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1 July 2016
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Cover Image
Cover Image
The cover shows a section of a skin biopsy from a mycosis fungoides patient. The staining displays a predominant infiltration of CD3 positive cells (blue) that encompass benign and malignant T cells accompanied by PU.1 cells (brown) in close proximity. For details, see the article by Vieyra-Garcia and colleagues on page 3328 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Molecular Pathways
Review
Cancer Therapy: Clinical
Author Choice
Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors
Daniel D. Von Hoff; Monica M. Mita; Ramesh K. Ramanathan; Glen J. Weiss; Alain C. Mita; Patricia M. LoRusso; Howard A. Burris, III; Lowell L. Hart; Susan C. Low; Donald M. Parsons; Stephen E. Zale; Jason M. Summa; Hagop Youssoufian; Jasgit C. Sachdev
Author Choice
Dose Escalation of Tamoxifen in Patients with Low Endoxifen Level: Evidence for Therapeutic Drug Monitoring—The TADE Study
Peter Fox; Rosemary L. Balleine; Clara Lee; Bo Gao; Bavanthi Balakrishnar; Alexander M. Menzies; Shang Heng Yeap; Sayed Sahanawaz Ali; Val Gebski; Pamela Provan; Sally Coulter; Christopher Liddle; Rina Hui; Richard Kefford; Jodi Lynch; Mark Wong; Nicholas Wilcken; Howard Gurney
A Randomized Phase II/III Study of Naptumomab Estafenatox + IFNα versus IFNα in Renal Cell Carcinoma: Final Analysis with Baseline Biomarker Subgroup and Trend Analysis
Robert E. Hawkins; Martin Gore; Yaroslav Shparyk; Vladimir Bondar; Oleg Gladkov; Tosho Ganev; Mihai Harza; Serhii Polenkov; Igor Bondarenko; Petr Karlov; Oleg Karyakin; Rustem Khasanov; Gunnar Hedlund; Goran Forsberg; Örjan Nordle; Timothy Eisen
Adjuvant Immunotherapy to Improve Outcome in High-Risk Pediatric Sarcomas
Melinda S. Merchant; Donna Bernstein; Martha Amoako; Kristin Baird; Thomas A. Fleisher; Michel Morre; Seth M. Steinberg; Marianna Sabatino; Dave F. Stroncek; Aradhana M. Venkatasan; Bradford J. Wood; Matthew Wright; Hua Zhang; Crystal L. Mackall
Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial
Hirofumi Yamamoto; Kohei Murata; Mutsumi Fukunaga; Tadashi Ohnishi; Shingo Noura; Yasuhiro Miyake; Takeshi Kato; Masahisa Ohtsuka; Yurika Nakamura; Ichiro Takemasa; Tsunekazu Mizushima; Masataka Ikeda; Masayuki Ohue; Mitsugu Sekimoto; Riichiro Nezu; Nariaki Matsuura; Morito Monden; Yuichiro Doki; Masaki Mori
A Phase I Clinical, Pharmacokinetic, and Pharmacodynamic Study of Weekly or Every Three Week Ixabepilone and Daily Sunitinib in Patients with Advanced Solid Tumors
Alberto J. Montero; Deukwoo Kwon; Aurea Flores; Krisztina Kovacs; Jonathan C. Trent; Pasquale Benedetto; Caio Rocha-Lima; Jaime R. Merchan
Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy
Satoshi Matsusaka; Diana L. Hanna; Shu Cao; Wu Zhang; Dongyun Yang; Yan Ning; Yu Sunakawa; Satoshi Okazaki; Martin D. Berger; Yuji Miyamato; Anish Parekh; Sebastian Stintzing; Fotios Loupakis; Heinz-Josef Lenz
Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors
Patricia M. LoRusso; Jing Li; Angelika Burger; Lance K. Heilbrun; Edward A. Sausville; Scott A. Boerner; Daryn Smith; Mary Jo Pilat; Jie Zhang; Sara M. Tolaney; James M. Cleary; Alice P. Chen; Lawrence Rubinstein; Julie L. Boerner; Adam Bowditch; Dongpo Cai; Tracy Bell; Andrew Wolanski; Allison M. Marrero; Yiping Zhang; Jiuping Ji; Katherine Ferry-Galow; Robert J. Kinders; Ralph E. Parchment; Geoffrey I. Shapiro
Author Choice
GTL001, A Therapeutic Vaccine for Women Infected with Human Papillomavirus 16 or 18 and Normal Cervical Cytology: Results of a Phase I Clinical Trial
Pierre Van Damme; Myriam Bouillette-Marussig; Annick Hens; Ilse De Coster; Christophe Depuydt; Anne Goubier; Viggo Van Tendeloo; Nathalie Cools; Herman Goossens; Thierry Hercend; Benedikt Timmerman; Marie-Christine Bissery
Personalized Medicine and Imaging
Immune Signatures Following Single Dose Trastuzumab Predict Pathologic Response to PreoperativeTrastuzumab and Chemotherapy in HER2-Positive Early Breast Cancer
Vinay Varadan; Hannah Gilmore; Kristy L.S. Miskimen; David Tuck; Shikha Parsai; Amad Awadallah; Ian E. Krop; Eric P. Winer; Veerle Bossuyt; George Somlo; Maysa M. Abu-Khalaf; Mary Anne Fenton; William Sikov; Lyndsay N. Harris
The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer
Francisco J. Sánchez-Martín; Beatriz Bellosillo; Mariona Gelabert-Baldrich; Alba Dalmases; Israel Cañadas; Joana Vidal; Alejandro Martinez; Guillem Argilés; Giulia Siravegna; Sabrina Arena; Klaus Koefoed; Laura Visa; Oriol Arpí; Ivan David Horak; Mar Iglesias; Christopher Stroh; Michael Kragh; Ana Rovira; Joan Albanell; Josep Tabernero; Alberto Bardelli; Clara Montagut
The Expression Quantitative Trait Loci in Immune Pathways and their Effect on Cutaneous Melanoma Prognosis
Matjaz Vogelsang; Carlos N. Martinez; Justin Rendleman; Anuj Bapodra; Karolina Malecek; Artur Romanchuk; Esther Kazlow; Richard L. Shapiro; Russell S. Berman; Michelle Krogsgaard; Iman Osman; Tomas Kirchhoff
Author Choice
Comprehensive Genomic Profiling Identifies Frequent Drug-Sensitive EGFR Exon 19 Deletions in NSCLC not Identified by Prior Molecular Testing
Alexa B. Schrock; Garrett M. Frampton; Dana Herndon; Joel R. Greenbowe; Kai Wang; Doron Lipson; Roman Yelensky; Zachary R. Chalmers; Juliann Chmielecki; Julia A. Elvin; Mira Wollner; Addie Dvir; Lior Soussan -Gutman; Rodolfo Bordoni; Nir Peled; Fadi Braiteh; Luis Raez; Rachel Erlich; Sai-Hong Ignatius Ou; Mohamed Mohamed; Jeffrey S. Ross; Philip J. Stephens; Siraj M. Ali; Vincent A. Miller
Cancer Therapy: Preclinical
Author Choice
A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Marina Bacac; Tanja Fauti; Johannes Sam; Sara Colombetti; Tina Weinzierl; Djamila Ouaret; Walter Bodmer; Steffi Lehmann; Thomas Hofer; Ralf J. Hosse; Ekkehard Moessner; Oliver Ast; Peter Bruenker; Sandra Grau-Richards; Teilo Schaller; Annette Seidl; Christian Gerdes; Mario Perro; Valeria Nicolini; Nathalie Steinhoff; Sherri Dudal; Sebastian Neumann; Thomas von Hirschheydt; Christiane Jaeger; Jose Saro; Vaios Karanikas; Christian Klein; Pablo Umaña
Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer–Initiating Cells and Is a Potent Target of Immunotherapy
Rena Morita; Yoshihiko Hirohashi; Toshihiko Torigoe; Satoko Ito-Inoda; Akari Takahashi; Tasuku Mariya; Hiroko Asanuma; Yasuaki Tamura; Tomohide Tsukahara; Takayuki Kanaseki; Terufumi Kubo; Goro Kutomi; Toru Mizuguchi; Takeshi Terui; Kunihiko Ishitani; Satoshi Hashino; Toru Kondo; Nozomi Minagawa; Norihiko Takahashi; Akinobu Taketomi; Satoru Todo; Masahiro Asaka; Noriyuki Sato
Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation
Mohammad Hedayati; Michael C. Haffner; Jonathan B. Coulter; Raju R. Raval; Yonggang Zhang; Haoming Zhou; Omar Mian; Emma J. Knight; Nina Razavi; Susan Dalrymple; John T. Isaacs; Aileen Santos; Russell Hales; William G. Nelson; Srinivasan Yegnasubramanian; Theodore L. DeWeese
Biology of Human Tumors
A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma
Maria Dvorkina; Valentina Nieddu; Shalini Chakelam; Annalisa Pezzolo; Sandra Cantilena; Ana Paula Leite; Olesya Chayka; Tarik Regad; Angela Pistorio; Angela Rita Sementa; Alex Virasami; Jack Barton; Ximena Montano; Tanguy Lechertier; Nicola Brindle; Daniel Morgenstern; Morgane Lebras; Alan J. Burns; Nigel J. Saunders; Kairbaan Hodivala-Dilke; Luigi Bagella; Hugues De The; John Anderson; Neil Sebire; Vito Pistoia; Arturo Sala; Paolo Salomoni
Letters to the Editor
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