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15 August 2014
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Cover Image
Cover Image
Integrative analysis of clear cell renal cell carcinoma shows predominant hypermethylation: A circos plot shows alterations in DNA methylation (hypermethyltion in blue, outer ring), copy number variations (amplifications in red and deletions in green, middle ring), and expression (underexpressed in green, overexpressed in orange; innermost ring) in renal cell carcinoma when compared. For details, see the article by Hu and colleagues on page 4349 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Statistics in Clinical Cancer Research
Molecular Pathways
Perspectives
Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma
Chand Khanna; Timothy M. Fan; Richard Gorlick; Lee J. Helman; Eugenie S. Kleinerman; Peter C. Adamson; Peter J. Houghton; William D. Tap; Danny R. Welch; Patricia S. Steeg; Glenn Merlino; Poul H.B. Sorensen; Paul Meltzer; David G. Kirsch; Katherine A. Janeway; Brenda Weigel; Lor Randall; Stephen J Withrow; Melissa Paoloni; Rosandra Kaplan; Beverly A. Teicher; Nita L. Seibel; Malcolm Smith; Aykut Üren; Shreyaskumar R. Patel; Jeffrey Trent; Sharon A. Savage; Lisa Mirabello; Denise Reinke; Donald A. Barkaukas; Mark Krailo; Mark Bernstein
Review
Design of Phase I Combination Trials: Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee
Channing J. Paller; Penelope A. Bradbury; S. Percy Ivy; Lesley Seymour; Patricia M. LoRusso; Laurence Baker; Larry Rubinstein; Erich Huang; Deborah Collyar; Susan Groshen; Steven Reeves; Lee M. Ellis; Daniel J. Sargent; Gary L. Rosner; Michael L. LeBlanc; Mark J. Ratain
Cancer Therapy: Clinical
Author Choice
Phase II Study of Single-Agent Orteronel (TAK-700) in Patients with Nonmetastatic Castration-Resistant Prostate Cancer and Rising Prostate-Specific Antigen
Maha Hussain; Paul G. Corn; M. Dror Michaelson; Hans J. Hammers; Joshi J. Alumkal; Charles J. Ryan; Justine Y. Bruce; Susan Moran; Shih-Yuan Lee; H. Mark Lin; Daniel J. George; for the Prostate Cancer Clinical Trials Consortium, a program of the Department of Defense Prostate Cancer Research Program and the Prostate Cancer Foundation
Treatment with Chemotherapy and Dendritic Cells Pulsed with Multiple Wilms' Tumor 1 (WT1)–Specific MHC Class I/II–Restricted Epitopes for Pancreatic Cancer
Shigeo Koido; Sadamu Homma; Masato Okamoto; Kazuki Takakura; Masako Mori; Shinji Yoshizaki; Shintaro Tsukinaga; Shunichi Odahara; Seita Koyama; Hiroo Imazu; Kan Uchiyama; Mikio Kajihara; Hiroshi Arakawa; Takeyuki Misawa; Yoichi Toyama; Satoru Yanagisawa; Masahiro Ikegami; Shin Kan; Kazumi Hayashi; Hideo Komita; Yuko Kamata; Masaki Ito; Takefumi Ishidao; Sei-ichi Yusa; Shigetaka Shimodaira; Jianlin Gong; Haruo Sugiyama; Toshifumi Ohkusa; Hisao Tajiri
Randomized Phase Ib/II Trial of Rilotumumab or Ganitumab with Panitumumab versus Panitumumab Alone in Patients with Wild-type KRAS Metastatic Colorectal Cancer
Eric Van Cutsem; Cathy Eng; Elzbieta Nowara; Anna Świeboda-Sadlej; Niall C. Tebbutt; Edith Mitchell; Irina Davidenko; Joe Stephenson; Elena Elez; Hans Prenen; Hongjie Deng; Rui Tang; Ian McCaffery; Kelly S. Oliner; Lisa Chen; Jennifer Gansert; Elwyn Loh; Dominic Smethurst; Josep Tabernero
Phase I Expansion and Pharmacodynamic Study of the Oral MEK Inhibitor RO4987655 (CH4987655) in Selected Patients with Advanced Cancer with RAS–RAF Mutations
Lisa Zimmer; Fabrice Barlesi; Maria Martinez-Garcia; Veronique Dieras; Jan H.M. Schellens; Jean-Philippe Spano; Mark R. Middleton; Emiliano Calvo; Luiz Paz-Ares; James Larkin; Simon Pacey; Miro Venturi; Françoise Kraeber-Bodéré; Jean J.L. Tessier; Wilfried Ernst Erich Eberhardt; Michel Paques; Ernesto Guarin; Valerie Meresse; Jean-Charles Soria
Cancer Therapy: Preclinical
Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors
Edmund K. Moon; Liang-Chuan Wang; Douglas V. Dolfi; Caleph B. Wilson; Raghuveer Ranganathan; Jing Sun; Veena Kapoor; John Scholler; Ellen Puré; Michael C. Milone; Carl H. June; James L. Riley; E. John Wherry; Steven M. Albelda
Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer
Russell Moser; Chang Xu; Michael Kao; James Annis; Luisa Angelica Lerma; Christopher M. Schaupp; Kay E. Gurley; In Sock Jang; Asel Biktasova; Wendell G. Yarbrough; Adam A. Margolin; Carla Grandori; Christopher J. Kemp; Eduardo Méndez
Author Choice
Intraperitoneal Oxidative Stress in Rabbits with Papillomavirus-Associated Head and Neck Cancer Induces Tumoricidal Immune Response That Is Adoptively Transferable
Annette Rossmann; Robert Mandic; Jochen Heinis; Helmut Höffken; Oliver Küssner; Ralf Kinscherf; Eberhard Weihe; Michael Bette
Acquired Resistance to Endocrine Treatments Is Associated with Tumor-Specific Molecular Changes in Patient-Derived Luminal Breast Cancer Xenografts
Paul Cottu; Ivan Bièche; Franck Assayag; Rania El Botty; Sophie Chateau-Joubert; Aurélie Thuleau; Thomas Bagarre; Benoit Albaud; Audrey Rapinat; David Gentien; Pierre de la Grange; Vonick Sibut; Sophie Vacher; Rana Hatem; Jean-Luc Servely; Jean-Jacques Fontaine; Didier Decaudin; Jean-Yves Pierga; Sergio Roman-Roman; Elisabetta Marangoni
Biology of Human Tumors
Kidney Cancer Is Characterized by Aberrant Methylation of Tissue-Specific Enhancers That Are Prognostic for Overall Survival
Caroline Y. Hu; Davoud Mohtat; Yiting Yu; Yi-An Ko; Niraj Shenoy; Sanchari Bhattacharya; Maria C. Izquierdo; Ae Seo Deok Park; Orsolya Giricz; Nishanth Vallumsetla; Krishna Gundabolu; Kristin Ware; Tushar D. Bhagat; Masako Suzuki; James Pullman; X. Shirley Liu; John M. Greally; Katalin Susztak; Amit Verma
Molecular Testing for Lymph Node Metastases as a Determinant of Colon Cancer Recurrence: Results from a Retrospective Multicenter Study
Daniel J. Sargent; Qian Shi; Sharlene Gill; Christophe Louvet; Richard B. Everson; Udo Kellner; Thomas E. Clancy; J. Marc Pipas; Murray B. Resnick; Michael O. Meyers; Tsung-Teh Wu; David Huntsman; Pierre Validire; Umar Farooq; Emily S. Pavey; Guillaume Beaudry; Jean-Francois Haince; Yves Fradet
Preoperative GNAS and KRAS Testing in the Diagnosis of Pancreatic Mucinous Cysts
Aatur D. Singhi; Marina N. Nikiforova; Kenneth E. Fasanella; Kevin M. McGrath; Reetesh K. Pai; N. Paul Ohori; Tanner L. Bartholow; Randall E. Brand; Jennifer S. Chennat; Xuong Lu; Georgios I. Papachristou; Adam Slivka; Herbert J. Zeh; Amer H. Zureikat; Kenneth K. Lee; Allan Tsung; Geeta S. Mantha; Asif Khalid
Circulating CD4+ T Cells That Produce IL4 or IL17 When Stimulated by Melan-A but Not by NY-ESO-1 Have Negative Impacts on Survival of Patients with Stage IV Melanoma
Henning Zelba; Benjamin Weide; Alexander Martens; Evelyna Derhovanessian; Jithendra Kini Bailur; Christina Kyzirakos; Annette Pflugfelder; Thomas K. Eigentler; Anna Maria Di Giacomo; Michele Maio; Erik H.J.G. Aarntzen; Jolanda de Vries; Antje Sucker; Dirk Schadendorf; Petra Büttner; Claus Garbe; Graham Pawelec
Corrections
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