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15 August 2015
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Cover Image
Cover Image
The cover shows the radiation-induced EndMT (endothelial-to-mesenchymal transition) in human pulmonary artery endothelial cells. Immunofluorescence staining shows the loss of VE-cadherin and the increases in CA9 and filamentous actin formation. For details, see the article by Choi and colleagues on page 3716 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
20th Anniversary Commentary
CCR Translations
CCR Perspectives in Drug Approval
FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia
R. Angelo de Claro; Karen M. McGinn; Nicole Verdun; Shwu-Luan Lee; Haw-Jyh Chiu; Haleh Saber; Margaret E. Brower; C.J. George Chang; Elimika Pfuma; Bahru Habtemariam; Julie Bullock; Yun Wang; Lei Nie; Xiao-Hong Chen; Donghao (Robert) Lu; Ali Al-Hakim; Robert C. Kane; Edvardas Kaminskas; Robert Justice; Ann T. Farrell; Richard Pazdur
CCR Drug Updates
Molecular Pathways
Review
Cancer Therapy: Clinical
A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients
Eudocia Q. Lee; Thomas J. Kaley; Dan G. Duda; David Schiff; Andrew B. Lassman; Eric T. Wong; Tom Mikkelsen; Benjamin W. Purow; Alona Muzikansky; Marek Ancukiewicz; Jason T. Huse; Shakti Ramkissoon; Jan Drappatz; Andrew D. Norden; Rameen Beroukhim; Stephanie E. Weiss; Brian M. Alexander; Christine S. McCluskey; Mary Gerard; Katrina H. Smith; Rakesh K. Jain; Tracy T. Batchelor; Keith L. Ligon; Patrick Y. Wen
Personalized Medicine and Imaging
Author Choice
Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and Its Association with Improved Clinical Outcome
Debraj GuhaThakurta; Nadeem A. Sheikh; Li-Qun Fan; Harini Kandadi; T. Craig Meagher; Simon J. Hall; Philip W. Kantoff; Celestia S. Higano; Eric J. Small; Thomas A. Gardner; Kate Bailey; Tuyen Vu; Todd DeVries; James B. Whitmore; Mark W. Frohlich; James B. Trager; Charles G. Drake
Author Choice
Broad, Hybrid Capture–Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches
Alexander Drilon; Lu Wang; Maria E. Arcila; Sohail Balasubramanian; Joel R. Greenbowe; Jeffrey S. Ross; Phil Stephens; Doron Lipson; Vincent A. Miller; Mark G. Kris; Marc Ladanyi; Naiyer A. Rizvi
Standardized Ki67 Diagnostics Using Automated Scoring—Clinical Validation in the GeparTrio Breast Cancer Study
Frederick Klauschen; Stephan Wienert; Wolfgang D. Schmitt; Sibylle Loibl; Bernd Gerber; Jens-Uwe Blohmer; Jens Huober; Thomas Rüdiger; Erhard Erbstößer; Keyur Mehta; Bianca Lederer; Manfred Dietel; Carsten Denkert; Gunter von Minckwitz
Safety and Tumor Specificity of Cetuximab-IRDye800 for Surgical Navigation in Head and Neck Cancer
Eben L. Rosenthal; Jason M. Warram; Esther de Boer; Thomas K. Chung; Melissa L. Korb; Margie Brandwein-Gensler; Theresa V. Strong; Cecelia E. Schmalbach; Anthony B. Morlandt; Garima Agarwal; Yolanda E. Hartman; William R. Carroll; Joshua S. Richman; Lisa K. Clemons; Lisle M. Nabell; Kurt R. Zinn
Cancer Therapy: Preclinical
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment
Sarah Bazzocco; Higinio Dopeso; Fernando Carton-Garcia; Irati Macaya; Elena Andretta; Fiona Chionh; Paulo Rodrigues; Miriam Garrido; Hafid Alazzouzi; Rocio Nieto; Alex Sanchez; Simo Schwartz, Jr; Josipa Bilic; John M. Mariadason; Diego Arango
A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis
Seo-Hyun Choi; Zhen-Yu Hong; Jae-Kyung Nam; Hae-June Lee; Junho Jang; Ran Ji Yoo; Yong Jin Lee; Chang Young Lee; Kyung Hwan Kim; Seungwoo Park; Young Hoon Ji; Yun-Sil Lee; Jaeho Cho; Yoon-Jin Lee
Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions
Alexander Filatenkov; Jeanette Baker; Antonia M.S. Mueller; Justin Kenkel; G-One Ahn; Suparna Dutt; Nigel Zhang; Holbrook Kohrt; Kent Jensen; Sussan Dejbakhsh-Jones; Judith A. Shizuru; Robert N. Negrin; Edgar G. Engleman; Samuel Strober
Biology of Human Tumors
Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype
Stephen C. Mack; Sameer Agnihotri; Kelsey C. Bertrand; Xin Wang; David J. Shih; Hendrik Witt; Nadia Hill; Kory Zayne; Mark Barszczyk; Vijay Ramaswamy; Marc Remke; Yuan Thompson; Marina Ryzhova; Luca Massimi; Wieslawa Grajkowska; Boleslaw Lach; Nalin Gupta; William A. Weiss; Abhijit Guha; Cynthia Hawkins; Sidney Croul; James T. Rutka; Stefan M. Pfister; Andrey Korshunov; Melike Pekmezci; Tarik Tihan; Joanna J. Philips; Nada Jabado; Gelareh Zadeh; Michael D. Taylor
Author Choice
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Jarle Bruun; Matthias Kolberg; Terje C. Ahlquist; Ellen C. Røyrvik; Torfinn Nome; Edward Leithe; Guro E. Lind; Marianne A. Merok; Torleiv O. Rognum; Geir Bjørkøy; Terje Johansen; Annika Lindblom; Xiao-Feng Sun; Aud Svindland; Knut Liestøl; Arild Nesbakken; Rolf I. Skotheim; Ragnhild A. Lothe
Author Choice
TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients
Dewan M. S. Hossain; Sumanta K. Pal; Dayson Moreira; Priyanka Duttagupta; Qifang Zhang; Haejung Won; Jeremy Jones; Massimo D'Apuzzo; Stephen Forman; Marcin Kortylewski
Letters to the Editor
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