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1 June 2015
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Cover Image
Cover Image
The cover shows VCaP prostate cancer cells stained with the androgen receptor for nuclear localization. The authors found that 5α-Adione treatment results in nuclear localization of the androgen receptor in VCaP cells. For details, see the article by Powell and colleagues on page 2569 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
20th Anniversary Commentary
CCR Translations
CCR New Strategies
CCR Perspectives in Drug Approval
FDA Approval: Ceritinib for the Treatment of Metastatic Anaplastic Lymphoma Kinase–Positive Non–Small Cell Lung Cancer
Sean Khozin; Gideon M. Blumenthal; Lijun Zhang; Shenghui Tang; Margaret Brower; Emily Fox; Whitney Helms; Ruby Leong; Pengfei Song; Yuzhuo Pan; Qi Liu; Ping Zhao; Hong Zhao; Donghao Lu; Zhe Tang; Ali Al Hakim; Karen Boyd; Patricia Keegan; Robert Justice; Richard Pazdur
Molecular Pathways
Review
Cancer Therapy: Clinical
Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors
Dejan Juric; Rodrigo Dienstmann; Andres Cervantes; Manuel Hidalgo; Wells Messersmith; George R. Blumenschein, Jr; Josep Tabernero; Desamparados Roda; Antonio Calles; Antonio Jimeno; Xiaodong Wang; Sandra Sanabria Bohórquez; Cecilia Leddy; Catherine Littman; Amy V. Kapp; David S. Shames; Elicia Penuel; Lukas C. Amler; Andrea Pirzkall; José Baselga
Phase I Trial of Arginine Deprivation Therapy with ADI-PEG 20 Plus Docetaxel in Patients with Advanced Malignant Solid Tumors
Benjamin K. Tomlinson; James A. Thomson; John S. Bomalaski; Monica Diaz; Taiwo Akande; Nichole Mahaffey; Tianhong Li; Mrinal P. Dutia; Karen Kelly; I-Yeh Gong; Thomas Semrad; David R. Gandara; Chong-Xian Pan; Primo N. Lara, Jr
Personalized Medicine and Imaging
Development of Circulating Tumor Cell-Endocrine Therapy Index in Patients with Hormone Receptor–Positive Breast Cancer
Costanza Paoletti; Maria C. Muñiz; Dafydd G. Thomas; Kent A. Griffith; Kelley M. Kidwell; Nahomi Tokudome; Martha E. Brown; Kimberly Aung; M. Craig Miller; Dorothy L. Blossom; Anne F. Schott; N. Lynn Henry; James M. Rae; Mark C. Connelly; David A. Chianese; Daniel F. Hayes
Evaluation of Diffusion-Weighted Magnetic Resonance Imaging for Follow-up and Treatment Response Assessment of Lymphoma: Results of an 18F-FDG-PET/CT–Controlled Prospective Study in 64 Patients
Marius E. Mayerhoefer; Georgios Karanikas; Kurt Kletter; Helmut Prosch; Barbara Kiesewetter; Cathrin Skrabs; Edit Porpaczy; Michael Weber; Thomas Knogler; Christian Sillaber; Ulrich Jaeger; Ingrid Simonitsch-Klupp; Philipp Ubl; Leonhard Müllauer; Werner Dolak; Julius Lukas; Markus Raderer
Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis
Ara Nazarian; Vahid Entezari; David Zurakowski; Nathan Calderon; John A. Hipp; Juan C. Villa-Camacho; Patrick P. Lin; Felix H. Cheung; Albert J. Aboulafia; Robert Turcotte; Megan E. Anderson; Mark C. Gebhardt; Edward Y. Cheng; Richard M. Terek; Michael Yaszemski; Timothy A. Damron; Brian D. Snyder
PIK3CA Pathway Mutations Predictive of Poor Response Following Standard Radiochemotherapy ± Cetuximab in Cervical Cancer Patients
Anne de la Rochefordiere; Maud Kamal; Anne Floquet; Laurence Thomas; Peter Petrow; Thierry Petit; Marius Pop; Michel Fabbro; Christine Kerr; Florence Joly; Emmanuel Sevin; Sophie Maillard; Hervé Curé; Béatrice Weber; Claire Brunaud; Mathieu Minsat; Laurence Gonzague; Dominique Berton-Rigaud; Maud Aumont; Laurence Gladieff; Karine Peignaux; Virginie Bernard; Quentin Leroy; Ivan Bieche; Audrey Margogne; AnaTereza Nadan; Virginie Fourchotte; Alhassane Diallo; Benard Asselain; Corine Plancher; Sébastien Armanet; Philippe Beuzeboc; Suzy M. Scholl
Cancer Therapy: Preclinical
Targeting the Spleen Tyrosine Kinase with Fostamatinib as a Strategy against Waldenström Macroglobulinemia
Isere Kuiatse; Veerabhadran Baladandayuthapani; Heather Y. Lin; Sheeba K. Thomas; Chad C. Bjorklund; Donna M. Weber; Michael Wang; Jatin J. Shah; Xing-Ding Zhang; Richard J. Jones; Stephen M. Ansell; Guang Yang; Steven P. Treon; Robert Z. Orlowski
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling
Jacob S. Bowers; Michelle H. Nelson; Sreenath Kundimi; Stefanie R. Bailey; Logan W. Huff; Kristina M. Schwartz; David J. Cole; Mark P. Rubinstein; Chrystal M. Paulos
Biology of Human Tumors
The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer
Shumei Song; Soichiro Honjo; Jiankang Jin; Shih-Shin Chang; Ailing W. Scott; Qiongrong Chen; Neda Kalhor; Arlene M. Correa; Wayne L. Hofstetter; Constance T. Albarracin; Tsung-Teh Wu; Randy L. Johnson; Mien-Chie Hung; Jaffer A. Ajani
Author Choice
Development and Clinical Validation of an In Situ Biopsy-Based Multimarker Assay for Risk Stratification in Prostate Cancer
Peter Blume-Jensen; David M. Berman; David L. Rimm; Michail Shipitsin; Mathew Putzi; Thomas P. Nifong; Clayton Small; Sibgat Choudhury; Teresa Capela; Louis Coupal; Christina Ernst; Aeron Hurley; Alex Kaprelyants; Hua Chang; Eldar Giladi; Julie Nardone; James Dunyak; Massimo Loda; Eric A. Klein; Cristina Magi-Galluzzi; Mathieu Latour; Jonathan I. Epstein; Philip Kantoff; Fred Saad
AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma
Toni M. Brand; Mari Iida; Andrew P. Stein; Kelsey L. Corrigan; Cara M. Braverman; John P. Coan; Hannah E. Pearson; Harsh Bahrar; Tyler L. Fowler; Bryan P. Bednarz; Sandeep Saha; David Yang; Parkash S. Gill; Mark W. Lingen; Vassiliki Saloura; Victoria M. Villaflor; Ravi Salgia; Randall J. Kimple; Deric L. Wheeler
Author Choice
Genomic Alterations in the RB Pathway Indicate Prognostic Outcomes of Early-Stage Lung Adenocarcinoma
Seongmin Choi; Hyeong Ryul Kim; Chang Ohk Sung; Jongkyu Kim; Sukjun Kim; Sung-Min Ahn; Chang-min Choi; Sung-Min Chun; Eun Kyung Choi; Sang-We Kim; Yong-Hee Kim; Ji-Young Lee; Joon Seon Song; Deokhoon Kim; Farhan Haq; Sun Young Lee; Jong-eun Lee; Wang-rim Jung; Hye Yoon Jang; Eunho Yang; Charles Lee; Eunsil Yu; Gu Kong; Daehyun Baek; Se Jin Jang
Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy
Daniel N. Cohen; Steven K. Lawson; Aaron C. Shaver; Liping Du; Harrison P. Nguyen; Qin He; Douglas B. Johnson; Wilfred A. Lumbang; Brent R. Moody; James L. Prescott; Pranil K. Chandra; Alan S. Boyd; Jeffrey P. Zwerner; Jason B. Robbins; Stephen K. Tyring; Peter L. Rady; James D. Chappell; Yu Shyr; Jeffrey R. Infante; Jeffrey A. Sosman
Author Choice
Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non–Small Cell Lung Cancer
Tom Donnem; Sigurd M. Hald; Erna-Elise Paulsen; Elin Richardsen; Samer Al-Saad; Thomas K. Kilvaer; Odd Terje Brustugun; Aslaug Helland; Marius Lund-Iversen; Mette Poehl; Karen Ege Olsen; Henrik J. Ditzel; Olfred Hansen; Khalid Al-Shibli; Yury Kiselev; Torkjel M. Sandanger; Sigve Andersen; Francesco Pezzella; Roy M. Bremnes; Lill-Tove Busund
Hotspot Mutation Panel Testing Reveals Clonal Evolution in a Study of 265 Paired Primary and Metastatic Tumors
Rashmi S. Goswami; Keyur P. Patel; Rajesh R. Singh; Funda Meric-Bernstam; E. Scott Kopetz; Vivek Subbiah; Ricardo H. Alvarez; Michael A. Davies; Kausar J. Jabbar; Sinchita Roy-Chowdhuri; Alexander J. Lazar; L. Jeffrey Medeiros; Russell R. Broaddus; Rajyalakshmi Luthra; Mark J. Routbort
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