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15 February 2015
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The cover shows a patient's plucked hair bulb 24 hours after receiving an infusion of DMS612, a novel bifunctional alkylating agent. Immunohistochemical staining shows γ-H2AX foci as markers of DMS-induced DNA double-strand breaks. For details, see the article by Appleman and colleagues on page 721 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR 20th Anniversary Commentary
CCR Translations
CCR Drug Updates
Molecular Pathways
Perspectives
Cancer Therapy: Clinical
Author Choice
Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors
Robin L. Jones; Edward S. Kim; Pilar Nava-Parada; Salma Alam; Faye M. Johnson; Andrew W. Stephens; Ronit Simantov; Srinivasu Poondru; Rich Gedrich; Scott M. Lippman; Stan B. Kaye; Craig P. Carden
Author Choice
A Phase I Study of Continuous Oral Dosing of OSI-906, a Dual Inhibitor of Insulin-Like Growth Factor-1 and Insulin Receptors, in Patients with Advanced Solid Tumors
Igor Puzanov; Colin R. Lindsay; Laura Goff; Jeff Sosman; Jill Gilbert; Jordan Berlin; Srinivasu Poondru; Ronit Simantov; Rich Gedrich; Andrew Stephens; Emily Chan; T.R. Jeffry Evans
Safety, Correlative Markers, and Clinical Results of Adjuvant Nivolumab in Combination with Vaccine in Resected High-Risk Metastatic Melanoma
Geoffrey T. Gibney; Ragini R. Kudchadkar; Ronald C. DeConti; Melissa S. Thebeau; Maria P. Czupryn; Leticia Tetteh; Cabell Eysmans; Allison Richards; Michael J. Schell; Kate J. Fisher; Christine E. Horak; H. David Inzunza; Bin Yu; Alberto J. Martinez; Ibrahim Younos; Jeffrey S. Weber
A Phase I Study of DMS612, a Novel Bifunctional Alkylating Agent
Leonard J. Appleman; Sanjeeve Balasubramaniam; Robert A. Parise; Christine Bryla; Christophe E. Redon; Asako J. Nakamura; William M. Bonner; John J. Wright; Richard Piekarz; David R. Kohler; Yixing Jiang; Chandra P. Belani; Julie Eiseman; Edward Chu; Jan H. Beumer; Susan E. Bates
A Phase Ib Dose-Escalation Study of the Oral Pan-PI3K Inhibitor Buparlisib (BKM120) in Combination with the Oral MEK1/2 Inhibitor Trametinib (GSK1120212) in Patients with Selected Advanced Solid Tumors
Philippe L. Bedard; Josep Tabernero; Filip Janku; Zev A. Wainberg; Luis Paz-Ares; Johan Vansteenkiste; Eric Van Cutsem; José Pérez-García; Anastasios Stathis; Carolyn D. Britten; Ngocdiep Le; Kirsten Carter; David Demanse; Denes Csonka; Malte Peters; Angela Zubel; Heidi Nauwelaerts; Cristiana Sessa
Antitumor Activity in RAS-Driven Tumors by Blocking AKT and MEK
Anthony W. Tolcher; Khurum Khan; Michael Ong; Udai Banerji; Vassiliki Papadimitrakopoulou; David R. Gandara; Amita Patnaik; Richard D. Baird; David Olmos; Christopher R. Garrett; Jeffrey M. Skolnik; Eric H. Rubin; Paul D. Smith; Pearl Huang; Maria Learoyd; Keith A. Shannon; Anne Morosky; Ernestina Tetteh; Ying-Ming Jou; Kyriakos P. Papadopoulos; Victor Moreno; Brianne Kaiser; Timothy A. Yap; Li Yan; Johann S. de Bono
Personalized Medicine and Imaging
Author Choice
Breast Cancers with a BRCA1-like DNA Copy Number Profile Recur Less Often Than Expected after High-Dose Alkylating Chemotherapy
Philip C. Schouten; Frederik Marmé; Sebastian Aulmann; Hans-Peter Sinn; Hendrik F. van Essen; Bauke Ylstra; Michael Hauptmann; Andreas Schneeweiss; Sabine C. Linn
Real-time, Near-Infrared Fluorescence Imaging with an Optimized Dye/Light Source/Camera Combination for Surgical Guidance of Prostate Cancer
Brian P. Neuman; John B. Eifler; Mark Castanares; Wasim H. Chowdhury; Ying Chen; Ronnie C. Mease; Rong Ma; Amarnath Mukherjee; Shawn E. Lupold; Martin G. Pomper; Ronald Rodriguez
Cancer Therapy: Preclinical
Vaccine-Induced Tumor Necrosis Factor–Producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death
Tetje C. van der Sluis; Suzanne van Duikeren; Suzanna Huppelschoten; Ekaterina S. Jordanova; Elham Beyranvand Nejad; Arjen Sloots; Louis Boon; Vincent T.H.B.M. Smit; Marij J.P. Welters; Ferry Ossendorp; Bob van de Water; Ramon Arens; Sjoerd H. van der Burg; Cornelis J.M. Melief
Translational Impact of Nanoparticle–Drug Conjugate CRLX101 with or without Bevacizumab in Advanced Ovarian Cancer
Elizabeth Pham; Michael J. Birrer; Scott Eliasof; Edward G. Garmey; Douglas Lazarus; Christina R. Lee; Shan Man; Ursula A. Matulonis; Christian G. Peters; Ping Xu; Carolyn Krasner; Robert S. Kerbel
Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program
Malcolm A. Smith; C. Patrick Reynolds; Min H. Kang; E. Anders Kolb; Richard Gorlick; Hernan Carol; Richard B. Lock; Stephen T. Keir; John M. Maris; Catherine A. Billups; Dmitry Lyalin; Raushan T. Kurmasheva; Peter J. Houghton
Biology of Human Tumors
Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes
Michaela K. Keck; Zhixiang Zuo; Arun Khattri; Thomas P. Stricker; Christopher D. Brown; Matin Imanguli; Damian Rieke; Katharina Endhardt; Petra Fang; Johannes Brägelmann; Rebecca DeBoer; Mohamed El-Dinali; Serdal Aktolga; Zhengdeng Lei; Patrick Tan; Steve G. Rozen; Ravi Salgia; Ralph R. Weichselbaum; Mark W. Lingen; Michael D. Story; K. Kian Ang; Ezra E.W. Cohen; Kevin P. White; Everett E. Vokes; Tanguy Y. Seiwert
pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma
Melanie Ruf; Christiane Mittmann; Anna M. Nowicka; Arndt Hartmann; Thomas Hermanns; Cédric Poyet; Maries van den Broek; Tullio Sulser; Holger Moch; Peter Schraml
Author Choice
MET Amplification Status in Therapy-Naïve Adeno- and Squamous Cell Carcinomas of the Lung
Hans-Ulrich Schildhaus; Anne M. Schultheis; Josef Rüschoff; Elke Binot; Sabine Merkelbach-Bruse; Jana Fassunke; Wolfgang Schulte; Yon-Dschun Ko; Andreas Schlesinger; Marc Bos; Masyar Gardizi; Walburga Engel-Riedel; Michael Brockmann; Monika Serke; Ulrich Gerigk; Khosro Hekmat; Konrad F. Frank; Marcel Reiser; Holger Schulz; Stefan Krüger; Erich Stoelben; Thomas Zander; Jürgen Wolf; Reinhard Buettner
Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer
Mariana Varna; Guillaume Gapihan; Jean-Paul Feugeas; Philippe Ratajczak; Sophie Tan; Irmine Ferreira; Christophe Leboeuf; Niclas Setterblad; Arnaud Duval; Jérôme Verine; Stéphane Germain; Pierre Mongiat-Artus; Anne Janin; Guilhem Bousquet
DNA-PK—A Candidate Driver of Hepatocarcinogenesis and Tissue Biomarker That Predicts Response to Treatment and Survival
Liam Cornell; Joanne M. Munck; Clara Alsinet; Augusto Villanueva; Laura Ogle; Catherine E. Willoughby; Despina Televantou; Huw D. Thomas; Jennifer Jackson; Alastair D. Burt; David Newell; John Rose; Derek M. Manas; Geoffrey I. Shapiro; Nicola J. Curtin; Helen L. Reeves
Letter to the Editor
Correction
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