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1 May 2014
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Cover Image
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The cover shows a section of an orthotopic xenograft of a human primary glioblastoma. Immunohistochemical staining shows strong human nestin expression within the tumor bulk. For details, see the article by Li and colleagues on page on page 2375 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
Molecular Pathways
Review
Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies
Catherine B. Meador; Christine M. Micheel; Mia A. Levy; Christine M. Lovly; Leora Horn; Jeremy L. Warner; Douglas B. Johnson; Zhongming Zhao; Ingrid A. Anderson; Jeffrey A. Sosman; Cindy L. Vnencak-Jones; Kimberly B. Dahlman; William Pao
Human Cancer Biology
PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ—Implications for Progression to Invasive Breast Carcinoma
Rita A. Sakr; Britta Weigelt; Sarat Chandarlapaty; Victor P. Andrade; Elena Guerini-Rocco; Dilip Giri; Charlotte K.Y. Ng; Catherine F. Cowell; Neal Rosen; Jorge S. Reis-Filho; Tari A. King
Prevalence and Clinical Implications of Epstein–Barr Virus Infection in De Novo Diffuse Large B-Cell Lymphoma in Western Countries
Chi Young Ok; Ling Li; Zijun Y. Xu-Monette; Carlo Visco; Alexander Tzankov; Ganiraju C. Manyam; Santiago Montes-Moreno; Karen Dybaer; April Chiu; Attilio Orazi; Youli Zu; Govind Bhagat; Jiayu Chen; Kristy L. Richards; Eric D. Hsi; William W. L. Choi; J. Han van Krieken; Jooryung Huh; Weiyun Ai; Maurilio Ponzoni; Andrés J.M. Ferreri; John P. Farnen; Michael B. Møller; Carlo E. Bueso-Ramos; Roberto N. Miranda; Jane N. Winter; Miguel A. Piris; L. Jeffrey Medeiros; Ken H. Young
Cancer Therapy: Preclinical
Author Choice
Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor
Teresa S. Kim; Michael J. Cavnar; Noah A. Cohen; Eric C. Sorenson; Jonathan B. Greer; Adrian M. Seifert; Megan H. Crawley; Benjamin L. Green; Rachel Popow; Nagavarakishore Pillarsetty; Darren R. Veach; Anson T. Ku; Ferdinand Rossi; Peter Besmer; Cristina R. Antonescu; Shan Zeng; Ronald P. DeMatteo
Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival
Qian Li; Olindi Wijesekera; Sussan J. Salas; Joanna Y. Wang; Mingxin Zhu; Colette Aprhys; Kaisorn L. Chaichana; David A. Chesler; Hao Zhang; Christopher L. Smith; Hugo Guerrero-Cazares; Andre Levchenko; Alfredo Quinones-Hinojosa
Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting
Jessica K. Altman; Amy Szilard; Dennis J. Goussetis; Antonella Sassano; Marco Colamonici; Elias Gounaris; Olga Frankfurt; Francis J. Giles; Elizabeth A. Eklund; Elspeth M. Beauchamp; Leonidas C. Platanias
Cancer Therapy: Clinical
Author Choice
Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245409 (XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with Advanced Solid Tumors
Kyriakos P. Papadopoulos; Josep Tabernero; Ben Markman; Amita Patnaik; Anthony W. Tolcher; José Baselga; Weiliang Shi; Coumaran Egile; Rodrigo Ruiz-Soto; A. Douglas Laird; Dale Miles; Patricia M. LoRusso
Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
Thinle Chodon; Begoña Comin-Anduix; Bartosz Chmielowski; Richard C. Koya; Zhongqi Wu; Martin Auerbach; Charles Ng; Earl Avramis; Elizabeth Seja; Arturo Villanueva; Tara A. McCannel; Akira Ishiyama; Johannes Czernin; Caius G. Radu; Xiaoyan Wang; David W. Gjertson; Alistair J. Cochran; Kenneth Cornetta; Deborah J.L. Wong; Paula Kaplan-Lefko; Omid Hamid; Wolfram Samlowski; Peter A. Cohen; Gregory A. Daniels; Bijay Mukherji; Lili Yang; Jerome A. Zack; Donald B. Kohn; James R. Heath; John A. Glaspy; Owen N. Witte; David Baltimore; James S. Economou; Antoni Ribas
Predictive Biomarkers and Personalized Medicine
Author Choice
Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
Jean E. Abraham; Qi Guo; Leila Dorling; Jonathan Tyrer; Susan Ingle; Richard Hardy; Anne-Laure Vallier; Louise Hiller; Russell Burns; Linda Jones; Sarah J. Bowden; Janet A. Dunn; Christopher J. Poole; Carlos Caldas; Paul P.D. Pharoah; Helena M. Earl
Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment
Elena Garralda; Keren Paz; Pedro P. López-Casas; Siân Jones; Amanda Katz; Lisa M. Kann; Fernando López-Rios; Francesca Sarno; Fátima Al-Shahrour; David Vasquez; Elizabeth Bruckheimer; Samuel V. Angiuoli; Antonio Calles; Luis A. Diaz; Victor E. Velculescu; Alfonso Valencia; David Sidransky; Manuel Hidalgo
Letters to the Editor
Corrections
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