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Issues

Volume 21, Issue 5
1 March 2015
Issue Cover
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  • Cover Image

    Cover Image

    issue cover
    The cover shows a section of a tumor biopsy from mice with the SW1 melanoma, which were treated with an anti-CTLA4/PD-1/CD137 mAb combination. Immunohistochemical staining shows a dramatic decrease of tumor-infiltrating CD19 cells. For details, see the article by Dai and colleagues on page 1127 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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20th Anniversary Commentary

CCR 20th Anniversary Commentary: In the Beginning, There Was PS-341
Beverly A. Teicher; Kenneth C. Anderson
View articletitled, <em>CCR</em> 20<sup>th</sup> Anniversary Commentary: In the Beginning, There Was PS-341
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CCR 20th Anniversary Commentary: Preclinical Study of Proteasome Inhibitor Bortezomib in Head and Neck Cancer
Clint T. Allen; Barbara Conley; John B. Sunwoo; Carter Van Waes
View articletitled, <em>CCR</em> 20<sup>th</sup> Anniversary Commentary: Preclinical Study of Proteasome Inhibitor Bortezomib in Head and Neck Cancer
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CCR Translations

Immunomodulatory Antibody Therapy of Cancer: The Closer, the Better
Roxana S. Dronca; Haidong Dong
View articletitled, Immunomodulatory Antibody Therapy of Cancer: The Closer, the Better
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Moving from Evaluation to Value in Cancer Care
Richard L. Schilsky
View articletitled, Moving from Evaluation to Value in Cancer Care
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CCR Perspectives in Drug Approval

FDA Approval: Siltuximab for the Treatment of Patients with Multicentric Castleman Disease
Albert Deisseroth; Chia-Wen Ko; Lei Nie; Jeanne F. Zirkelbach; Liang Zhao; Julie Bullock; Nitin Mehrotra; Pedro Del Valle; Haleh Saber; Christopher Sheth; Brenda Gehrke; Robert Justice; Ann Farrell; Richard Pazdur
View articletitled, FDA Approval: Siltuximab for the Treatment of Patients with Multicentric Castleman Disease
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Molecular Pathways

Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer
Rebecca A. Previs; Robert L. Coleman; Adrian L. Harris; Anil K. Sood
View articletitled, Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer
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Molecular Pathways: Linking Tumor Microenvironment to Epithelial–Mesenchymal Transition in Metastasis
Hae-Yun Jung; Laurent Fattet; Jing Yang
View articletitled, Molecular Pathways: Linking Tumor Microenvironment to Epithelial–Mesenchymal Transition in Metastasis
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Reviews

Zebrafish: A New Companion for Translational Research in Oncology
Jorge Barriuso; Raghavendar Nagaraju; Adam Hurlstone
View articletitled, Zebrafish: A New Companion for Translational Research in Oncology
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Cancer Immunotherapy: A Future Paradigm Shift in the Treatment of Non–Small Cell Lung Cancer
Valsamo K. Anagnostou; Julie R. Brahmer
View articletitled, Cancer Immunotherapy: A Future Paradigm Shift in the Treatment of Non–Small Cell Lung Cancer
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Cancer Therapy: Clinical

A Phase I Study of Oral ARRY-614, a p38 MAPK/Tie2 Dual Inhibitor, in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes
Guillermo Garcia-Manero; Hanna J. Khoury; Elias Jabbour; Jeffrey Lancet; Shannon L. Winski; LouAnn Cable; Selena Rush; Lara Maloney; Grant Hogeland; Mieke Ptaszynski; Monica Cabrero Calvo; Zach Bohannan; Alan List; Hagop Kantarjian; Rami Komrokji
View articletitled, A Phase I Study of Oral ARRY-614, a p38 MAPK/Tie2 Dual Inhibitor, in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes
Supplementary data
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CDK 4/6 Inhibitor Palbociclib (PD0332991) in Rb+ Advanced Breast Cancer: Phase II Activity, Safety, and Predictive Biomarker Assessment
Angela DeMichele; Amy S. Clark; Kay See Tan; Daniel F. Heitjan; Kristi Gramlich; Maryann Gallagher; Priti Lal; Michael Feldman; Paul Zhang; Christopher Colameco; David Lewis; Melissa Langer; Noah Goodman; Susan Domchek; Keerthi Gogineni; Mark Rosen; Kevin Fox; Peter O'Dwyer
View articletitled, CDK 4/6 Inhibitor Palbociclib (PD0332991) in Rb<sup>+</sup> Advanced Breast Cancer: Phase II Activity, Safety, and Predictive Biomarker Assessment
Supplementary data
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Author Choice
Phase I Dose-Escalation Trial of the Oral Investigational Hedgehog Signaling Pathway Inhibitor TAK-441 in Patients with Advanced Solid Tumors
Jonathan Goldman; S. Gail Eckhardt; Mitesh J. Borad; Kelly K. Curtis; Manuel Hidalgo; Emiliano Calvo; David P. Ryan; Lori J. Wirth; Asit Parikh; James Partyka; Helene Faessel; Esha Gangolli; Sally Stewart; Lee S. Rosen; Daniel W. Bowles
View articletitled, Phase I Dose-Escalation Trial of the Oral Investigational Hedgehog Signaling Pathway Inhibitor TAK-441 in Patients with Advanced Solid Tumors
Supplementary data
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Angiogenic Cytokines Are Antibody Targets During Graft-versus-Leukemia Reactions
Matthias Piesche; Vincent T. Ho; Haesook Kim; Yukoh Nakazaki; Michael Nehil; Nasser K. Yaghi; Dmitriy Kolodin; Jeremy Weiser; Peter Altevogt; Helena Kiefel; Edwin P. Alyea; Joseph H. Antin; Corey Cutler; John Koreth; Christine Canning; Jerome Ritz; Robert J. Soiffer; Glenn Dranoff
View articletitled, Angiogenic Cytokines Are Antibody Targets During Graft-versus-Leukemia Reactions
Supplementary data
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A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1–Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
Paul F. Robbins; Sadik H. Kassim; Thai L.N. Tran; Jessica S. Crystal; Richard A. Morgan; Steven A. Feldman; James C. Yang; Mark E. Dudley; John R. Wunderlich; Richard M. Sherry; Udai S. Kammula; Marybeth S. Hughes; Nicholas P. Restifo; Mark Raffeld; Chyi-Chia R. Lee; Yong F. Li; Mona El-Gamil; Steven A. Rosenberg
View articletitled, A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1–Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
Supplementary data
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Redifferentiation of Iodine-Refractory BRAF V600E-Mutant Metastatic Papillary Thyroid Cancer with Dabrafenib
S. Michael Rothenberg; David G. McFadden; Edwin L. Palmer; Gilbert H. Daniels; Lori J. Wirth
View articletitled, Redifferentiation of Iodine-Refractory <em>BRAF</em> V600E-Mutant Metastatic Papillary Thyroid Cancer with Dabrafenib
Supplementary data
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Raising the Bar for Antineoplastic Agents: How to Choose Threshold Values for Superiority Trials in Advanced Solid Tumors
Alberto F. Sobrero; Alessandro Pastorino; Daniel J. Sargent; Paolo Bruzzi
View articletitled, Raising the Bar for Antineoplastic Agents: How to Choose Threshold Values for Superiority Trials in Advanced Solid Tumors
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Author Choice
A Phase I Study of PF-04449913, an Oral Hedgehog Inhibitor, in Patients with Advanced Solid Tumors
Andrew J. Wagner; Wells A. Messersmith; M. Naveed Shaik; Sherry Li; Xianxian Zheng; Karen R. McLachlan; Rossano Cesari; Rachel Courtney; Wendy J. Levin; Anthony B. El-Khoueiry
View articletitled, A Phase I Study of PF-04449913, an Oral Hedgehog Inhibitor, in Patients with Advanced Solid Tumors
Supplementary data
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Personalized Medicine and Imaging

Nottingham Clinico-Pathological Response Index (NPRI) after Neoadjuvant Chemotherapy (Neo-ACT) Accurately Predicts Clinical Outcome in Locally Advanced Breast Cancer
Tarek M. Abdel-Fatah; Graham Ball; Andrew H.S. Lee; Sarah Pinder; R. Douglas MacMilan; Eleanor Cornford; Paul M. Moseley; Rafael Silverman; James Price; Bruce Latham; David Palmer; Arlene Chan; Ian O. Ellis; Stephen Y.T. Chan
View articletitled, Nottingham Clinico-Pathological Response Index (NPRI) after Neoadjuvant Chemotherapy (Neo-ACT) Accurately Predicts Clinical Outcome in Locally Advanced Breast Cancer
Supplementary data
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Longitudinal Noninvasive Imaging of Progesterone Receptor as a Predictive Biomarker of Tumor Responsiveness to Estrogen Deprivation Therapy
Szeman Ruby Chan; Amy M. Fowler; Julie A. Allen; Dong Zhou; Carmen S. Dence; Terry L. Sharp; Nicole M. Fettig; Farrokh Dehdashti; John A. Katzenellenbogen
View articletitled, Longitudinal Noninvasive Imaging of Progesterone Receptor as a Predictive Biomarker of Tumor Responsiveness to Estrogen Deprivation Therapy
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Correlation of PD-L1 Tumor Expression and Treatment Outcomes in Patients with Renal Cell Carcinoma Receiving Sunitinib or Pazopanib: Results from COMPARZ, a Randomized Controlled Trial
Toni K. Choueiri; David J. Figueroa; André P. Fay; Sabina Signoretti; Yuan Liu; Robert Gagnon; Keith Deen; Christopher Carpenter; Peter Benson; Thai H. Ho; Lini Pandite; Paul de Souza; Thomas Powles; Robert J. Motzer
View articletitled, Correlation of PD-L1 Tumor Expression and Treatment Outcomes in Patients with Renal Cell Carcinoma Receiving Sunitinib or Pazopanib: Results from COMPARZ, a Randomized Controlled Trial
Supplementary data
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Gene Expression Markers of Efficacy and Resistance to Cetuximab Treatment in Metastatic Colorectal Cancer: Results from CALGB 80203 (Alliance)
Stephanie M. Cushman; Chen Jiang; Ace J. Hatch; Ivo Shterev; Alexander B. Sibley; Donna Niedzwiecki; Alan P. Venook; Kouros Owzar; Herbert I. Hurwitz; Andrew B. Nixon
View articletitled, Gene Expression Markers of Efficacy and Resistance to Cetuximab Treatment in Metastatic Colorectal Cancer: Results from CALGB 80203 (Alliance)
Supplementary data
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Clinical Relevance of KRAS-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy
Pierre Laurent-Puig; Deniz Pekin; Corinne Normand; Steve K. Kotsopoulos; Philippe Nizard; Karla Perez-Toralla; Rachel Rowell; Jeff Olson; Preethi Srinivasan; Delphine Le Corre; Thevy Hor; Zakaria El Harrak; Xinyu Li; Darren R. Link; Olivier Bouché; Jean-François Emile; Bruno Landi; Valérie Boige; J. Brian Hutchison; Valerie Taly
View articletitled, Clinical Relevance of <em>KRAS</em>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy
Supplementary data
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Circulating Tumor Cell Analysis in Metastatic Triple-Negative Breast Cancers
Mark Jesus M. Magbanua; Lisa A. Carey; Amy DeLuca; Jimmy Hwang; Janet H. Scott; Mothaffar F. Rimawi; Erica L. Mayer; P. Kelly Marcom; Minetta C. Liu; Francisco J. Esteva; John W. Park; Hope S. Rugo; for the Translational Breast Cancer Research Consortium
View articletitled, Circulating Tumor Cell Analysis in Metastatic Triple-Negative Breast Cancers
Supplementary data
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Author Choice
Neuregulin 1 Expression Is a Predictive Biomarker for Response to AV-203, an ERBB3 Inhibitory Antibody, in Human Tumor Models
Kristan Meetze; Sylvie Vincent; Steven Tyler; Elizabeth K. Mazsa; Andrea R. Delpero; Steve Bottega; Donna McIntosh; Richard Nicoletti; William M. Winston; Solly Weiler; Bin Feng; Jeno Gyuris; Zhigang Weng
View articletitled, Neuregulin 1 Expression Is a Predictive Biomarker for Response to AV-203, an ERBB3 Inhibitory Antibody, in Human Tumor Models
Supplementary data
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Cancer Therapy: Preclinical

Author Choice
The Human Agonistic CD40 Antibody ADC-1013 Eradicates Bladder Tumors and Generates T-cell–Dependent Tumor Immunity
Sara M. Mangsbo; Sissela Broos; Erika Fletcher; Niina Veitonmäki; Christina Furebring; Eva Dahlén; Per Norlén; Malin Lindstedt; Thomas H. Tötterman; Peter Ellmark
View articletitled, The Human Agonistic CD40 Antibody ADC-1013 Eradicates Bladder Tumors and Generates T-cell–Dependent Tumor Immunity
Supplementary data
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Curing Mice with Large Tumors by Locally Delivering Combinations of Immunomodulatory Antibodies
Min Dai; Yuen Yee Yip; Ingegerd Hellstrom; Karl Erik Hellstrom
View articletitled, Curing Mice with Large Tumors by Locally Delivering Combinations of Immunomodulatory Antibodies
Supplementary data
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Activity of MM-398, Nanoliposomal Irinotecan (nal-IRI), in Ewing's Family Tumor Xenografts Is Associated with High Exposure of Tumor to Drug and High SLFN11 Expression
Min H. Kang; Jing Wang; Monish R. Makena; Joo-Sang Lee; Nancy Paz; Connor P. Hall; Michael M. Song; Ruben I. Calderon; Riza E. Cruz; Ashly Hindle; Winford Ko; Jonathan B. Fitzgerald; Daryl C. Drummond; Timothy J. Triche; C. Patrick Reynolds
View articletitled, Activity of MM-398, Nanoliposomal Irinotecan (nal-IRI), in Ewing's Family Tumor Xenografts Is Associated with High Exposure of Tumor to Drug and High <em>SLFN11</em> Expression
Supplementary data
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Author Choice
Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects
Catharina M.L. Zegers; Nicolle H. Rekers; Dana H.F. Quaden; Natasja G. Lieuwes; Ala Yaromina; Wilfred T.V. Germeraad; Lotte Wieten; Erik A.L. Biessen; Louis Boon; Dario Neri; Esther G.C. Troost; Ludwig J. Dubois; Philippe Lambin
View articletitled, Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects
Supplementary data
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Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin
Sevim Dalva-Aydemir; Richa Bajpai; Maylyn Martinez; Kehinde U.A. Adekola; Irawati Kandela; Changyong Wei; Seema Singhal; Jennifer E. Koblinski; Noopur S. Raje; Steven T. Rosen; Mala Shanmugam
View articletitled, Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin
Supplementary data
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Patient-Derived Xenografts from Non–Small Cell Lung Cancer Brain Metastases Are Valuable Translational Platforms for the Development of Personalized Targeted Therapy
Hye Won Lee; Jung-il Lee; Se Jeong Lee; Hyun Jung Cho; Hye Jin Song; Da Eun Jeong; Yun Jee Seo; Sang Shin; Je-Gun Joung; Yong-Jun Kwon; Yoon-La Choi; Woong-Yang Park; Hyun Moo Lee; Ho Jun Seol; Young Mog Shim; Kyeung Min Joo; Do-Hyun Nam
View articletitled, Patient-Derived Xenografts from Non–Small Cell Lung Cancer Brain Metastases Are Valuable Translational Platforms for the Development of Personalized Targeted Therapy
Supplementary data
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Author Choice
Integrinβ6-Targeted Immunoliposomes Mediate Tumor-Specific Drug Delivery and Enhance Therapeutic Efficacy in Colon Carcinoma
Benjia Liang; Muhammad Shahbaz; Yang Wang; Huijie Gao; Ruliang Fang; Zhengchuan Niu; Song Liu; Ben Wang; Qi Sun; Weibo Niu; Enyu Liu; Jiayong Wang; Jun Niu
View articletitled, Integrinβ6-Targeted Immunoliposomes Mediate Tumor-Specific Drug Delivery and Enhance Therapeutic Efficacy in Colon Carcinoma
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Biology of Human Tumors

Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Andrew Feber; Manit Arya; Patricia de Winter; Muhammad Saqib; Raj Nigam; Peter R. Malone; Wei Shen Tan; Simon Rodney; Matthias Lechner; Alex Freeman; Charles Jameson; Asif Muneer; Stephan Beck; John D. Kelly
View articletitled, Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary data
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A Serum MicroRNA Signature Predicts Tumor Relapse and Survival in Triple-Negative Breast Cancer Patients
Kristine Kleivi Sahlberg; Giulia Bottai; Bjørn Naume; Barbara Burwinkel; George A. Calin; Anne-Lise Børresen-Dale; Libero Santarpia
View articletitled, A Serum MicroRNA Signature Predicts Tumor Relapse and Survival in Triple-Negative Breast Cancer Patients
Supplementary data
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Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma
Raphaël Maréchal; Jean-Baptiste Bachet; Annabelle Calomme; Pieter Demetter; Jean Robert Delpero; Magali Svrcek; Jérôme Cros; Armelle Bardier-Dupas; Francesco Puleo; Geneviève Monges; Pascal Hammel; Christophe Louvet; François Paye; Philippe Bachelier; Yves Patrice Le Treut; Jean-Christophe Vaillant; Alain Sauvanet; Thierry André; Isabelle Salmon; Jacques Devière; Jean-François Emile; Jean-Luc Van Laethem
View articletitled, Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma
Supplementary data
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Direct Serum Assay for Cell-Free Bmi-1 mRNA and Its Potential Diagnostic and Prognostic Value for Colorectal Cancer
Xin Zhang; Xiaoyun Yang; Yanli Zhang; Xinfeng Liu; Guixi Zheng; Yongmei Yang; Lili Wang; Lutao Du; Chuanxin Wang
View articletitled, Direct Serum Assay for Cell-Free <em>Bmi-1</em> mRNA and Its Potential Diagnostic and Prognostic Value for Colorectal Cancer
Supplementary data
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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