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15 May 2015
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Cover Image
Cover Image
The cover shows a section of a bone marrow biopsy from a patient with acute myeloid leukemia (AML). Immunohistochemical staining shows Desert Hedgehog positive osteoblasts underlining the hypothesis of paracrine Hedgehog pathway activation in AML cells. For details, see the article by Wellbrock and colleagues on page 2388 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
20th Anniversary Commentary
CCR Translations
Molecular Pathways
CCR Focus
Special Report
Cancer Therapy: Clinical
Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer
Shinichi Kageyama; Hiroaki Ikeda; Yoshihiro Miyahara; Naoko Imai; Mikiya Ishihara; Kanako Saito; Sahoko Sugino; Shugo Ueda; Takeshi Ishikawa; Satoshi Kokura; Hiroaki Naota; Kohshi Ohishi; Taizo Shiraishi; Naoki Inoue; Masashige Tanabe; Tomohide Kidokoro; Hirofumi Yoshioka; Daisuke Tomura; Ikuei Nukaya; Junichi Mineno; Kazutoh Takesako; Naoyuki Katayama; Hiroshi Shiku
Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma
Ling Zhang; Richard A. Morgan; Joal D. Beane; Zhili Zheng; Mark E. Dudley; Sadik H. Kassim; Azam V. Nahvi; Lien T. Ngo; Richard M. Sherry; Giao Q. Phan; Marybeth S. Hughes; Udai S. Kammula; Steven A. Feldman; Mary Ann Toomey; Sid P. Kerkar; Nicholas P. Restifo; James C. Yang; Steven A. Rosenberg
Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition
Richard D. Carvajal; Donald P. Lawrence; Jeffrey S. Weber; Thomas F. Gajewski; Rene Gonzalez; Jose Lutzky; Steven J. O'Day; Omid Hamid; Jedd D. Wolchok; Paul B. Chapman; Ryan J. Sullivan; Jerrold B. Teitcher; Nikhil Ramaiya; Anita Giobbie-Hurder; Cristina R. Antonescu; Michael C. Heinrich; Boris C. Bastian; Christopher L. Corless; Jonathan A. Fletcher; F. Stephen Hodi
The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation
Martijn P. Lolkema; Hilde H. Bohets; Hendrik-Tobias Arkenau; Ann Lampo; Erio Barale; Maja J.A. de Jonge; Leni van Doorn; Peter Hellemans; Johann S. de Bono; Ferry A.L.M. Eskens
Personalized Medicine and Imaging
Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer
Arun A. Azad; Stanislav V. Volik; Alexander W. Wyatt; Anne Haegert; Stephane Le Bihan; Robert H. Bell; Shawn A. Anderson; Brian McConeghy; Robert Shukin; Jenny Bazov; Jack Youngren; Pamela Paris; George Thomas; Eric J. Small; Yuzhuo Wang; Martin E. Gleave; Colin C. Collins; Kim N. Chi
Cancer Therapy: Preclinical
Biology of Human Tumors
Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein
Murali Janakiram; Jordan M. Chinai; Susan Fineberg; Andras Fiser; Cristina Montagna; Ramadevi Medavarapu; Ekaterina Castano; Hyungjun Jeon; Kim C. Ohaegbulam; Ruihua Zhao; Aimin Zhao; Steven C. Almo; Joseph A. Sparano; Xingxing Zang
Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects
Jasmin Wellbrock; Emily Latuske; Julian Köhler; Katharina Wagner; Hauke Stamm; Eik Vettorazzi; Gabi Vohwinkel; Marianne Klokow; Roswitha Uibeleisen; Patrick Ehm; Kristoffer Riecken; Sonja Loges; Felicitas Thol; Claudia Schubert; Michael Amling; Manfred Jücker; Carsten Bokemeyer; Michael Heuser; Jürgen Krauter; Walter Fiedler
Correction
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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