Issues

The cover depicts a tumor-targeting nanoscale drug formulation based on layer-by-layer (LbL) self-assembly, here penetrating deeply through a dense tumor spheroid as imaged by confocal fluorescence microscopy. The authors show that these nanotechnologies can further enhance drug synergy associated with simultaneous blockade of MAPK and PI3K pathway signaling in tumor cells, eliciting disease stabilization in vivo in the absence of dose-limiting toxic effects observed from the free drug combination. For details, see the article by Dreaden and colleagues on page 4410 of this issue.