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1 February 2015
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Cover Image
Cover Image
The cover shows NFκB translocation in tumor-infiltrating lymphocytes from a patient with metastatic melanoma. Immunocytochemistry staining shows NFκB (p65) translocation (red is nucleus; green is NFκB; and yellow is overlay [translocation]) in the nucleus of tumor-infiltrating lymphocytes expanded with IL-2 and an anti-4-1BB antibody. For details, see the article by Chacon and colleagues on page 611 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR 20th Anniversary Commentary
CCR Translations
Molecular Pathways
Special Report
Electronic Nicotine Delivery Systems: A Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology
Thomas H. Brandon; Maciej L. Goniewicz; Nasser H. Hanna; Dorothy K. Hatsukami; Roy S. Herbst; Jennifer A. Hobin; Jamie S. Ostroff; Peter G. Shields; Benjamin A. Toll; Courtney A. Tyne; Kasisomayajula Viswanath; Graham W. Warren
Review
Cancer Therapy: Clinical
Persistence of CTL Clones Targeting Melanocyte Differentiation Antigens Was Insufficient to Mediate Significant Melanoma Regression in Humans
Smita S. Chandran; Biman C. Paria; Abhishek K. Srivastava; Luke D. Rothermel; Daniel J. Stephens; Mark E. Dudley; Robert Somerville; John R. Wunderlich; Richard M. Sherry; James C. Yang; Steven A. Rosenberg; Udai S. Kammula
Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
Han Sang Kim; Hyeong Ju Kwon; Inkyung Jung; Mi Ran Yun; Myung-Ju Ahn; Byung Woog Kang; Jong-Mu Sun; Sung Bae Kim; Dok-Hyun Yoon; Keon Uk Park; Se-Hoon Lee; Yoon Woo Koh; Se Hun Kim; Eun Chang Choi; Dong Hoe Koo; Jin Hee Sohn; Bomi Kim; Nak-Jung Kwon; Hwan Jung Yun; Min Goo Lee; Ji Hyun Lee; Tae-Min Kim; Hye Ryun Kim; Joo Hang Kim; Soonmyung Paik; Byoung Chul Cho
Author Choice
First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma
Jordi Rodon; Michael A. Carducci; Juan M Sepulveda-Sánchez; Analia Azaro; Emiliano Calvo; Joan Seoane; Irene Braña; Elisabet Sicart; Ivelina Gueorguieva; Ann L. Cleverly; N. Sokalingum Pillay; Durisala Desaiah; Shawn T. Estrem; Luis Paz-Ares; Matthias Holdhoff; Jaishri Blakeley; Michael M. Lahn; Jose Baselga
Personalized Medicine and Imaging
Author Choice
The High-Dose Aldesleukin “Select” Trial: A Trial to Prospectively Validate Predictive Models of Response to Treatment in Patients with Metastatic Renal Cell Carcinoma
David F. McDermott; Su-Chun Cheng; Sabina Signoretti; Kim A. Margolin; Joseph I. Clark; Jeffrey A. Sosman; Janice P. Dutcher; Theodore F. Logan; Brendan D. Curti; Marc S. Ernstoff; Leonard Appleman; Michael K.K. Wong; Nikhil I. Khushalani; Leslie Oleksowicz; Ulka N. Vaishampayan; James W. Mier; David J. Panka; Rupal S. Bhatt; Alexandra S. Bailey; Bradley C. Leibovich; Eugene D. Kwon; Fairooz F. Kabbinavar; Arie S. Belldegrun; Robert A. Figlin; Allan J. Pantuck; Meredith M. Regan; Michael B. Atkins
Author Choice
High HER2 Expression Correlates with Response to the Combination of Lapatinib and Trastuzumab
Maurizio Scaltriti; Paolo Nuciforo; Ian Bradbury; Jeff Sperinde; Dominique Agbor-Tarh; Christine Campbell; Ahmed Chenna; John Winslow; Violeta Serra; Josep Lluis Parra; Ludmila Prudkin; José Jimenez; Claudia Aura; Nadia Harbeck; Lajos Pusztai; Catherine Ellis; Holger Eidtmann; Joaquin Arribas; Javier Cortes; Evandro de Azambuja; Martine Piccart; José Baselga
Optical Mammography Using Diffuse Optical Spectroscopy for Monitoring Tumor Response to Neoadjuvant Chemotherapy in Women with Locally Advanced Breast Cancer
Boudewijn E. Schaafsma; Martijn van de Giessen; Ayoub Charehbili; Vincent T.H.B.M. Smit; Judith R. Kroep; Boudewijn P.F. Lelieveldt; Gerrit-Jan Liefers; Alan Chan; Clemens W.G.M. Löwik; Jouke Dijkstra; Cornelis J.H. van de Velde; Martin N.J.M. Wasser; Alexander L. Vahrmeijer
A Five-Gene Hedgehog Signature Developed as a Patient Preselection Tool for Hedgehog Inhibitor Therapy in Medulloblastoma
Yaping Shou; Douglas M. Robinson; Dereck D. Amakye; Kristine L. Rose; Yoon-Jae Cho; Keith L. Ligon; Thad Sharp; Asifa S. Haider; Raj Bandaru; Yuichi Ando; Birgit Geoerger; François Doz; David M. Ashley; Darren R. Hargrave; Michela Casanova; Hussein A. Tawbi; Jordi Rodon; Anne L. Thomas; Alain C. Mita; Tobey J. MacDonald; Mark W. Kieran
Differential Platelet Levels Affect Response to Taxane-Based Therapy in Ovarian Cancer
Justin Bottsford-Miller; Hyun-Jin Choi; Heather J. Dalton; Rebecca L. Stone; Min Soon Cho; Monika Haemmerle; Alpa M. Nick; Sunila Pradeep; Behrouz Zand; Rebecca A. Previs; Chad V. Pecot; Erin King Crane; Wei Hu; Susan K. Lutgendorf; Vahid Afshar-Kharghan; Anil K. Sood
Cancer Therapy: Preclinical
Author Choice
Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
Jessica Ann Chacon; Amod A. Sarnaik; Jie Qing Chen; Caitlin Creasy; Charuta Kale; John Robinson; Jeffrey Weber; Patrick Hwu; Shari Pilon-Thomas; Laszlo Radvanyi
Biology of Human Tumors
Serum CA19-9 Is Significantly Upregulated up to 2 Years before Diagnosis with Pancreatic Cancer: Implications for Early Disease Detection
Darragh P. O'Brien; Neomal S. Sandanayake; Claire Jenkinson; Aleksandra Gentry-Maharaj; Sophia Apostolidou; Evangelia-Ourania Fourkala; Stephane Camuzeaux; Oleg Blyuss; Richard Gunu; Anne Dawnay; Alexey Zaikin; Ross C. Smith; Ian J. Jacobs; Usha Menon; Eithne Costello; Stephen P. Pereira; John F. Timms
Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas
Tanguy Y. Seiwert; Zhixiang Zuo; Michaela K. Keck; Arun Khattri; Chandra S. Pedamallu; Thomas Stricker; Christopher Brown; Trevor J. Pugh; Petar Stojanov; Juok Cho; Michael S. Lawrence; Gad Getz; Johannes Brägelmann; Rebecca DeBoer; Ralph R. Weichselbaum; Alexander Langerman; Louis Portugal; Elizabeth Blair; Kerstin Stenson; Mark W. Lingen; Ezra E.W. Cohen; Everett E. Vokes; Kevin P. White; Peter S. Hammerman
Podoplanin-Positive Cancer-Associated Fibroblasts in the Tumor Microenvironment Induce Primary Resistance to EGFR-TKIs in Lung Adenocarcinoma with EGFR Mutation
Tatsuya Yoshida; Genichiro Ishii; Koichi Goto; Shinya Neri; Hiroko Hashimoto; Kiyotaka Yoh; Seiji Niho; Shigeki Umemura; Shingo Matsumoto; Hironobu Ohmatsu; Shinsuke Iida; Akio Niimi; Kanji Nagai; Yuichiro Ohe; Atsushi Ochiai
Germline Mutation in BRCA1 or BRCA2 and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer
Francisco J. Candido-dos-Reis; Honglin Song; Ellen L. Goode; Julie M. Cunningham; Brooke L. Fridley; Melissa C. Larson; Kathryn Alsop; Ed Dicks; Patricia Harrington; Susan J. Ramus; Anna de Fazio; Gillian Mitchell; Sian Fereday; Kelly L. Bolton; Charlie Gourley; Caroline Michie; Beth Karlan; Jenny Lester; Christine Walsh; Ilana Cass; Håkan Olsson; Martin Gore; Javier J. Benitez; Maria J. Garcia; Irene Andrulis; Anna Marie Mulligan; Gord Glendon; Ignacio Blanco; Conxi Lazaro; Alice S. Whittemore; Valerie McGuire; Weiva Sieh; Marco Montagna; Elisa Alducci; Siegal Sadetzki; Angela Chetrit; Ava Kwong; Susanne K. Kjaer; Allan Jensen; Estrid Høgdall; Susan Neuhausen; Robert Nussbaum; Mary Daly; Mark H. Greene; Phuong L. Mai; Jennifer T. Loud; Kirsten Moysich; Amanda E. Toland; Diether Lambrechts; Steve Ellis; Debra Frost; James D. Brenton; Marc Tischkowitz; Douglas F. Easton; Antonis Antoniou; Georgia Chenevix-Trench; Simon A. Gayther; David Bowtell; Paul D.P. Pharoah; for EMBRACE
Letters to the Editor
Corrections
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