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15 January 2015
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Cover Image
Detection of surface expression of human endogenous retrovirus-K (HERV-K) envelope protein by immunocytochemistry in primary tumor cells obtained from ascites of a patient diagnosed with ovarian serous carcinoma. Blue (DAPI) represents nuclear stain and green (Alexa fluor 488) represents surface HERV-K expression. For details, see the article by Rycaj and colleagues on page 471 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR 20th Anniversary Commentary
CCR Translations
Molecular Pathways
Reviews
Cancer Therapy: Clinical
A Phase I Monotherapy Study of RG7212, a First-in-Class Monoclonal Antibody Targeting TWEAK Signaling in Patients with Advanced Cancers
Ulrik N. Lassen; Didier Meulendijks; Lilian L. Siu; Vaios Karanikas; Morten Mau-Sorensen; Jan H.M. Schellens; Derek J. Jonker; Aaron R. Hansen; Mary E. Simcox; Kathleen J. Schostack; Dean Bottino; Hua Zhong; Markus Roessler; Suzana M. Vega-Harring; Tiantom Jarutat; David Geho; Ka Wang; Mark DeMario; Glenwood D. Goss
A Phase I Trial of AT9283 (a Selective Inhibitor of Aurora Kinases) in Children and Adolescents with Solid Tumors: A Cancer Research UK Study
Lucas Moreno; Lynley V. Marshall; Andrew D.J. Pearson; Bruce Morland; Martin Elliott; Quentin Campbell-Hewson; Guy Makin; Sarah E.R. Halford; Gary Acton; Philip Ross; Shamim Kazmi-Stokes; Victoria Lock; Ana Rodriguez; John F. Lyons; Alan V. Boddy; Melanie J. Griffin; Murray Yule; Darren Hargrave
Reduction of Regulatory T Cells by Mogamulizumab, a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients with Aggressive/Refractory Mycosis Fungoides and Sézary Syndrome
Xiao Ni; Jeffrey L. Jorgensen; Meghali Goswami; Pramoda Challagundla; William K. Decker; Youn H. Kim; Madeleine A. Duvic
Induction of Robust Type-I CD8+ T-cell Responses in WHO Grade 2 Low-Grade Glioma Patients Receiving Peptide-Based Vaccines in Combination with Poly-ICLC
Hideho Okada; Lisa H. Butterfield; Ronald L. Hamilton; Aki Hoji; Masashi Sakaki; Brian J. Ahn; Gary Kohanbash; Jan Drappatz; Johnathan Engh; Nduka Amankulor; Mark O. Lively; Michael D. Chan; Andres M. Salazar; Edward G. Shaw; Douglas M. Potter; Frank S. Lieberman
Sequential Intravesical Mitomycin plus Bacillus Calmette–Guérin for Non–Muscle-Invasive Urothelial Bladder Carcinoma: Translational and Phase I Clinical Trial
Robert S. Svatek; Xiang Ru. Zhao; Edwin E. Morales; Mithilesh K. Jha; Timothy Y. Tseng; Cory M. Hugen; Vincent Hurez; Javier Hernandez; Tyler J. Curiel
Phase II Clinical Trial of Multiple Peptide Vaccination for Advanced Head and Neck Cancer Patients Revealed Induction of Immune Responses and Improved OS
Yoshihiro Yoshitake; Daiki Fukuma; Akira Yuno; Masatoshi Hirayama; Hideki Nakayama; Takuya Tanaka; Masashi Nagata; Yasuo Takamune; Kenta Kawahara; Yoshihiro Nakagawa; Ryoji Yoshida; Akiyuki Hirosue; Hidenao Ogi; Akimitsu Hiraki; Hirofumi Jono; Akinobu Hamada; Koji Yoshida; Yasuharu Nishimura; Yusuke Nakamura; Masanori Shinohara
Personalized Medicine and Imaging
Whole-Exome Sequencing Reveals Defective CYP3A4 Variants Predictive of Paclitaxel Dose-Limiting Neuropathy
María Apellániz-Ruiz; Mi-Young Lee; Lara Sánchez-Barroso; Gerardo Gutiérrez-Gutiérrez; Isabel Calvo; Laura García-Estévez; María Sereno; Jesús García-Donás; Beatriz Castelo; Eva Guerra; Luis J. Leandro-García; Alberto Cascón; Inger Johansson; Mercedes Robledo; Magnus Ingelman-Sundberg; Cristina Rodríguez-Antona
Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia
Mohsen Ben Tanfous; Bahram Sharif-Askari; Francesco Ceppi; Haithem Laaribi; Vincent Gagné; Julie Rousseau; Malgorzata Labuda; Lewis B. Silverman; Stephen E. Sallan; Donna Neuberg; Jeffery L. Kutok; Daniel Sinnett; Caroline Laverdière; Maja Krajinovic
Identification of a Variant in KDR Associated with Serum VEGFR2 and Pharmacodynamics of Pazopanib
Michael L. Maitland; Chun-Fang Xu; Yu-Ching Cheng; Emily Kistner-Griffin; Kathleen A. Ryan; Theodore G. Karrison; Soma Das; Dara Torgerson; Eric R. Gamazon; Vasiliki Thomeas; Matthew R. Levine; Paul A. Wilson; Nan Bing; Yuan Liu; Lon R. Cardon; Lini N. Pandite; Jeffrey R. O'Connell; Nancy J. Cox; Braxton D. Mitchell; Mark J. Ratain; Alan R. Shuldiner
Cancer Therapy: Preclinical
Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer
Brinda Alagesan; Gianmarco Contino; Alexander R. Guimaraes; Ryan B. Corcoran; Vikram Deshpande; Gregory R. Wojtkiewicz; Aram F. Hezel; Kwok-Kin Wong; Massimo Loda; Ralph Weissleder; Cyril Benes; Jeffrey A. Engelman; Nabeel Bardeesy
A Vaccinia Virus Armed with Interleukin-10 Is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer
Louisa S. Chard; Eleni Maniati; Pengju Wang; Zhongxian Zhang; Dongling Gao; Jiwei Wang; Fengyu Cao; Jahangir Ahmed; Margueritte El Khouri; Jonathan Hughes; Shengdian Wang; Xiaozhu Li; Bela Denes; Istvan Fodor; Thorsten Hagemann; Nicholas R. Lemoine; Yaohe Wang
A Novel E2F/Sphingosine Kinase 1 Axis Regulates Anthracycline Response in Squamous Cell Carcinoma
Mehlika Hazar-Rethinam; Lilia Merida de Long; Orla M. Gannon; Eleni Topkas; Samuel Boros; Ana Cristina Vargas; Marcin Dzienis; Pamela Mukhopadhyay; Fiona Simpson; Liliana Endo-Munoz; Nicholas A. Saunders
Immunotherapy Targeting Folate Receptor Induces Cell Death Associated with Autophagy in Ovarian Cancer
Yunfei Wen; Whitney S. Graybill; Rebecca A. Previs; Wei Hu; Cristina Ivan; Lingegowda S. Mangala; Behrouz Zand; Alpa M. Nick; Nicholas B. Jennings; Heather J. Dalton; Vasudha Sehgal; Prahlad Ram; Ju-Seog Lee; Pablo E. Vivas-Mejia; Robert L. Coleman; Anil K. Sood
Biology of Human Tumors
Letter to the Editor
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