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15 July 2016
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Cover Image
Cover Image
The cover shows intratumoral bone deposition, shown by strong Alizarin Red staining, in a malignant rhabdoid tumor xenograft treated with low-dose LBH589. For details, see the article by Muscat and colleagues on page 3560 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
Review
Cancer Therapy: Clinical
IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function
Daniel A. Vallera; Martin Felices; Ron McElmurry; Valarie McCullar; Xianzheng Zhou; Joerg Uwe Schmohl; Bin Zhang; Alexander J. Lenvik; Angela Panoskaltsis-Mortari; Michael R. Verneris; Jakub Tolar; Sarah Cooley; Daniel J. Weisdorf; Bruce R. Blazar; Jeffrey S. Miller
High Levels of Antibody that Neutralize B-cell Infection of Epstein–Barr Virus and that Bind EBV gp350 Are Associated with a Lower Risk of Nasopharyngeal Carcinoma
Anna E. Coghill; Wei Bu; Hanh Nguyen; Wan-Lun Hsu; Kelly J. Yu; Pei-Jen Lou; Cheng-Ping Wang; Chien-Jen Chen; Allan Hildesheim; Jeffrey I. Cohen
Personalized Medicine and Imaging
Author Choice
Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair–Proficient Stage II Colon Cancer
Pradipta Ghosh; Jeanne Tie; Andrea Muranyi; Shalini Singh; Patrick Brunhoeber; Katherine Leith; Rebecca Bowermaster; Zhiming Liao; Yifei Zhu; Bonnie LaFleur; Ben Tran; Jayesh Desai; Ian Jones; Matthew Croxford; Rodrigo Jover; Ajay Goel; Paul Waring; Song Hu; Volker Teichgraber; Ulrich-Peter Rohr; Ruediger Ridder; Kandavel Shanmugam; Peter Gibbs
Cancer Therapy: Preclinical
Author Choice
TNF-Related Apoptosis-Inducing Ligand (TRAIL)–Armed Exosomes Deliver Proapoptotic Signals to Tumor Site
Licia Rivoltini; Claudia Chiodoni; Paola Squarcina; Monica Tortoreto; Antonello Villa; Barbara Vergani; Maja Bürdek; Laura Botti; Ivano Arioli; Agata Cova; Giorgio Mauri; Elisabetta Vergani; Beatrice Bianchi; Pamela Della Mina; Laura Cantone; Valentina Bollati; Nadia Zaffaroni; Alessandro Massimo Gianni; Mario Paolo Colombo; Veronica Huber
Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation
Kamalakannan Palanichamy; Krishnan Thirumoorthy; Suman Kanji; Nicolaus Gordon; Rajbir Singh; John R. Jacob; Nikhil Sebastian; Kevin T. Litzenberg; Disha Patel; Emily Bassett; Brinda Ramasubramanian; Tim Lautenschlaeger; Steven M. Fischer; Abhik Ray-Chaudhury; Arnab Chakravarti
Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis
Subapriya Rajamanickam; Subbarayalu Panneerdoss; Aparna Gorthi; Santosh Timilsina; Benjamin Onyeagucha; Dmytro Kovalskyy; Dmitri Ivanov; Martha A. Hanes; Ratna K. Vadlamudi; Yidong Chen; Alexander J. Bishop; Jack L. Arbiser; Manjeet K. Rao
HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia
Tsung-Huei Lai; Brett Ewald; Alma Zecevic; Chaomei Liu; Melanie Sulda; Dimitrios Papaioannou; Ramiro Garzon; James S. Blachly; William Plunkett; Deepa Sampath
Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma
Kristy A. Warner; Felipe Nör; Gerson A. Acasigua; Manoela D. Martins; Zhaocheng Zhang; Scott A. McLean; Matthew E. Spector; Douglas B. Chepeha; Joseph Helman; Michael J. Wick; Christopher A. Moskaluk; Rogerio M. Castilho; Alexander T. Pearson; Shaomeng Wang; Jacques E. Nör
Author Choice
Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors
Andrea Muscat; Dean Popovski; W. Samantha N. Jayasekara; Fernando J. Rossello; Melissa Ferguson; Kieren D. Marini; Muhammad Alamgeer; Elizabeth M. Algar; Peter Downie; D. Neil Watkins; Jason E. Cain; David M. Ashley
Biology of Human Tumors
Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma
Zijun Y. Xu-Monette; Qipan Deng; Ganiraju C. Manyam; Alexander Tzankov; Ling Li; Yi Xia; Xiao-xiao Wang; Dehui Zou; Carlo Visco; Karen Dybkær; Jun Li; Li Zhang; Han Liang; Santiago Montes-Moreno; April Chiu; Attilio Orazi; Youli Zu; Govind Bhagat; Kristy L. Richards; Eric D. Hsi; William W.L. Choi; J. Han van Krieken; Jooryung Huh; Maurilio Ponzoni; Andrés J.M. Ferreri; Ben M. Parsons; Michael B. Møller; Sa A. Wang; Roberto N. Miranda; Miguel A. Piris; Jane N. Winter; L. Jeffrey Medeiros; Yong Li; Ken H. Young
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma–like and Non–Small Cell Carcinoma–like Subsets
Natasha Rekhtman; Maria C. Pietanza; Matthew D. Hellmann; Jarushka Naidoo; Arshi Arora; Helen Won; Darragh F. Halpenny; Hangjun Wang; Shaozhou K. Tian; Anya M. Litvak; Paul K. Paik; Alexander E. Drilon; Nicholas Socci; John T. Poirier; Ronglai Shen; Michael F. Berger; Andre L. Moreira; William D. Travis; Charles M. Rudin; Marc Ladanyi
Author Choice
Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma
Yanyan Lou; Lixia Diao; Edwin Roger Parra Cuentas; Warren L. Denning; Limo Chen; You Hong Fan; Lauren A. Byers; Jing Wang; Vassiliki A. Papadimitrakopoulou; Carmen Behrens; Jaime Canales Rodriguez; Patrick Hwu; Ignacio I. Wistuba; John V. Heymach; Don L. Gibbons
Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group
Kieuhoa T. Vo; Jeremy V. Edwards; C. Lorrie Epling; Elizabeth Sinclair; Douglas S. Hawkins; Holcombe E. Grier; Katherine A. Janeway; Phillip Barnette; Elizabeth McIlvaine; Mark D. Krailo; Donald A. Barkauskas; Katherine K. Matthay; Richard B. Womer; Richard G. Gorlick; Stephen L. Lessnick; Crystal L. Mackall; Steven G. DuBois
Tumor Evolution Inferred by Patterns of microRNA Expression through the Course of Disease, Therapy, and Recurrence in Breast Cancer
Maya Dadiani; Noa Bossel Ben-Moshe; Shani Paluch-Shimon; Gili Perry; Nora Balint; Irina Marin; Anya Pavlovski; Dana Morzaev; Smadar Kahana-Edwin; Ady Yosepovich; Einav Nili Gal-Yam; Raanan Berger; Iris Barshack; Eytan Domany; Bella Kaufman
Functional Analyses of Mutations in Receptor Tyrosine Kinase Genes in Non–Small Cell Lung Cancer: Double-Edged Sword of DDR2
Masato Terashima; Yosuke Togashi; Katsuaki Sato; Hiroshi Mizuuchi; Kazuko Sakai; Kenichi Suda; Yu Nakamura; Eri Banno; Hidetoshi Hayashi; Marco A. De Velasco; Yoshihiko Fujita; Shuta Tomida; Tetsuya Mitsudomi; Kazuto Nishio
ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer
Shuai Gao; Huihui Ye; Sean Gerrin; Hongyun Wang; Ankur Sharma; Sen Chen; Akash Patnaik; Adam G. Sowalsky; Olga Voznesensky; Wanting Han; Ziyang Yu; Elahe A. Mostaghel; Peter S. Nelson; Mary-Ellen Taplin; Steven P. Balk; Changmeng Cai
Author Choice
Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays
Apurva K. Srivastava; Melinda G. Hollingshead; Jennifer Weiner; Tony Navas; Yvonne A. Evrard; Sonny A. Khin; Jiuping Jay Ji; Yiping Zhang; Suzanne Borgel; Thomas D. Pfister; Robert J. Kinders; Donald P. Bottaro; W. Marston Linehan; Joseph E. Tomaszewski; James H. Doroshow; Ralph E. Parchment
Obituary
Letters to the Editor
Corrections
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