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15 September 2016
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Cover Image
Cover Image
The cover shows digital image analysis of androgen receptor splice variant AR-V7 expression as detected by chromogenic RNA in situ hybridization assay in a primary prostate tumor. Blue pixels highlight tumor epithelial cells and red pixels highlight areas of AR-V7 RNA expression. For details, see the article by Guedes and colleagues on page 4651 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval: Uridine Triacetate for the Treatment of Patients Following Fluorouracil or Capecitabine Overdose or Exhibiting Early-Onset Severe Toxicities Following Administration of These Drugs
Gwynn Ison; Julia A. Beaver; W. David McGuinn, Jr; Todd R. Palmby; Jeannette Dinin; Rosane Charlab; Anshu Marathe; Runyan Jin; Qi Liu; Xiao Hong Chen; Xavier Ysern; Olen Stephens; Ge Bai; Yaning Wang; Sarah E. Dorff; Joyce Cheng; Shenghui Tang; Rajeshwari Sridhara; William Pierce; Amy E. McKee; Amna Ibrahim; Geoffrey Kim; Richard Pazdur
Molecular Pathways
Perspectives
Cancer Therapy: Clinical
Author Choice
Phase I Clinical Trial of Marizomib (NPI-0052) in Patients with Advanced Malignancies Including Multiple Myeloma: Study NPI-0052-102 Final Results
Simon J. Harrison; Paul Mainwaring; Timothy Price; Michael J. Millward; Peeter Padrik; Craig R. Underhill; Paul K. Cannell; Steven D. Reich; Mohit Trikha; Andrew Spencer
A Phase I Dose-Escalation Study Evaluating the Safety Tolerability and Pharmacokinetics of CUDC-427, a Potent, Oral, Monovalent IAP Antagonist, in Patients with Refractory Solid Tumors
Anthony W. Tolcher; Johanna C. Bendell; Kyriakos P. Papadopoulos; Howard A. Burris; Amita Patnaik; Wayne J. Fairbrother; Harvey Wong; Nageshwar Budha; Walter C. Darbonne; Franklin Peale; Michael Mamounas; Stephanie Royer-Joo; Ron Yu; Chia C. Portera; Jeffrey R. Infante
EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Justin F. Gainor; Alice T. Shaw; Lecia V. Sequist; Xiujun Fu; Christopher G. Azzoli; Zofia Piotrowska; Tiffany G. Huynh; Ling Zhao; Linnea Fulton; Katherine R. Schultz; Emily Howe; Anna F. Farago; Ryan J. Sullivan; James R. Stone; Subba Digumarthy; Teresa Moran; Aaron N. Hata; Yukako Yagi; Beow Y. Yeap; Jeffrey A. Engelman; Mari Mino-Kenudson
Dual Block with Lapatinib and Trastuzumab Versus Single-Agent Trastuzumab Combined with Chemotherapy as Neoadjuvant Treatment of HER2-Positive Breast Cancer: A Meta-analysis of Randomized Trials
Matteo Clavarezza; Matteo Puntoni; Alessandra Gennari; Laura Paleari; Nicoletta Provinciali; Mauro D'Amico; Andrea DeCensi
Personalized Medicine and Imaging
Author Choice
Development and Clinical Validation of a Blood Test Based on 29-Gene Expression for Early Detection of Colorectal Cancer
Laura Ciarloni; Sahar Hosseinian Ehrensberger; Natsuko Imaizumi; Sylvain Monnier-Benoit; Cristina Nichita; Seung-Jae Myung; Joo Sung Kim; Si Young Song; Tae Il Kim; Boudewijn van der Weg; Rémy Meier; Jan Borovicka; Christoph Beglinger; Cédric Vallet; Philippe Maerten; Curzio Rüegg; Gian Dorta
WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy
Linda J.W. Bosch; Yanxin Luo; Victoria V. Lao; Petur Snaebjornsson; Geert Trooskens; Ilse Vlassenbroeck; Sandra Mongera; Weiliang Tang; Piri Welcsh; James G. Herman; Miriam Koopman; Iris D. Nagtegaal; Cornelis J.A. Punt; Wim van Criekinge; Gerrit A. Meijer; Raymond J. Monnat, Jr; Beatriz Carvalho; William M. Grady
Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer
Martin G. Dalin; Alexis Desrichard; Nora Katabi; Vladimir Makarov; Logan A. Walsh; Ken-Wing Lee; Qingguo Wang; Joshua Armenia; Lyndsay West; Snjezana Dogan; Lu Wang; Deepa Ramaswami; Alan L. Ho; Ian Ganly; David B. Solit; Michael F. Berger; Nikolaus D. Schultz; Jorge S. Reis-Filho; Timothy A. Chan; Luc G.T. Morris
Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer
Heath D. Skinner; Uma Giri; Liang Yang; Sang Hyeok Woo; Michael D. Story; Curtis R. Pickering; Lauren A. Byers; Michelle D. Williams; Adel El-Naggar; Jing Wang; Lixia Diao; Li Shen; You Hong Fan; David P. Molkentine; Beth M. Beadle; Raymond E. Meyn; Jeffrey N. Myers; John V. Heymach
Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer
Liana B. Guedes; Carlos L. Morais; Fawaz Almutairi; Michael C. Haffner; Qizhi Zheng; John T. Isaacs; Emmanuel S. Antonarakis; Changxue Lu; Harrison Tsai; Jun Luo; Angelo M. De Marzo; Tamara L. Lotan
Cancer Therapy: Preclinical
A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort
Kathryn L. Terry; Helena Schock; Renée T. Fortner; Anika Hüsing; Raina N. Fichorova; Hidemi S. Yamamoto; Allison F. Vitonis; Theron Johnson; Kim Overvad; Anne Tjønneland; Marie-Christine Boutron-Ruault; Sylvie Mesrine; Gianluca Severi; Laure Dossus; Sabina Rinaldi; Heiner Boeing; Vassiliki Benetou; Pagona Lagiou; Antonia Trichopoulou; Vittorio Krogh; Elisabetta Kuhn; Salvatore Panico; H. Bas Bueno-de-Mesquita; N. Charlotte Onland-Moret; Petra H. Peeters; Inger Torhild Gram; Elisabete Weiderpass; Eric J. Duell; Maria-Jose Sanchez; Eva Ardanaz; Nerea Etxezarreta; Carmen Navarro; Annika Idahl; Eva Lundin; Karin Jirström; Jonas Manjer; Nicholas J. Wareham; Kay-Tee Khaw; Karl Smith Byrne; Ruth C. Travis; Marc J. Gunter; Melissa A. Merritt; Elio Riboli; Daniel W. Cramer; Rudolf Kaaks
A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers
Georg Karpel-Massler; Basil A. Horst; Chang Shu; Lily Chau; Takashi Tsujiuchi; Jeffrey N. Bruce; Peter Canoll; Lloyd A. Greene; James M. Angelastro; Markus D. Siegelin
Biology of Human Tumors
Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures
Yanxiao Zhang; Lada A. Koneva; Shama Virani; Anna E. Arthur; Alisha Virani; Pelle B. Hall; Charles D. Warden; Thomas E. Carey; Douglas B. Chepeha; Mark E. Prince; Jonathan B. McHugh; Gregory T. Wolf; Laura S. Rozek; Maureen A. Sartor
APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma
Brandon Leonard; Gabriel J. Starrett; Matthew J. Maurer; Ann L. Oberg; Mieke Van Bockstal; Jo Van Dorpe; Olivier De Wever; Jozien Helleman; Anieta M. Sieuwerts; Els M.J.J. Berns; John W.M. Martens; Brett D. Anderson; William L. Brown; Kimberly R. Kalli; Scott H. Kaufmann; Reuben S. Harris
Correction
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