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1 October 2016
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Cover Image
Cover Image
The cover shows a section of a double immunofluorescence staining of lumican (green) and SMAD4 (red) expressions in human pancreatic stellate cells after treatment with TGF-β and SB431542 at 2-hour exposure. For details, see the article by Kang and colleagues on page 4934 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
Editorial
CCR Translations
Review
Cancer Therapy: Clinical
A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma
Roy Rampling; Sharon Peoples; Paul J. Mulholland; Allan James; Omar Al-Salihi; Christopher J. Twelves; Catherine McBain; Sarah Jefferies; Alan Jackson; Willie Stewart; Juha Lindner; Sarah Kutscher; Norbert Hilf; Lesley McGuigan; Jane Peters; Karen Hill; Oliver Schoor; Harpreet Singh-Jasuja; Sarah E. Halford; James W.A. Ritchie
Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial
Ran Xu; Fumiko Shimizu; Koos Hovinga; Kathryn Beal; Sasan Karimi; Leif Droms; Kyung K. Peck; Philip Gutin; J. Bryan Iorgulescu; Thomas Kaley; Lisa DeAngelis; Elena Pentsova; Craig Nolan; Christian Grommes; Timothy Chan; Dylan Bobrow; Adilia Hormigo; Justin R. Cross; Nian Wu; Naoko Takebe; Katherine Panageas; Percy Ivy; Jeffrey G. Supko; Viviane Tabar; Antonio Omuro
Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082)
Wolfgang Wick; Thierry Gorlia; Pierre Bady; Michael Platten; Martin J. van den Bent; Martin J.B. Taphoorn; Jonathan Steuve; Alba A. Brandes; Marie-France Hamou; Antje Wick; Markus Kosch; Michael Weller; Roger Stupp; Patrick Roth; Vassilis Golfinopoulos; Jean-Sebastien Frenel; Mario Campone; Damien Ricard; Christine Marosi; Salvador Villa; Astrid Weyerbrock; Kirsten Hopkins; Krisztian Homicsko; Benoit Lhermitte; Gianfranco Pesce; Monika E. Hegi
Phase I Study of Inotuzumab Ozogamicin Combined with R-CVP for Relapsed/Refractory CD22+ B-cell Non-Hodgkin Lymphoma
Michinori Ogura; Kensei Tobinai; Kiyohiko Hatake; Andrew Davies; Michael Crump; Revathi Ananthakrishnan; Taro Ishibashi; M. Luisa Paccagnella; Joseph Boni; Erik Vandendries; David MacDonald
Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
Katy J. McCann; Ann Mander; Angelica Cazaly; Lindsey Chudley; Jana Stasakova; Stephen M. Thirdborough; Andrew King; Paul Lloyd-Evans; Emily Buxton; Ceri Edwards; Sarah Halford; Andrew Bateman; Ann O'Callaghan; Sally Clive; Alan Anthoney; Duncan I. Jodrell; Toni Weinschenk; Petra Simon; Ugur Sahin; Gareth J. Thomas; Freda K. Stevenson; Christian H. Ottensmeier
Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors
Sandra Ortiz-Cuaran; Matthias Scheffler; Dennis Plenker; llona Dahmen; Andreas H. Scheel; Lynnette Fernandez-Cuesta; Lydia Meder; Christine M. Lovly; Thorsten Persigehl; Sabine Merkelbach-Bruse; Marc Bos; Sebastian Michels; Rieke Fischer; Kerstin Albus; Katharina König; Hans-Ulrich Schildhaus; Jana Fassunke; Michaela A. Ihle; Helen Pasternack; Carina Heydt; Christian Becker; Janine Altmüller; Hongbin Ji; Christian Müller; Alexandra Florin; Johannes M. Heuckmann; Peter Nuernberg; Sascha Ansén; Lukas C. Heukamp; Johannes Berg; William Pao; Martin Peifer; Reinhard Buettner; Jürgen Wolf; Roman K. Thomas; Martin L. Sos
Personalized Medicine and Imaging
Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab
Alexander Martens; Kilian Wistuba-Hamprecht; Jianda Yuan; Michael A. Postow; Phillip Wong; Mariaelena Capone; Gabriele Madonna; Amir Khammari; Bastian Schilling; Antje Sucker; Dirk Schadendorf; Peter Martus; Brigitte Dreno; Paolo A. Ascierto; Jedd D. Wolchok; Graham Pawelec; Claus Garbe; Benjamin Weide
Author Choice
Biomarker Analyses of Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib with or without Erlotinib in the SEARCH Trial
Andrew X. Zhu; Yoon-Koo Kang; Olivier Rosmorduc; T.R. Jeffry Evans; Armando Santoro; Paul Ross; Edward Gane; Arndt Vogel; Michael Jeffers; Gerold Meinhardt; Carol E.A. Peña
Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy
Daniel L. Hertz; Kouros Owzar; Sherrie Lessans; Claudia Wing; Chen Jiang; William Kevin Kelly; Jai Patel; Susan Halabi; Yoichi Furukawa; Heather E. Wheeler; Alexander B. Sibley; Cameron Lassiter; Lois Weisman; Dorothy Watson; Stefanie D. Krens; Flora Mulkey; Cynthia L. Renn; Eric J. Small; Phillip G. Febbo; Ivo Shterev; Deanna L. Kroetz; Paula N. Friedman; John F. Mahoney; Michael A. Carducci; Michael J. Kelley; Yusuke Nakamura; Michiaki Kubo; Susan G. Dorsey; M. Eileen Dolan; Michael J. Morris; Mark J. Ratain; Howard L. McLeod
Cancer Therapy: Preclinical
Lenalidomide, Thalidomide, and Pomalidomide Reactivate the Epstein–Barr Virus Lytic Cycle through Phosphoinositide 3-Kinase Signaling and Ikaros Expression
Richard J. Jones; Tawin Iempridee; Xiaobin Wang; Hans C. Lee; Janet E. Mertz; Shannon C. Kenney; Heather C. Lin; Veerabhadran Baladandayuthapani; Christopher W. Dawson; Jatin J. Shah; Donna M. Weber; Robert Z. Orlowski
BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer
Alice Bartolini; Sabrina Cardaci; Simona Lamba; Daniele Oddo; Caterina Marchiò; Paola Cassoni; Carla Azzurra Amoreo; Giorgio Corti; Alessandro Testori; Federico Bussolino; Renata Pasqualini; Wadih Arap; Davide Corà; Federica Di Nicolantonio; Serena Marchiò
Biology of Human Tumors
Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors
Ya'an Kang; David Roife; Yeonju Lee; Hailong Lv; Rei Suzuki; Jianhua Ling; Mayrim V. Rios Perez; Xinqun Li; BingBing Dai; Michael Pratt; Mark J. Truty; Deyali Chatterjee; Huamin Wang; Ryan M. Thomas; Yu Wang; Eugene J. Koay; Paul J. Chiao; Matthew H. Katz; Jason B. Fleming
Letter to the Editor
Retraction
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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