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15 December 2014
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Cover Image
Cover Image
The cover shows a section of B16 melanoma. Immunohistochemical staining shows aberrant Clever-1 expression on tumor vasculature. For details, see the article by Karikoski and colleagues on page 6452 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
Molecular Pathways
Perspectives
Review
Cancer Therapy: Clinical
Sequential Use of the Androgen Synthesis Inhibitors Ketoconazole and Abiraterone Acetate in Castration-Resistant Prostate Cancer and the Predictive Value of Circulating Androgens
Won Kim; Li Zhang; John H. Wilton; Gerald Fetterly; James L. Mohler; Vivian Weinberg; Allison Morse; Russell Z. Szmulewitz; Terence W. Friedlander; Lawrence Fong; Amy M. Lin; Andrea L. Harzstark; Arturo Molina; Eric J. Small; Charles J. Ryan
Phase I, Dose-Escalation Study of the Targeted Cytotoxic LHRH Analog AEZS-108 in Patients with Castration- and Taxane-Resistant Prostate Cancer
Stephen V. Liu; Denice D. Tsao-Wei; Shigang Xiong; Susan Groshen; Tanya B. Dorff; David I. Quinn; Yu-Chong Tai; Juergen Engel; Debra Hawes; Andrew V. Schally; Jacek K. Pinski
A Phase I, Dose-Escalation Study of the Multitargeted Receptor Tyrosine Kinase Inhibitor, Golvatinib, in Patients with Advanced Solid Tumors
L. Rhoda Molife; Emma Jane Dean; Montserrat Blanco-Codesido; Matthew G. Krebs; Andre T. Brunetto; Alastair Peter Greystoke; Gennaro Daniele; Lucy Lee; Galina Kuznetsov; Khin Than Myint; Karen Wood; Begoña de las Heras; Malcolm Richard Ranson
Author Choice
A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors
David C. Smith; Peter D. Eisenberg; Georgy Manikhas; Rashmi Chugh; Matthew A. Gubens; Robert J. Stagg; Ann M. Kapoun; Lu Xu; Jakob Dupont; Branimir Sikic
A Phase II, Randomized, Study of Weekly APG101+Reirradiation versus Reirradiation in Progressive Glioblastoma
Wolfgang Wick; Harald Fricke; Klaus Junge; Grigory Kobyakov; Tobias Martens; Oliver Heese; Benedikt Wiestler; Maximilian G. Schliesser; Andreas von Deimling; Josef Pichler; Elena Vetlova; Inga Harting; Jürgen Debus; Christian Hartmann; Claudia Kunz; Michael Platten; Martin Bendszus; Stephanie E. Combs
Personalized Medicine and Imaging
Screening for Cardiac Dysfunction in Anthracycline-Exposed Childhood Cancer Survivors
Saro H. Armenian; Sarah K. Gelehrter; Tabitha Vase; Rajkumar Venkatramani; Wendy Landier; Karla D. Wilson; Claudia Herrera; Leah Reichman; John-David Menteer; Leo Mascarenhas; David R. Freyer; Kalyanasundaram Venkataraman; Smita Bhatia
Analysis of 1,115 Patients Tested for MET Amplification and Therapy Response in the MD Anderson Phase I Clinic
Denis L.F. Jardim; Chad Tang; Debora De Melo Gagliato; Gerald S. Falchook; Kenneth Hess; Filip Janku; Siqing Fu; Jennifer J. Wheler; Ralph G. Zinner; Aung Naing; Apostolia M. Tsimberidou; Vijaykumar Holla; Marylin M. Li; Sinchita Roy-Chowdhuri; Raja Luthra; Ravi Salgia; Razelle Kurzrock; Funda Meric-Bernstam; David S. Hong
Author Choice
DNA Methylation Status of Key Cell-Cycle Regulators Such as CDKNA2/p16 and CCNA1 Correlates with Treatment Response to Doxorubicin and 5-Fluorouracil in Locally Advanced Breast Tumors
Jovana Klajic; Florence Busato; Hege Edvardsen; Nizar Touleimat; Thomas Fleischer; Ida Bukholm; Anne-Lise Børresen-Dale; Per Eystein Lønning; Jörg Tost; Vessela N. Kristensen
Applications of ImmunoPET: Using 124I-Anti-PSCA A11 Minibody for Imaging Disease Progression and Response to Therapy in Mouse Xenograft Models of Prostate Cancer
Scott M. Knowles; Richard Tavaré; Kirstin A. Zettlitz; Matthew M. Rochefort; Felix B. Salazar; Ziyue Karen Jiang; Robert E. Reiter; Anna M. Wu
A Tissue Biomarker–Based Model That Identifies Patients with a High Risk of Distant Metastasis and Differential Survival by Length of Androgen Deprivation Therapy in RTOG Protocol 92-02
Alan Pollack; James J. Dignam; Dayssy A. Diaz; Qian Wu; Radka Stoyanova; Kyounghwa Bae; Adam P. Dicker; Howard Sandler; Gerald E. Hanks; Felix Y. Feng
Author Choice
In Vivo Quantification of Hypoxic and Metabolic Status of NSCLC Tumors Using [18F]HX4 and [18F]FDG-PET/CT Imaging
Catharina M.L. Zegers; Wouter van Elmpt; Bart Reymen; Aniek J.G. Even; Esther G.C. Troost; Michel C. Öllers; Frank J.P. Hoebers; Ruud M.A. Houben; Jonas Eriksson; Albert D. Windhorst; Felix M. Mottaghy; Dirk De Ruysscher; Philippe Lambin
Minimal Residual Disease after Conventional Treatment Significantly Impacts on Progression-Free Survival of Patients with Follicular Lymphoma: The FIL FOLL05 Trial
Sara Galimberti; Stefano Luminari; Elena Ciabatti; Susanna Grassi; Francesca Guerrini; Alessandra Dondi; Luigi Marcheselli; Marco Ladetto; Pier Paolo Piccaluga; Anna Gazzola; Claudia Mannu; Luigia Monitillo; Barbara Mantoan; Ilaria Del Giudice; Irene Della Starza; Marzia Cavalli; Luca Arcaini; Alessandra Tucci; Giuseppe Alberto Palumbo; Luigi Rigacci; Alessandro Pulsoni; Umberto Vitolo; Carola Boccomini; Daniele Vallisa; Giovanni Bertoldero; Gianluca Gaidano; Pellegrino Musto; Mario Petrini; Massimo Federico
Cancer Therapy: Preclinical
Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
Julius Chapiro; Surojit Sur; Lynn Jeanette Savic; Shanmugasundaram Ganapathy-Kanniappan; Juvenal Reyes; Rafael Duran; Sivarajan Chettiar Thiruganasambandam; Cassandra Rae Moats; MingDe Lin; Weibo Luo; Phuoc T. Tran; Joseph M. Herman; Gregg L. Semenza; Andrew J. Ewald; Bert Vogelstein; Jean-François Geschwind
Zinc Finger Nucleases Targeting the Human Papillomavirus E7 Oncogene Induce E7 Disruption and a Transformed Phenotype in HPV16/18-Positive Cervical Cancer Cells
Wencheng Ding; Zheng Hu; Da Zhu; Xiaohui Jiang; Lan Yu; Xiaoli Wang; Changlin Zhang; Liming Wang; Teng Ji; Kezhen Li; Dan He; Xi Xia; Dan Liu; Jianfeng Zhou; Ding Ma; Hui Wang
The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer
Fang Fang; Joanne Munck; Jessica Tang; Pietro Taverna; Yinu Wang; David F.B. Miller; Jay Pilrose; Gavin Choy; Mohammad Azab; Katherine S. Pawelczak; Pamela VanderVere-Carozza; Michael Wagner; John Lyons; Daniela Matei; John J. Turchi; Kenneth P. Nephew
Author Choice
Dual HER2 Targeting Impedes Growth of HER2 Gene–Amplified Uterine Serous Carcinoma Xenografts
Jolijn W. Groeneweg; Silvia F. Hernandez; Virginia F. Byron; Celeste M. DiGloria; Hector Lopez; Vanessa Scialabba; Minji Kim; Ling Zhang; Darrell R. Borger; Rosemary Tambouret; Rosemary Foster; Bo R. Rueda; Whitfield B. Growdon
Biology of Human Tumors
RhoB Determines Tumor Aggressiveness in a Murine EGFRL858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer
Olivier Calvayrac; Anne Pradines; Isabelle Raymond-Letron; Isabelle Rouquette; Emilie Bousquet; Valérie Lauwers-Cances; Thomas Filleron; Jacques Cadranel; Michèle Beau-Faller; Anne Casanova; Julie Milia; Gilles Favre; Julien Mazières
Identification of Recurrent FGFR3–TACC3 Fusion Oncogenes from Lung Adenocarcinoma
Marzia Capelletti; Michael E. Dodge; Dalia Ercan; Peter S. Hammerman; Seung-Il Park; Jhingook Kim; Hidefumi Sasaki; David M. Jablons; Doron Lipson; Lauren Young; Phil J. Stephens; Vincent A. Miller; Neal I. Lindeman; Kiara J. Munir; William G. Richards; Pasi A. Jänne
miR-154* and miR-379 in the DLK1-DIO3 MicroRNA Mega-Cluster Regulate Epithelial to Mesenchymal Transition and Bone Metastasis of Prostate Cancer
Murali Gururajan; Sajni Josson; Gina Chia-Yi Chu; Chia-Lun Lu; Yi-Tsung Lu; Christopher L. Haga; Haiyen E. Zhau; Chunyan Liu; Jake Lichterman; Peng Duan; Edwin M. Posadas; Leland W.K. Chung
Alterations Associated with Androgen Receptor Gene Activation in Salivary Duct Carcinoma of Both Sexes: Potential Therapeutic Ramifications
Yoshitsugu Mitani; Pulivarthi H. Rao; Sankar N. Maity; Yu-Chen Lee; Renata Ferrarotto; Julian C. Post; Lisa Licitra; Scott M. Lippman; Merrill S. Kies; Randal S. Weber; Carlos Caulin; Sue-Hwa Lin; Adel K. El-Naggar
Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma
Curtis R. Pickering; Jane H. Zhou; J. Jack Lee; Jennifer A. Drummond; S. Andrew Peng; Rami E. Saade; Kenneth Y. Tsai; Jonathan L. Curry; Michael T. Tetzlaff; Stephen Y. Lai; Jun Yu; Donna M. Muzny; Harshavardhan Doddapaneni; Eve Shinbrot; Kyle R. Covington; Jianhua Zhang; Sahil Seth; Carlos Caulin; Gary L. Clayman; Adel K. El-Naggar; Richard A. Gibbs; Randal S. Weber; Jeffrey N. Myers; David A. Wheeler; Mitchell J. Frederick
Genetic Evolution of T-cell Resistance in the Course of Melanoma Progression
Antje Sucker; Fang Zhao; Birgit Real; Christina Heeke; Nicola Bielefeld; Stefan Maβen; Susanne Horn; Iris Moll; Raffaela Maltaner; Peter A. Horn; Bastian Schilling; Francesco Sabbatino; Volker Lennerz; Matthias Kloor; Soldano Ferrone; Dirk Schadendorf; Christine S. Falk; Klaus Griewank; Annette Paschen
Author Choice
Whole-Exome Sequencing of Muscle-Invasive Bladder Cancer Identifies Recurrent Mutations of UNC5C and Prognostic Importance of DNA Repair Gene Mutations on Survival
Kai Lee Yap; Kazuma Kiyotani; Kenji Tamura; Tatjana Antic; Miran Jang; Magdeline Montoya; Alexa Campanile; Poh Yin Yew; Cory Ganshert; Tomoaki Fujioka; Gary D. Steinberg; Peter H. O'Donnell; Yusuke Nakamura
Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver
Catherine Emmanuel; Yoke-Eng Chiew; Joshy George; Dariush Etemadmoghadam; Michael S. Anglesio; Raghwa Sharma; Peter Russell; Catherine Kennedy; Sian Fereday; Jillian Hung; Laura Galletta; Russell Hogg; Gerard V. Wain; Alison Brand; Rosemary Balleine; Laura MacConaill; Emanuele Palescandolo; Sally M. Hunter; Ian Campbell; Alexander Dobrovic; Stephen Q. Wong; Hongdo Do; Christine L. Clarke; Paul R. Harnett; David D.L. Bowtell; Anna deFazio; for the Australian Ovarian Cancer Study (AOCS)
Letters to the Editor
Acknowledgment to Reviewers
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