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1 November 2014
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The cover shows immunohistochemical sections of xenografts derived from gemcitabine-sensitive CAL29 bladder cancer cells. Sections were stained for Dck, and nuclear positivity was quantified using Aperio scanscope software, using the Nuclear v9 algorithm. For details, see the article by Kerr and colleagues on page 5435 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
CCR Perspectives in Drug Approval
CCR Drug Updates
Molecular Pathways
Review
Cancer Therapy: Clinical
A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study
Anish Thomas; Arun Rajan; Eva Szabo; Yusuke Tomita; Corey A. Carter; Barbara Scepura; Ariel Lopez-Chavez; Min-Jung Lee; Christophe E. Redon; Ari Frosch; Cody J. Peer; Yuanbin Chen; Richard Piekarz; Seth M. Steinberg; Jane B. Trepel; William D. Figg; David S. Schrump; Giuseppe Giaccone
Personalized Medicine and Imaging
Cancer Therapy: Preclinical
Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8+ T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ
Ruey-Shyang Soong; Liwen Song; Janson Trieu; Jayne Knoff; Liangmei He; Ya-Chea Tsai; Warner Huh; Yung-Nien Chang; Wen-Fang Cheng; Richard B.S. Roden; T.-C. Wu; Cornelia L. Trimble; Chien-Fu Hung
The Retinoblastoma Tumor Suppressor Modulates DNA Repair and Radioresponsiveness
Chellappagounder Thangavel; Ettickan Boopathi; Steve Ciment; Yi Liu; Raymond O' Neill; Ankur Sharma; Steve B. McMahon; Hestia Mellert; Sankar Addya; Adam Ertel; Ruth Birbe; Paolo Fortina; Adam P. Dicker; Karen E. Knudsen; Robert B. Den
Upregulation of IGF1R by Mutant RAS in Leukemia and Potentiation of RAS Signaling Inhibitors by Small-Molecule Inhibition of IGF1R
Ellen Weisberg; Atsushi Nonami; Zhao Chen; Erik Nelson; Yongfei Chen; Feiyang Liu; HaeYeon Cho; Jianming Zhang; Martin Sattler; Constantine Mitsiades; Kwok-Kin Wong; Qingsong Liu; Nathanael S. Gray; James D. Griffin
Biology of Human Tumors
Deficient Cutaneous Antibacterial Competence in Cutaneous T-Cell Lymphomas: Role of Th2-Mediated Biased Th17 Function
Kerstin Wolk; Hiroshi Mitsui; Katrin Witte; Sylke Gellrich; Nicholas Gulati; Daniel Humme; Ellen Witte; Melanie Gonsior; Marc Beyer; Marshall E. Kadin; Hans-Dieter Volk; James G. Krueger; Wolfram Sterry; Robert Sabat
Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with BRAFV600 Mutations
Amanda D. Bucheit; Guo Chen; Alan Siroy; Michael Tetzlaff; Russell Broaddus; Denai Milton; Patricia Fox; Roland Bassett; Patrick Hwu; Jeffrey E. Gershenwald; Alexander J. Lazar; Michael A. Davies
Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target
Guo Chen; Nitin Chakravarti; Kimberly Aardalen; Alexander J. Lazar; Michael T. Tetzlaff; Bradley Wubbenhorst; Sang-Bae Kim; Scott Kopetz; Alicia A. Ledoux; Y.N. Vashisht Gopal; Cristiano Goncalves Pereira; Wanleng Deng; Ju-Seog Lee; Katherine L. Nathanson; Kenneth D. Aldape; Victor G. Prieto; Darrin Stuart; Michael A. Davies
Author Choice
Canonical Androstenedione Reduction Is the Predominant Source of Signaling Androgens in Hormone-Refractory Prostate Cancer
Matthew Fankhauser; Yuen Tan; Geoff Macintyre; Izhak Haviv; Matthew K.H. Hong; Anne Nguyen; John S. Pedersen; Anthony J. Costello; Christopher M. Hovens; Niall M. Corcoran
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