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1 November 2015
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Cover Image
Cover Image
The cover shows the migratory ability of DU145 prostate cancer cell lines transfected with miRNA negative control lentiviral vector (miR-NC) by wound healing. For details, see the article by Cai and colleagues on page 4922 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
20th Anniversary Commentary
CCR Translations
CCR New Strategies
CCR Perspectives in Drug Approval
FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor–Positive, HER2-Negative Metastatic Breast Cancer
Julia A. Beaver; Laleh Amiri-Kordestani; Rosane Charlab; Wei Chen; Todd Palmby; Amy Tilley; Jeanne Fourie Zirkelbach; Jingyu Yu; Qi Liu; Liang Zhao; Joyce Crich; Xiao Hong Chen; Minerva Hughes; Erik Bloomquist; Shenghui Tang; Rajeshwari Sridhara; Paul G. Kluetz; Geoffrey Kim; Amna Ibrahim; Richard Pazdur; Patricia Cortazar
CCR Drug Updates
Molecular Pathways
Review
Cancer Therapy: Clinical
Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma
David S. Hong; Razelle Kurzrock; Jennifer J. Wheler; Aung Naing; Gerald S. Falchook; Siqing Fu; Kevin B. Kim; Michael A. Davies; Ly M. Nguyen; Goldy C. George; Lucy Xu; Robert Shumaker; Min Ren; Jennifer Mink; Cynthia Bedell; Corina Andresen; Pallavi Sachdev; James P. O'Brien; John Nemunaitis
Personalized Medicine and Imaging
SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial
Manuel Hidalgo; Carlos Plaza; Monica Musteanu; Peter Illei; Carrie B. Brachmann; Carla Heise; Daniel Pierce; Pedro P. Lopez-Casas; Camino Menendez; Josep Tabernero; Alfredo Romano; Xinyu Wei; Fernando Lopez-Rios; Daniel D. Von Hoff
Cancer Therapy: Preclinical
Author Choice
Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins
Noriaki Tanaka; Ameeta A. Patel; Jiping Wang; Mitchell J. Frederick; Nene N. Kalu; Mei Zhao; Alison L. Fitzgerald; Tong-xin Xie; Natalie L. Silver; Carlos Caulin; Ge Zhou; Heath D. Skinner; Faye M. Johnson; Jeffrey N. Myers; Abdullah A. Osman
siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer
Yoshiaki Yamamoto; Paulo J.C. Lin; Eliana Beraldi; Fan Zhang; Yoshihisa Kawai; Jeffrey Leong; Hidemasa Katsumi; Ladan Fazli; Robert Fraser; Pieter R. Cullis; Martin Gleave
Biology of Human Tumors
LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival
Sofía Torres; Irene Garcia-Palmero; Mercedes Herrera; Rubén A. Bartolomé; Cristina Peña; M. Jesús Fernandez-Aceñero; Guillermo Padilla; Alberto Peláez-García; María Lopez-Lucendo; Rufo Rodriguez-Merlo; Antonio García de Herreros; Félix Bonilla; J. Ignacio Casal
A miRNA-Based Signature Detected in Primary Melanoma Tissue Predicts Development of Brain Metastasis
Doug Hanniford; Judy Zhong; Lisa Koetz; Avital Gaziel-Sovran; Daniel J. Lackaye; Shulian Shang; Anna Pavlick; Richard Shapiro; Russell Berman; Farbod Darvishian; Yongzhao Shao; Iman Osman; Eva Hernando
Author Choice
Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis
Angela Bellini; Virginie Bernard; Quentin Leroy; Thomas Rio Frio; Gaelle Pierron; Valérie Combaret; Eve Lapouble; Nathalie Clement; Herve Rubie; Estelle Thebaud; Pascal Chastagner; Anne Sophie Defachelles; Christophe Bergeron; Nimrod Buchbinder; Sophie Taque; Anne Auvrignon; Dominique Valteau-Couanet; Jean Michon; Isabelle Janoueix-Lerosey; Olivier Delattre; Gudrun Schleiermacher
miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer
Chao Cai; Qing-Biao Chen; Zhao-Dong Han; Yan-Qiong Zhang; Hui-Chan He; Jia-Hong Chen; Yan-Ru Chen; Sheng-Bang Yang; Yong-Ding Wu; Yan-Ru Zeng; Guo-Qiang Qin; Yu-Xiang Liang; Qi-Shan Dai; Fu-Neng Jiang; Shu-lin Wu; Guo-Hua Zeng; Wei-De Zhong; Chin-Lee Wu
Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma
Konstantin Agelopoulos; Günther H.S. Richter; Eva Schmidt; Uta Dirksen; Kristina von Heyking; Benjamin Moser; Hans-Ulrich Klein; Udo Kontny; Martin Dugas; Kathrin Poos; Eberhard Korsching; Thorsten Buch; Matthias Weckesser; Isabell Schulze; Regina Besoke; Anika Witten; Monika Stoll; Gabriele Köhler; Wolfgang Hartmann; Eva Wardelmann; Claudia Rossig; Daniel Baumhoer; Heribert Jürgens; Stefan Burdach; Wolfgang E. Berdel; Carsten Müller-Tidow
Author Choice
Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array
Vinod Vathipadiekal; Victoria Wang; Wei Wei; Levi Waldron; Ronny Drapkin; Michael Gillette; Steven Skates; Michael Birrer
Identification and Functional Validation of Reciprocal microRNA–mRNA Pairings in African American Prostate Cancer Disparities
Bi-Dar Wang; Kristin Ceniccola; Qi Yang; Ramez Andrawis; Vyomesh Patel; Youngmi Ji; Johng Rhim; Jacqueline Olender; Anastas Popratiloff; Patricia Latham; Yinglei Lai; Steven R. Patierno; Norman H. Lee
Letter to the Editor
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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