C. Kenney; Heather C. Lin; Veerabhadran Baladandayuthapani; Christopher W. Dawson; Jatin J. Shah; Donna M. Weber; Robert Z. Orlowski
BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer
Alice Bartolini; Sabrina Cardaci; Simona Lamba; Daniele Oddo; Caterina Marchiò; Paola Cassoni; Carla Azzurra Amoreo; Giorgio Corti; Alessandro Testori; Federico Bussolino; Renata Pasqualini; Wadih Arap; Davide Corà; Federica Di Nicolantonio; Serena Marchiò
Biology of Human Tumors
Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors
Ya'an Kang; David Roife; Yeonju Lee; Hailong Lv; Rei Suzuki; Jianhua Ling; Mayrim V. Rios Perez; Xinqun Li; BingBing Dai; Michael Pratt; Mark J. Truty; Deyali Chatterjee; Huamin Wang; Ryan M. Thomas; Yu Wang; Eugene J. Koay; Paul J. Chiao; Matthew H. Katz; Jason B. Fleming
Letter to the Editor
Retraction
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