Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 21, Issue 20
15 October 2015
Issue Cover
All Issues
  • Cover Image

    Cover Image

    issue cover

    This is a section of human LN-229 glioblastoma growing in the brain of nude mice. Immunohistochemical staining shows heterogeneous expression of endothelin receptors ETAR depicted in green and ETBR depicted in red. For details see the article by Kim and colleagues on page 4630 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
Open the PDF for in another window

20th Anniversary Commentary

CCR 20th Anniversary Commentary: Prospects and Challenges of Therapeutic Nanoparticles in Cancer
Mohammad Aminur Rahman; Dong M. Shin
View articletitled, <em>CCR</em> 20<sup>th</sup> Anniversary Commentary: Prospects and Challenges of Therapeutic Nanoparticles in Cancer
Open the PDF for in another window

CCR Translations

Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography
Yana K. Reshetnyak
View articletitled, Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography
Open the PDF for in another window
Docetaxel Resistance in Prostate Cancer: Taking It Up a Notch
Tian Zhang; Andrew J. Armstrong
View articletitled, Docetaxel Resistance in Prostate Cancer: Taking It Up a Notch
Open the PDF for in another window

Molecular Pathways

Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling
Fabio Conforti; Yisong Wang; Jose A. Rodriguez; Anna Teresa Alberobello; Yu-Wen Zhang; Giuseppe Giaccone
View articletitled, Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling
Open the PDF for in another window

Review

Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise
Jaegil Kim; Rehan Akbani; Chad J. Creighton; Seth P. Lerner; John N. Weinstein; Gad Getz; David J. Kwiatkowski
View articletitled, Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise
Open the PDF for in another window

CCR Focus

On Innovating and Inspiring the Clinical Trial Enterprise
Susan E. Bates
View articletitled, On Innovating and Inspiring the Clinical Trial Enterprise
Open the PDF for in another window
Advancing Clinical Trials to Streamline Drug Development
Susan E. Bates; Donald A. Berry; Sanjeeve Balasubramaniam; Stuart Bailey; Patricia M. LoRusso; Eric H. Rubin
View articletitled, Advancing Clinical Trials to Streamline Drug Development
Open the PDF for in another window
Next-Generation Sequencing to Guide Clinical Trials
Lillian L. Siu; Barbara A. Conley; Scott Boerner; Patricia M. LoRusso
View articletitled, Next-Generation Sequencing to Guide Clinical Trials
Open the PDF for in another window
Expansion Cohorts in First-in-Human Solid Tumor Oncology Trials
Marc R. Theoret; Lee H. Pai-Scherf; Meredith K. Chuk; Tatiana M. Prowell; Sanjeeve Balasubramaniam; Tamy Kim; Geoffrey Kim; Paul G. Kluetz; Patricia Keegan; Richard Pazdur
View articletitled, Expansion Cohorts in First-in-Human Solid Tumor Oncology Trials
Open the PDF for in another window
Failures in Phase III: Causes and Consequences
Bostjan Seruga; Alberto Ocana; Eitan Amir; Ian F. Tannock
View articletitled, Failures in Phase III: Causes and Consequences
Supplementary data
Open the PDF for in another window
Author Choice
The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases
David J. Stewart; Gerald Batist; Hagop M. Kantarjian; John-Peter Bradford; Joan H. Schiller; Razelle Kurzrock
View articletitled, The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases
Open the PDF for in another window

Cancer Therapy: Clinical

Phase I Clinical Trial to Determine the Feasibility and Maximum Tolerated Dose of Panitumumab to Standard Gemcitabine-Based Chemoradiation in Locally Advanced Pancreatic Cancer
Annette A. van Zweeden; Hans J. van der Vliet; Johanna W. Wilmink; Martijn R. Meijerink; Otto W.M. Meijer; Anna M.E. Bruynzeel; Geertjan van Tienhoven; Elisa Giovannetti; Geert Kazemier; Maarten A.J.M. Jacobs; Henk M.W. Verheul
View articletitled, Phase I Clinical Trial to Determine the Feasibility and Maximum Tolerated Dose of Panitumumab to Standard Gemcitabine-Based Chemoradiation in Locally Advanced Pancreatic Cancer
Supplementary data
Open the PDF for in another window

Personalized Medicine and Imaging

Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo
Charles W. Kimbrough; Anil Khanal; Matthew Zeiderman; Bigya R. Khanal; Neal C. Burton; Kelly M. McMasters; Selwyn M. Vickers; William E. Grizzle; Lacey R. McNally
View articletitled, Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes <em>In Vivo</em>
Supplementary data
Open the PDF for in another window
Serial Next-Generation Sequencing of Circulating Cell-Free DNA Evaluating Tumor Clone Response To Molecularly Targeted Drug Administration
Jean Sebastien Frenel; Suzanne Carreira; Jane Goodall; Desam Roda; Raquel Perez-Lopez; Nina Tunariu; Ruth Riisnaes; Susana Miranda; Ines Figueiredo; Daniel Nava-Rodrigues; Alan Smith; Christophe Leux; Isaac Garcia-Murillas; Roberta Ferraldeschi; David Lorente; Joaquin Mateo; Michael Ong; Timothy A. Yap; Udai Banerji; Delila Gasi Tandefelt; Nick Turner; Gerhardt Attard; Johann S. de Bono
View articletitled, Serial Next-Generation Sequencing of Circulating Cell-Free DNA Evaluating Tumor Clone Response To Molecularly Targeted Drug Administration
Supplementary data
Open the PDF for in another window
Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies
Netanya I. Pollock; Lin Wang; Gerald Wallweber; William E. Gooding; Weidong Huang; Ahmed Chenna; John Winslow; Malabika Sen; Kara A. DeGrave; Hua Li; Yan Zeng; Jennifer R. Grandis
View articletitled, Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies
Supplementary data
Open the PDF for in another window

Cancer Therapy: Preclinical

Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma
Güllü Görgün; Mehmet K. Samur; Kristen B. Cowens; Steven Paula; Giada Bianchi; Julie E. Anderson; Randie E. White; Ahaana Singh; Hiroto Ohguchi; Rikio Suzuki; Shohei Kikuchi; Takeshi Harada; Teru Hideshima; Yu-Tzu Tai; Jacob P. Laubach; Noopur Raje; Florence Magrangeas; Stephane Minvielle; Herve Avet-Loiseau; Nikhil C. Munshi; David M. Dorfman; Paul G. Richardson; Kenneth C. Anderson
View articletitled, Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma
Supplementary data
Open the PDF for in another window
Notch Pathway Inhibition Using PF-03084014, a γ-Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer
Di Cui; Jinlu Dai; Jill M. Keller; Atsushi Mizokami; Shujie Xia; Evan T. Keller
View articletitled, Notch Pathway Inhibition Using PF-03084014, a γ-Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer
Supplementary data
Open the PDF for in another window
Author Choice
Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice
Sun-Jin Kim; Ho Jeong Lee; Mark Seungwook Kim; Hyun Jin Choi; Junqin He; Qiuyu Wu; Kenneth Aldape; Jeffrey S. Weinberg; W.K. Alfred Yung; Charles A. Conrad; Robert R. Langley; François Lehembre; Urs Regenass; Isaiah J. Fidler
View articletitled, Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice
Supplementary data
Open the PDF for in another window
Treatment with Ibrutinib Inhibits BTK- and VLA-4–Dependent Adhesion of Chronic Lymphocytic Leukemia Cells In Vivo
Sarah E.M. Herman; Rashida Z. Mustafa; Jade Jones; Deanna H. Wong; Mohammed Farooqui; Adrian Wiestner
View articletitled, Treatment with Ibrutinib Inhibits BTK- and VLA-4–Dependent Adhesion of Chronic Lymphocytic Leukemia Cells <em>In Vivo</em>
Supplementary data
Open the PDF for in another window
Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models
Yusuke Kobayashi; Hiroyasu Kashima; Ren-Chin Wu; Jin-Gyoung Jung; Jen-Chun Kuan; Jinghua Gu; Jianhua Xuan; Lori Sokoll; Kala Visvanathan; Ie-Ming Shih; Tian-Li Wang
View articletitled, Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models
Supplementary data
Open the PDF for in another window
Dual Targeting of Protein Degradation Pathways with the Selective HDAC6 Inhibitor ACY-1215 and Bortezomib Is Synergistic in Lymphoma
Jennifer E. Amengual; Paul Johannet; Maximilian Lombardo; Kelly Zullo; Daniela Hoehn; Govind Bhagat; Luigi Scotto; Xavier Jirau-Serrano; Dejan Radeski; Jennifer Heinen; Hongfeng Jiang; Serge Cremers; Yuan Zhang; Simon Jones; Owen A. O'Connor
View articletitled, Dual Targeting of Protein Degradation Pathways with the Selective HDAC6 Inhibitor ACY-1215 and Bortezomib Is Synergistic in Lymphoma
Supplementary data
Open the PDF for in another window

Biology of Human Tumors

Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK–Mediated Phosphorylation of Akt
Naitao Wang; Ming Yao; Jin Xu; Yizhou Quan; Kaiqing Zhang; Ru Yang; Wei-Qiang Gao
View articletitled, Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK–Mediated Phosphorylation of Akt
Supplementary data
Open the PDF for in another window
Author Choice
SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Carminia Maria Della Corte; Claudio Bellevicine; Giovanni Vicidomini; Donata Vitagliano; Umberto Malapelle; Marina Accardo; Alessio Fabozzi; Alfonso Fiorelli; Morena Fasano; Federica Papaccio; Erika Martinelli; Teresa Troiani; Giancarlo Troncone; Mario Santini; Roberto Bianco; Fortunato Ciardiello; Floriana Morgillo
View articletitled, SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Supplementary data
Open the PDF for in another window
SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
Xiaotun Zhang; Ilsa M. Coleman; Lisha G. Brown; Lawrence D. True; Lori Kollath; Jared M. Lucas; Hung-Ming Lam; Ruth Dumpit; Eva Corey; Lisly Chéry; Bryce Lakely; Celestia S. Higano; Bruce Montgomery; Martine Roudier; Paul H. Lange; Peter S. Nelson; Robert L. Vessella; Colm Morrissey
View articletitled, SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
Supplementary data
Open the PDF for in another window
Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer
Rebeca Sanz-Pamplona; Adriana Lopez-Doriga; Laia Paré-Brunet; Kira Lázaro; Fernando Bellido; M. Henar Alonso; Susanna Aussó; Elisabet Guinó; Sergi Beltrán; Francesc Castro-Giner; Marta Gut; Xavier Sanjuan; Adria Closa; David Cordero; Francisco D. Morón-Duran; Antonio Soriano; Ramón Salazar; Laura Valle; Victor Moreno
View articletitled, Exome Sequencing Reveals <em>AMER1</em> as a Frequently Mutated Gene in Colorectal Cancer
Supplementary data
Open the PDF for in another window
Keap1–Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein
Ming-Hsien Chien; Wei-Jiunn Lee; Feng-Koo Hsieh; Chia-Feng Li; Tsu-Yao Cheng; Ming-Yang Wang; Jin-Shing Chen; Jyh-Ming Chow; Yi-Hua Jan; Michael Hsiao; Kuo-Tai Hua; Min-Liang Kuo
View articletitled, Keap1–Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein
Supplementary data
Open the PDF for in another window
Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group
Pooja Hingorani; Edoardo Missiaglia; Janet Shipley; James R. Anderson; Timothy J. Triche; Mauro Delorenzi; Julie Gastier-Foster; Michele Wing; Douglas S. Hawkins; Stephen X. Skapek
View articletitled, Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group
Supplementary data
Open the PDF for in another window

Letter to the Editor

Siltuximab for Multicentric Castleman Disease—Letter
Raphael Teipel; Rainer Ordemann; Ulrike Proske; Frank Dietrich; Marika Mende; Gerhard Ehninger; Frank Kroschinsky; Uwe Platzbecker
View articletitled, Siltuximab for Multicentric Castleman Disease—Letter
Open the PDF for in another window

Advertisement

  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

AACR Journals

 

 

  • Copyright © 2023 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept