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1 March 2014
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Cover Image
Cover Image
The cover shows a chest coronal section of a whole body PET-CT scan from an EML4-ALK lung cancer bearing mutant mouse harboring a crizotinib resistant tumor that is subsequently treated with an HSP90 inhibitor, 17-DMAG. Complete tumor regression is observed. For details, see the article by Chen and colleagues on page 1204 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
Molecular Pathways
Special Report
Turning the Tide Against Cancer Through Sustained Medical Innovation: The Pathway to Progress
Amy Abernethy; Edward Abrahams; Anna Barker; Ken Buetow; Randy Burkholder; William S. Dalton; Margaret Foti; Felix Frueh; Richard B. Gaynor; Marcia Kean; Zeba Khan; Tracy Lessor; J. Leonard Lichtenfeld; John Mendelsohn; Laura van't Veer
Perspectives
Reviews
Human Cancer Biology
LINE-1 Hypomethylation, DNA Copy Number Alterations, and CDK6 Amplification in Esophageal Squamous Cell Carcinoma
Yoshifumi Baba; Masayuki Watanabe; Asuka Murata; Hironobu Shigaki; Keisuke Miyake; Takatsugu Ishimoto; Masaaki Iwatsuki; Shiro Iwagami; Naoya Yoshida; Eiji Oki; Kentaro Sakamaki; Mitsuyoshi Nakao; Hideo Baba
A Genome-Wide Aberrant RNA Splicing in Patients with Acute Myeloid Leukemia Identifies Novel Potential Disease Markers and Therapeutic Targets
Sophia Adamia; Benjamin Haibe-Kains; Patrick M. Pilarski; Michal Bar-Natan; Samuel Pevzner; Herve Avet-Loiseau; Laurence Lode; Sigitas Verselis; Edward A. Fox; John Burke; Ilene Galinsky; Ibiayi Dagogo-Jack; Martha Wadleigh; David P. Steensma; Gabriela Motyckova; Daniel J. Deangelo; John Quackenbush; Richard Stone; James D. Griffin
Prevalence and Characteristics of MUTYH-Associated Polyposis in Patients with Multiple Adenomatous and Serrated Polyps
Carla Guarinos; Miriam Juárez; Cecilia Egoavil; María Rodríguez-Soler; Lucía Pérez-Carbonell; Ramón Salas; Joaquín Cubiella; Francisco Rodríguez-Moranta; Luisa de-Castro; Luis Bujanda; Anna Serradesanferm; David Nicolás-Pérez; Maite Herráiz; Fernando Fernández-Bañares; Alberto Herreros-de-Tejada; Elena Aguirre; Judith Balmaña; María-Luisa Rincón; Angeles Pizarro; Francisco Polo-Ortiz; Adela Castillejo; Cristina Alenda; Artemio Payá; José-Luis Soto; Rodrigo Jover
Frequent Overexpression of HMGA2 in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation with let-7a3/let-7b miRNA
Keqiang Zhang; Hanlin Gao; Xiwei Wu; Jinhui Wang; Wendi Zhou; Guihua Sun; Jinghan Wang; Yafan Wang; Bing Mu; Charles Kim; Peiguo Chu; Donald M. Ho; David K. Ann; Tai-Tong Wong; Yun Yen
Cancer Therapy: Preclinical
Co-Clinical Trials Demonstrate Superiority of Crizotinib to Chemotherapy in ALK-Rearranged Non–Small Cell Lung Cancer and Predict Strategies to Overcome Resistance
Zhao Chen; Esra Akbay; Oliver Mikse; Tanya Tupper; Katherine Cheng; Yuchuan Wang; Xiaohong Tan; Abigail Altabef; Sue-Ann Woo; Liang Chen; Jacob B. Reibel; Pasi A. Janne; Norman E. Sharpless; Jeffrey A. Engelman; Geoffrey I. Shapiro; Andrew L. Kung; Kwok-Kin Wong
Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors
Joseph D. Valentino; Jing Li; Yekaterina Y. Zaytseva; W. Conan Mustain; Victoria A. Elliott; Ji Tae Kim; Jennifer W. Harris; Katherine Campbell; Heidi Weiss; Chi Wang; Jun Song; Lowell Anthony; Courtney M. Townsend, Jr; B. Mark Evers
Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma
Carlos Rodrigo Gil del Alcazar; Molly Catherine Hardebeck; Bipasha Mukherjee; Nozomi Tomimatsu; Xiaohuan Gao; Jingsheng Yan; Xian-Jin Xie; Robert Bachoo; Li Li; Amyn A. Habib; Sandeep Burma
Author Choice
Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer
S. John Weroha; Marc A. Becker; Sergio Enderica-Gonzalez; Sean C. Harrington; Ann L. Oberg; Matthew J. Maurer; Sarah E. Perkins; Mariam AlHilli; Kristina A. Butler; Sarah McKinstry; Stephanie Fink; Robert B. Jenkins; Xiaonan Hou; Kimberly R. Kalli; Karin M. Goodman; Jann N. Sarkaria; Beth Y. Karlan; Amanika Kumar; Scott H. Kaufmann; Lynn C. Hartmann; Paul Haluska
Imaging, Diagnosis, Prognosis
The PAM50 Risk-of-Recurrence Score Predicts Risk for Late Distant Recurrence after Endocrine Therapy in Postmenopausal Women with Endocrine-Responsive Early Breast Cancer
Martin Filipits; Torsten O. Nielsen; Margaretha Rudas; Richard Greil; Herbert Stöger; Raimund Jakesz; Zsuzsanna Bago-Horvath; Otto Dietze; Peter Regitnig; Christine Gruber-Rossipal; Elisabeth Müller-Holzner; Christian F. Singer; Brigitte Mlineritsch; Peter Dubsky; Thomas Bauernhofer; Michael Hubalek; Michael Knauer; Harald Trapl; Christian Fesl; Carl Schaper; Sean Ferree; Shuzhen Liu; J. Wayne Cowens; Michael Gnant; for the Austrian Breast and Colorectal Cancer Study Group
Genetic Profiling to Determine Risk of Relapse-Free Survival in High-Risk Localized Prostate Cancer
Christine M. Barnett; Michael C. Heinrich; Jeong Lim; Dylan Nelson; Carol Beadling; Andrea Warrick; Tanaya Neff; Celestia S. Higano; Mark Garzotto; David Qian; Christopher L. Corless; George V. Thomas; Tomasz M. Beer
Molecular Classification of Malignant Pleural Mesothelioma: Identification of a Poor Prognosis Subgroup Linked to the Epithelial-to-Mesenchymal Transition
Aurélien de Reyniès; Marie-Claude Jaurand; Annie Renier; Gabrielle Couchy; Ilir Hysi; Nabila Elarouci; Françoise Galateau-Sallé; Marie-Christine Copin; Paul Hofman; Aurélie Cazes; Pascal Andujar; Sandrine Imbeaud; Fabien Petel; Jean-Claude Pairon; Francoise Le Pimpec-Barthes; Jessica Zucman-Rossi; Didier Jean
Cancer Therapy: Clinical
Author Choice
Phase I/II Trial of Orteronel (TAK-700)—an Investigational 17,20-Lyase Inhibitor—in Patients with Metastatic Castration-Resistant Prostate Cancer
Robert Dreicer; David MacLean; Ajit Suri; Walter M. Stadler; Daniel Shevrin; Lowell Hart; Gary R. MacVicar; Omid Hamid; John Hainsworth; Mitchell E. Gross; Yuanjun Shi; Iain J. Webb; David B. Agus
Improved Recurrence-Free Survival with ARCON for Anemic Patients with Laryngeal Cancer
Geert O. Janssens; Saskia E. Rademakers; Chris H. Terhaard; Patricia A. Doornaert; Hendrik P. Bijl; Piet van den Ende; Alim Chin; Robert P. Takes; Remco de Bree; Ilse J. Hoogsteen; Johan Bussink; Paul N. Span; Johannes H. Kaanders
Author Choice
Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells
Aaron P. Rapoport; Nicole A. Aqui; Edward A. Stadtmauer; Dan T. Vogl; Yin Yan Xu; Michael Kalos; Ling Cai; Hong-Bin Fang; Brendan M. Weiss; Ashraf Badros; Saul Yanovich; Gorgun Akpek; Patricia Tsao; Alan Cross; Dean Mann; Sunita Philip; Naseem Kerr; Andrea Brennan; Zhaohui Zheng; Kathleen Ruehle; Todd Milliron; Scott E. Strome; Andres M. Salazar; Bruce L. Levine; Carl H. June
Inflammatory Markers and Development of Symptom Burden in Patients with Multiple Myeloma during Autologous Stem Cell Transplantation
Xin Shelley Wang; Qiuling Shi; Nina D. Shah; Cobi J. Heijnen; Evan N. Cohen; James M. Reuben; Robert Z. Orlowski; Muzaffar H. Qazilbash; Valen E. Johnson; Loretta A. Williams; Tito R. Mendoza; Charles S. Cleeland
Predictive Biomarkers and Personalized Medicine
Lung Cancers with Concomitant EGFR Mutations and ALK Rearrangements: Diverse Responses to EGFR-TKI and Crizotinib in Relation to Diverse Receptors Phosphorylation
Jin-Ji Yang; Xu-Chao Zhang; Jian Su; Chong-Rui Xu; Qing Zhou; Hong-Xia Tian; Zhi Xie; Hua-Jun Chen; Yi-Sheng Huang; Ben-Yuan Jiang; Zhen Wang; Bin-Chao Wang; Xue-Ning Yang; Wen-Zhao Zhong; Qiang Nie; Ri-Qiang Liao; Tony S. Mok; Yi-Long Wu
Letters to the Editor
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