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Volume 20, Issue 24

15 December 2014

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Cover Image

Cover Image

The cover shows a section of B16 melanoma. Immunohistochemical staining shows aberrant Clever-1 expression on tumor vasculature. For details, see the article by Karikoski and colleagues on page 6452 of this issue.
Table of Contents

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Highlights
CCR Translations
CCR New Strategies
Molecular Pathways
Perspectives
Review
Cancer Therapy: Clinical
Personalized Medicine and Imaging
Cancer Therapy: Preclinical
Biology of Human Tumors
Letters to the Editor
Acknowledgment to Reviewers

Highlights

Highlights of This Issue

Extract

View articletitled, Highlights of This Issue

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CCR Translations

Paracrine Network: Another Step in the Complexity of Resistance to EGFR Blockade?

Ramon Salazar; Gabriel Capellà; Josep Tabernero

Abstract

View articletitled, Paracrine Network: Another Step in the Complexity of Resistance to EGFR Blockade?

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Galectin-1 and Immune Suppression during Radiotherapy

James W. Welsh; Steven N. Seyedin; Maria Angelica Cortez; Amit Maity; Stephen M. Hahn

Abstract

View articletitled, Galectin-1 and Immune Suppression during Radiotherapy

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CCR New Strategies

New Strategies in Acute Myelogenous Leukemia: Leukemogenesis and Personalized Medicine

Ivana Gojo; Judith E. Karp

Abstract

View articletitled, New Strategies in Acute Myelogenous Leukemia: Leukemogenesis and Personalized Medicine

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New Strategies in Breast Cancer: The Significance of Molecular Subtypes in Systemic Adjuvant Treatment for Small T_1a,bN₀M₀ Tumors

Amir Sonnenblick; Debora Fumagalli; Hatem A. Azim, Jr; Christos Sotiriou; Martine Piccart

Abstract

View articletitled, New Strategies in Breast Cancer: The Significance of Molecular Subtypes in Systemic Adjuvant Treatment for Small T1a,bN0M0 Tumors

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Molecular Pathways

Molecular Pathways: microRNAs, Cancer Cells, and Microenvironment

Ioana Berindan-Neagoe; George A. Calin

Abstract

View articletitled, Molecular Pathways: microRNAs, Cancer Cells, and Microenvironment

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Perspectives

Modernizing the Diagnostic and Decision-Making Pathway for Prostate Cancer

Thomas J. Polascik; Niccolo' M. Passoni; Arnauld Villers; Peter L. Choyke

Abstract

View articletitled, Modernizing the Diagnostic and Decision-Making Pathway for Prostate Cancer

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Review

Author Choice

Immuno-oncology Combinations: A Review of Clinical Experience and Future Prospects

Scott J. Antonia; James Larkin; Paolo A. Ascierto

Abstract

View articletitled, Immuno-oncology Combinations: A Review of Clinical Experience and Future Prospects

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Cancer Therapy: Clinical

Sequential Use of the Androgen Synthesis Inhibitors Ketoconazole and Abiraterone Acetate in Castration-Resistant Prostate Cancer and the Predictive Value of Circulating Androgens

Won Kim; Li Zhang; John H. Wilton; Gerald Fetterly; James L. Mohler; Vivian Weinberg; Allison Morse; Russell Z. Szmulewitz; Terence W. Friedlander; Lawrence Fong; Amy M. Lin; Andrea L. Harzstark; Arturo Molina; Eric J. Small; Charles J. Ryan

Abstract

View articletitled, Sequential Use of the Androgen Synthesis Inhibitors Ketoconazole and Abiraterone Acetate in Castration-Resistant Prostate Cancer and the Predictive Value of Circulating Androgens

Supplementary data

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Phase I, Dose-Escalation Study of the Targeted Cytotoxic LHRH Analog AEZS-108 in Patients with Castration- and Taxane-Resistant Prostate Cancer

Stephen V. Liu; Denice D. Tsao-Wei; Shigang Xiong; Susan Groshen; Tanya B. Dorff; David I. Quinn; Yu-Chong Tai; Juergen Engel; Debra Hawes; Andrew V. Schally; Jacek K. Pinski

Abstract

View articletitled, Phase I, Dose-Escalation Study of the Targeted Cytotoxic LHRH Analog AEZS-108 in Patients with Castration- and Taxane-Resistant Prostate Cancer

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A Phase I, Dose-Escalation Study of the Multitargeted Receptor Tyrosine Kinase Inhibitor, Golvatinib, in Patients with Advanced Solid Tumors

L. Rhoda Molife; Emma Jane Dean; Montserrat Blanco-Codesido; Matthew G. Krebs; Andre T. Brunetto; Alastair Peter Greystoke; Gennaro Daniele; Lucy Lee; Galina Kuznetsov; Khin Than Myint; Karen Wood; Begoña de las Heras; Malcolm Richard Ranson

Abstract

View articletitled, A Phase I, Dose-Escalation Study of the Multitargeted Receptor Tyrosine Kinase Inhibitor, Golvatinib, in Patients with Advanced Solid Tumors

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Author Choice

A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors

David C. Smith; Peter D. Eisenberg; Georgy Manikhas; Rashmi Chugh; Matthew A. Gubens; Robert J. Stagg; Ann M. Kapoun; Lu Xu; Jakob Dupont; Branimir Sikic

Abstract

View articletitled, A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors

Supplementary data

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A Phase II, Randomized, Study of Weekly APG101+Reirradiation versus Reirradiation in Progressive Glioblastoma

Wolfgang Wick; Harald Fricke; Klaus Junge; Grigory Kobyakov; Tobias Martens; Oliver Heese; Benedikt Wiestler; Maximilian G. Schliesser; Andreas von Deimling; Josef Pichler; Elena Vetlova; Inga Harting; Jürgen Debus; Christian Hartmann; Claudia Kunz; Michael Platten; Martin Bendszus; Stephanie E. Combs

Abstract

View articletitled, A Phase II, Randomized, Study of Weekly APG101+Reirradiation versus Reirradiation in Progressive Glioblastoma

Supplementary data

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Personalized Medicine and Imaging

Screening for Cardiac Dysfunction in Anthracycline-Exposed Childhood Cancer Survivors

Saro H. Armenian; Sarah K. Gelehrter; Tabitha Vase; Rajkumar Venkatramani; Wendy Landier; Karla D. Wilson; Claudia Herrera; Leah Reichman; John-David Menteer; Leo Mascarenhas; David R. Freyer; Kalyanasundaram Venkataraman; Smita Bhatia

Abstract

View articletitled, Screening for Cardiac Dysfunction in Anthracycline-Exposed Childhood Cancer Survivors

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Author Choice

MMP-1 and Pro-MMP-10 as Potential Urinary Pharmacodynamic Biomarkers of FGFR3-Targeted Therapy in Patients with Bladder Cancer

Xiangnan Du; Benjamin C. Lin; Qian-Rena Wang; Hao Li; Ellen Ingalla; Janet Tien; Isabelle Rooney; Avi Ashkenazi; Elicia Penuel; Jing Qing

Abstract

View articletitled, MMP-1 and Pro-MMP-10 as Potential Urinary Pharmacodynamic Biomarkers of FGFR3-Targeted Therapy in Patients with Bladder Cancer

Supplementary data

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Analysis of 1,115 Patients Tested for MET Amplification and Therapy Response in the MD Anderson Phase I Clinic

Denis L.F. Jardim; Chad Tang; Debora De Melo Gagliato; Gerald S. Falchook; Kenneth Hess; Filip Janku; Siqing Fu; Jennifer J. Wheler; Ralph G. Zinner; Aung Naing; Apostolia M. Tsimberidou; Vijaykumar Holla; Marylin M. Li; Sinchita Roy-Chowdhuri; Raja Luthra; Ravi Salgia; Razelle Kurzrock; Funda Meric-Bernstam; David S. Hong

Abstract

View articletitled, Analysis of 1,115 Patients Tested for MET Amplification and Therapy Response in the MD Anderson Phase I Clinic

Supplementary data

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Circulating pEGFR Is a Candidate Response Biomarker of Cetuximab Therapy in Colorectal Cancer

Theodora Katsila; Mercè Juliachs; Josep Gregori; Teresa Macarulla; Laura Villarreal; Alberto Bardelli; Chris Torrance; Elena Elez; Josep Tabernero; Josep Villanueva

Abstract

View articletitled, Circulating pEGFR Is a Candidate Response Biomarker of Cetuximab Therapy in Colorectal Cancer

Supplementary data

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Author Choice

DNA Methylation Status of Key Cell-Cycle Regulators Such as CDKNA2/p16 and CCNA1 Correlates with Treatment Response to Doxorubicin and 5-Fluorouracil in Locally Advanced Breast Tumors

Jovana Klajic; Florence Busato; Hege Edvardsen; Nizar Touleimat; Thomas Fleischer; Ida Bukholm; Anne-Lise Børresen-Dale; Per Eystein Lønning; Jörg Tost; Vessela N. Kristensen

Abstract

View articletitled, DNA Methylation Status of Key Cell-Cycle Regulators Such as CDKNA2/p16 and CCNA1 Correlates with Treatment Response to Doxorubicin and 5-Fluorouracil in Locally Advanced Breast Tumors

Supplementary data

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Applications of ImmunoPET: Using ¹²⁴I-Anti-PSCA A11 Minibody for Imaging Disease Progression and Response to Therapy in Mouse Xenograft Models of Prostate Cancer

Scott M. Knowles; Richard Tavaré; Kirstin A. Zettlitz; Matthew M. Rochefort; Felix B. Salazar; Ziyue Karen Jiang; Robert E. Reiter; Anna M. Wu

Abstract

View articletitled, Applications of ImmunoPET: Using 124I-Anti-PSCA A11 Minibody for Imaging Disease Progression and Response to Therapy in Mouse Xenograft Models of Prostate Cancer

Supplementary data

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A Tissue Biomarker–Based Model That Identifies Patients with a High Risk of Distant Metastasis and Differential Survival by Length of Androgen Deprivation Therapy in RTOG Protocol 92-02

Alan Pollack; James J. Dignam; Dayssy A. Diaz; Qian Wu; Radka Stoyanova; Kyounghwa Bae; Adam P. Dicker; Howard Sandler; Gerald E. Hanks; Felix Y. Feng

Abstract

View articletitled, A Tissue Biomarker–Based Model That Identifies Patients with a High Risk of Distant Metastasis and Differential Survival by Length of Androgen Deprivation Therapy in RTOG Protocol 92-02

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Author Choice

In Vivo Quantification of Hypoxic and Metabolic Status of NSCLC Tumors Using [¹⁸F]HX4 and [¹⁸F]FDG-PET/CT Imaging

Catharina M.L. Zegers; Wouter van Elmpt; Bart Reymen; Aniek J.G. Even; Esther G.C. Troost; Michel C. Öllers; Frank J.P. Hoebers; Ruud M.A. Houben; Jonas Eriksson; Albert D. Windhorst; Felix M. Mottaghy; Dirk De Ruysscher; Philippe Lambin

Abstract

View articletitled, In Vivo Quantification of Hypoxic and Metabolic Status of NSCLC Tumors Using [18F]HX4 and [18F]FDG-PET/CT Imaging

Supplementary data

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Minimal Residual Disease after Conventional Treatment Significantly Impacts on Progression-Free Survival of Patients with Follicular Lymphoma: The FIL FOLL05 Trial

Sara Galimberti; Stefano Luminari; Elena Ciabatti; Susanna Grassi; Francesca Guerrini; Alessandra Dondi; Luigi Marcheselli; Marco Ladetto; Pier Paolo Piccaluga; Anna Gazzola; Claudia Mannu; Luigia Monitillo; Barbara Mantoan; Ilaria Del Giudice; Irene Della Starza; Marzia Cavalli; Luca Arcaini; Alessandra Tucci; Giuseppe Alberto Palumbo; Luigi Rigacci; Alessandro Pulsoni; Umberto Vitolo; Carola Boccomini; Daniele Vallisa; Giovanni Bertoldero; Gianluca Gaidano; Pellegrino Musto; Mario Petrini; Massimo Federico

Abstract

View articletitled, Minimal Residual Disease after Conventional Treatment Significantly Impacts on Progression-Free Survival of Patients with Follicular Lymphoma: The FIL FOLL05 Trial

Supplementary data

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Cancer Therapy: Preclinical

Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer

Julius Chapiro; Surojit Sur; Lynn Jeanette Savic; Shanmugasundaram Ganapathy-Kanniappan; Juvenal Reyes; Rafael Duran; Sivarajan Chettiar Thiruganasambandam; Cassandra Rae Moats; MingDe Lin; Weibo Luo; Phuoc T. Tran; Joseph M. Herman; Gregg L. Semenza; Andrew J. Ewald; Bert Vogelstein; Jean-François Geschwind

Abstract

View articletitled, Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer

Supplementary data

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Author Choice

Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma

Huiping Gao; Kesang Li; Hong Tu; Xiaorong Pan; Hua Jiang; Bizhi Shi; Juan Kong; Hongyang Wang; Shengli Yang; Jianren Gu; Zonghai Li

Abstract

View articletitled, Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma

Supplementary data

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TGFα and Amphiregulin Paracrine Network Promotes Resistance to EGFR Blockade in Colorectal Cancer Cells

Sebastijan Hobor; Beth O. Van Emburgh; Emily Crowley; Sandra Misale; Federica Di Nicolantonio; Alberto Bardelli

Abstract

View articletitled, TGFα and Amphiregulin Paracrine Network Promotes Resistance to EGFR Blockade in Colorectal Cancer Cells

Supplementary data

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iNOS Expression in CD4⁺ T Cells Limits Treg Induction by Repressing TGFβ1: Combined iNOS Inhibition and Treg Depletion Unmask Endogenous Antitumor Immunity

Padmini Jayaraman; Matthew G. Alfarano; Peter F. Svider; Falguni Parikh; Geming Lu; Sarah Kidwai; Huabao Xiong; Andrew G. Sikora

Abstract

View articletitled, iNOS Expression in CD4+ T Cells Limits Treg Induction by Repressing TGFβ1: Combined iNOS Inhibition and Treg Depletion Unmask Endogenous Antitumor Immunity

Supplementary data

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Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis

Marika Karikoski; Fumiko Marttila-Ichihara; Kati Elima; Pia Rantakari; Maija Hollmén; Tiina Kelkka; Heidi Gerke; Ville Huovinen; Heikki Irjala; Rikard Holmdahl; Marko Salmi; Sirpa Jalkanen

Abstract

View articletitled, Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis

Supplementary data

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Dual Disruption of DNA Repair and Telomere Maintenance for the Treatment of Head and Neck Cancer

Shayanne A. Lajud; Danish A. Nagda; Taku Yamashita; Jun Zheng; Nobuaki Tanaka; Waleed M. Abuzeid; Alyssa Civantos; Orysia Bezpalko; Bert W. O'Malley, Jr; Daqing Li

Abstract

View articletitled, Dual Disruption of DNA Repair and Telomere Maintenance for the Treatment of Head and Neck Cancer

Supplementary data

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Doxorubicin Synergizes with 34.5ENVE to Enhance Antitumor Efficacy against Metastatic Ovarian Cancer

Chelsea Bolyard; Ji Young Yoo; Pin-Yi Wang; Uksha Saini; Kellie S. Rath; Timothy P. Cripe; Jianying Zhang; Karuppaiyah Selvendiran; Balveen Kaur

Abstract

View articletitled, Doxorubicin Synergizes with 34.5ENVE to Enhance Antitumor Efficacy against Metastatic Ovarian Cancer

Supplementary data

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Zinc Finger Nucleases Targeting the Human Papillomavirus E7 Oncogene Induce E7 Disruption and a Transformed Phenotype in HPV16/18-Positive Cervical Cancer Cells

Wencheng Ding; Zheng Hu; Da Zhu; Xiaohui Jiang; Lan Yu; Xiaoli Wang; Changlin Zhang; Liming Wang; Teng Ji; Kezhen Li; Dan He; Xi Xia; Dan Liu; Jianfeng Zhou; Ding Ma; Hui Wang

Abstract

View articletitled, Zinc Finger Nucleases Targeting the Human Papillomavirus E7 Oncogene Induce E7 Disruption and a Transformed Phenotype in HPV16/18-Positive Cervical Cancer Cells

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The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer

Fang Fang; Joanne Munck; Jessica Tang; Pietro Taverna; Yinu Wang; David F.B. Miller; Jay Pilrose; Gavin Choy; Mohammad Azab; Katherine S. Pawelczak; Pamela VanderVere-Carozza; Michael Wagner; John Lyons; Daniela Matei; John J. Turchi; Kenneth P. Nephew

Abstract

View articletitled, The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer

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Author Choice

Dual HER2 Targeting Impedes Growth of HER2 Gene–Amplified Uterine Serous Carcinoma Xenografts

Jolijn W. Groeneweg; Silvia F. Hernandez; Virginia F. Byron; Celeste M. DiGloria; Hector Lopez; Vanessa Scialabba; Minji Kim; Ling Zhang; Darrell R. Borger; Rosemary Tambouret; Rosemary Foster; Bo R. Rueda; Whitfield B. Growdon

Abstract

View articletitled, Dual HER2 Targeting Impedes Growth of HER2 Gene–Amplified Uterine Serous Carcinoma Xenografts

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Biology of Human Tumors

Extracellular Lumican Inhibits Pancreatic Cancer Cell Growth and Is Associated with Prolonged Survival after Surgery

Xinqun Li; Mark A. Truty; Ya'an Kang; Xavier Chopin-Laly; Ran Zhang; David Roife; Deyali Chatterjee; E. Lin; Ryan M. Thomas; Huamin Wang; Matthew H. Katz; Jason B. Fleming

Abstract

View articletitled, Extracellular Lumican Inhibits Pancreatic Cancer Cell Growth and Is Associated with Prolonged Survival after Surgery

Supplementary data

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RhoB Determines Tumor Aggressiveness in a Murine EGFR^L858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer

Olivier Calvayrac; Anne Pradines; Isabelle Raymond-Letron; Isabelle Rouquette; Emilie Bousquet; Valérie Lauwers-Cances; Thomas Filleron; Jacques Cadranel; Michèle Beau-Faller; Anne Casanova; Julie Milia; Gilles Favre; Julien Mazières

Abstract

View articletitled, RhoB Determines Tumor Aggressiveness in a Murine EGFRL858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer

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Identification of Recurrent FGFR3–TACC3 Fusion Oncogenes from Lung Adenocarcinoma

Marzia Capelletti; Michael E. Dodge; Dalia Ercan; Peter S. Hammerman; Seung-Il Park; Jhingook Kim; Hidefumi Sasaki; David M. Jablons; Doron Lipson; Lauren Young; Phil J. Stephens; Vincent A. Miller; Neal I. Lindeman; Kiara J. Munir; William G. Richards; Pasi A. Jänne

Abstract

View articletitled, Identification of Recurrent FGFR3–TACC3 Fusion Oncogenes from Lung Adenocarcinoma

Supplementary data

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miR-154* and miR-379 in the DLK1-DIO3 MicroRNA Mega-Cluster Regulate Epithelial to Mesenchymal Transition and Bone Metastasis of Prostate Cancer

Murali Gururajan; Sajni Josson; Gina Chia-Yi Chu; Chia-Lun Lu; Yi-Tsung Lu; Christopher L. Haga; Haiyen E. Zhau; Chunyan Liu; Jake Lichterman; Peng Duan; Edwin M. Posadas; Leland W.K. Chung

Abstract

View articletitled, miR-154* and miR-379 in the DLK1-DIO3 MicroRNA Mega-Cluster Regulate Epithelial to Mesenchymal Transition and Bone Metastasis of Prostate Cancer

Supplementary data

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Alterations Associated with Androgen Receptor Gene Activation in Salivary Duct Carcinoma of Both Sexes: Potential Therapeutic Ramifications

Yoshitsugu Mitani; Pulivarthi H. Rao; Sankar N. Maity; Yu-Chen Lee; Renata Ferrarotto; Julian C. Post; Lisa Licitra; Scott M. Lippman; Merrill S. Kies; Randal S. Weber; Carlos Caulin; Sue-Hwa Lin; Adel K. El-Naggar

Abstract

View articletitled, Alterations Associated with Androgen Receptor Gene Activation in Salivary Duct Carcinoma of Both Sexes: Potential Therapeutic Ramifications

Supplementary data

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Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma

Curtis R. Pickering; Jane H. Zhou; J. Jack Lee; Jennifer A. Drummond; S. Andrew Peng; Rami E. Saade; Kenneth Y. Tsai; Jonathan L. Curry; Michael T. Tetzlaff; Stephen Y. Lai; Jun Yu; Donna M. Muzny; Harshavardhan Doddapaneni; Eve Shinbrot; Kyle R. Covington; Jianhua Zhang; Sahil Seth; Carlos Caulin; Gary L. Clayman; Adel K. El-Naggar; Richard A. Gibbs; Randal S. Weber; Jeffrey N. Myers; David A. Wheeler; Mitchell J. Frederick

Abstract

View articletitled, Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma

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Genetic Evolution of T-cell Resistance in the Course of Melanoma Progression

Antje Sucker; Fang Zhao; Birgit Real; Christina Heeke; Nicola Bielefeld; Stefan Maβen; Susanne Horn; Iris Moll; Raffaela Maltaner; Peter A. Horn; Bastian Schilling; Francesco Sabbatino; Volker Lennerz; Matthias Kloor; Soldano Ferrone; Dirk Schadendorf; Christine S. Falk; Klaus Griewank; Annette Paschen

Abstract

View articletitled, Genetic Evolution of T-cell Resistance in the Course of Melanoma Progression

Supplementary data

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Author Choice

Whole-Exome Sequencing of Muscle-Invasive Bladder Cancer Identifies Recurrent Mutations of UNC5C and Prognostic Importance of DNA Repair Gene Mutations on Survival

Kai Lee Yap; Kazuma Kiyotani; Kenji Tamura; Tatjana Antic; Miran Jang; Magdeline Montoya; Alexa Campanile; Poh Yin Yew; Cory Ganshert; Tomoaki Fujioka; Gary D. Steinberg; Peter H. O'Donnell; Yusuke Nakamura

Abstract

View articletitled, Whole-Exome Sequencing of Muscle-Invasive Bladder Cancer Identifies Recurrent Mutations of UNC5C and Prognostic Importance of DNA Repair Gene Mutations on Survival

Supplementary data

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Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver

Catherine Emmanuel; for the Australian Ovarian Cancer Study (AOCS); Yoke-Eng Chiew; for the Australian Ovarian Cancer Study (AOCS); Joshy George; for the Australian Ovarian Cancer Study (AOCS); Dariush Etemadmoghadam; for the Australian Ovarian Cancer Study (AOCS); Michael S. Anglesio; for the Australian Ovarian Cancer Study (AOCS); Raghwa Sharma; for the Australian Ovarian Cancer Study (AOCS); Peter Russell; for the Australian Ovarian Cancer Study (AOCS); Catherine Kennedy; for the Australian Ovarian Cancer Study (AOCS); Sian Fereday; for the Australian Ovarian Cancer Study (AOCS); Jillian Hung; for the Australian Ovarian Cancer Study (AOCS); Laura Galletta; for the Australian Ovarian Cancer Study (AOCS); Russell Hogg; for the Australian Ovarian Cancer Study (AOCS); Gerard V. Wain; for the Australian Ovarian Cancer Study (AOCS); Alison Brand; for the Australian Ovarian Cancer Study (AOCS); Rosemary Balleine; for the Australian Ovarian Cancer Study (AOCS); Laura MacConaill; for the Australian Ovarian Cancer Study (AOCS); Emanuele Palescandolo; for the Australian Ovarian Cancer Study (AOCS); Sally M. Hunter; for the Australian Ovarian Cancer Study (AOCS); Ian Campbell; for the Australian Ovarian Cancer Study (AOCS); Alexander Dobrovic; for the Australian Ovarian Cancer Study (AOCS); Stephen Q. Wong; for the Australian Ovarian Cancer Study (AOCS); Hongdo Do; for the Australian Ovarian Cancer Study (AOCS); Christine L. Clarke; for the Australian Ovarian Cancer Study (AOCS); Paul R. Harnett; for the Australian Ovarian Cancer Study (AOCS); David D.L. Bowtell; for the Australian Ovarian Cancer Study (AOCS); Anna deFazio; for the Australian Ovarian Cancer Study (AOCS)

Abstract

View articletitled, Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver

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