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1 September 2015
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Cover Image
Cover Image
The cover shows a surgically resected tumor specimen from a patient with non-small cell lung cancer positive for the EML4-ALK fusion gene. PD-L1 immunoreactivity is detected at the cell membrane or in the cytoplasm (or both) of the tumor cells. For details, see the article by Ota and colleagues on page 4014 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
20th Anniversary Commentary
CCR Translations
CCR New Strategies
CCR Drug Updates
Molecular Pathways
Reviews
Cancer Therapy: Clinical
Author Choice
A Randomized Phase II Trial of Sipuleucel-T with Concurrent versus Sequential Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer
Eric J. Small; Raymond S. Lance; Thomas A. Gardner; Lawrence I. Karsh; Lawrence Fong; Candice McCoy; Todd DeVries; Nadeem A. Sheikh; Debraj GuhaThakurta; Nancy Chang; Charles H. Redfern; Neal D. Shore
First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors
Alexander N. Starodub; Allyson J. Ocean; Manish A. Shah; Michael J. Guarino; Vincent J. Picozzi, Jr; Linda T. Vahdat; Sajeve S. Thomas; Serengulam V. Govindan; Pius P. Maliakal; William A. Wegener; Steven A. Hamburger; Robert M. Sharkey; David M. Goldenberg
Personalized Medicine and Imaging
Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma
Ingo Janssen; Elise M. Blanchet; Karen Adams; Clara C. Chen; Corina M. Millo; Peter Herscovitch; David Taieb; Electron Kebebew; Hendrik Lehnert; Antonio T. Fojo; Karel Pacak
Cancer Therapy: Preclinical
Author Choice
The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies
Matthew J. Niederst; Haichuan Hu; Hillary E. Mulvey; Elizabeth L. Lockerman; Angel R. Garcia; Zofia Piotrowska; Lecia V. Sequist; Jeffrey A. Engelman
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
Antonia Cagnetta; Irene Caffa; Chirag Acharya; Debora Soncini; Prakrati Acharya; Sophia Adamia; Ivana Pierri; Micaela Bergamaschi; Anna Garuti; Giulio Fraternali; Luca Mastracci; Alessandro Provenzani; Chiara Zucal; Gianluca Damonte; Annalisa Salis; Fabrizio Montecucco; Franco Patrone; Alberto Ballestrero; Santina Bruzzone; Marco Gobbi; Alessio Nencioni; Michele Cea
MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma
Suresh Mohan; Robert Vander Broek; Sujay Shah; Danielle F. Eytan; Matthew L. Pierce; Sophie G. Carlson; Jamie F. Coupar; Jialing Zhang; Hui Cheng; Zhong Chen; Carter Van Waes
Biology of Human Tumors
Author Choice
Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Janis M. Taube; Geoffrey D. Young; Tracee L. McMiller; Shuming Chen; January T. Salas; Theresa S. Pritchard; Haiying Xu; Alan K. Meeker; Jinshui Fan; Chris Cheadle; Alan E. Berger; Drew M. Pardoll; Suzanne L. Topalian
A Leukemia-Associated CD34/CD123/CD25/CD99+ Immunophenotype Identifies FLT3-Mutated Clones in Acute Myeloid Leukemia
Daniela F. Angelini; Tiziana Ottone; Gisella Guerrera; Serena Lavorgna; Michela Cittadini; Francesco Buccisano; Marco De Bardi; Francesca Gargano; Luca Maurillo; Mariadomenica Divona; Nélida I. Noguera; Maria Irno Consalvo; Giovanna Borsellino; Giorgio Bernardi; Sergio Amadori; Adriano Venditti; Luca Battistini; Francesco Lo-Coco
Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas
Esteban Braggio; Scott Van Wier; Juhi Ojha; Ellen McPhail; Yan W. Asmann; Jan Egan; Jackline Ayres da Silva; David Schiff; M. Beatriz Lopes; Paul A. Decker; Riccardo Valdez; Raoul Tibes; Bruce Eckloff; Thomas E. Witzig; A. Keith Stewart; Rafael Fonseca; Brian Patrick O'Neill
Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy
Mario Giuliano; Huizhong Hu; Yen-Chao Wang; Xiaoyong Fu; Agostina Nardone; Sabrina Herrera; Sufeng Mao; Alejandro Contreras; Carolina Gutierrez; Tao Wang; Susan G. Hilsenbeck; Carmine De Angelis; Nicholas J. Wang; Laura M. Heiser; Joe W. Gray; Sara Lopez-Tarruella; Anne C. Pavlick; Meghana V. Trivedi; Gary C. Chamness; Jenny C. Chang; C. Kent Osborne; Mothaffar F. Rimawi; Rachel Schiff
Induction of PD-L1 Expression by the EML4–ALK Oncoprotein and Downstream Signaling Pathways in Non–Small Cell Lung Cancer
Keiichi Ota; Koichi Azuma; Akihiko Kawahara; Satoshi Hattori; Eiji Iwama; Junko Tanizaki; Taishi Harada; Koichiro Matsumoto; Koichi Takayama; Shinzo Takamori; Masayoshi Kage; Tomoaki Hoshino; Yoichi Nakanishi; Isamu Okamoto
Letters to the Editor
Correction
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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