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15 November 2014
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Cover Image
Cover Image
The cover shows that the morphology of SW480 colorectal cancer cells in response to the treatment with TGFβ for 48 hours have migrated through 8 μm-diameter pores in a Transwell assay. Cells have been stained with Giemsa (magnification × 400). For details, see the article by Wang and colleagues on page 5835 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
CCR Focus
Cancer Therapy: Clinical
Phase II Study of Perifosine and Sorafenib Dual-Targeted Therapy in Patients with Relapsed or Refractory Lymphoproliferative Diseases
Anna Guidetti; Carmelo Carlo-Stella; Silvia L. Locatelli; Walter Malorni; Roberta Mortarini; Simonetta Viviani; Domenico Russo; Alfonso Marchianò; Roberto Sorasio; Anna Dodero; Lucia Farina; Laura Giordano; Massimo Di Nicola; Andrea Anichini; Paolo Corradini; Alessandro M. Gianni
Phase I Trial of Bortezomib (PS-341; NSC 681239) and “Nonhybrid” (Bolus) Infusion Schedule of Alvocidib (Flavopiridol; NSC 649890) in Patients with Recurrent or Refractory Indolent B-cell Neoplasms
Beata Holkova; Maciej Kmieciak; E. Brent Perkins; Prithviraj Bose; Rachid C. Baz; G. David Roodman; Robert K. Stuart; Viswanathan Ramakrishnan; Wen Wan; Cody J. Peer; Jana Dawson; Loveleen Kang; Connie Honeycutt; Mary Beth Tombes; Ellen Shrader; Caryn Weir-Wiggins; Martha Wellons; Heidi Sankala; Kevin T. Hogan; A. Dimitrios Colevas; L. Austin Doyle; William D. Figg; Domenico Coppola; John D. Roberts; Daniel Sullivan; Steven Grant
Dose–Response Relationship in Phase I Clinical Trials: A European Drug Development Network (EDDN) Collaboration Study
Victor Moreno García; David Olmos; Carlos Gomez-Roca; Philippe A. Cassier; Rafael Morales-Barrera; Gianluca Del Conte; Elisa Gallerani; Andre T. Brunetto; Patrick Schöffski; Silvia Marsoni; Jan H.M. Schellens; Nicolas Penel; Emile Voest; Jeffrey Evans; Ruth Plummer; Richard H. Wilson; Jean Charles Soria; Josep Tabernero; Jaap Verweij; Stan B. Kaye
Interrogating Two Schedules of the AKT Inhibitor MK-2206 in Patients with Advanced Solid Tumors Incorporating Novel Pharmacodynamic and Functional Imaging Biomarkers
Timothy A. Yap; Li Yan; Amita Patnaik; Nina Tunariu; Andrea Biondo; Ivy Fearen; Kyriakos P. Papadopoulos; David Olmos; Richard Baird; Liliana Delgado; Ernestina Tetteh; Robert A. Beckman; Lisa Lupinacci; Ruth Riisnaes; Shaun Decordova; Simon P. Heaton; Karen Swales; Nandita M. deSouza; Martin O. Leach; Michelle D. Garrett; Daniel M. Sullivan; Johann S. de Bono; Anthony W. Tolcher
Personalized Medicine and Imaging
Two Novel ALK Mutations Mediate Acquired Resistance to the Next-Generation ALK Inhibitor Alectinib
Ryohei Katayama; Luc Friboulet; Sumie Koike; Elizabeth L. Lockerman; Tahsin M. Khan; Justin F. Gainor; A. John Iafrate; Kengo Takeuchi; Makoto Taiji; Yasushi Okuno; Naoya Fujita; Jeffrey A. Engelman; Alice T. Shaw
Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins
Miguel F. Sanmamed; Omar Carranza-Rua; Carlos Alfaro; Carmen Oñate; Salvador Martín-Algarra; Guiomar Perez; Sara F. Landazuri; Álvaro Gonzalez; Stefanie Gross; Inmaculada Rodriguez; Cecilia Muñoz-Calleja; María Rodríguez-Ruiz; Bruno Sangro; José M. López-Picazo; Manglio Rizzo; Guillermo Mazzolini; Juan I. Pascual; Maria Pilar Andueza; Jose Luis Perez-Gracia; Ignacio Melero
Cancer Therapy: Preclinical
Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies
Drew C. Deniger; Sourindra N. Maiti; Tiejuan Mi; Kirsten C. Switzer; Vijaya Ramachandran; Lenka V. Hurton; Sonny Ang; Simon Olivares; Brian A. Rabinovich; M. Helen Huls; Dean A. Lee; Robert C. Bast, Jr; Richard E. Champlin; Laurence J.N. Cooper
Neuroblastoma Killing Properties of Vδ2 and Vδ2-Negative γδT Cells Following Expansion by Artificial Antigen-Presenting Cells
Jonathan P.H. Fisher; Mengyong Yan; Jennifer Heuijerjans; Lisa Carter; Ayda Abolhassani; Jennifer Frosch; Rebecca Wallace; Barry Flutter; Anna Capsomidis; Mike Hubank; Nigel Klein; Robin Callard; Kenth Gustafsson; John Anderson
Human Anaplastic Thyroid Carcinoma Cells Are Sensitive to NK Cell–Mediated Lysis via ULBP2/5/6 and Chemoattract NK Cells
Erik Wennerberg; Aline Pfefferle; Lars Ekblad; Yuya Yoshimoto; Veronika Kremer; Vitaliy O Kaminskyy; C Christofer Juhlin; Anders Höög; Inger Bodin; Vitalijs Svjatoha; Catharina Larsson; Jan Zedenius; Johan Wennerberg; Andreas Lundqvist
Author Choice
Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients
Andrew P. Garner; Joseph M. Gozgit; Rana Anjum; Sadanand Vodala; Alexa Schrock; Tianjun Zhou; Cesar Serrano; Grant Eilers; Meijun Zhu; Julia Ketzer; Scott Wardwell; Yaoyu Ning; Youngchul Song; Anna Kohlmann; Frank Wang; Tim Clackson; Michael C. Heinrich; Jonathan A. Fletcher; Sebastian Bauer; Victor M. Rivera
Biology of Human Tumors
Lung Squamous Cell Carcinomas with Basaloid Histology Represent a Specific Molecular Entity
Christian Brambilla; Julien Laffaire; Sylvie Lantuejoul; Denis Moro-Sibilot; Hélène Mignotte; François Arbib; Anne-Claire Toffart; Fabien Petel; Pierre Hainaut; Sophie Rousseaux; Saadi Khochbin; Aurélien de Reyniès; Elisabeth Brambilla
Author Choice
A HGF/cMET Autocrine Loop Is Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent a Novel Therapeutic Target
Arianna Ferrucci; Michele Moschetta; Maria Antonia Frassanito; Simona Berardi; Ivana Catacchio; Roberto Ria; Vito Racanelli; Antonella Caivano; Antonio Giovanni Solimando; Daniele Vergara; Michele Maffia; Dominga Latorre; Antonia Rizzello; Alfredo Zito; Paolo Ditonno; Eugenio Maiorano; Domenico Ribatti; Angelo Vacca
Tumor-Suppressive miR148a Is Silenced by CpG Island Hypermethylation in IDH1-Mutant Gliomas
Sichen Li; Reshmi Chowdhury; Fei Liu; Arthur P. Chou; Tie Li; Reema R. Mody; Jerry J. Lou; Weidong Chen; Jean Reiss; Horacio Soto; Robert Prins; Linda M. Liau; Paul S. Mischel; Phioanh L. Nghiemphu; William H. Yong; Timothy F. Cloughesy; Albert Lai
The Renin–Angiotensin System Mediates EGF Receptor–Vitamin D Receptor Cross-Talk in Colitis-Associated Colon Cancer
Urszula Dougherty; Reba Mustafi; Farhana Sadiq; Anas Almoghrabi; Devkumar Mustafi; Maggi Kreisheh; Sumana Sundaramurthy; Weicheng Liu; Vani J. Konda; Joel Pekow; Sharad Khare; John Hart; Loren Joseph; Alice Wyrwicz; Gregory S. Karczmar; Yan Chun Li; Marc Bissonnette
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