Skip Nav Destination
Issues
1 September 2014
-
Cover Image
Cover Image
The cover shows the crystal structure of the SAR650984-Fab in complex with human CD38 resolved at 1.53 Å resolution. A close-up view of the epitope highlights the interface between human CD38 and SAR650984-Fab, which involves mainly antibody heavy chain CDR loop H3 (yellow) and light chain CDR loops L1, L2 and L3 (green). For details, see the article by Deckert and colleagues on page 4574 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
CCR Perspectives in Drug Approval
FDA Approval: Ado-Trastuzumab Emtansine for the Treatment of Patients with HER2-Positive Metastatic Breast Cancer
Laleh Amiri-Kordestani; Gideon M. Blumenthal; Qiang Casey Xu; Lijun Zhang; Shenghui W. Tang; Linan Ha; Wendy C. Weinberg; Bo Chi; Reyes Candau-Chacon; Patricia Hughes; Anne M. Russell; Sarah Pope Miksinski; Xiao Hong Chen; W. David McGuinn; Todd Palmby; Sarah J. Schrieber; Qi Liu; Jian Wang; Pengfei Song; Nitin Mehrotra; Lisa Skarupa; Kathleen Clouse; Ali Al-Hakim; Rajeshwari Sridhara; Amna Ibrahim; Robert Justice; Richard Pazdur; Patricia Cortazar
Molecular Pathways
Cancer Therapy: Clinical
Dose Selection, Pharmacokinetics, and Pharmacodynamics of BRAF Inhibitor Dabrafenib (GSK2118436)
Gerald S. Falchook; Georgina V. Long; Razelle Kurzrock; Kevin B. Kim; H.-Tobias Arkenau; Michael P. Brown; Omid Hamid; Jeffrey R. Infante; Michael Millward; Anna Pavlick; Melvin T. Chin; Steven J. O'Day; Samuel C. Blackman; C. Martin Curtis; Peter Lebowitz; Bo Ma; Daniele Ouellet; Richard F. Kefford
p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8+ T-cell Responses
Nicola R. Hardwick; Mary Carroll; Teodora Kaltcheva; Dajun Qian; Dean Lim; Lucille Leong; Peiguo Chu; Joseph Kim; Joseph Chao; Marwan Fakih; Yun Yen; Jonathan Espenschied; Joshua D. I. Ellenhorn; Don J. Diamond; Vincent Chung
Phase I Safety and Pharmacodynamic of Inecalcitol, a Novel VDR Agonist with Docetaxel in Metastatic Castration-Resistant Prostate Cancer Patients
Jacques Medioni; Gael Deplanque; Jean-Marc Ferrero; Tristan Maurina; Jean-Michel P. Rodier; Eric Raymond; Jorge Allyon; Gerard Maruani; Pascal Houillier; Sarah Mackenzie; Stephanie Renaux; Jean-Francois Dufour-Lamartinie; Reza Elaidi; Celine Lerest; Stephane Oudard
Personalized Medicine and Imaging
Biomarker Analyses from a Placebo-Controlled Phase II Study Evaluating Erlotinib ± Onartuzumab in Advanced Non–Small Cell Lung Cancer: MET Expression Levels Are Predictive of Patient Benefit
Hartmut Koeppen; Wei Yu; Jiping Zha; Ajay Pandita; Elicia Penuel; Linda Rangell; Rajiv Raja; Sankar Mohan; Rajesh Patel; Rupal Desai; Ling Fu; An Do; Vaishali Parab; Xiaoling Xia; Tom Januario; Sharianne G. Louie; Ellen Filvaroff; David S. Shames; Ignacio Wistuba; Marina Lipkind; Jenny Huang; Mirella Lazarov; Vanitha Ramakrishnan; Lukas Amler; See-Chun Phan; Premal Patel; Amy Peterson; Robert L. Yauch
A let-7 microRNA-Binding Site Polymorphism in KRAS Predicts Improved Outcome in Patients with Metastatic Colorectal Cancer Treated with Salvage Cetuximab/Panitumumab Monotherapy
Zenia Saridaki; Joanne B. Weidhaas; Heinz-Josef Lenz; Pierre Laurent-Puig; Bart Jacobs; Jef De Schutter; Wendy De Roock; David W. Salzman; Wu Zhang; Dongyun Yang; Camilla Pilati; Olivier Bouché; Hubert Piessevaux; Sabine Tejpar
FcγRIIa and FcγRIIIa Polymorphisms and Cetuximab Benefit in the Microscopic Disease
Francesco Sclafani; David Gonzalez de Castro; David Cunningham; Sanna Hulkki Wilson; Clare Peckitt; Jaume Capdevila; Bengt Glimelius; Susana Roselló Keränen; Andrew Wotherspoon; Gina Brown; Diana Tait; Ruwaida Begum; Janet Thomas; Jacqueline Oates; Ian Chau
Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
Santi Suryani; Hernan Carol; Triona Ni Chonghaile; Viktoras Frismantas; Chintanu Sarmah; Laura High; Beat Bornhauser; Mark J. Cowley; Barbara Szymanska; Kathryn Evans; Ingrid Boehm; Elise Tonna; Luke Jones; Donya Moradi Manesh; Raushan T. Kurmasheva; Catherine Billups; Warren Kaplan; Anthony Letai; Jean-Pierre Bourquin; Peter J. Houghton; Malcolm A. Smith; Richard B. Lock
Author Choice
The Combination of Circulating Ang1 and Tie2 Levels Predicts Progression-Free Survival Advantage in Bevacizumab-Treated Patients with Ovarian Cancer
Alison Backen; Andrew G. Renehan; Andrew R. Clamp; Carlo Berzuini; Cong Zhou; Amit Oza; Selina Bannoo; Stefan J. Scherer; Rosamonde E. Banks; Caroline Dive; Gordon C. Jayson
Cancer Therapy: Preclinical
Author Choice
Functional Genetic Approach Identifies MET, HER3, IGF1R, INSR Pathways as Determinants of Lapatinib Unresponsiveness in HER2-Positive Gastric Cancer
Zhe Zhang; Jiping Wang; Dongmei Ji; Chenchen Wang; Rujiao Liu; Zheng Wu; Lian Liu; Dan Zhu; Jinjia Chang; Ruixuan Geng; Lei Xiong; Qiangyi Fang; Jin Li
SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies
Jutta Deckert; Marie-Cécile Wetzel; Laura M. Bartle; Anna Skaletskaya; Victor S. Goldmacher; François Vallée; Qing Zhou-Liu; Paul Ferrari; Stéphanie Pouzieux; Charlotte Lahoute; Charles Dumontet; Adriana Plesa; Marielle Chiron; Pascale Lejeune; Thomas Chittenden; Peter U. Park; Véronique Blanc
Biology of Human Tumors
Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Zhaojun Liu; Jun Zhang; Yanhong Gao; Lirong Pei; Jing Zhou; Liankun Gu; Lianhai Zhang; Budong Zhu; Naoko Hattori; Jiafu Ji; Yasuhito Yuasa; Wooho Kim; Toshikazu Ushijima; Huidong Shi; Dajun Deng
Noninvasive Diagnosis of Actionable Mutations by Deep Sequencing of Circulating Free DNA in Lung Cancer from Never-Smokers: A Proof-of-Concept Study from BioCAST/IFCT-1002
Sébastien Couraud; Felipe Vaca-Paniagua; Stéphanie Villar; Javier Oliver; Tibor Schuster; Hélène Blanché; Nicolas Girard; Jean Trédaniel; Laurent Guilleminault; Radj Gervais; Nathalie Prim; Michel Vincent; Jacques Margery; Sébastien Larivé; Pascal Foucher; Bernard Duvert; Maxime Vallee; Florence Le Calvez-Kelm; James McKay; Pascale Missy; Franck Morin; Gérard Zalcman; Magali Olivier; Pierre-Jean Souquet; for the BioCAST/IFCT-1002 investigators
Expression of Androgen and Estrogen Signaling Components and Stem Cell Markers to Predict Cancer Progression and Cancer-Specific Survival in Patients with Metastatic Prostate Cancer
Tetsuya Fujimura; Satoru Takahashi; Tomohiko Urano; Kenichi Takayama; Toru Sugihara; Daisuke Obinata; Yuta Yamada; Jimpei Kumagai; Haruki Kume; Yasuyoshi Ouchi; Satoshi Inoue; Yukio Homma
miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Sajni Josson; Murali Gururajan; Peizhen Hu; Chen Shao; Gina Chia-Yi Chu; Haiyen E. Zhau; Chunyan Liu; Kaiqin Lao; Chia-Lun Lu; Yi-Tsung Lu; Jake Lichterman; Srinivas Nandana; Quanlin Li; Andre Rogatko; Dror Berel; Edwin M. Posadas; Ladan Fazli; Dhruv Sareen; Leland W.K. Chung
Nondisruptive p53 Mutations Are Associated with Shorter Survival in Patients with Advanced Non–Small Cell Lung Cancer
Miguel A. Molina-Vila; Jordi Bertran-Alamillo; Amaya Gascó; Clara Mayo-de-las-Casas; María Sánchez-Ronco; Laia Pujantell-Pastor; Laura Bonanno; Adolfo G. Favaretto; Andrés F. Cardona; Alain Vergnenègre; Margarita Majem; Bartomeu Massuti; Teresa Morán; Enric Carcereny; Santiago Viteri; Rafael Rosell
An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non–Small Cell Lung Cancer
Satoshi Noguchi; Akira Saito; Masafumi Horie; Yu Mikami; Hiroshi I. Suzuki; Yasuyuki Morishita; Mitsuhiro Ohshima; Yoshimitsu Abiko; Johanna Sofia Margareta Mattsson; Helena König; Miriam Lohr; Karolina Edlund; Johan Botling; Patrick Micke; Takahide Nagase
To “Grow” or “Go”: TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN
Daniel J. Shiwarski; Chunbo Shao; Anke Bill; Jean Kim; Dong Xiao; Carol A. Bertrand; Raja S. Seethala; Daisuke Sano; Jeffery N. Myers; Patrick Ha; Jennifer Grandis; L. Alex Gaither; Manojkumar A. Puthenveedu; Umamaheswar Duvvuri
Author Choice
TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome
Tiantian Sun; Wan Du; Hua Xiong; Yanan Yu; Yurong Weng; Linlin Ren; Huijun Zhao; Yingchao Wang; Yingxuan Chen; Jie Xu; Yongbing Xiang; Wenxin Qin; Weibiao Cao; Weiping Zou; Haoyan Chen; Jie Hong; Jing-Yuan Fang
Advertisement
Email alerts
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
RSS Feeds