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15 September 2014
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Cover Image
Cover Image
The cover shows results from FISH analysis of prostate cancer cells with ERG rearrangement (top; loss of one green signal indicating translocation through deletion) and hemizygous PTEN deletion (bottom; loss of one red signal with preservation of green centromeric signals). For details, see the article by Khani and colleagues on page 4925 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
Cancer Therapy: Clinical
Author Choice
Phase I Dose-Escalation Study of MEDI-573, a Bispecific, Antiligand Monoclonal Antibody against IGFI and IGFII, in Patients with Advanced Solid Tumors
Paul Haluska; Michael Menefee; Elizabeth R. Plimack; Jonathan Rosenberg; Donald Northfelt; Theresa LaVallee; Li Shi; Xiang-Qing Yu; Patricia Burke; Jaiqi Huang; Jaye Viner; Jennifer McDevitt; Patricia LoRusso
Personalized Medicine and Imaging
A Three-microRNA Signature Predicts Responses to Platinum-Based Doublet Chemotherapy in Patients with Lung Adenocarcinoma
Motonobu Saito; Kouya Shiraishi; Kenji Matsumoto; Aaron J. Schetter; Hiroko Ogata-Kawata; Naoto Tsuchiya; Hideo Kunitoh; Hiroshi Nokihara; Shun-ichi Watanabe; Koji Tsuta; Kensuke Kumamoto; Seiichi Takenoshita; Jun Yokota; Curtis C. Harris; Takashi Kohno
Clinical Significance of EpCAM mRNA-Positive Circulating Tumor Cells in Hepatocellular Carcinoma by an Optimized Negative Enrichment and qRT-PCR–Based Platform
Wei Guo; Xin-Rong Yang; Yun-Fan Sun; Min-Na Shen; Xiao-Lu Ma; Jiong Wu; Chun-Yan Zhang; Yan Zhou; Yang Xu; Bo Hu; Xin Zhang; Jian Zhou; Jia Fan
Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer Using 3′-Deoxy-3′-[18F]-Fluorothymidine Positron Emission Tomography
Francesca Iommelli; Viviana De Rosa; Sara Gargiulo; Mariarosaria Panico; Marcello Monti; Adelaide Greco; Matteo Gramanzini; Giovanni Ortosecco; Rosa Fonti; Arturo Brunetti; Silvana Del Vecchio
Functional Ex Vivo Assay to Select Homologous Recombination–Deficient Breast Tumors for PARP Inhibitor Treatment
Kishan A.T. Naipal; Nicole S. Verkaik; Najim Ameziane; Carolien H.M. van Deurzen; Petra ter Brugge; Matty Meijers; Anieta M. Sieuwerts; John W. Martens; Mark J. O'Connor; Harry Vrieling; Jan H.J. Hoeijmakers; Jos Jonkers; Roland Kanaar; Johan P. de Winter; Maaike P. Vreeswijk; Agnes Jager; Dik C. van Gent
Personalized Medicine for Patients with Advanced Cancer in the Phase I Program at MD Anderson: Validation and Landmark Analyses
Apostolia-Maria Tsimberidou; Sijin Wen; David S. Hong; Jennifer J. Wheler; Gerald S. Falchook; Siqing Fu; Sarina Piha-Paul; Aung Naing; Filip Janku; Kenneth Aldape; Yang Ye; Razelle Kurzrock; Donald Berry
Cancer Therapy: Preclinical
Biology of Human Tumors
Novel MSH6 Mutations in Treatment-Naïve Glioblastoma and Anaplastic Oligodendroglioma Contribute to Temozolomide Resistance Independently of MGMT Promoter Methylation
Stephanie A. Nguyen; Owen D.M. Stechishin; H. Artee Luchman; Xueqing Q. Lun; Donna L. Senger; Stephen M. Robbins; J. Gregory Cairncross; Samuel Weiss
SPINK1 Protein Expression and Prostate Cancer Progression
Richard Flavin; Andreas Pettersson; Whitney K. Hendrickson; Michelangelo Fiorentino; Stephen Finn; Lauren Kunz; Gregory L. Judson; Rosina Lis; Dyane Bailey; Christopher Fiore; Elizabeth Nuttall; Neil E. Martin; Edward Stack; Kathryn L. Penney; Jennifer R. Rider; Jennifer Sinnott; Christopher Sweeney; Howard D. Sesso; Katja Fall; Edward Giovannucci; Philip Kantoff; Meir Stampfer; Massimo Loda; Lorelei A. Mucci
Evidence for Molecular Differences in Prostate Cancer between African American and Caucasian Men
Francesca Khani; Juan Miguel Mosquera; Kyung Park; Mirjam Blattner; Catherine O'Reilly; Theresa Y. MacDonald; Zhengming Chen; Abhishek Srivastava; Ashutosh K. Tewari; Christopher E. Barbieri; Mark A. Rubin; Brian D. Robinson
Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer
Michael L. Nickerson; Garrett M. Dancik; Kate M. Im; Michael G. Edwards; Sevilay Turan; Joseph Brown; Christina Ruiz-Rodriguez; Charles Owens; James C. Costello; Guangwu Guo; Shirley X. Tsang; Yingrui Li; Quan Zhou; Zhiming Cai; Lee E. Moore; M. Scott Lucia; Michael Dean; Dan Theodorescu
Excess of Proximal Microsatellite-Stable Colorectal Cancer in African Americans from a Multiethnic Study
Rosa M. Xicola; Molly Gagnon; Julia R. Clark; Timothy Carroll; Weihua Gao; Christian Fernandez; Dragana Mijic; James B. Rawson; Ashley Janoski; Cenk K. Pusatcioglu; Priyanka Rajaram; Adam B. Gluskin; Maureen Regan; Vivek Chaudhry; Herand Abcarian; Jennifer Blumetti; Jose Cintron; Joshua Melson; Hui Xie; Grace Guzman; Rajyasree Emmadi; Victoria Alagiozian-Angelova; Sonia S. Kupfer; Carol Braunschweig; Nathan A. Ellis; Xavier Llor
Letters to the Editor
Correction
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