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15 February 2014
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Cover Image
Cover Image
The cover shows a section of an intracerebellar xenograft of medulloblastoma derived from a patient with MYC-amplified medulloblastoma. Immunohistochemical staining shows reduced expression of the Ki-67 proliferation marker following treatment with the BET-bromodomain inhibitor JQ1. For details, see the article by Bandopadhayay and colleagues on page 912 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
Molecular Pathways
Review
Human Cancer Biology
DNA Methyltransferase Inhibition Reverses Epigenetically Embedded Phenotypes in Lung Cancer Preferentially Affecting Polycomb Target Genes
Antje Hascher; Ann-Kristin Haase; Katja Hebestreit; Christian Rohde; Hans-Ulrich Klein; Maria Rius; Dominik Jungen; Anika Witten; Monika Stoll; Isabell Schulze; Seishi Ogawa; Rainer Wiewrodt; Lara Tickenbrock; Wolfgang E. Berdel; Martin Dugas; Nils H. Thoennissen; Carsten Müller-Tidow
Author Choice
PID1 (NYGGF4), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Anat Erdreich-Epstein; Nathan Robison; Xiuhai Ren; Hong Zhou; Jingying Xu; Tom B. Davidson; Mathew Schur; Floyd H. Gilles; Lingyun Ji; Jemily Malvar; Gregory M. Shackleford; Ashley S. Margol; Mark D. Krieger; Alexander R. Judkins; David T.W. Jones; Stefan M. Pfister; Marcel Kool; Richard Sposto; Shahab Asgharazadeh
Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Yasmine Touil; Wassila Igoudjil; Matthieu Corvaisier; Anne-Frédérique Dessein; Jérôme Vandomme; Didier Monté; Laurence Stechly; Nicolas Skrypek; Carole Langlois; Georges Grard; Guillaume Millet; Emmanuelle Leteurtre; Patrick Dumont; Stéphanie Truant; François-René Pruvot; Mohamed Hebbar; Fan Fan; Lee M. Ellis; Pierre Formstecher; Isabelle Van Seuningen; Christian Gespach; Renata Polakowska; Guillemette Huet
HIF-1α of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target
Roberto Ria; Ivana Catacchio; Simona Berardi; Annunziata De Luisi; Antonella Caivano; Claudia Piccoli; Vitalba Ruggieri; Maria Antonia Frassanito; Domenico Ribatti; Beatrice Nico; Tiziana Annese; Simona Ruggieri; Attilio Guarini; Carla Minoia; Paolo Ditonno; Emanuele Angelucci; Daniele Derudas; Michele Moschetta; Franco Dammacco; Angelo Vacca
Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
Wojciech Mydlarz; Mamoru Uemura; Sun Ahn; Patrick Hennessey; Steven Chang; Semra Demokan; Wenyue Sun; Chunbo Shao; Justin Bishop; Julie Krosting; Elizabeth Mambo; William Westra; Patrick Ha; David Sidransky; Joseph Califano
Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma
Hsueh-Li Tan; Akshay Sood; Hameed A. Rahimi; Wenle Wang; Nilesh Gupta; Jessica Hicks; Stacy Mosier; Christopher D. Gocke; Jonathan I. Epstein; George J. Netto; Wennuan Liu; William B. Isaacs; Angelo M. De Marzo; Tamara L. Lotan
Cancer Therapy: Preclinical
BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
Pratiti Bandopadhayay; Guillaume Bergthold; Brian Nguyen; Simone Schubert; Sharareh Gholamin; Yujie Tang; Sara Bolin; Steven E. Schumacher; Rhamy Zeid; Sabran Masoud; Furong Yu; Nujsaubnusi Vue; William J. Gibson; Brenton R. Paolella; Siddhartha S. Mitra; Samuel H. Cheshier; Jun Qi; Kun-Wei Liu; Robert Wechsler-Reya; William A. Weiss; Fredrik J. Swartling; Mark W. Kieran; James E. Bradner; Rameen Beroukhim; Yoon-Jae Cho
Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
Radosław Polański; Cassandra L. Hodgkinson; Alberto Fusi; Daisuke Nonaka; Lynsey Priest; Paul Kelly; Francesca Trapani; Paul W. Bishop; Anne White; Susan E. Critchlow; Paul D. Smith; Fiona Blackhall; Caroline Dive; Christopher J. Morrow
Targeting Epithelial-to-Mesenchymal Transition with Met Inhibitors Reverts Chemoresistance in Small Cell Lung Cancer
Israel Cañadas; Federico Rojo; Álvaro Taus; Oriol Arpí; Montserrat Arumí-Uría; Lara Pijuan; Silvia Menéndez; Sandra Zazo; Manuel Dómine; Marta Salido; Sergi Mojal; Antonio García de Herreros; Ana Rovira; Joan Albanell; Edurne Arriola
T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo
Claudia Geldres; Barbara Savoldo; Valentina Hoyos; Ignazio Caruana; Ming Zhang; Eric Yvon; Michele Del Vecchio; Chad J. Creighton; Michael Ittmann; Soldano Ferrone; Gianpietro Dotti
EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss
John H. Sampson; Bryan D. Choi; Luis Sanchez-Perez; Carter M. Suryadevara; David J. Snyder; Catherine T. Flores; Robert J. Schmittling; Smita K. Nair; Elizabeth A. Reap; Pamela K. Norberg; James E. Herndon, II; Chien-Tsun Kuan; Richard A. Morgan; Steven A. Rosenberg; Laura A. Johnson
Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)
Anne T. Nies; Elke Schaeffeler; Heiko van der Kuip; Ingolf Cascorbi; Oliver Bruhn; Michael Kneba; Christiane Pott; Ute Hofmann; Christopher Volk; Shuiying Hu; Sharyn D. Baker; Alex Sparreboom; Peter Ruth; Hermann Koepsell; Matthias Schwab
Synergistic Antitumor Activity of Cetuximab and Namitecan in Human Squamous Cell Carcinoma Models Relies on Cooperative Inhibition of EGFR Expression and Depends on High EGFR Gene Copy Number
Michelandrea De Cesare; Calogero Lauricella; Silvio Marco Veronese; Denis Cominetti; Claudio Pisano; Franco Zunino; Nadia Zaffaroni; Valentina Zuco
Imaging, Diagnosis, Prognosis
Distinction between Asymptomatic Monoclonal B-cell Lymphocytosis with Cyclin D1 Overexpression and Mantle Cell Lymphoma: From Molecular Profiling to Flow Cytometry
Blanca Espinet; Ana Ferrer; Beatriz Bellosillo; Lara Nonell; Antonio Salar; Concepción Fernández-Rodríguez; Eulàlia Puigdecanet; Javier Gimeno; Mar Garcia-Garcia; Maria Carmen Vela; Elisa Luño; Rosa Collado; José Tomás Navarro; Esmeralda de la Banda; Pau Abrisqueta; Leonor Arenillas; Cristina Serrano; Josep Lloreta; Belén Miñana; Andrea Cerutti; Lourdes Florensa; Alberto Orfao; Ferran Sanz; Francesc Solé; David Dominguez-Sola; Sergio Serrano
Mesothelin Overexpression Is a Marker of Tumor Aggressiveness and Is Associated with Reduced Recurrence-Free and Overall Survival in Early-Stage Lung Adenocarcinoma
Stefan S. Kachala; Adam J. Bograd; Jonathan Villena-Vargas; Kei Suzuki; Elliot L. Servais; Kyuichi Kadota; Joanne Chou; Camelia S. Sima; Eva Vertes; Valerie W. Rusch; William D. Travis; Michel Sadelain; Prasad S. Adusumilli
Cancer Therapy: Clinical
Predictive Biomarkers and Personalized Medicine
Letters to the Editor
Biomarkers and Response to Bevacizumab—Response
Fiona Collinson; Michelle Hutchinson; Rachel A. Craven; David A. Cairns; Zougman Alexandre; Tobias C. Wind; Narinder Gahir; Michael P. Messenger; Sharon Jackson; Douglas Thompson; Cybil Adusei; Jonathan Ledermann; Geoffrey Hall; Gordon C. Jayson; Peter J. Selby; Rosamonde E. Banks
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