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1 August 2014
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Cover Image
Cover Image
The cover shows a molecular network related to EGFR-TKI resistance in non-small cell lung cancer. Tyrosine phosphoproteomics identifies Src family kinases (SFK) as a central signaling hub in TKI-resistant cells with T790M gatekeeper mutation. For details, see the article by Yoshida and colleagues on page 4059 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Drug Approval
U.S. Food and Drug Administration Approval: Obinutuzumab in Combination with Chlorambucil for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia
Hyon-Zu Lee; Barry W. Miller; Virginia E. Kwitkowski; Stacey Ricci; Pedro DelValle; Haleh Saber; Joseph Grillo; Julie Bullock; Jeffry Florian; Nitin Mehrotra; Chia-Wen Ko; Lei Nie; Marjorie Shapiro; Mate Tolnay; Robert C. Kane; Edvardas Kaminskas; Robert Justice; Ann T. Farrell; Richard Pazdur
Molecular Pathways
Review
Cancer Therapy: Clinical
Personalized Medicine and Imaging
Author Choice
89Zr-trastuzumab and 89Zr-bevacizumab PET to Evaluate the Effect of the HSP90 Inhibitor NVP-AUY922 in Metastatic Breast Cancer Patients
Sietske B.M. Gaykema; Carolien P. Schröder; Joanna Vitfell-Rasmussen; Sue Chua; Thijs H. Oude Munnink; Adrienne H. Brouwers; Alfons H.H. Bongaerts; Mikhail Akimov; Cristina Fernandez-Ibarra; Marjolijn N. Lub-de Hooge; Elisabeth G.E. de Vries; Charles Swanton; Udai Banerji
Biomarkers of Bone Remodeling in Multiple Myeloma Patients to Tailor Bisphosphonate Therapy
Chirayu G. Patel; Andrew J. Yee; Tyler A. Scullen; Neeharika Nemani; Loredana Santo; Paul G. Richardson; Jacob P. Laubach; Irene M. Ghobrial; Robert L. Schlossman; Nikhil C. Munshi; Kenneth C. Anderson; Noopur S. Raje
Differences in the Transcriptional Response to Fulvestrant and Estrogen Deprivation in ER-Positive Breast Cancer
Neill Patani; Anita K. Dunbier; Helen Anderson; Zara Ghazoui; Ricardo Ribas; Elizabeth Anderson; Qiong Gao; Roger A'hern; Alan Mackay; Justin Lindemann; Robert Wellings; Jill Walker; Irene Kuter; Lesley-Ann Martin; Mitch Dowsett
Cancer Therapy: Preclinical
NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia
Beatriz Sánchez-Sánchez; Sara Gutiérrez-Herrero; Guillermo López-Ruano; Rodrigo Prieto-Bermejo; Marta Romo-González; Marcial Llanillo; Atanasio Pandiella; Carmen Guerrero; Jesús F. San Miguel; Fermín Sánchez-Guijo; Consuelo del Cañizo; Angel Hernández-Hernández
Author Choice
Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein
Nicholas Veomett; Tao Dao; Hong Liu; Jingyi Xiang; Dmitry Pankov; Leonid Dubrovsky; Joseph A. Whitten; Sun-Mi Park; Tatyana Korontsvit; Victoria Zakhaleva; Emily Casey; Michael Curcio; Michael G. Kharas; Richard J. O'Reilly; Cheng Liu; David A. Scheinberg
Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer
Takeshi Yoshida; Guolin Zhang; Matthew A. Smith; Alex S. Lopez; Yun Bai; Jiannong Li; Bin Fang; John Koomen; Bhupendra Rawal; Kate J. Fisher; Ann Y. Chen; Michiko Kitano; Yume Morita; Haruka Yamaguchi; Kiyoko Shibata; Takafumi Okabe; Isamu Okamoto; Kazuhiko Nakagawa; Eric B. Haura
Biology of Human Tumors
FGFR1/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non–Small Cell Lung Cancer
Rui Wang; Lei Wang; Yuan Li; Haichuan Hu; Lei Shen; Xuxia Shen; Yunjian Pan; Ting Ye; Yang Zhang; Xiaoyang Luo; Yiliang Zhang; Bin Pan; Bin Li; Hang Li; Jie Zhang; William Pao; Hongbin Ji; Yihua Sun; Haiquan Chen
Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Gabriel G. Malouf; Xiaoping Su; Hui Yao; Jianjun Gao; Liangwen Xiong; Qiuming He; Eva Compérat; Jérôme Couturier; Vincent Molinié; Bernard Escudier; Philippe Camparo; Denaha J. Doss; Erika J. Thompson; David Khayat; Christopher G. Wood; Willie Yu; Bin T. Teh; John Weinstein; Nizar M. Tannir
microRNAome Expression in Chronic Lymphocytic Leukemia: Comparison with Normal B-cell Subsets and Correlations with Prognostic and Clinical Parameters
Massimo Negrini; Giovanna Cutrona; Cristian Bassi; Sonia Fabris; Barbara Zagatti; Monica Colombo; Manuela Ferracin; Lucilla D'Abundo; Elena Saccenti; Serena Matis; Marta Lionetti; Luca Agnelli; Massimo Gentile; Anna Grazia Recchia; Sabrina Bossio; Daniele Reverberi; Gianmatteo Rigolin; George A. Calin; Silvia Sabbioni; Giandomenico Russo; Pierfrancesco Tassone; Fortunato Morabito; Manlio Ferrarini; Antonino Neri
Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non–Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway
Chunli Shao; James P. Sullivan; Luc Girard; Alexander Augustyn; Paul Yenerall; Jaime Rodriguez-Canales; Hui Liu; Carmen Behrens; Jerry W. Shay; Ignacio I. Wistuba; John D. Minna
Letter to the Editor
Correction
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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