Skip Nav Destination
Issues
15 March 2015
-
Cover Image
Cover Image
The cover shows a section of a skin biopsy from a basal cell carcinoma patient after hedgehog inhibitor treatment. Immunohistochemical staining reveals a post-therapy increase of peri- and intratumor CD4+ T cells in the tumor area. For details, see the article by Otsuka and colleagues on page 1289 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
20th Anniversary Commentary
CCR Translations
Molecular Pathways
Reviews
Clinical Trial Brief Report
Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies
Veronika Bachanova; Arthur E. Frankel; Qing Cao; Dixie Lewis; Bartosz Grzywacz; Michael R. Verneris; Celalettin Ustun; Aleksandr Lazaryan; Brian McClune; Erica D. Warlick; Hagop Kantarjian; Daniel J. Weisdorf; Jeffrey S. Miller; Daniel A. Vallera
Cancer Therapy: Clinical
Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors
Eddy J. Chen; Adam G. Sowalsky; Shuai Gao; Changmeng Cai; Olga Voznesensky; Rachel Schaefer; Massimo Loda; Lawrence D. True; Huihui Ye; Patricia Troncoso; Rosina L. Lis; Philip W. Kantoff; Robert B. Montgomery; Peter S. Nelson; Glenn J. Bubley; Steven P. Balk; Mary-Ellen Taplin
Author Choice
A First-in-Human Phase I Study of MORAb-004, a Monoclonal Antibody to Endosialin in Patients with Advanced Solid Tumors
Luis A. Diaz, Jr; Christina M. Coughlin; Susan C. Weil; Jean Fishel; Mrinal M. Gounder; Susan Lawrence; Nilofer Azad; Daniel J. O'Shannessy; Luigi Grasso; Jason Wustner; Wolfgang Ebel; Richard D. Carvajal
Pathological Response and Circulating Tumor Cell Count Identifies Treated HER2+ Inflammatory Breast Cancer Patients with Excellent Prognosis: BEVERLY-2 Survival Data
Jean-Yves Pierga; Thierry Petit; Christelle Lévy; Jean-Marc Ferrero; Mario Campone; Joseph Gligorov; Florence Lerebours; Henri Roché; Thomas Bachelot; Emmanuelle Charafe-Jauffret; Jacques Bonneterre; Juana Hernandez; François-Clément Bidard; Patrice Viens
Pilot Trial of Combined BRAF and EGFR Inhibition in BRAF-Mutant Metastatic Colorectal Cancer Patients
Rona Yaeger; Andrea Cercek; Eileen M. O'Reilly; Diane L. Reidy; Nancy Kemeny; Tamar Wolinsky; Marinela Capanu; Marc J. Gollub; Neal Rosen; Michael F. Berger; Mario E. Lacouture; Efsevia Vakiani; Leonard B. Saltz
Author Choice
Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study
Peter Johnson; Ruth Challis; Ferdousi Chowdhury; Yifang Gao; Melanie Harvey; Tom Geldart; Paul Kerr; Claude Chan; Anna Smith; Neil Steven; Ceri Edwards; Margaret Ashton-Key; Elisabeth Hodges; Alison Tutt; Christian Ottensmeier; Martin Glennie; Anthony Williams
Personalized Medicine and Imaging
Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting
Benoit Beuselinck; Sylvie Job; Etienne Becht; Alexandra Karadimou; Virginie Verkarre; Gabrielle Couchy; Nicolas Giraldo; Nathalie Rioux-Leclercq; Vincent Molinié; Mathilde Sibony; Reza Elaidi; Corinne Teghom; Jean-Jacques Patard; Arnaud Méjean; Wolf Herman Fridman; Catherine Sautès-Fridman; Aurélien de Reyniès; Stéphane Oudard; Jessica Zucman-Rossi
Cancer Therapy: Preclinical
Tyrosine Kinase Inhibition in Leukemia Induces an Altered Metabolic State Sensitive to Mitochondrial Perturbations
Francesca Alvarez-Calderon; Mark A. Gregory; Catherine Pham-Danis; Deborah DeRyckere; Brett M. Stevens; Vadym Zaberezhnyy; Amanda A. Hill; Lelisa Gemta; Amit Kumar; Vijay Kumar; Michael F. Wempe; Daniel A. Pollyea; Craig T. Jordan; Natalie J. Serkova; Douglas K. Graham; James DeGregori
Trabectedin Efficacy in Ewing Sarcoma Is Greatly Increased by Combination with Anti-IGF Signaling Agents
Ana Teresa Amaral; Cecilia Garofalo; Roberta Frapolli; Maria Cristina Manara; Caterina Mancarella; Sarah Uboldi; Silvana Di Giandomenico; Jose Luis Ordóñez; Victoria Sevillano; Roberta Malaguarnera; Piero Picci; A. Bass Hassan; Enrique De Alava; Maurizio D'Incalci; Katia Scotlandi
Effective Targeting of the P53–MDM2 Axis in Preclinical Models of Infant MLL-Rearranged Acute Lymphoblastic Leukemia
Jennifer Richmond; Hernan Carol; Kathryn Evans; Laura High; Agnes Mendomo; Alissa Robbins; Claus Meyer; Nicola C. Venn; Rolf Marschalek; Michelle Henderson; Rosemary Sutton; Raushan T. Kurmasheva; Ursula R. Kees; Peter J. Houghton; Malcolm A. Smith; Richard B. Lock
Biology of Human Tumors
Author Choice
Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and Its Nuclear Accumulation Suppresses Gastric Tumorigenesis
Longlong Cao; Jiechao Zhou; Junrong Zhang; Sijin Wu; Xintao Yang; Xin Zhao; Huifang Li; Ming Luo; Qian Yu; Guangtan Lin; Huizhong Lin; Jianwei Xie; Ping Li; Xiaoqing Hu; Chaohui Zheng; Guojun Bu; Yun-wu Zhang; Huaxi Xu; Yongliang Yang; Changming Huang; Jie Zhang
A Comparative Study of Molecular Characteristics of Diffuse Large B-cell Lymphoma from Patients with and without Human Immunodeficiency Virus Infection
Chun Chao; Michael J. Silverberg; Lanfang Xu; Lie-Hong Chen; Brandon Castor; Otoniel Martínez-Maza; Donald I. Abrams; Hongbin D. Zha; Reina Haque; Jonathan Said
Tumor-Associated Macrophages in SHH Subgroup of Medulloblastomas
Ashley S. Margol; Nathan J. Robison; Janahan Gnanachandran; Long T. Hung; Rebekah J. Kennedy; Marzieh Vali; Girish Dhall; Jonathan L. Finlay; Anat Erdreich-Epstein; Mark D. Krieger; Rachid Drissi; Maryam Fouladi; Floyd H. Gilles; Alexander R. Judkins; Richard Sposto; Shahab Asgharzadeh
Author Choice
Impaired Self-Renewal and Increased Colitis and Dysplastic Lesions in Colonic Mucosa of AKR1B8-Deficient Mice
Yi Shen; Jun Ma; Ruilan Yan; Hongyan Ling; Xiaoning Li; Wancai Yang; John Gao; Chenfei Huang; Yiwen Bu; Yu Cao; Yingchun He; Laxiang Wan; Xuyu Zu; Jianghua Liu; Mei Chris Huang; William F. Stenson; Duan-Fang Liao; Deliang Cao
Author Choice
Integrating RAS Status into Prognostic Signatures for Adenocarcinomas of the Lung
Maud HW. Starmans; Melania Pintilie; Michelle Chan-Seng-Yue; Nathalie C. Moon; Syed Haider; Francis Nguyen; Suzanne K. Lau; Ni Liu; Arek Kasprzyk; Bradly G. Wouters; Sandy D. Der; Frances A. Shepherd; Igor Jurisica; Linda Z. Penn; Ming-Sound Tsao; Philippe Lambin; Paul C. Boutros
Author Choice
PEST Domain Mutations in Notch Receptors Comprise an Oncogenic Driver Segment in Triple-Negative Breast Cancer Sensitive to a γ-Secretase Inhibitor
Kai Wang; Qin Zhang; Danan Li; Keith Ching; Cathy Zhang; Xianxian Zheng; Mark Ozeck; Stephanie Shi; Xiaorong Li; Hui Wang; Paul Rejto; James Christensen; Peter Olson
Letters to the Editor
Corrections
Advertisement
Email alerts
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
RSS Feeds