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15 June 2016
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Cover Image
Cover Image
The cover depicts gene expression differences between clear cell Renal Cell Carcinoma (ccRCC) patients from the Cancer Genome Atlas (TCGA) classified as either the clear cell A (ccA) or B (ccB) subtype. ccA and ccB patients separated by the activation of distinct metabolic genes associated with increased glycogen synthesis. For details, see the article by Brooks and colleagues on page 2950 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Molecular Pathways
Clinical Trial Brief Report
Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer
Sunil R. Hingorani; William P. Harris; J. Thaddeus Beck; Boris A. Berdov; Stephanie A. Wagner; Eduard M. Pshevlotsky; Sergei A. Tjulandin; Oleg A. Gladkov; Randall F. Holcombe; Ronald Korn; Natarajan Raghunand; Samuel Dychter; Ping Jiang; H. Michael Shepard; Craig E. Devoe
Cancer Therapy: Clinical
Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation–Associated Breast Cancer
Eve T. Rodler; Brenda F. Kurland; Melissa Griffin; Julie R. Gralow; Peggy Porter; Rosa F. Yeh; Vijayakrishna K. Gadi; Jamie Guenthoer; Jan H. Beumer; Larissa Korde; Sandra Strychor; Brian F. Kiesel; Hannah M. Linden; John A. Thompson; Elizabeth Swisher; Xiaoyu Chai; Stacie Shepherd; Vincent Giranda; Jennifer M. Specht
Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors
Saoirse O. Dolly; Andrew J. Wagner; Johanna C. Bendell; Hedy L. Kindler; Lee M. Krug; Tanguy Y. Seiwert; Marjorie G. Zauderer; Martijn P. Lolkema; Doris Apt; Ru-Fang Yeh; Jill O. Fredrickson; Jill M. Spoerke; Hartmut Koeppen; Joseph A. Ware; Jennifer O. Lauchle; Howard A. Burris, 3rd; Johann S. de Bono
Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma
William T. Curry, Jr; Ramana Gorrepati; Matthias Piesche; Tetsuro Sasada; Pankaj Agarwalla; Pamela S. Jones; Elizabeth R. Gerstner; Alexandra J. Golby; Tracy T. Batchelor; Patrick Y. Wen; Martin C. Mihm; Glenn Dranoff
Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors
Valentine M. Macaulay; Mark R. Middleton; S. Gail Eckhardt; Charles M. Rudin; Rosalyn A. Juergens; Richard Gedrich; Sven Gogov; Sean McCarthy; Srinivasu Poondru; Andrew W. Stephens; Shirish M. Gadgeel
Personalized Medicine and Imaging
Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab
Alexander Martens; Kilian Wistuba-Hamprecht; Marnix Geukes Foppen; Jianda Yuan; Michael A. Postow; Phillip Wong; Emanuela Romano; Amir Khammari; Brigitte Dreno; Mariaelena Capone; Paolo A. Ascierto; Anna Maria Di Giacomo; Michele Maio; Bastian Schilling; Antje Sucker; Dirk Schadendorf; Jessica C. Hassel; Thomas K. Eigentler; Peter Martus; Jedd D. Wolchok; Christian Blank; Graham Pawelec; Claus Garbe; Benjamin Weide
Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study
Sydney Dubois; Pierre-Julien Viailly; Sylvain Mareschal; Elodie Bohers; Philippe Bertrand; Philippe Ruminy; Catherine Maingonnat; Jean-Philippe Jais; Pauline Peyrouze; Martin Figeac; Thierry J. Molina; Fabienne Desmots; Thierry Fest; Corinne Haioun; Thierry Lamy; Christiane Copie-Bergman; Josette Brière; Tony Petrella; Danielle Canioni; Bettina Fabiani; Bertrand Coiffier; Richard Delarue; Frédéric Peyrade; André Bosly; Marc André; Nicolas Ketterer; Gilles Salles; Hervé Tilly; Karen Leroy; Fabrice Jardin
Author Choice
A Novel Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer
Charlotte E.S. Hoogstins; Quirijn R.J.G. Tummers; Katja N. Gaarenstroom; Cor D. de Kroon; J. Baptist M.Z. Trimbos; Tjalling Bosse; Vincent T.H.B.M. Smit; Jaap Vuyk; Cornelis J.H. van de Velde; Adam F. Cohen; Philip S. Low; Jacobus Burggraaf; Alexander L. Vahrmeijer
Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma
Nicole G. Chau; Yvonne Y. Li; Vickie Y. Jo; Guilherme Rabinowits; Jochen H. Lorch; Roy B. Tishler; Danielle N. Margalit; Jonathan D. Schoenfeld; Don J. Annino; Laura A. Goguen; Tom Thomas; Hailey Becker; Tyler Haddad; Jeffrey F. Krane; Neal I. Lindeman; Geoffrey I. Shapiro; Robert I. Haddad; Peter S. Hammerman
Alternate Metabolic Programs Define Regional Variation of Relevant Biological Features in Renal Cell Carcinoma Progression
Samira A. Brooks; Amir H. Khandani; Julia R. Fielding; Weili Lin; Tiffany Sills; Yueh Lee; Alexandra Arreola; Mathew I. Milowsky; Eric M. Wallen; Michael E. Woods; Angie B. Smith; Mathew E. Nielsen; Joel S. Parker; David S. Lalush; W. Kimryn Rathmell
Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial
Cécile Jovelet; Ecaterina Ileana; Marie-Cécile Le Deley; Nelly Motté; Silvia Rosellini; Alfredo Romero; Celine Lefebvre; Marion Pedrero; Noémie Pata-Merci; Nathalie Droin; Marc Deloger; Christophe Massard; Antoine Hollebecque; Charles Ferté; Amélie Boichard; Sophie Postel-Vinay; Maud Ngo-Camus; Thierry De Baere; Philippe Vielh; Jean-Yves Scoazec; Gilles Vassal; Alexander Eggermont; Fabrice André; Jean-Charles Soria; Ludovic Lacroix
Cancer Therapy: Preclinical
Not all NOTCH Is Created Equal: The Oncogenic Role of NOTCH2 in Bladder Cancer and Its Implications for Targeted Therapy
Tetsutaro Hayashi; Kilian M. Gust; Alexander W. Wyatt; Akihiro Goriki; Wolfgang Jäger; Shannon Awrey; Na Li; Htoo Zarni Oo; Manuel Altamirano-Dimas; Ralph Buttyan; Ladan Fazli; Akio Matsubara; Peter C. Black
Author Choice
PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity
Joao Incio; Josh Tam; Nuh N. Rahbari; Priya Suboj; Dan T. McManus; Shan M. Chin; Trupti D. Vardam; Ana Batista; Suboj Babykutty; Keehoon Jung; Anna Khachatryan; Tai Hato; Jennifer A. Ligibel; Ian E. Krop; Stefan B. Puchner; Christopher L. Schlett; Udo Hoffmman; Marek Ancukiewicz; Masabumi Shibuya; Peter Carmeliet; Raquel Soares; Dan G. Duda; Rakesh K. Jain; Dai Fukumura
Biology of Human Tumors
Author Choice
Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma
Suhendan Ekmekcioglu; Michael A. Davies; Keiji Tanese; Jason Roszik; Myung Shin-Sim; Roland L. Bassett, Jr; Denái R. Milton; Scott E. Woodman; Victor G. Prieto; Jeffrey E. Gershenwald; Donald L. Morton; Dave S. Hoon; Elizabeth A. Grimm
Author Choice
Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma
Steffen Böhm; Anne Montfort; Oliver M.T. Pearce; Joanne Topping; Probir Chakravarty; Gemma L.A. Everitt; Andrew Clear; Jackie R. McDermott; Darren Ennis; Thomas Dowe; Amanda Fitzpatrick; Elly C. Brockbank; Alexandra C. Lawrence; Arjun Jeyarajah; Asma Z. Faruqi; Iain A. McNeish; Naveena Singh; Michelle Lockley; Frances R. Balkwill
MET Amplification and Exon 14 Splice Site Mutation Define Unique Molecular Subgroups of Non–Small Cell Lung Carcinoma with Poor Prognosis
Joanna H. Tong; Sai F. Yeung; Anthony W.H. Chan; Lau Y. Chung; Shuk L. Chau; Raymond Wai Ming Lung; Carol Y. Tong; Chit Chow; Edith K.Y. Tin; Yau H. Yu; Hui Li; Yi Pan; Wing P. Chak; Calvin S.H. Ng; Tony S.K. Mok; Ka F. To
Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care
Safia El Messaoudi; Florent Mouliere; Stanislas Du Manoir; Caroline Bascoul-Mollevi; Brigitte Gillet; Michelle Nouaille; Catherine Fiess; Evelyne Crapez; Frederic Bibeau; Charles Theillet; Thibault Mazard; Denis Pezet; Muriel Mathonnet; Marc Ychou; Alain R. Thierry
Author Choice
IgG Glycome in Colorectal Cancer
Frano Vučković; Evropi Theodoratou; Kujtim Thaçi; Maria Timofeeva; Aleksandar Vojta; Jerko Štambuk; Maja Pučić-Baković; Pauline M. Rudd; Lovorka Đerek; Dražen Servis; Annika Wennerström; Susan M. Farrington; Markus Perola; Yurii Aulchenko; Malcolm G. Dunlop; Harry Campbell; Gordan Lauc
HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients
Andrea Napolitano; Daniel J. Antoine; Laura Pellegrini; Francine Baumann; Ian Pagano; Sandra Pastorino; Chandra M. Goparaju; Kirill Prokrym; Claudia Canino; Harvey I. Pass; Michele Carbone; Haining Yang
Correction
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