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Issues

Volume 21, Issue 21
1 November 2015
Issue Cover
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  • Cover Image

    Cover Image

    issue cover
    The cover shows the migratory ability of DU145 prostate cancer cell lines transfected with miRNA negative control lentiviral vector (miR-NC) by wound healing. For details, see the article by Cai and colleagues on page 4922 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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20th Anniversary Commentary

CCR 20th Anniversary Commentary: Gene-Expression Signature in Breast Cancer—Where Did It Start and Where Are We Now?
Isabelle Gingras; Christine Desmedt; Michail Ignatiadis; Christos Sotiriou
View articletitled, <em>CCR</em> 20<sup>th</sup> Anniversary Commentary: Gene-Expression Signature in Breast Cancer—Where Did It Start and Where Are We Now?
Supplementary data
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CCR Translations

Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations
Rani E. George
View articletitled, Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations
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Less Can Be More for Gene Dose and Drug Sensitivity
Susanne A. Gatz; Janet M. Shipley
View articletitled, Less Can Be More for Gene Dose and Drug Sensitivity
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CCR New Strategies

New Strategies in Sarcoma: Linking Genomic and Immunotherapy Approaches to Molecular Subtype
Jamie Lim; Neal M. Poulin; Torsten O. Nielsen
View articletitled, New Strategies in Sarcoma: Linking Genomic and Immunotherapy Approaches to Molecular Subtype
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CCR Perspectives in Drug Approval

FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor–Positive, HER2-Negative Metastatic Breast Cancer
Julia A. Beaver; Laleh Amiri-Kordestani; Rosane Charlab; Wei Chen; Todd Palmby; Amy Tilley; Jeanne Fourie Zirkelbach; Jingyu Yu; Qi Liu; Liang Zhao; Joyce Crich; Xiao Hong Chen; Minerva Hughes; Erik Bloomquist; Shenghui Tang; Rajeshwari Sridhara; Paul G. Kluetz; Geoffrey Kim; Amna Ibrahim; Richard Pazdur; Patricia Cortazar
View articletitled, FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor–Positive, HER2-Negative Metastatic Breast Cancer
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CCR Drug Updates

Author Choice
Panobinostat for the Treatment of Multiple Myeloma
Jacob P. Laubach; Philippe Moreau; Jesús F. San-Miguel; Paul G. Richardson
View articletitled, Panobinostat for the Treatment of Multiple Myeloma
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Molecular Pathways

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer
Leticia Corrales; Thomas F. Gajewski
View articletitled, Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer
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Molecular Pathways: Targeting ATR in Cancer Therapy
Larry M. Karnitz; Lee Zou
View articletitled, Molecular Pathways: Targeting ATR in Cancer Therapy
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Review

Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility
Michail Ignatiadis; Mark Lee; Stefanie S. Jeffrey
View articletitled, Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility
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Cancer Therapy: Clinical

Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma
David S. Hong; Razelle Kurzrock; Jennifer J. Wheler; Aung Naing; Gerald S. Falchook; Siqing Fu; Kevin B. Kim; Michael A. Davies; Ly M. Nguyen; Goldy C. George; Lucy Xu; Robert Shumaker; Min Ren; Jennifer Mink; Cynthia Bedell; Corina Andresen; Pallavi Sachdev; James P. O'Brien; John Nemunaitis
View articletitled, Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma
Supplementary data
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Personalized Medicine and Imaging

SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial
Manuel Hidalgo; Carlos Plaza; Monica Musteanu; Peter Illei; Carrie B. Brachmann; Carla Heise; Daniel Pierce; Pedro P. Lopez-Casas; Camino Menendez; Josep Tabernero; Alfredo Romano; Xinyu Wei; Fernando Lopez-Rios; Daniel D. Von Hoff
View articletitled, SPARC Expression Did Not Predict Efficacy of <em>nab</em>-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial
Supplementary data
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Cancer Therapy: Preclinical

Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors
Shengjun Lu; Jinyu Zhang; Dai Liu; Guangfu Li; Kevin F. Staveley-O'Carroll; Zihai Li; Jennifer D. Wu
View articletitled, Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors
Supplementary data
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Author Choice
Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins
Noriaki Tanaka; Ameeta A. Patel; Jiping Wang; Mitchell J. Frederick; Nene N. Kalu; Mei Zhao; Alison L. Fitzgerald; Tong-xin Xie; Natalie L. Silver; Carlos Caulin; Ge Zhou; Heath D. Skinner; Faye M. Johnson; Jeffrey N. Myers; Abdullah A. Osman
View articletitled, Wee-1 Kinase Inhibition Sensitizes High-Risk HPV<sup>+</sup> HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins
Supplementary data
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siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer
Yoshiaki Yamamoto; Paulo J.C. Lin; Eliana Beraldi; Fan Zhang; Yoshihisa Kawai; Jeffrey Leong; Hidemasa Katsumi; Ladan Fazli; Robert Fraser; Pieter R. Cullis; Martin Gleave
View articletitled, siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer
Supplementary data
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Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model
Ruben Bill; Ernesta Fagiani; Adrian Zumsteg; Helena Antoniadis; David Johansson; Simon Haefliger; Imke Albrecht; Frank Hilberg; Gerhard Christofori
View articletitled, Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model
Supplementary data
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Biology of Human Tumors

Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3–FOXO1-Positive Alveolar Rhabdomyosarcoma
Julie J.G. Kephart; Rosanne G.J. Tiller; Lisa E.S. Crose; Katherine K. Slemmons; Po-Han Chen; Ashley R. Hinson; Rex C. Bentley; Jen-Tsan Ashley Chi; Corinne M. Linardic
View articletitled, Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3–FOXO1-Positive Alveolar Rhabdomyosarcoma
Supplementary data
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MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16
Dong Qian; Kailin Chen; Haixia Deng; Huilan Rao; Huiqiang Huang; Yiji Liao; Xiaofei Sun; Suying Lu; Zhiyong Yuan; Dan Xie; Qingqing Cai
View articletitled, MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16
Supplementary data
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LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival
Sofía Torres; Irene Garcia-Palmero; Mercedes Herrera; Rubén A. Bartolomé; Cristina Peña; M. Jesús Fernandez-Aceñero; Guillermo Padilla; Alberto Peláez-García; María Lopez-Lucendo; Rufo Rodriguez-Merlo; Antonio García de Herreros; Félix Bonilla; J. Ignacio Casal
View articletitled, LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival
Supplementary data
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A miRNA-Based Signature Detected in Primary Melanoma Tissue Predicts Development of Brain Metastasis
Doug Hanniford; Judy Zhong; Lisa Koetz; Avital Gaziel-Sovran; Daniel J. Lackaye; Shulian Shang; Anna Pavlick; Richard Shapiro; Russell Berman; Farbod Darvishian; Yongzhao Shao; Iman Osman; Eva Hernando
View articletitled, A miRNA-Based Signature Detected in Primary Melanoma Tissue Predicts Development of Brain Metastasis
Supplementary data
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Author Choice
Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis
Angela Bellini; Virginie Bernard; Quentin Leroy; Thomas Rio Frio; Gaelle Pierron; Valérie Combaret; Eve Lapouble; Nathalie Clement; Herve Rubie; Estelle Thebaud; Pascal Chastagner; Anne Sophie Defachelles; Christophe Bergeron; Nimrod Buchbinder; Sophie Taque; Anne Auvrignon; Dominique Valteau-Couanet; Jean Michon; Isabelle Janoueix-Lerosey; Olivier Delattre; Gudrun Schleiermacher
View articletitled, Deep Sequencing Reveals Occurrence of Subclonal <em>ALK</em> Mutations in Neuroblastoma at Diagnosis
Supplementary data
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miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer
Chao Cai; Qing-Biao Chen; Zhao-Dong Han; Yan-Qiong Zhang; Hui-Chan He; Jia-Hong Chen; Yan-Ru Chen; Sheng-Bang Yang; Yong-Ding Wu; Yan-Ru Zeng; Guo-Qiang Qin; Yu-Xiang Liang; Qi-Shan Dai; Fu-Neng Jiang; Shu-lin Wu; Guo-Hua Zeng; Wei-De Zhong; Chin-Lee Wu
View articletitled, miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer
Supplementary data
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Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma
Konstantin Agelopoulos; Günther H.S. Richter; Eva Schmidt; Uta Dirksen; Kristina von Heyking; Benjamin Moser; Hans-Ulrich Klein; Udo Kontny; Martin Dugas; Kathrin Poos; Eberhard Korsching; Thorsten Buch; Matthias Weckesser; Isabell Schulze; Regina Besoke; Anika Witten; Monika Stoll; Gabriele Köhler; Wolfgang Hartmann; Eva Wardelmann; Claudia Rossig; Daniel Baumhoer; Heribert Jürgens; Stefan Burdach; Wolfgang E. Berdel; Carsten Müller-Tidow
View articletitled, Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma
Supplementary data
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CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma
Mary E. Olanich; Wenyue Sun; Stephen M. Hewitt; Zied Abdullaev; Svetlana D. Pack; Frederic G. Barr
View articletitled, <em>CDK4</em> Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma
Supplementary data
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Author Choice
Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array
Vinod Vathipadiekal; Victoria Wang; Wei Wei; Levi Waldron; Ronny Drapkin; Michael Gillette; Steven Skates; Michael Birrer
View articletitled, Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array
Supplementary data
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Identification and Functional Validation of Reciprocal microRNA–mRNA Pairings in African American Prostate Cancer Disparities
Bi-Dar Wang; Kristin Ceniccola; Qi Yang; Ramez Andrawis; Vyomesh Patel; Youngmi Ji; Johng Rhim; Jacqueline Olender; Anastas Popratiloff; Patricia Latham; Yinglei Lai; Steven R. Patierno; Norman H. Lee
View articletitled, Identification and Functional Validation of Reciprocal microRNA–mRNA Pairings in African American Prostate Cancer Disparities
Supplementary data
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Letter to the Editor

AMER1 Is a Frequently Mutated Gene in Colorectal Cancer—Letter
Pilar Mur; Gemma Aiza; Rebeca Sanz-Pamplona; Sara González; Matilde Navarro; Victor Moreno; Gabriel Capellá; Laura Valle
View articletitled, <em>AMER1</em> Is a Frequently Mutated Gene in Colorectal Cancer—Letter
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