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1 July 2016
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Cover Image
Cover Image
The cover shows a section of a skin biopsy from a mycosis fungoides patient. The staining displays a predominant infiltration of CD3 positive cells (blue) that encompass benign and malignant T cells accompanied by PU.1 cells (brown) in close proximity. For details, see the article by Vieyra-Garcia and colleagues on page 3328 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Molecular Pathways
Review
Cancer Therapy: Clinical
Author Choice
Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors
Daniel D. Von Hoff; Monica M. Mita; Ramesh K. Ramanathan; Glen J. Weiss; Alain C. Mita; Patricia M. LoRusso; Howard A. Burris, III; Lowell L. Hart; Susan C. Low; Donald M. Parsons; Stephen E. Zale; Jason M. Summa; Hagop Youssoufian; Jasgit C. Sachdev
Author Choice
Dose Escalation of Tamoxifen in Patients with Low Endoxifen Level: Evidence for Therapeutic Drug Monitoring—The TADE Study
Peter Fox; Rosemary L. Balleine; Clara Lee; Bo Gao; Bavanthi Balakrishnar; Alexander M. Menzies; Shang Heng Yeap; Sayed Sahanawaz Ali; Val Gebski; Pamela Provan; Sally Coulter; Christopher Liddle; Rina Hui; Richard Kefford; Jodi Lynch; Mark Wong; Nicholas Wilcken; Howard Gurney
A Randomized Phase II/III Study of Naptumomab Estafenatox + IFNα versus IFNα in Renal Cell Carcinoma: Final Analysis with Baseline Biomarker Subgroup and Trend Analysis
Robert E. Hawkins; Martin Gore; Yaroslav Shparyk; Vladimir Bondar; Oleg Gladkov; Tosho Ganev; Mihai Harza; Serhii Polenkov; Igor Bondarenko; Petr Karlov; Oleg Karyakin; Rustem Khasanov; Gunnar Hedlund; Goran Forsberg; Örjan Nordle; Timothy Eisen
Adjuvant Immunotherapy to Improve Outcome in High-Risk Pediatric Sarcomas
Melinda S. Merchant; Donna Bernstein; Martha Amoako; Kristin Baird; Thomas A. Fleisher; Michel Morre; Seth M. Steinberg; Marianna Sabatino; Dave F. Stroncek; Aradhana M. Venkatasan; Bradford J. Wood; Matthew Wright; Hua Zhang; Crystal L. Mackall
Differential Effect on Bone Lesions of Targeting Integrins: Randomized Phase II Trial of Abituzumab in Patients with Metastatic Castration-Resistant Prostate Cancer
Maha Hussain; Sylvestre Le Moulec; Claude Gimmi; Rolf Bruns; Josef Straub; Kurt Miller; on behalf of the PERSEUS Study Group; on behalf of the PERSEUS Study Group; on behalf of the PERSEUS Study Group; on behalf of the PERSEUS Study Group; on behalf of the PERSEUS Study Group; on behalf of the PERSEUS Study Group
Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial
Hirofumi Yamamoto; Kohei Murata; Mutsumi Fukunaga; Tadashi Ohnishi; Shingo Noura; Yasuhiro Miyake; Takeshi Kato; Masahisa Ohtsuka; Yurika Nakamura; Ichiro Takemasa; Tsunekazu Mizushima; Masataka Ikeda; Masayuki Ohue; Mitsugu Sekimoto; Riichiro Nezu; Nariaki Matsuura; Morito Monden; Yuichiro Doki; Masaki Mori
A Phase I Clinical, Pharmacokinetic, and Pharmacodynamic Study of Weekly or Every Three Week Ixabepilone and Daily Sunitinib in Patients with Advanced Solid Tumors
Alberto J. Montero; Deukwoo Kwon; Aurea Flores; Krisztina Kovacs; Jonathan C. Trent; Pasquale Benedetto; Caio Rocha-Lima; Jaime R. Merchan
Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy
Satoshi Matsusaka; Diana L. Hanna; Shu Cao; Wu Zhang; Dongyun Yang; Yan Ning; Yu Sunakawa; Satoshi Okazaki; Martin D. Berger; Yuji Miyamato; Anish Parekh; Sebastian Stintzing; Fotios Loupakis; Heinz-Josef Lenz
Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors
Patricia M. LoRusso; Jing Li; Angelika Burger; Lance K. Heilbrun; Edward A. Sausville; Scott A. Boerner; Daryn Smith; Mary Jo Pilat; Jie Zhang; Sara M. Tolaney; James M. Cleary; Alice P. Chen; Lawrence Rubinstein; Julie L. Boerner; Adam Bowditch; Dongpo Cai; Tracy Bell; Andrew Wolanski; Allison M. Marrero; Yiping Zhang; Jiuping Ji; Katherine Ferry-Galow; Robert J. Kinders; Ralph E. Parchment; Geoffrey I. Shapiro
Author Choice
GTL001, A Therapeutic Vaccine for Women Infected with Human Papillomavirus 16 or 18 and Normal Cervical Cytology: Results of a Phase I Clinical Trial
Pierre Van Damme; Myriam Bouillette-Marussig; Annick Hens; Ilse De Coster; Christophe Depuydt; Anne Goubier; Viggo Van Tendeloo; Nathalie Cools; Herman Goossens; Thierry Hercend; Benedikt Timmerman; Marie-Christine Bissery
Personalized Medicine and Imaging
Immune Signatures Following Single Dose Trastuzumab Predict Pathologic Response to PreoperativeTrastuzumab and Chemotherapy in HER2-Positive Early Breast Cancer
Vinay Varadan; Hannah Gilmore; Kristy L.S. Miskimen; David Tuck; Shikha Parsai; Amad Awadallah; Ian E. Krop; Eric P. Winer; Veerle Bossuyt; George Somlo; Maysa M. Abu-Khalaf; Mary Anne Fenton; William Sikov; Lyndsay N. Harris
The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer
Francisco J. Sánchez-Martín; Beatriz Bellosillo; Mariona Gelabert-Baldrich; Alba Dalmases; Israel Cañadas; Joana Vidal; Alejandro Martinez; Guillem Argilés; Giulia Siravegna; Sabrina Arena; Klaus Koefoed; Laura Visa; Oriol Arpí; Ivan David Horak; Mar Iglesias; Christopher Stroh; Michael Kragh; Ana Rovira; Joan Albanell; Josep Tabernero; Alberto Bardelli; Clara Montagut
The Expression Quantitative Trait Loci in Immune Pathways and their Effect on Cutaneous Melanoma Prognosis
Matjaz Vogelsang; Carlos N. Martinez; Justin Rendleman; Anuj Bapodra; Karolina Malecek; Artur Romanchuk; Esther Kazlow; Richard L. Shapiro; Russell S. Berman; Michelle Krogsgaard; Iman Osman; Tomas Kirchhoff
Author Choice
Comprehensive Genomic Profiling Identifies Frequent Drug-Sensitive EGFR Exon 19 Deletions in NSCLC not Identified by Prior Molecular Testing
Alexa B. Schrock; Garrett M. Frampton; Dana Herndon; Joel R. Greenbowe; Kai Wang; Doron Lipson; Roman Yelensky; Zachary R. Chalmers; Juliann Chmielecki; Julia A. Elvin; Mira Wollner; Addie Dvir; Lior Soussan -Gutman; Rodolfo Bordoni; Nir Peled; Fadi Braiteh; Luis Raez; Rachel Erlich; Sai-Hong Ignatius Ou; Mohamed Mohamed; Jeffrey S. Ross; Philip J. Stephens; Siraj M. Ali; Vincent A. Miller
Cancer Therapy: Preclinical
Author Choice
A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Marina Bacac; Tanja Fauti; Johannes Sam; Sara Colombetti; Tina Weinzierl; Djamila Ouaret; Walter Bodmer; Steffi Lehmann; Thomas Hofer; Ralf J. Hosse; Ekkehard Moessner; Oliver Ast; Peter Bruenker; Sandra Grau-Richards; Teilo Schaller; Annette Seidl; Christian Gerdes; Mario Perro; Valeria Nicolini; Nathalie Steinhoff; Sherri Dudal; Sebastian Neumann; Thomas von Hirschheydt; Christiane Jaeger; Jose Saro; Vaios Karanikas; Christian Klein; Pablo Umaña
Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer–Initiating Cells and Is a Potent Target of Immunotherapy
Rena Morita; Yoshihiko Hirohashi; Toshihiko Torigoe; Satoko Ito-Inoda; Akari Takahashi; Tasuku Mariya; Hiroko Asanuma; Yasuaki Tamura; Tomohide Tsukahara; Takayuki Kanaseki; Terufumi Kubo; Goro Kutomi; Toru Mizuguchi; Takeshi Terui; Kunihiko Ishitani; Satoshi Hashino; Toru Kondo; Nozomi Minagawa; Norihiko Takahashi; Akinobu Taketomi; Satoru Todo; Masahiro Asaka; Noriyuki Sato
Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation
Mohammad Hedayati; Michael C. Haffner; Jonathan B. Coulter; Raju R. Raval; Yonggang Zhang; Haoming Zhou; Omar Mian; Emma J. Knight; Nina Razavi; Susan Dalrymple; John T. Isaacs; Aileen Santos; Russell Hales; William G. Nelson; Srinivasan Yegnasubramanian; Theodore L. DeWeese
Biology of Human Tumors
A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma
Maria Dvorkina; Valentina Nieddu; Shalini Chakelam; Annalisa Pezzolo; Sandra Cantilena; Ana Paula Leite; Olesya Chayka; Tarik Regad; Angela Pistorio; Angela Rita Sementa; Alex Virasami; Jack Barton; Ximena Montano; Tanguy Lechertier; Nicola Brindle; Daniel Morgenstern; Morgane Lebras; Alan J. Burns; Nigel J. Saunders; Kairbaan Hodivala-Dilke; Luigi Bagella; Hugues De The; John Anderson; Neil Sebire; Vito Pistoia; Arturo Sala; Paolo Salomoni
Letters to the Editor
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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