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1 August 2014
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The cover shows a molecular network related to EGFR-TKI resistance in non-small cell lung cancer. Tyrosine phosphoproteomics identifies Src family kinases (SFK) as a central signaling hub in TKI-resistant cells with T790M gatekeeper mutation. For details, see the article by Yoshida and colleagues on page 4059 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Drug Approval
U.S. Food and Drug Administration Approval: Obinutuzumab in Combination with Chlorambucil for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia
Hyon-Zu Lee; Barry W. Miller; Virginia E. Kwitkowski; Stacey Ricci; Pedro DelValle; Haleh Saber; Joseph Grillo; Julie Bullock; Jeffry Florian; Nitin Mehrotra; Chia-Wen Ko; Lei Nie; Marjorie Shapiro; Mate Tolnay; Robert C. Kane; Edvardas Kaminskas; Robert Justice; Ann T. Farrell; Richard Pazdur
Molecular Pathways
Review
Cancer Therapy: Clinical
Personalized Medicine and Imaging
Author Choice
89Zr-trastuzumab and 89Zr-bevacizumab PET to Evaluate the Effect of the HSP90 Inhibitor NVP-AUY922 in Metastatic Breast Cancer Patients
Sietske B.M. Gaykema; Carolien P. Schröder; Joanna Vitfell-Rasmussen; Sue Chua; Thijs H. Oude Munnink; Adrienne H. Brouwers; Alfons H.H. Bongaerts; Mikhail Akimov; Cristina Fernandez-Ibarra; Marjolijn N. Lub-de Hooge; Elisabeth G.E. de Vries; Charles Swanton; Udai Banerji
Biomarkers of Bone Remodeling in Multiple Myeloma Patients to Tailor Bisphosphonate Therapy
Chirayu G. Patel; Andrew J. Yee; Tyler A. Scullen; Neeharika Nemani; Loredana Santo; Paul G. Richardson; Jacob P. Laubach; Irene M. Ghobrial; Robert L. Schlossman; Nikhil C. Munshi; Kenneth C. Anderson; Noopur S. Raje
Differences in the Transcriptional Response to Fulvestrant and Estrogen Deprivation in ER-Positive Breast Cancer
Neill Patani; Anita K. Dunbier; Helen Anderson; Zara Ghazoui; Ricardo Ribas; Elizabeth Anderson; Qiong Gao; Roger A'hern; Alan Mackay; Justin Lindemann; Robert Wellings; Jill Walker; Irene Kuter; Lesley-Ann Martin; Mitch Dowsett
Cancer Therapy: Preclinical
NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia
Beatriz Sánchez-Sánchez; Sara Gutiérrez-Herrero; Guillermo López-Ruano; Rodrigo Prieto-Bermejo; Marta Romo-González; Marcial Llanillo; Atanasio Pandiella; Carmen Guerrero; Jesús F. San Miguel; Fermín Sánchez-Guijo; Consuelo del Cañizo; Angel Hernández-Hernández
Author Choice
Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein
Nicholas Veomett; Tao Dao; Hong Liu; Jingyi Xiang; Dmitry Pankov; Leonid Dubrovsky; Joseph A. Whitten; Sun-Mi Park; Tatyana Korontsvit; Victoria Zakhaleva; Emily Casey; Michael Curcio; Michael G. Kharas; Richard J. O'Reilly; Cheng Liu; David A. Scheinberg
Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer
Takeshi Yoshida; Guolin Zhang; Matthew A. Smith; Alex S. Lopez; Yun Bai; Jiannong Li; Bin Fang; John Koomen; Bhupendra Rawal; Kate J. Fisher; Ann Y. Chen; Michiko Kitano; Yume Morita; Haruka Yamaguchi; Kiyoko Shibata; Takafumi Okabe; Isamu Okamoto; Kazuhiko Nakagawa; Eric B. Haura
Biology of Human Tumors
FGFR1/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non–Small Cell Lung Cancer
Rui Wang; Lei Wang; Yuan Li; Haichuan Hu; Lei Shen; Xuxia Shen; Yunjian Pan; Ting Ye; Yang Zhang; Xiaoyang Luo; Yiliang Zhang; Bin Pan; Bin Li; Hang Li; Jie Zhang; William Pao; Hongbin Ji; Yihua Sun; Haiquan Chen
Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Gabriel G. Malouf; Xiaoping Su; Hui Yao; Jianjun Gao; Liangwen Xiong; Qiuming He; Eva Compérat; Jérôme Couturier; Vincent Molinié; Bernard Escudier; Philippe Camparo; Denaha J. Doss; Erika J. Thompson; David Khayat; Christopher G. Wood; Willie Yu; Bin T. Teh; John Weinstein; Nizar M. Tannir
microRNAome Expression in Chronic Lymphocytic Leukemia: Comparison with Normal B-cell Subsets and Correlations with Prognostic and Clinical Parameters
Massimo Negrini; Giovanna Cutrona; Cristian Bassi; Sonia Fabris; Barbara Zagatti; Monica Colombo; Manuela Ferracin; Lucilla D'Abundo; Elena Saccenti; Serena Matis; Marta Lionetti; Luca Agnelli; Massimo Gentile; Anna Grazia Recchia; Sabrina Bossio; Daniele Reverberi; Gianmatteo Rigolin; George A. Calin; Silvia Sabbioni; Giandomenico Russo; Pierfrancesco Tassone; Fortunato Morabito; Manlio Ferrarini; Antonino Neri
Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non–Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway
Chunli Shao; James P. Sullivan; Luc Girard; Alexander Augustyn; Paul Yenerall; Jaime Rodriguez-Canales; Hui Liu; Carmen Behrens; Jerry W. Shay; Ignacio I. Wistuba; John D. Minna
Letter to the Editor
Correction
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