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15 March 2014
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The cover shows a section of an intracranial glioblastoma (GBM); GBM cells express the fluorescent protein citrine (green) and the High-mobility group protein B1 (HMGB1) fused to the red fluorescent protein cherry. In living cells HMGB1 is located in the nucleus; upon cell death, HMGB1 is translocated to the cytoplasm and is eventually secreted. Circulating levels of HMGB1 may constitute a noninvasive surrogate biomarker of therapeutic efficacy. For details, see the article by Candolfi and colleagues on page 1555 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Statistics in Clinical Cancer Research
Molecular Pathways
CCR Focus
Evidence of Clinical Utility: An Unmet Need in Molecular Diagnostics for Patients with Cancer
David R. Parkinson; Robert T. McCormack; Susan M. Keating; Steven I. Gutman; Stanley R. Hamilton; Elizabeth A. Mansfield; Margaret A. Piper; Patricia DeVerka; Felix W. Frueh; J. Milburn Jessup; Lisa M. McShane; Sean R. Tunis; Caroline C. Sigman; Gary J. Kelloff
Human Cancer Biology
hERG1 Channels Regulate VEGF-A Secretion in Human Gastric Cancer: Clinicopathological Correlations and Therapeutical Implications
Olivia Crociani; Elena Lastraioli; Luca Boni; Serena Pillozzi; Maria Raffaella Romoli; Massimo D'Amico; Matteo Stefanini; Silvia Crescioli; Antonio Taddei; Lapo Bencini; Marco Bernini; Marco Farsi; Stefania Beghelli; Aldo Scarpa; Luca Messerini; Anna Tomezzoli; Carla Vindigni; Paolo Morgagni; Luca Saragoni; Elisa Giommoni; Silvia Gasperoni; Francesco Di Costanzo; Franco Roviello; Giovanni De Manzoni; Paolo Bechi; Annarosa Arcangeli
Cancer Therapy: Preclinical
Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease
Antonio Garcia-Gomez; Dalia Quwaider; Miriam Canavese; Enrique M. Ocio; Ze Tian; Juan F. Blanco; Allison J. Berger; Carlos Ortiz-de-Solorzano; Teresa Hernández-Iglesias; Anton C.M. Martens; Richard W.J. Groen; Joaquín Mateo-Urdiales; Susana Fraile; Miguel Galarraga; Dharminder Chauhan; Jesús F. San Miguel; Noopur Raje; Mercedes Garayoa
Imaging, Diagnosis, Prognosis
Myeloid-Derived Suppressor Cells Predict Survival of Patients with Advanced Melanoma: Comparison with Regulatory T Cells and NY-ESO-1- or Melan-A–Specific T Cells
Benjamin Weide; Alexander Martens; Henning Zelba; Christina Stutz; Evelyna Derhovanessian; Anna Maria Di Giacomo; Michele Maio; Antje Sucker; Bastian Schilling; Dirk Schadendorf; Petra Büttner; Claus Garbe; Graham Pawelec
Author Choice
Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer
Oliver Delgado; Kimberly G. Batten; James A. Richardson; Xian-Jin Xie; Adi F. Gazdar; Aadil A. Kaisani; Luc Girard; Carmen Behrens; Milind Suraokar; Gail Fasciani; Woodring E. Wright; Michael D. Story; Ignacio I. Wistuba; John D. Minna; Jerry W. Shay
EASL- and mRECIST-Evaluated Responses to Combination Therapy of Sorafenib with Transarterial Chemoembolization Predict Survival in Patients with Hepatocellular Carcinoma
Lei Liu; Weijuan Wang; Hui Chen; Yan Zhao; Wei Bai; Zhanxin Yin; Chuangye He; Jia Jia; Man Yang; Jielai Xia; Daiming Fan; Guohong Han
Cancer Therapy: Clinical
A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Panobinostat, an HDAC Inhibitor, Combined with Erlotinib in Patients with Advanced Aerodigestive Tract Tumors
Jhanelle E. Gray; Eric Haura; Alberto Chiappori; Tawee Tanvetyanon; Charles C. Williams; Mary Pinder-Schenck; Julie A. Kish; Jenny Kreahling; Richard Lush; Anthony Neuger; Leticia Tetteh; Angela Akar; Xiuhua Zhao; Michael J. Schell; Gerold Bepler; Soner Altiok
Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies
Daniel W. Bowles; Jennifer R. Diamond; Elaine T. Lam; Colin D. Weekes; David P. Astling; Ryan T. Anderson; Stephen Leong; Lia Gore; Marileila Varella-Garcia; Brian W. Vogler; Stephen B. Keysar; Elizabeth Freas; Dara L. Aisner; Chen Ren; Aik-Chook Tan; Francois Wilhelm; Manoj Maniar; S. Gail Eckhardt; Wells A. Messersmith; Antonio Jimeno
Phase I Dose-Escalation Study of Onartuzumab as a Single Agent and in Combination with Bevacizumab in Patients with Advanced Solid Malignancies
Ravi Salgia; Premal Patel; John Bothos; Wei Yu; Steve Eppler; Priti Hegde; Shuang Bai; Surinder Kaur; Ihsan Nijem; Daniel V.T. Catenacci; Amy Peterson; Mark J. Ratain; Blase Polite; Janice M. Mehnert; Rebecca A. Moss
Predictive Biomarkers and Personalized Medicine
A Functional Germline Variant in GLI1 Implicates Hedgehog Signaling in Clinical Outcome of Stage II and III Colon Carcinoma Patients
Joanna Szkandera; Martin Pichler; Gudrun Absenger; Michael Stotz; Melanie Weissmueller; Hellmut Samonigg; Martin Asslaber; Sigurd Lax; Gerhard Leitner; Thomas Winder; Wilfried Renner; Armin Gerger
Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA
Geoffrey R. Oxnard; Cloud P. Paweletz; Yanan Kuang; Stacy L. Mach; Allison O'Connell; Melissa M. Messineo; Jason J. Luke; Mohit Butaney; Paul Kirschmeier; David M. Jackman; Pasi A. Jänne
Correction
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