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1 December 2014
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Cover Image
Cover Image
The cover shows a digital image of collagen IV-stained T11 tumor sections after analysis using color deconvolution methods. The markup images of collagen IV highlight the staining, which is color-coded according to classification based on staining intensity (blue, undetectable; yellow, weak; orange, medium; and red, strong). For details, see the article by Song and colleagues on page 6083 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
CCR Drug Updates
Molecular Pathways
Reviews
Cancer Therapy: Clinical
First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer
Sarah Blagden; Aurelius Olmin; Debra Josephs; Chara Stavraka; Andrea Zivi; David J. Pinato; Alan Anthoney; Shaun Decordova; Karen Swales; Ruth Riisnaes; Lorna Pope; Kohei Noguchi; Rie Shiokawa; Michiyasu Inatani; Jenny Prince; Keith Jones; Chris Twelves; James Spicer; Udai Banerji
Author Choice
An Open-Label Phase Ib Dose-Escalation Study of TRC105 (Anti-Endoglin Antibody) with Bevacizumab in Patients with Advanced Cancer
Michael S. Gordon; Francisco Robert; Daniela Matei; David S. Mendelson; Jonathan W. Goldman; E. Gabriela Chiorean; Robert M. Strother; Ben K. Seon; William D. Figg; Cody J. Peer; Delia Alvarez; Bonne J. Adams; Charles P. Theuer; Lee S. Rosen
Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma
Raffit Hassan; Hedy L. Kindler; Thierry Jahan; Lyudmila Bazhenova; Martin Reck; Anish Thomas; Ira Pastan; Jeff Parno; Daniel J. O'Shannessy; Penny Fatato; Julia D. Maltzman; Bruce A. Wallin
Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
Edward J. Kim; Vaibhav Sahai; Ethan V. Abel; Kent A. Griffith; Joel K. Greenson; Naoko Takebe; Gazala N. Khan; John L. Blau; Ronald Craig; Ulysses G. Balis; Mark M. Zalupski; Diane M. Simeone
Synergy Between VEGF/VEGFR Inhibitors and Chemotherapy Agents in the Phase I Clinic
Chad Tang; Kenneth Hess; Denis Leonardo F. Jardim; Debora De Melo Gagliato; Apostolia M. Tsimberidou; Gerald Falchook; Siqing Fu; Filip Janku; Aung Naing; Sarina Piha-Paul; Vivek Subbiah; Jennifer Wheler; Ralph G. Zinner; Razelle Kurzrock; Lee M. Ellis; Funda Meric-Berstam; David S. Hong
Safety and Preliminary Evidence of Biologic Efficacy of a Mammaglobin-A DNA Vaccine in Patients with Stable Metastatic Breast Cancer
Venkataswarup Tiriveedhi; Natalia Tucker; John Herndon; Lijin Li; Mark Sturmoski; Matthew Ellis; Cynthia Ma; Michael Naughton; A. Craig Lockhart; Feng Gao; Timothy Fleming; Peter Goedegebuure; Thalachallour Mohanakumar; William E. Gillanders
A Phase II Study of the Efficacy and Safety of the Combination Therapy of the MEK Inhibitor Refametinib (BAY 86-9766) Plus Sorafenib for Asian Patients with Unresectable Hepatocellular Carcinoma
Ho Yeong Lim; Jeong Heo; Hye Jin Choi; Cheng-Yao Lin; Jung-Hwan Yoon; Chiun Hsu; Kun-Ming Rau; Ronnie T.P. Poon; Winnie Yeo; Joong-Won Park; Miah Hiang Tay; Wen-Son Hsieh; Christian Kappeler; Prabhu Rajagopalan; Heiko Krissel; Michael Jeffers; Chia-Jui Yen; Won Young Tak
Personalized Medicine and Imaging
Cancer Therapy: Preclinical
The Novel Organic Arsenical Darinaparsin Induces MAPK-Mediated and SHP1-Dependent Cell Death in T-cell Lymphoma and Hodgkin Lymphoma Cells and Human Xenograft Models
Dashnamoorthy Ravi; Savita Bhalla; Ronald B. Gartenhaus; Jennifer Crombie; Irawati Kandela; Jaya Sharma; Andrew Mazar; Andrew M. Evens
Author Choice
LY2875358, a Neutralizing and Internalizing Anti-MET Bivalent Antibody, Inhibits HGF-Dependent and HGF-Independent MET Activation and Tumor Growth
Ling Liu; Wei Zeng; Mark A. Wortinger; S. Betty Yan; Paul Cornwell; Victoria L. Peek; Jennifer R. Stephens; Jonathan W. Tetreault; Jinqi Xia; Jason R. Manro; Kelly M. Credille; Darryl W. Ballard; Patricia Brown-Augsburger; Volker Wacheck; Chi-Kin Chow; Lihua Huang; Yong Wang; Irene Denning; Julian Davies; Ying Tang; Peter Vaillancourt; Jirong Lu
Phosphoinositide 3-Kinase Inhibitors Combined with Imatinib in Patient-Derived Xenograft Models of Gastrointestinal Stromal Tumors: Rationale and Efficacy
Thomas Van Looy; Agnieszka Wozniak; Giuseppe Floris; Raf Sciot; Haifu Li; Jasmien Wellens; Ulla Vanleeuw; Jonathan A. Fletcher; Paul W. Manley; Maria Debiec-Rychter; Patrick Schöffski
Effects of Tumor Microenvironment Heterogeneity on Nanoparticle Disposition and Efficacy in Breast Cancer Tumor Models
Gina Song; David B. Darr; Charlene M. Santos; Mark Ross; Alain Valdivia; Jamie L. Jordan; Bentley R. Midkiff; Stephanie Cohen; Nana Nikolaishvili-Feinberg; C. Ryan Miller; Teresa K. Tarrant; Arlin B. Rogers; Andrew C. Dudley; Charles M. Perou; William C. Zamboni
Biology of Human Tumors
Author Choice
Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST
Agnieszka Wozniak; Piotr Rutkowski; Patrick Schöffski; Isabelle Ray-Coquard; Isabelle Hostein; Hans-Ulrich Schildhaus; Axel Le Cesne; Elzbieta Bylina; Janusz Limon; Jean-Yves Blay; Janusz A. Siedlecki; Eva Wardelmann; Raf Sciot; Jean-Michel Coindre; Maria Debiec-Rychter
ABO Blood Group IgM Isoagglutinins Interact with Tumor-Associated O-Glycan Structures in Pancreatic Cancer
Bianca T. Hofmann; Anne Stehr; Thorsten Dohrmann; Cenap Güngör; Lena Herich; Jens Hiller; Sönke Harder; Florian Ewald; Florian Gebauer; Michael Tachezy; Clarissa Precht; Jakob R. Izbicki; Maximilian Bockhorn; Christoph Wagener; Gerrit Wolters-Eisfeld
Author Choice
Genome-wide DNA Methylation Analysis of Lung Carcinoma Reveals One Neuroendocrine and Four Adenocarcinoma Epitypes Associated with Patient Outcome
Anna Karlsson; Mats Jönsson; Martin Lauss; Hans Brunnström; Per Jönsson; Åke Borg; Göran Jönsson; Markus Ringnér; Maria Planck; Johan Staaf
AMACR Amplification in Myxofibrosarcomas: A Mechanism of Overexpression That Promotes Cell Proliferation with Therapeutic Relevance
Chien-Feng Li; Fu-Min Fang; Jui Lan; Jun-Wen Wang; Hsing-Jien Kung; Li-Tzong Chen; Tzu-Ju Chen; Shau-Hsuan Li; Yu-Hui Wang; Hui-Chun Tai; Shih-Chen Yu; Hsuan-Ying Huang
Complement Pathway Is Frequently Altered in Endometriosis and Endometriosis-Associated Ovarian Cancer
Swati Suryawanshi; Xin Huang; Esther Elishaev; Raluca A. Budiu; Lixin Zhang; SungHwan Kim; Nicole Donnellan; Gina Mantia-Smaldone; Tianzhou Ma; George Tseng; Ted Lee; Suketu Mansuria; Robert P. Edwards; Anda M. Vlad
Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence
Yuji Toiyama; Koji Tanaka; Takahito Kitajima; Tadanobu Shimura; Mikio Kawamura; Aya Kawamoto; Yoshinaga Okugawa; Susumu Saigusa; Junichiro Hiro; Yasuhiro Inoue; Yasuhiko Mohri; Ajay Goel; Masato Kusunoki
miR-204-5p Inhibits Proliferation and Invasion and Enhances Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating RAB22A
Yuan Yin; Binbin Zhang; Weili Wang; Bojian Fei; Chao Quan; Jiwei Zhang; Mingxu Song; Zehua Bian; Qifeng Wang; Shujuan Ni; Yaling Hu; Yong Mao; Leyuan Zhou; Yugang Wang; Jian Yu; Xiang Du; Dong Hua; Zhaohui Huang
Author Choice
Functional p38 MAPK Identified by Biomarker Profiling of Pancreatic Cancer Restrains Growth through JNK Inhibition and Correlates with Improved Survival
Yi Zhong; Yoshiki Naito; Leslie Cope; Salvador Naranjo-Suarez; Tyler Saunders; Seung-Mo Hong; Michael G. Goggins; Joseph M. Herman; Christopher L. Wolfgang; Christine A. Iacobuzio-Donahue
Obituary
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