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15 July 2014
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Cover Image
Cover Image
Reverse-phase protein array on different breast cancer biospecimens: fine needle aspirate, core needle biopsy, and surgical samples. The correlation between different biospecimens for each biomarker is depicted as a heatmap. Red, high positive correlation; green, negative correlation. For details, see the article by Meric-Bernstam and colleagues on page 3870 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
Editorial
CCR Translations
CCR Drug Updates
Molecular Pathways
Review
Cancer Therapy: Clinical
Author Choice
A Randomized, Multicenter, Placebo-Controlled Clinical Trial of Racotumomab-Alum Vaccine as Switch Maintenance Therapy in Advanced Non–Small Cell Lung Cancer Patients
Sailyn Alfonso; Anet Valdés-Zayas; Eduardo R. Santiesteban; Yoanna I. Flores; Fernando Areces; Maurenis Hernández; Carmen E. Viada; Ivis C. Mendoza; Pedro P. Guerra; Elena García; Ramón A. Ortiz; Ana V. de la Torre; Meylán Cepeda; Kirenia Pérez; Eric Chong; Ana María Hernández; Darien Toledo; Zuyén González; Zaima Mazorra; Tania Crombet; Rolando Pérez; Ana María Vázquez; Amparo E. Macías
A Randomized Phase II Presurgical Trial of Transdermal 4-Hydroxytamoxifen Gel versus Oral Tamoxifen in Women with Ductal Carcinoma In Situ of the Breast
Oukseub Lee; Katherine Page; David Ivancic; Irene Helenowski; Vamsi Parini; Megan E. Sullivan; Julie A. Margenthaler; Robert T. Chatterton, Jr; Borko Jovanovic; Barbara K. Dunn; Brandy M. Heckman-Stoddard; Kathleen Foster; Miguel Muzzio; Julia Shklovskaya; Silvia Skripkauskas; Piotr Kulesza; David Green; Nora M. Hansen; Kevin P. Bethke; Jacqueline S. Jeruss; Raymond Bergan; Seema A. Khan
A Phase I Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma
Donald W. Northfelt; Ramesh K. Ramanathan; Peter A. Cohen; Daniel D. Von Hoff; Glen J. Weiss; Gregory N. Dietsch; Kristi L. Manjarrez; Tressa D. Randall; Robert M. Hershberg
Real-Time Immune Monitoring to Guide Plasmid DNA Vaccination Schedule Targeting Prostatic Acid Phosphatase in Patients with Castration-Resistant Prostate Cancer
Douglas G. McNeel; Jordan T. Becker; Jens C. Eickhoff; Laura E. Johnson; Eric Bradley; Isabel Pohlkamp; Mary Jane Staab; Glenn Liu; George Wilding; Brian M. Olson
Personalized Medicine and Imaging
Cancer Therapy: Preclinical
Discordant In Vitro and In Vivo Chemopotentiating Effects of the PARP Inhibitor Veliparib in Temozolomide-Sensitive versus -Resistant Glioblastoma Multiforme Xenografts
Shiv K. Gupta; Ann C. Mladek; Brett L. Carlson; Felix Boakye-Agyeman; Katrina K. Bakken; Sani H. Kizilbash; Mark A. Schroeder; Joel Reid; Jann N. Sarkaria
Preclinical Optimization of MDM2 Antagonist Scheduling for Cancer Treatment by Using a Model-Based Approach
Brian Higgins; Kelli Glenn; Antje Walz; Christian Tovar; Zoran Filipovic; Sazzad Hussain; Edmund Lee; Kenneth Kolinsky; Shahid Tannu; Violeta Adames; Rosario Garrido; Michael Linn; Christophe Meille; David Heimbrook; Lyubomir Vassilev; Kathryn Packman
CSPG4-Specific Immunity and Survival Prolongation in Dogs with Oral Malignant Melanoma Immunized with Human CSPG4 DNA
Federica Riccardo; Selina Iussich; Lorella Maniscalco; Saray Lorda Mayayo; Giuseppe La Rosa; Maddalena Arigoni; Raffaella De Maria; Francesca Gattino; Stefania Lanzardo; Elena Lardone; Marina Martano; Emanuela Morello; Simone Prestigio; Alessandra Fiore; Elena Quaglino; Sara Zabarino; Soldano Ferrone; Paolo Buracco; Federica Cavallo
Author Choice
Semi-Mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Antitumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts
Sonya C. Tate; Shufen Cai; Rose T. Ajamie; Teresa Burke; Richard P. Beckmann; Edward M. Chan; Alfonso De Dios; Graham N. Wishart; Lawrence M. Gelbert; Damien M. Cronier
Primary and Acquired Resistance of Colorectal Cancer Cells to Anti-EGFR Antibodies Converge on MEK/ERK Pathway Activation and Can Be Overcome by Combined MEK/EGFR Inhibition
Teresa Troiani; Stefania Napolitano; Donata Vitagliano; Floriana Morgillo; Anna Capasso; Vincenzo Sforza; Anna Nappi; Davide Ciardiello; Fortunato Ciardiello; Erika Martinelli
Bortezomib-Induced Unfolded Protein Response Increases Oncolytic HSV-1 Replication Resulting in Synergistic Antitumor Effects
Ji Young Yoo; Brian S. Hurwitz; Chelsea Bolyard; Jun-Ge Yu; Jianying Zhang; Karuppaiyah Selvendiran; Kellie S. Rath; Shun He; Zachary Bailey; David Eaves; Timothy P. Cripe; Deborah S. Parris; Michael A. Caligiuri; Jianhua Yu; Matthew Old; Balveen Kaur
Biology of Human Tumors
CLIC4, ERp29, and Smac/DIABLO Derived from Metastatic Cancer Stem–like Cells Stratify Prognostic Risks of Colorectal Cancer
Yong-Jian Deng; Na Tang; Chao Liu; Jiang-Yu Zhang; Sheng-Li An; Yin-Li Peng; Li-Li Ma; Guang-Qiu Li; Qiang Jiang; Chun-Ting Hu; Ya-Nan Wang; Yao-Ze Liang; Xiu-Wu Bian; Wei-Gang Fang; Yan-Qing Ding
Circulating Tumor Cells in Patients with Testicular Germ Cell Tumors
Paulina Nastały; Christian Ruf; Pascal Becker; Natalia Bednarz-Knoll; Małgorzata Stoupiec; Refik Kavsur; Hendrik Isbarn; Cord Matthies; Walter Wagner; Dirk Höppner; Margit Fisch; Carsten Bokemeyer; Sascha Ahyai; Friedemann Honecker; Sabine Riethdorf; Klaus Pantel
Squamous Cell Carcinoma of the Oral Tongue in Young Non-Smokers Is Genomically Similar to Tumors in Older Smokers
Curtis R. Pickering; Jiexin Zhang; David M. Neskey; Mei Zhao; Samar A. Jasser; Jiping Wang; Alexandra Ward; C. Jillian Tsai; Marcus V. Ortega Alves; Jane H. Zhou; Jennifer Drummond; Adel K. El-Naggar; Richard Gibbs; John N. Weinstein; David A. Wheeler; Jing Wang; Mitchell J. Frederick; Jeffrey N. Myers
VEGF/VEGFR-2 Upregulates EZH2 Expression in Lung Adenocarcinoma Cells and EZH2 Depletion Enhances the Response to Platinum-Based and VEGFR-2–Targeted Therapy
Erick Riquelme; Milind Suraokar; Carmen Behrens; Heather Y. Lin; Luc Girard; Monique B. Nilsson; George Simon; Jing Wang; Kevin R. Coombes; J. Jack Lee; Waun Ki Hong; John Heymach; John D. Minna; Ignacio I. Wistuba
Influence of Biospecimen Variables on Proteomic Biomarkers in Breast Cancer
Funda Meric-Bernstam; Argun Akcakanat; Huiqin Chen; Aysegul Sahin; Emily Tarco; Selin Carkaci; Beatriz E. Adrada; Gopal Singh; Kim-Anh Do; Zerzhinski M. Garces; Elizabeth Mittendorf; Gildy Babiera; Isabelle Bedrosian; Rosa Hwang; Savitri Krishnamurthy; William F. Symmans; Ana Maria Gonzalez-Angulo; Gordon B. Mills
FANCD2 Is a Potential Therapeutic Target and Biomarker in Alveolar Rhabdomyosarcoma Harboring the PAX3–FOXO1 Fusion Gene
Mamata Singh; Justin M. Leasure; Christopher Chronowski; Brian Geier; Kathryn Bondra; Wenrui Duan; Lauren A. Hensley; Miguel Villalona-Calero; Ning Li; Anthony M. Vergis; Raushan T. Kurmasheva; Changxian Shen; Gary Woods; Nikhil Sebastian; Denise Fabian; Rita Kaplon; Sue Hammond; Kamalakannan Palanichamy; Arnab Chakravarti; Peter J. Houghton
Correction
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